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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： zi-fa Zhang Shu-Ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:GEPIA database showed that NUDT5 expression was significantly increased in GBM *** the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM ***,TRIM47 was highly expressed in GBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for GMB treatment.

关键词： Glioblastoma multiforme NUDT5 TRIM47 Growth Metastasis Warburg effect

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-fa Nie Chen-Yang Wang Lei Li Cheng Yang zi-Ming Zhu Jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensity-

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

Forecast of cosmological constraints with superluminous supernovae from the Chinese Space Station Telescope

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Xuan-Dong Jia Jian-Ping Hu fa-Yin Wang zi-Gao Dai School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education Department of Astronomy University of Science and Technology of China

Superluminous supernovae（SLSNe） are a class of intense celestial events that can be standardized for measuring cosmological parameters, bridging the gap between type Ia supernovae and the cosmic microwave background. In this work, we discuss the cosmological applications of SLSNe from the Chinese Space Station Telescope（CSST）. Our estimation suggests that SLSNe rate is biased tracing the cosmic star formation rate, exhibiting a factor of（1 + z）1.2. We futher predict that CSST is poised to observe ～ 360 SLSNe in the 10 square degrees ultra-deep field survey within a span of 2.5 years. A stringent constraint on cosmological parameters can be derived from their peak-color relationship. CSST is anticipated to uncover a substantial number of SLSNe, contributing to a deeper understanding of their central engines and shedding light on the nature of dark energy at high redshifts.

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Rapid progress of an iris metastasis from esophageal cancer:a case report and review of literature

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1557-1567页

作者： Meng Xie Xing-Hua Wang Jun-Jie Yang zi-Xuan Su Jia-Hui Huang Peng-Cheng Li fa-Gang Jiang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic *** emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic *** treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and *** challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.

关键词： iris metastasis esophageal cancer positron emission tomography-computed tomography review

Scintillation Arc from FRB 20220912A

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： zi-Wei Wu Robert AMain Wei-Wei Zhu Bing Zhang Peng Jiang Jia-Rui Niu Jin-Lin Han Di Li Ke-Jia Lee Dong-zi Li Yuan-Pei Yang fa-Yin Wang Rui Luo Pei Wang Chen-Hui Niu Heng Xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang Yi Feng De-Jiang Zhou Yong-Hua Xu Can-Min Deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-Planck-Institut für Radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA CAS Key Laboratory of faST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa Department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy Research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China CSIRO Space and Astronomy Epping 1710Australia Department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi Key Laboratory for Relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fast radio burst(FRB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Aperture Spherical Radio Telescope(faST).We detect a scintillation arc in the FRB’s secondary spectrum,which describes the power in terms of the scattered FRB signals’time delay and Doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis favors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FRBs and in our Galaxy.

关键词： fast radio burst scintillation FRB 20220912A

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人工磁场下各向异性偶极玻色气体的量子相变

物理学报 2024年第13期73卷 73-84页

作者：高吉明狄国文鱼自发唐荣安徐红萍薛具奎西北师范大学物理与电子工程学院兰州730070

光晶格中的冷原子系统是实现量子模拟和量子计算的有效平台之一,其相变特性的研究有助于系统中新奇量子态物理机制的探索和实验观测.本文利用朗道相变理论和非均匀平均场方法,研究了人工磁场下光晶格中各向异性偶极玻色气体的相变,得到... 详细信息

光晶格中的冷原子系统是实现量子模拟和量子计算的有效平台之一,其相变特性的研究有助于系统中新奇量子态物理机制的探索和实验观测.本文利用朗道相变理论和非均匀平均场方法,研究了人工磁场下光晶格中各向异性偶极玻色气体的相变,得到了系统不可压缩相(Mott绝缘相、棋盘或条纹密度波相)-可压缩相(超流、棋盘或条纹超固相)的解析相变条件,给出了系统的完整相图.有趣的是,各向异性偶极相互作用会使得系统中的棋盘密度波相和棋盘超固相变为条纹密度波相和条纹超固相,人工磁场会稳定绝缘相和超固相,使得绝缘相和超固相在相图中的存在区域变大.此外,引入外加谐振势后发现系统中的不同量子相可以共存.

关键词：光晶格各向异性偶极相互作用人工磁场超固相

我国重点地区臭氧变化特征及与气象要素的关系

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中国环境科学 2024年第4期44卷 1894-1904页

作者：米艺华杜惠云李杰杨文夷王涛王自发中国科学院大气物理研究所大气边界层物理和大气化学国家重点实验室北京100029 中国科学院大学北京100049

利用2015~2019年历史数据,分析我国臭氧(O_(3))时间、空间变化特征,结合同期气象数据研究重点区域臭氧污染与气象要素的关系.结果表明:2015~2019年我国O_(3)浓度整体呈上升趋势,全国O_(3)浓度年均值由83.8μg/m3增至92.4μg/m^(3).O_(3... 详细信息

利用2015~2019年历史数据,分析我国臭氧(O_(3))时间、空间变化特征,结合同期气象数据研究重点区域臭氧污染与气象要素的关系.结果表明:2015~2019年我国O_(3)浓度整体呈上升趋势,全国O_(3)浓度年均值由83.8μg/m3增至92.4μg/m^(3).O_(3)浓度变化主要呈"双峰型",2017年呈"单峰型".5~9月为O_(3)浓度的高值时段.1~3月、10~11月O_(3)浓度波动比4~9月大.我国O_(3)浓度呈"东高西低"的空间分布特征,高值区主要集中在京津冀地区.O_(3)浓度与日照时数呈正相关,与最高温度呈正相关,与相对湿度呈负相关.气象要素对O_(3)浓度的影响存在地区差异,大部分地区O_(3)浓度与温度的正相关性较强(r>0.5),而青藏地区O_(3)浓度与温度呈负相关(-0.2

关键词：臭氧污染变化特征气象要素

通过聚阳离子取代策略实现压缩黄铜矿型硒化物[Rb3BaCl][In_(8)Se_(14)]以获得优异的非线性光学性能

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Science China Materials 2024年第6期67卷 2000-2007页

作者：吴帆陈文发吴子璇姜小明刘彬文郭国聪 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China Fujian College University of Chinese Academy of SciencesFuzhou 350002China

单价Ag+或Li+引入到类金刚石结构的MQ22-(M=Ga,In;Q=S,Se)阴离子基团中能合成出良好的二阶非线性光学(NLO)晶体材料.然而,这些晶体分别面临着较低的抗激光损伤阈值(LIDT)或二氧化硅易被腐蚀等缺点,严重限制了其在高功率激光应用中的实用... 详细信息

单价Ag+或Li+引入到类金刚石结构的MQ22-(M=Ga,In;Q=S,Se)阴离子基团中能合成出良好的二阶非线性光学(NLO)晶体材料.然而,这些晶体分别面临着较低的抗激光损伤阈值(LIDT)或二氧化硅易被腐蚀等缺点,严重限制了其在高功率激光应用中的实用性.在本研究中,基于类金刚石结构的ZnSe,我们采用[Se_(4)Zn_(13)]Se_(2)4→[ClRb_(3)Ba]Se_(24)非常规的聚阳离子取代策略,设计并合成了一种新型的盐包硫属化合物[Rb_(3)BaCl][In_(8)Se_(14)](1).化合物1属于压缩黄铜矿型硒化物并保持了与AgInSe_(2)相同的晶体对称性(I-42d空间群).值得注意的是,由于InSe_(4)四面体结构单元的平行排列,化合物1具有相位匹配的强二次谐波(SHG)响应(2.0倍于AgGaS_(2)@2.90μm).此外,聚阳离子[Rb_(3)BaCl]^(4+)的引入促进了光学带隙(2.02 eV)的增强,有效地避免了对2.09μm激光的双光子吸收;同时结合较低的热膨胀系数,使得化合物1表现出高的LIDT(3.2倍于AgGaS2@2.09μm).本研究验证了在类金刚石结构中进行聚阳离子取代的可行性,并成功获得了性能优异的中远红外NLO材料.

关键词： chalcogenide nonlinear optical material substitution strategy diamond-like structure structure-property relationship

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上海软X射线自由电子激光单脉冲成像定时的设计与实现

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物理学报 2024年第12期73卷 89-95页

作者：聂勇敢高梓宸佟亚军范家东刘功发江怀东中国科学技术大学国家同步辐射实验室合肥230029 上海科技大学大科学中心上海201210

上海软X射线自由电子激光装置(SXFEL)是我国首台X射线自由电子激光用户装置,目前建有2条波荡器线、2条光束线以及5个实验站.装置可提供2—15 nm波长(80—620 eV)的X射线脉冲,用于高时空分辨的前沿科学研究.利用XFEL高亮度、短脉冲和全... 详细信息

上海软X射线自由电子激光装置(SXFEL)是我国首台X射线自由电子激光用户装置,目前建有2条波荡器线、2条光束线以及5个实验站.装置可提供2—15 nm波长(80—620 eV)的X射线脉冲,用于高时空分辨的前沿科学研究.利用XFEL高亮度、短脉冲和全相干的特性实现单脉冲相干衍射成像,可以有效地减轻辐射损伤,提高图像的空间分辨率.SXFEL设计重复频率为50 Hz,实现单脉冲成像的关键在于通过定时系统能够精确地控制X射线脉冲到达样品点的时间,以确保只有一个脉冲被选中用于成像.同时,还需要与成像系统的触发进行同步,以确保成像系统在正确的时间采集X射线脉冲与样品作用后的图像.本文介绍了SXFEL单脉冲成像定时的设计与实现.通过单脉冲成像的结果表明该定时方案能满足在50 Hz的SXFEL开展单脉冲成像的需求.

关键词：相干X射线衍射成像 X射线自由电子激光单脉冲成像定时系统

海蓬子(Salicornia europaea)生态浮床对富营养化海水的净化效果研究

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生态与农村环境学报 2024年第4期40卷 548-555页

作者：罗梓峻李秋芬田文杰左涛陈聚法中国水产科学研究院黄海水产研究所山东青岛266071 上海海洋大学水产与生命学院上海201306

因陆源污染输入和沿岸养殖业发展,我国近岸和入海口海域富营养化严重。该研究利用海蓬子(Salicornia europaea)高耐盐碱性、潮汐带生长的特点,通过浮床栽培探究了其对富营养海水的净化效果。实验构建褐牙鲆(Paralichthys olivaceus)养... 详细信息

因陆源污染输入和沿岸养殖业发展,我国近岸和入海口海域富营养化严重。该研究利用海蓬子(Salicornia europaea)高耐盐碱性、潮汐带生长的特点,通过浮床栽培探究了其对富营养海水的净化效果。实验构建褐牙鲆(Paralichthys olivaceus)养殖池和浮床净化池的循环水净化系统,模拟持续污染的富营养化海水环境。通过在浮床上移植海蓬子幼苗,测定不同水体中氨氮(NH_(4)^(+)-N)、硝态氮(NO_(3)^(-)-N)、亚硝态氮(NO_(2)^(-)-N)和磷酸盐(PO_(4)^(3-)-P)浓度4种营养盐指标的变化情况及植物存活、生长状况,研究海蓬子的净化效果。实验结果表明,海蓬子对NH_(4)^(+)-N吸收效果显著(P<0.05),在12 h的水力停留时间下最高去除率为32.97%;对NO_(2)^(-)-N的净化效果显著(P<0.05),最高去除率为35.66%;对PO_(4)^(3-)-P和NO_(3)^(-)-N有去除效果,但不显著;浮床上的海蓬子存活率达93%以上,植株有明显生长,25 d总体长度增长12%,鲜重增加102%,干重增加83%。研究结果说明海蓬子可以作为生态浮床的工具植物,对近岸和入海口富营养化海水进行净化,为海洋生态环境保护提供技术支撑。

关键词：海蓬子生态浮床生境修复富营养化海水