Histopathological assessment of the microscopic activity in inflammatory bowel diseases:What are we looking for?

作     者：Ondrej Fabian Lukas Bajer 

作者机构：Clinical and Transplant Pathology CentreInstitute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Pathology and Molecular Medicine3rd Faculty of MedicineCharles University and Thomayer HospitalPrague 14059Czech Republic Hepatogastroenterology DepartmentInstitute for Clinical and Experimental MedicinePrague 14021Czech Republic Institute of MicrobiologyCzech Academy of SciencesPrague 14220Czech Republic 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第36期

页      面：5300-5312页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Ministry of Health of the Czech Republic No. NV18-09-00493 and No. NU21J-06-00027 

主　　题：Crohn’s disease Microscopy Predictor Score Ulcerative colitis 

摘      要：Advances in diagnostics of inflammatory bowel diseases(IBD)and improved treatment strategies allowed the establishment of new therapeutic ***,it is desirable not only to cease clinical symptoms,but mainly to achieve endoscopic remission,a macroscopic normalization of the bowel ***,up to one-third of IBD patients in remission exhibit persisting microscopic activity of the *** evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse,surgical intervention,need for therapy escalation,or development of colorectal *** proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been ***,a majority of them have not been validated and no scoring index became a part of the routine bioptic *** review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD,describes the most commonly used scoring indices for Crohn s disease and ulcerative colitis,and comments on current limitations and unresolved issues.