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中华预防医学杂志 2011年第4期45卷 370-370页

作者： fabbri m Bottoni A Shimizu m 李海山不详中国检验检疫科学研究院化学品中心

染色体异常（13q、17p、11q缺失）与慢性淋巴细胞白咖病（CLL）的发生和再发有关，是一种常见的发病途径，但通过何种染色体异常影响CLL的发牛和结局的分子机制是未知的。

关键词：慢性淋巴细胞白血病蛋白p53 发病染色体异常环路反馈肿瘤分子机制

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心力衰竭患者的社会孤立感知及预后

中华高血压杂志 2018年第7期26卷 617-617页

作者：刘青叶鹏 manemann Sm Chamberlain Am Roger VL Griffin Jm Boyd Cm Cudjoe TKm Jensen D Weston SA fabbri m Jiang R Finney Rutten LJ

已有研究表明,患者感知到的社会孤立感对健康预后有负面影响,尤其是在老年人中。然而,这种关系在心力衰竭患者中尚未得到充分研究。Sheila等获取2013年1月1日至2015年3月31日期间,来自明尼苏达州东南部的11个州的心力衰竭[首次国际疾病... 详细信息

已有研究表明,患者感知到的社会孤立感对健康预后有负面影响,尤其是在老年人中。然而,这种关系在心力衰竭患者中尚未得到充分研究。Sheila等获取2013年1月1日至2015年3月31日期间,来自明尼苏达州东南部的11个州的心力衰竭[首次国际疾病分类第9次修订版（ICD-9）代码为428]患者（n=3867）资料,应用患者报告的结果测量信息系统（the patient-reported outcomes measurement information system,PROmIS）-社会孤立简表4a v2.0进行前瞻性研究，调查患者对社会孤立感的感知情况及其与不良预后发生的关系。

关键词：心力衰竭患者不良预后孤立感知国际疾病分类明尼苏达州信息系统老年人

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慢性阻塞性肺疾病新药:罗氟司特

中国处方药 2010年第11期9卷 58-页

作者： Leonardo m.fabbri Bianca Beghé Uma Yasothan 梁伟

慢性阻塞性肺疾病(oopd)是发生在气道和肺部的慢性炎症性疾病,以气道进行性受限为特征,不能完全逆转.主要发病原因是吸烟,职业和环境污染也有一定的作用.oopd有一些慢性共患病,比如心力衰竭和代谢综合征,对oopd的临床表现和进展也有一... 详细信息

慢性阻塞性肺疾病(oopd)是发生在气道和肺部的慢性炎症性疾病,以气道进行性受限为特征,不能完全逆转.主要发病原因是吸烟,职业和环境污染也有一定的作用.oopd有一些慢性共患病,比如心力衰竭和代谢综合征,对oopd的临床表现和进展也有一定的影响.

关键词：慢性阻塞性肺疾病新药慢性炎症性疾病心力衰竭气道临床表现环境污染发病原因共患病综合职业吸烟特征肺部代谢

Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin

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Journal of Environmental Sciences 2013年第7期25卷 1408-1418页

作者： Gabriela V. Aguirre-martínez Sara Buratti Elena fabbri Angel T. DelValls m. Laura martín-Díaz Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain Andalusian Center for marine Science and Technology (CACYTmAR) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability （LmS） has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LmS in Ruditapes philippinarum haemolymph using the neutral red retention assay （NRRA）. Clamswere exposed in laboratory conditions to caffeine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, carbamazepine and novobiocin （both at 0.1, 1, 10, 50 μg/L） for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations （p 〈 0.05）（caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L）, compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status （retention time 〈45 min）, significantlyworse than controls （96 min）（p 〈 0.05）. The predicted no environmental effect concentration （PNEC） results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. measurement of the alteration of LmS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker.

关键词： neutral red pharmaceuticals bioassay haemolymph bivalves health status manila clam

Olfactory receptor gene evolution is unusually rapid across Tetrapoda and outpaces chemosensory phenotypic change

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Current Zoology 2020年第5期66卷 505-514页

作者： Laurel R.Yohe matteo fabbri michael Hanson Bhart-Anjan S.Bhullar Department of Earth&Planetary Science Peabody Museum of Natural HistoryYale UniversityNew HavenCT06511USA

Chemosensation is the most ubiquitous sense in animals,enacted by the products of complex gene families that detect environmental chemical cues and larger-scale sensory structures that process these *** there is a general conception that olfactory receptor(OR)genes evolve rapidly,the universality of this phenomenon across vertebrates,and its magnitude,are *** supposed correlation between molecular rates of chemosensory evolution and phenotypic diversity of chemosensory systems is largely *** combine comparative genomics and sensory morphology to test whether OR genes and olfactory phenotypic traits evolve at faster rates than other genes or *** published genomes,we identified ORs in 21 tetrapods,including amphibia ns,reptiles,birds,and mammals and compared their rates of evolution to those of orthologous non-OR protein-coding *** found that,for all clades investigated,most OR genes evolve nearly an order of magnitude faster than other protein-coding genes,with many OR genes showing signatures of diversifying selection across nearly all taxa in this *** rapid rate of evolution suggests that chemoreceptor genes are in "evolutionary overdrive,"perhaps evolving in response to the ever-changing chemical space of the *** obtain complementary morphological data,we stained whole fixed specimens with iodine,μCT-scanned the specimens,and digitally segmented chemosensory and nonchemosensory brain *** then estimated phenotypic variation within traits and among *** we found considerable variation in chemosensory structures,they were no more diverse than nonchemosensory *** suggest chemoreceptor genes evolve quickly in reflection of an ever-changing chemical space,whereas chemosensory phe no types and processing regions are more conserved because they use a standardized or constrained architecture to receive and process a range of chemical cues.

关键词： chemosensation diversifying selection olfaction olfactory bulb olfactory receptor tetrapod

Is the pancreas affected in patients with septic shock?——a prospective study

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 191-195页

作者： Raffaele Pezzilli Alessandra Barassi Andrea Imbrogno Dario fabbri Antonina Pigna Antonio m.morselli-Labate Roberto Corinaldesi Gianvico melzi d'Eril Department of Digestive Diseases and Internal medicine Sant'Orsola-malpighi Hospital Alma Mater Studiorum University of Bologna Department of medicine Surgery and OdontoiatricsUniversity of Milan Department of Surgery and Anesthesiology Sant'Orsola-malpighi Hospital Alma Mater Studiorum University of Bologna

BACKGROUND:Hyperamylasemia can be observed anecdotally during the course of severe sepsis or septic *** study aimed to investigate the possibility of pancreatic involvement in patients with septic shock using serum pancreatic enzyme determinations and imaging techniques in 21 consecutive patients with septic shock and 21 healthy subjects as controls. mETHODS:The serum activity of pancreatic amylase and lipase was assayed initially in all subjects and 24 and 48 hours after the initial observation in the 21 patients with septic shock All patients also underwent radiological examination to detect pancreatic abnormalities. RESULTS:The serum activity of pancreatic amylase was significantly higher in the 21 patients with septic shock than in the 21 control subjects during the study period while the serum activity of lipase was similar to that of the control *** and lipase serum activity did not significantly changed throughout the study period in the 21 patients with septic *** of the patients with pancreatic hyperenzymemia had clinical signs or morphological alterations compatible with acute pancreatitis CONCLUSION:The presence of pancreatic hyperenzymemia in septic shock patients is not a biochemical manifestation of acute pancreatic damage,and the management of these patients should be dependent on the clinical situation and not merely the biochemical results.

关键词： amylase lipase clinical medicine shock sepsis systemic inflammatory response syndrome

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温、湿控制生土三轴试验装置的研制与应用

岩土力学 2022年第8期43卷 2327-2336页

作者：徐龙飞翁效林 WONG Henry fabbri Antonin 朱谭谭长安大学公路学院陕西西安710064 里昂大学国立国家公共工程学院里昂法国69000

为研究温度和湿度对生土力学特性的影响,自主研发了温、湿控制生土三轴试验装置。基于常规三轴压力室,借助电涡流非接触位移传感器搭建高精度变形测试系统,实现环境变化下生土应变的连续性捕捉。针对法国里昂地区生土材料,开展不同湿度... 详细信息

为研究温度和湿度对生土力学特性的影响,自主研发了温、湿控制生土三轴试验装置。基于常规三轴压力室,借助电涡流非接触位移传感器搭建高精度变形测试系统,实现环境变化下生土应变的连续性捕捉。针对法国里昂地区生土材料,开展不同湿度、围压和温度作用下生土三轴循环加载-卸载试验,实测生土在不同工况下的三轴剪切破坏强度、应力-应变曲线及体积变化,通过分析滞回曲线,研究弹性模量和残余应变随应力水平的演化特征;同时进行了变湿度条件下生土气态水迁移效应试验。结果表明:该装置能够稳定控制生土环境变化条件,模拟再现生土单元体实际服役工况,精确测量试验过程中生土力学指标及湿度、温度与压力等环境指标,初步检验了装置性能的可靠性和准确性。相关成果可为荷载-湿-热耦合作用下非饱和生土变形机制的研究与本构模型的建立提供技术支撑。

关键词：生土温、湿控制三轴试验循环加载-卸载力学特性

Patient-reported outcomes in subjects with neuroendocrine tumors of the pancreas

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World Journal of Gastroenterology 2009年第40期15卷 5067-5073页

作者： Raffaele Pezzilli Davide Campana Antonio m morselli-Labate maria C fabbri Emilio Brocchi Paola Tomassetti Department of Digestive Diseases and Internal medicine Sant'Orsola-Malpighi HospitalUniversity of Bologna

AIm: To assess the patient-reported outcomes (PROs) of pancreatic neuroendocrine tumor (PNET) patients. mETHODS: Fifty-one consecutive patients (21 male, 30 female, 61.0 ± 10.3 years) with proven PNETs were studied. An SF-12 questionnaire capable of exploring the physical (PCS) and mental (mCS) aspects of daily life was used. Four questionnaires were also used [12 items General Health Questionnaire (GHQ-12) for non-psychotic psychiatric disorders, State Trait AnxietyInventory (STAI) Y-1 and Y-2 for anxiety and BDI-for depressive symptoms] to explore the psychological aspects of the disease. Forty-four sex-and age-matched Italian normative subjects were included and evaluated using the SF-12, STAI Y-1 and Y-2 ***: Seven patients refused to participate to the study; they were clinically similar to the 44 participants who agreed to complete the questionnaires. PNET patients had a PCS score (44.7 ± 11.0) were not signifi cantly different from the norms (46.1 ± 9.9, P = 0.610), whereas the mCS score was signifi cantly lower in patients (42.4 ± 13.0) as compared to the norms (48.2 ± 9.8, P = 0.036). GHQ-12 identified 11 patients (25.0%) as having non-psychotic psychiatric *** STAI scores were similar in the patients and inthe normative population. Finally, BDI-identifiedeight patients (18.2%) with moderate depression and 9 (20.5%) with mild depression whereas 27 patients (61.4%) had no ***: The PNET patients had a good physical but an impaired mental component of their quality of life; in addition, mild or moderate depressive symptoms are present in about 40% of PNET patients.

关键词： Endocrine gland neoplasms Pancreatic neoplasms Somatostatin Quality of life Quality indicators Health care

Optimization with Genetic Algorithms of PVT System Global Efficiency

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Journal of Energy and Power Engineering 2012年第7期6卷 1035-1041页

作者： Giampietro fabbri matteo Greppi marco Lorenzini Department of Energy Nuclear and Environmental Protection Bologna University Bologna 40136 Italy Faculty of Engineering Bologna University Forli 47100 Italy

PV （photovoltaic） solar panels generally produce electricity in the 6% to 12% efficiency range, the rest is being dissipated in thermal losses. To recover this amount, hybrid photovoltaic thermal systems （PV/T） have been devised. These are devices that simultaneously convert solar energy into electricity and heat. It is thus interesting to study the PV/T system as part of a closed loop single phase water CDU （coolant distribution unit） in laminar forced convection. In particular, the analysis was conducted on the optimal cooling performance of the thermal part, testing polynomial channel profiles of varying order （from zero to fourth） for channels of a real industrial module heat sink, under the following conditions： ideal flux of 1,000 W/m2 on one side, insulation on the opposite side, periodic conditions on the remaining sides, fully developed thermal and velocity profile in laminar flow of water. Through the use of a genetic algorithm, we have optimized the shape of the channel＇s sidewalls in terms of heat transfer maximization. In terms of Nusselt number, results show that fourth order profiles are the most efficient. When limits to allowable pressure loss and module weight are introduced, these bring generally to a lower efficiency of the system than the unconstrained case.

关键词： Fins genetic alghoritms multi objective optimization cooling PVT systems.

变湿度条件下生土材料持水特性及气态水迁移效应试验研究

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岩土力学 2021年第9期42卷 2489-2498页

作者：徐龙飞翁效林张爱军赵高文 WONG Henry fabbri Antonin 长安大学公路学院陕西西安710064 里昂大学国立国家公共工程学院法国里昂69000 西北农林科技大学水利与建筑工程学院陕西杨陵712100

湿度变化诱发气态水迁移,进而对生土的变形和强度产生重要影响。研究变湿度条件下生土材料持水特性及气态水迁移效应是揭示服役期生土结构病害孕育机制的关键。针对法国里昂地区两种生土建筑材料,采用两种试验方法,即饱和盐溶液法和动... 详细信息

湿度变化诱发气态水迁移,进而对生土的变形和强度产生重要影响。研究变湿度条件下生土材料持水特性及气态水迁移效应是揭示服役期生土结构病害孕育机制的关键。针对法国里昂地区两种生土建筑材料,采用两种试验方法,即饱和盐溶液法和动态水蒸气吸附法开展等温吸湿试验,分析生土持水特性;通过气态水迁移效应试验,探究生土试样底部进气端和顶部出气端的湿度及水气相对压力变化规律,并对气态水迁移过程中生土试样变形进行分析。试验结果表明:两种方法测得生土吸湿曲线较为一致,可分为单层吸附阶段、多层吸附阶段和毛细凝聚阶段,并且土体持水能力随黏土颗粒活性增加而增强;在气态水迁移效应试验中,生土材料持水特性对出气端湿度与进气端水气相对压力影响明显,生土试样发生膨胀变形。

关键词：生土持水特性气态水迁移等温吸湿试验膨胀变形