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Scarcity events analysis in adequacy studies using CN2 rule mining

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能源与人工智能(英文) 2022年第2期8卷 116-123页

作者： fabian Heymann Ricardo Bessa Mario Liebensteiner Konstantinos Parginos Juan Carlos Martin Hinojar Pablo Duenas Center for Power and Energy Systems INESC TEC Porto Portugal School of Business Economics and Society Friedrich-Alexander-Universitat Erlangen-Nuremberg NurembergGermany System Development ENTSO-E Brussels Belgium MIT Energy Initiative Massachusetts Institute of Technology Cambridge(MA) United States PERSEE Mines ParisTech

Dealing with scarcity events is nowadays gaining relevance in electricity market studies, as traditionally predictable generation and consumption patterns are fading. Policymakers and system planners use therefore adequacy studies to a) understand if the current market design will attract sufficient generation capacity to meet electricity demand in the future and b) to comprehend what drives system inadequacy or resource scarcity when future scenarios lack adequate capacity. This work addressed the latter and showcases a first in-its-kind rulebased methodology that filters scarcity events from a large set of electricity market simulations. In this proof-of-concept, a rule-mining algorithm is applied to outputs from ENTSO-E’s Pan-European electricity market model, which is run for 700 model scenarios, each covering 8760 time steps. The developed methodology shows how to unveil potential reasons behind scarcity events in an automated, interpretable, and scalable manner.

关键词： Electricity markets Data mining Security of supply Renewable energy Interpretability

In vitro Cyto and Blood Compatibility of Titanium Containing Diamond-Like Carbon Prepared by Hybrid Sputtering Method

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Plasma Science and Technology 2012年第9期14卷 829-836页

作者： Krishnasamy NAVANEETHA PANDIYARAJ Jan HEEG Andreas LAMPKA fabian JUNGE Torsten BARFELS Marion WIENECKE Young Ha RHEE Hyoung Woo KIM Department of Physics Sri Shakthi Institute of Engineering and Technology Institute of Surface and Thin Film Technology Hochschule WismarGermany Department of Microbiology College of Bioscience&BiotechnologyChungnam National University

In recent years, diamond-like carbon films （DLC） have been given more attention in research in the biomedical industry due to their potential application as surface coating on biomedical materials such as metals and polymer substrates. There are many ways to prepare metal containing DLC films deposited on polymeric film substrates, such as coatings from car- bonaceous precursors and some means that incorporate other elements. In this study, we in- vestigated both the surface and biocompatible properties of titanium containing DLC （Ti-DLC） films. The Ti-DLC films were prepared on the surface of poly （ethylene terephthalate）（PET） film as a function of the deposition power level using reactive sputtering technique. The films＇ hydrophilicity was studied by contact angle and surface energy tests. Their surface morphology was studied by scanning electron microscopy （SEM） and atomic force microscopy （AFM）. Their elemental chemical composition was analyzed using energy dispersive X-spectra （EDX） and X-ray photoelectron spectroscopy （XPS）. Their blood and cell compatibility was studied by in vitro tests, including tests on platelet adhesion, thrombus formation, whole blood clotting time and osteoblast cell compatibility. Significant changes in the morphological and chemical composition of the Ti-DLC films were observed and found to be a function of the deposition level. These morphological and chemical changes reduced the interfacial tension between Ti-DLC and blood proteins as well as resisted the adhesion and activation of platelets on the surface of the Ti-DLC films. The cell compatibility results exhibited significant growth of osteoblast cells on the surface of Ti incorporated DLC film compared with that of DLC film surface.

关键词： Ti-DLC hybrid reactive sputtering technique surface analysis cyto and blood compatibility

Variation-aware fault modeling

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Science China(Information Sciences) 2011年第9期54卷 1813-1826页

作者： HOPSCH fabian BECKER Bernd HELLEBRAND Sybille POLIAN Ilia STRAUBE Bernd VERMEIREN Wolfgang WUNDERLICH Hans-Joachim Fraunhofer IIS/EAS University of Freiburg University of Paderborn University of Passau University of Stuttgart

To achieve a high product quality for nano-scale systems,both realistic defect mechanisms and process variations must be taken into *** existing approaches for variation-aware digital testing either restrict themselves to special classes of defects or assume given probability distributions to model variabilities,the proposed approach combines defect-oriented testing with statistical library *** uses Monte Carlo simulations at electrical level to extract delay distributions of cells in the presence of defects and for the defect-free *** allows distinguishing the effects of process variations on the cell delay from defect-induced cell delays under process *** provide a suitable interface for test algorithms at higher levels of abstraction,the distributions are represented as histograms and stored in a histogram data base (HDB).Thus,the computationally expensive defect analysis needs to be performed only once as a preprocessing step for library characterization,and statistical test algorithms do not require any low level information beyond the *** generation of the HDB is demonstrated for primitive cells in 45 nm technology.

关键词： process variations test methods statistical test histogram data base

A New Statistical Tool： Scalar Score Function

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Computer Technology and Application 2011年第2期2卷 109-116页

作者： Zdenek fabian Institute of Computer Science Academy of Sciences CR Pod Vod6renskou vY2i 2 Prague 182 00 Czech Republic

The basic inference function of mathematical statistics, the score function, is a vector function. The author has introduced the scalar score, a scalar inference function, which reflects main features of a continuous probability distribution and which is simple. Its simplicity makes it possible to introduce new relevant numerical characteristics of continuous distributions. The t-mean and score variance are descriptions of distributions without the drawbacks of the mean and variance, which may not exist even in cases of regular distributions. Their sample counterparts appear to be alternative descriptions of the observed data. The scalar score itself appears to be a new mathematical tool, which could be used in solving traditional statistical problems for models far from the normal one, skewed and heavy-tailed.

关键词：分布分数统计工具标量数字特征数理统计评价函数向量函数概率分布

ME0X1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

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Signal Transduction and Targeted Therapy 2022年第1期7卷 19-21页

作者： David Schumacher fabian Peisker Rafael Kramann nstitute of Experimental Medicine and Systems Biology University Hospital AachenRWTH Aachen UniversityAachenGermany Department of Anesthesiology University Hospital AachenRWTH Aachen UniversityAachenGermany Department of Internal Medicine Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands Department of Nephrology and Clinical Immunology University Hospital AachenRWTH Aachen UniversityAachenGermany

Sin gle-cell genomic tech no logy has bee n used to ide ntify MEOX1 as a potential cell-specific,druggable target in cardiac *** this effect,a Iandmark study was recently published in Nature by Alexanian and colleagues.^(1) Fibrosis is a comm on resp onse to chronic repetitive injury to vital organs and considered an important therapeutic target to slow dow n,in hi bit,or reverse progressio n of orga n *** there is broad interest in developing novel antifibrotic therapeutics,currently,only nintedanib and pirfenidone have been approved to treat fibrosis for one disease entity;idiopathic pulmonary fibrosis.^(2)

关键词： cardiac organs drug

Open wedge re-correction high tibial osteotomy in an elderly patient with a varus angulated non-united dome-shaped high tibial osteotomy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1054-1058页

作者： Steffen SCHROTER Lukas KONSTANTINIDIS Tobias M. KRAUS fabian STUBY Ulrich STOCKLE Thomas FREUDE Department of Traumatology and Reconstructive Surgery BG Trauma Center Department of Orthopaedics and Trauma Surgery University Medical Centre Freiburg

The high tibial osteotomy(HTO)is a wellestablished and commonly used treatment for younger and active patients with a medial unicompartmental osteoarthritis of the knee and varus *** aim of this technique is to shift the load to a functional lateral compartment in order to delay total knee *** dome-shaped HTO was introduced by Blaimont et al.(1975)and later popularized by Maquet(1980).Out of 118 cases,96 cases of overcorrection,13 cases of undercorrection,and 9 cases

关键词： HTO MPTA high

In vitro Evaluation with 5SBF of Alloy ASTM F75 Thermally Treated with Wollastonite

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Journal of Wuhan University of Technology(Materials Science) 2016年第3期31卷 487-490页

作者： MUNIZ Rodrigo ORTIZ Juan LUNA Jesus MARTINEZ Jesus RODRIGEZ Nelly HERNANDEZ Marco OROZCO Pilar EQUIHUA fabian Faculty of Engineering Autonomous University of CoahuilaCUSaltilloMexico Department of Metal Mechanics Technological Institute of SaltilloMexico Faculty of Engineering Mechanical and Electrical Autonomous University of Nuevo LeonMexico Faculty of Engineering Autonomous University of Zacatecas Faculty of Mechanical and Electrical Engineering Autonomous University of Coahuila North UnitMonclovaMexico

Samples of a cobalt-based alloy that underwent a surface treatment were evaluated. The samples, which were obtained by casting alloy ASTM F 75, were ground and polished on one side until a mirror finish was obtained. The samples were encapsulated in wollastonite （W） using uniaxial pressure, treated at 1 220 ~C for 1 h and subsequently tempered in water. The characterisation of the sample indicated that part of the ceramic encapsulating material was mechanically incorporated on the metallic surface by growth of the oxide layer of the alloy. After thermal treatment, a series of specimens were submerged in a solution with 5-fold simulated body fluid （5SBF） for 3, 5 and 21 days. Characterisation by scanning electron microscopy （SEM）, energy dispersive spectroscopy （EDS） and X-ray diffraction （XRD） indicated nucleation and growth of a homogenous layer of apatite, beginning on the third day when the sample was submerged.

关键词： cobalt-based alloy wollastonite 5SBF apatite.

Preparation and application of highly porous aerogel-based bioactive materials in dentistry

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Frontiers of Materials Science 2014年第1期8卷 46-52页

作者： Andrea KUTTOR Melinda SZALOKI TLinde RENTE Farkas KERENYI Jozsef BAKO Istvan fabian Istvan LAZAR Attila JENEI Csaba HEGEDUES Department of Prosthetic Dentistry and Biomaterials Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Aerogel Research Group Department of Inorganic and Analytical Chemistry Faculty of Science University of Debrecen 4010 Debrecen Hungary Department of Dental Biochemistry Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Department of Biophysics and Cell Biology Faculty of Medicine University of Debrecen 4012 Debrecen Hungary

In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and *** phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in themesoporous region with a maximum pore diameter of 7,4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scant electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy.

关键词： aerogel sol-gel technique bioactive matedal SAOS-2 cell

Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

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Journal of Sport and Health Science 2020年第6期9卷 595-603页

作者： Daniel A.Bizjak fabian Tomschi Gunnar Bales Elie Nader Marc Romana Philippe Connes Wilhelm Bloch Marijke Grau Department of Molecular and Cellular Sports Medicine German Sport University CologneCologne 50933Germany Laboratoire LIBM EA7424-Equipe“Biologie Vasculaire et du Globule Rouge” UniversitéClaude Bernard Lyon 1Villeurbanne 69100France Laboratoire d’Excellence du Globule Rouge GR-Ex Paris 75015France Universitédes Antilles InsermUnitéBiologie Intégrée du Globule RougeCHU de PointeàPitrePointe_a PitreGuadeloupe 97157France Institut Universitaire de France Paris 75231France The German Research Centre of Elite Sport German Sport University CologneCologne 50933Germany

Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related ***:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the *** from each participant were fractioned according to density and age into 4 RBC *** were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine *** and plasma nitrite levels were measured as indicators of nitric oxide ***:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after *** relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction *** externalization and RBC-derived microparticles *** deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old ***:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation.

关键词： Cellular adaptation Hemorheology Nitric oxide Performance RBC physiology and aging