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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-fa fan Ke Song Yuan-Guo Li Run-Ze Ye fang-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China national Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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基于EDAS和共识模型的动态概率语言多属性群决策方法

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控制与决策 2024年第4期39卷 1379-1386页

作者：张发明朱姝琪桂林电子科技大学商学院广西桂林541004

针对评价信息为概率语言术语且属性权重未知的多属性群决策问题,提出一种新的、基于离平均解距离(EDAS)和共识模型的概率语言多属性后悔理论群决策方法.首先,考虑到现实决策中决策者面对方案选择时会呈现“有限理性”的行为,将后悔理论... 详细信息

针对评价信息为概率语言术语且属性权重未知的多属性群决策问题,提出一种新的、基于离平均解距离(EDAS)和共识模型的概率语言多属性后悔理论群决策方法.首先,考虑到现实决策中决策者面对方案选择时会呈现“有限理性”的行为,将后悔理论融入群决策方法的研究中,通过计算决策者的后悔-欣喜值来度量其感知效用;其次,将EDAS方法与概率语言信息处理相结合用于方案排序,并基于最大化偏差法思想,给出一种概率语言多属性决策问题属性权重的确定方法,以得到初始解决方案;然后,对初始解决方案进行共识测度,进一步根据个人属性集得到个人方案集,通过共识模型的动态反馈调整,得到符合大多数决策者意愿的最终解决方案;最后,以共享自行车设计方案的选择为例对所提出方法进行验证,并通过对比分析说明方法的可行性和有效性.

关键词：共识模型后悔理论概率语言多属性群决策 EDAS方法属性权重

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Pay attention to the application of indocyanine green fluorescence imaging technology in laparoscopic liver cancer resection

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World Journal of Clinical Cases 2024年第23期12卷 5288-5293页

作者： Li-Min Kang Fu-Wei Zhang fa-Kun Yu Lei Xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

Traditional laparoscopic liver cancer resection faces challenges,such as difficultiesin tumor localization and accurate marking of liver segments,as well as theinability to provide real-time intraoperative *** approach falls shortof meeting the demands for precise and anatomical liver *** introductionof fluorescence imaging technology,particularly indocyanine green,hasdemonstrated significant advantages in visualizing bile ducts,tumor localization,segment staining,microscopic lesion display,margin examination,and lymphnode *** technology addresses the inherent limitations oftraditional laparoscopy,which lacks direct tactile feedback,and is increasinglybecoming the standard in laparoscopic *** by fluorescenceimaging technology,laparoscopic liver cancer resection is poised to become thepredominant technique for liver tumor removal,enhancing the accuracy,safetyand efficiency of the procedure.

关键词： Indocyanine green Fluorescence imaging technology Laparoscopy Hepatectomy Liver tumor

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Groundwater and environmental challenges in Asia

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Journal of Groundwater Science and Engineering 2024年第2期12卷 223-236页

作者： Yan-pei Cheng fa-wang Zhang Hua Dong Xue-ru Wen Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of natural ResourcesZhengding 050803HebeiChina Center for Hydrogeology and Environmental Geology Survey China Geological SurveyBaoding 071051HebeiChina

Asia stands out as the most populous and geographically diverse region *** pressing issues of water resource development and the resulting ecological impacts are exacerbated by the region's rapid population growth and economic ***,a vital source of water in Asia,faces significant disparities in distribution and suffers from unsustainable exploitation *** study applies groundwater system theory and categorizes Asia into 11 primary groundwater systems and 36 secondary ones,based on intercontinental geological structures,climate,terrain,and hydrogeological *** of the end of 2010,Asia's assessed groundwater resources totalled 4.677×10^(9) m^(3)/a,with exploitable resources amounting to 3.274×10^(9) m^(3)/*** considering the geological environmental impacts of groundwater development and the distinctive characteristics of terrain and landforms,six categories of effect zones with varying distribution patterns are *** current research on Asia's groundwater resources,environmental dynamics,and human impacts aims to provide a theoretical foundation for sustainable groundwater management and environmental conservation in the region.

关键词： Asia Groundwater resources Groundwater quality Ecological environment Environmental impacts

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Construction of Electrochemical Biosensors based on the CRISPR/Cas12 System for Applications

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Materials Sciences and Applications 2024年第9期15卷 285-304页

作者： Hongqu Liang Liu Huang Peng Yan fa Huang Hongchao Zhang Qisheng Luo Department of Neurosureery Affiliated Hospital of Youjiang Medical University for Nationalities Baise China Graduate School Youjiang Medical University for Nationalities Baise China

The current major issue in improving detection sensitivity and selectivity is to design an electrochemical sensor that does not require PCR amplification for nucleic acid identification and measurement. Because of their great sensitivity, precision, and simplicity of downsizing, electrochemical biosensors have emerged as a research hotspot in the field of nucleic acid detection. The CRISPR/Cas12 system has emerged as a potent tool for nucleic acid detection due to its powerful cleavage activity and selectivity. Specific electrode changes combined with the CRISPR/Cas12 system can greatly improve the performance of electrochemical biosensors. In this study, the design concepts of electrochemical biosensors based on the CRISPR/Cas12 system and their application advancements in nucleic acid detection are discussed.

关键词： CRISPR Cas12 Electrochemical Biosensor

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中国城市旅游业绿色发展效率的时空分异及空间溢出效应分析

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长江流域资源与环境 2024年第1期33卷 1-13页

作者：曹开军龙顺发新疆大学旅游学院新疆乌鲁木齐830046 新疆历史文化旅游可持续发展重点实验室新疆乌鲁木齐830046

绿色发展是旅游业可持续发展的应有之义,旅游业绿色发展效率是衡量旅游业绿色发展水平的重要标准。综合运用Super-SBM-Undesirable模型、Markov链、Dagum基尼系数、空间杜宾模型等多种方法分析2010~2019年中国城市旅游业绿色发展效率的... 详细信息

绿色发展是旅游业可持续发展的应有之义,旅游业绿色发展效率是衡量旅游业绿色发展水平的重要标准。综合运用Super-SBM-Undesirable模型、Markov链、Dagum基尼系数、空间杜宾模型等多种方法分析2010~2019年中国城市旅游业绿色发展效率的动态演进趋势、空间差异大小及差异来源、以及其影响因素的空间溢出效应等。结果表明:(1)2010~2019年中国城市旅游业绿色发展效率呈现明显的“W”型阶段变化特征,在空间上具有较为显著的集聚特征。(2)中国城市旅游业旅游发展效率存在明显的“俱乐部趋同”现象,并且短期内难以实现跨越式增长。高效率城市的倒退风险高于其他等级,主要向较高效率下移。(3)中国城市旅游业绿色发展效率的总体基尼系数整体上呈现略微下降的趋势,但是波动性较强,并且阶段性特征较为明显。在2013年之前,空间差异呈现逐渐扩大趋势,随后在2014~2017年,呈现较为显著地缩小趋势,而后呈现略微扩大趋势。旅游业绿色发展效率存在空间差异的主要原因是区域内差异。(4)旅游专业化水平、交通通达度表现出正向溢出效应,而经济发展水平表现出负向溢出效应。最后,基于研究结论,提出相应建议,对促进中国城市旅游业高质量发展具有重要意义。

关键词：旅游业绿色发展效率时空分异空间溢出 Dagum基尼系数城市

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An Analysis of the Low Moving Speed of Landfalling Typhoon In-fa in 2021

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Journal of Tropical Meteorology 2024年第1期30卷 51-60页

作者：郑丽娜吕新刚李瑞 Jinan Meteorological Bureau of Shandong Province Jinan 250102 China

The movement speed of Typhoon In-fa(2021)was notably slow,at 10 km h-1or less,for over 20 hours following its landfall in Zhejiang,China,in contrast to other typhoons that have made *** study examines the factors contributing to the slow movement of Typhoon In-fa,including the steering flow,diabatic heating,vertical wind shear(VWS),and surface synoptic situation,by comparing it with Typhoons Yagi(2018)and Rumbia(2018)which followed similar *** findings reveal that the movement speed of Typhoons Yagi and Rumbia is most closely associated with their respective 500 h Pa environmental winds,with a steering flow of 10^(-12)m s^(-1).In contrast,Typhoon Infa’s movement speed is most strongly correlated with the 850 h Pa environmental wind field,with a steering flow speed of only 2 m s^(-1).Furthermore,as Typhoon In-fa moves northwest after landfall,its intensity is slightly greater than that of Typhoons Yagi and Rumbia,and the pressure gradient in front of Typhoon In-fa is notably smaller,leading to its slow ***,the precipitation distribution of Typhoon In-fa differs from that of the other two typhoons,resulting in a weak asymmetry of wavenumber-1 diabatic heating,which indirectly affects its movement *** analysis indicates that VWS can alter the typhoon’s structure,weaken its intensity,and ultimately impact its movement.

关键词： landfalling typhoon steering flow diabatic heating VWS

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基因治疗的双重考察

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中国医学伦理学 2024年第2期37卷 138-144页

作者：丁敏虞法湖南大学马克思主义学院湖南长沙410082

从生物学上看,基因是人之为人的关键。随着人类对基因技术的不断推进,基因治疗成为当前生命科学领域极富活力也面临巨大争议的前沿话题:在给人类带来更多疾病治愈希望的同时,它也引发了诸多伦理争论。整理了基因治疗所面临的伦理质疑,... 详细信息

从生物学上看,基因是人之为人的关键。随着人类对基因技术的不断推进,基因治疗成为当前生命科学领域极富活力也面临巨大争议的前沿话题:在给人类带来更多疾病治愈希望的同时,它也引发了诸多伦理争论。整理了基因治疗所面临的伦理质疑,从中提炼出个人权利、社会公平、自然秩序等多个方面所受到的挑战,并一一进行回应,由此说明基因治疗的开展在原则上并不违背这些伦理价值。然而,基因编辑事件的发生,为我们敲响警钟:基因治疗的实施边界究竟应在何处?通过对基因编辑事件与“柏林病人”案件的对比分析指出:技术安全层面的考察才是基因治疗安全应用于临床应用的关键所在。

关键词：基因治疗伦理审查技术安全 “柏林病人”案

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Series Reports from Professor Wei's Group of Chongqing University:Advancements in Electrochemical Energy Conversions(1/4):Report 1:High-performance Oxygen Reduction Catalysts for Fuel Cells

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电化学（中英文） 2024年第7期30卷 1-27页

作者： fa-Dong Chen Zhuo-Yang Xie Meng-Ting Li Si-Guo Chen Wei Ding Li Li Jing Li Zi-Dong Wei State Key Laboratory of Advanced Chemical Power Sources(Chongqing University) College of Chemistry and Chemical EngineeringChongqing UniversityChongqing400044China

Two major challenges,high cost and short lifespan,have been hindering the commercialization process of lowtemperature fuel *** Wei's group has been focusing on decreasing cathode Pt loadings without losses of activity and durability,and their research advances in this area over the past three decades are briefly reviewed *** the Pt-based catalysts and the low Pt usage,they have firstly tried to clarify the degradation mechanism of Pt/C catalysts,and then demonstrated that the activity and stability could be improved by three strategies:regulating the nanostructures of the active sites,enhancing the effects of support materials,and optimizing structures of the three-phase *** Pt-free catalysts,especialiy carbon-based ones,several strategies that they proposed to enhance the activity of nitrogen-/heteroatom-doped carbon catalysts are firstly ***,an indepth understanding of the degradation mechanism for carbon-based catalysts is discussed,and followed by the corresponding stability enhancement ***,the carbon-based electrode at the micrometer-scale,faces the challenges such as low active-site density,thick catalytic layer,and the effect of hydrogen peroxide,which require rational structure design for the integral cathodic *** review finally gives a brief conclusion and outlook about the low cost and long lifespan of cathodic oxygen reduction catalysts.

关键词： Fuel cell Oxygen reduction reaction Pt-based catalyst Carbon-based catalyst

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影像学检查在子宫良恶性病变鉴别诊断中的价值

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中国实用妇科与产科杂志 2024年第9期40卷 895-898页

作者：吕发金王璐重庆医科大学附属第一医院放射科重庆医科大学生物医学工程学院(超声医学工程国家重点实验室) 重庆400016

微无创治疗因其创伤小、恢复快等优势,在子宫病变治疗中应用广泛。超声、CT以及磁共振成像(MRI)等影像诊断手段能够在术前辅助确定病变的良恶性,有助于制定个性化治疗方案,确保治疗的精确性和安全性,对患者的康复和生活质量具有重要意义... 详细信息

微无创治疗因其创伤小、恢复快等优势,在子宫病变治疗中应用广泛。超声、CT以及磁共振成像(MRI)等影像诊断手段能够在术前辅助确定病变的良恶性,有助于制定个性化治疗方案,确保治疗的精确性和安全性,对患者的康复和生活质量具有重要意义。MRI具有高软组织及空间分辨率,在术前诊断中可作为首选的影像检查,文章主要阐述MRI的不同成像序列在子宫良恶性病变诊断中的应用及鉴别要点。

关键词：磁共振成像子宫疾病良恶性鉴别

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