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Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2015年第7期21卷 2030-2039页

作者： Young-Sun Nam Nayoun Kim Keon-Il im Jung-Yeon lim Eun-Sol lee Seok-Goo Cho Institute for Translational Research and Molecular imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematology Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

Aim:To investigate the effects of mesenchymal stem cells(MSCs)on dextran sulfate sodium-induced inflammatory bowel disease(IBD).METHODS:C57Bl/6 mice were fed 3.5%(g/l)dextran sulfate *** day seven,the mice received intraperitoneal injections of 1×106 *** survival rate,disease activity index values,and body weight,were monitored *** day ten,colon lengths and histopathologic changes were *** addition,immunoregulatory changes following MSC administration were evaluated by determining the levels of effector T cell responses in the spleen and mesenteric lymph nodes,and the expression levels of inflammatory cytokines in homogenized ***:Intraperitoneal administration of MSCs did not prevent development of colitis and did not reduce the clinicopathologic severity of *** significant difference was evident in either survival rate or disease activity index score between the control and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either colon length or histopathologic ***,the MSC-treated group exhibited elevated levels of interleukin(Il)-6 and transforming growth factor-β,and a reduced level of Il-10,in spleens,mesenteric lymph nodes,and homogenized *** Il-17 level was lower in the mesenteric lymph nodes of the MSC-treated group(P=0.0126).In homogenized colons,the Il-17 and tumor necrosis factor-α(P=0.0092)expression levels were also lower in the treated ***:MSC infusion provided no significanthistopathologic or clinical improvement,thus representing a limited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sulfate sodium Inflammator

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KCNQ钾通道及其小分子调节剂研究进展

生命科学 2016年第9期28卷 965-977页

作者：刘妮吕伟南发俊华东师范大学化学与分子工程学院上海200062 中国科学院上海药物研究所国家新药筛选中心上海201203

KCNQ钾通道是一类电压门控钾离子通道,具有慢激活和不失活的特点,参与调控细胞的正常代谢。KCNQ钾通道包括KCNQ1~KCNQ5五个亚型,在心脏、神经元和平滑肌等组织广泛分布,并在调节细胞兴奋性和离子平衡中发挥着重要的生理功能。KCNQ功能... 详细信息

KCNQ钾通道是一类电压门控钾离子通道,具有慢激活和不失活的特点,参与调控细胞的正常代谢。KCNQ钾通道包括KCNQ1~KCNQ5五个亚型,在心脏、神经元和平滑肌等组织广泛分布,并在调节细胞兴奋性和离子平衡中发挥着重要的生理功能。KCNQ功能失调导致多种人类疾病,因此被认为是治疗癫痫、心律失常、疼痛、耳聋和认知功能障碍等疾病的重要药物靶点。2011年,FDa批准KCNQ激动剂Retigabine上市,进一步促进了以KCNQ为靶点的小分子调节剂的研究。在综述中主要介绍了KCNQ钾通道小分子调节剂的研究进展。

关键词： KCNQ钾通道 im电流癫痫 KCNQ钾通道调节剂

Effects of ice massage of the head and spine on heart rate variability in healthy volunteers

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Journal of Integrative Medicine 2016年第4期14卷 306-310页

作者： A. Mooventhan l. Nivethitha Sri Dharmasthala Manjunatheshwara College of Naturopathy and Yogic Sciences and Hospital Ujire-574240 Karnataka India Swami Vivekananda Yoga Anusandhana Samsthana University Bengaluru-560019 Karnataka India

OBJECTIVE： Ice massage （im） is one of the treatment procedures used in hydrotherapy. Though its various physiological/therapeutic effects have been reported, effects of im of the head and spine on heart rate variability （HRV） have not been studied. Thus, this study evaluated the effects of im of the head and spine on HRV in healthy volunteers.METHODS： Thirty subjects were randomly divided into 3 sessions：（1） im, （2） tap water massage （TWM） and （3） prone rest （PR）. Heart rate （HR） and HRV were assessed before and after each intervention session.RESUlTS： A significant increase in the mean of the intervals between adjacent QRS complexes or the instantaneous HR （RRI）, square root of mean of sum of squares of differences between adjacent normal to normal （NN） intervals （RMSSD）, number of interval differences of successive NN intervals greater than 50 milliseconds （NN50）, proportion derived by dividing NN50 by total number of NN intervals along with significant reduction in HR after im session; significant increase in RRI along with significant reduction in HR after TWM, and a significant increase only in RMSSD after PR were observed. However, there was no significant difference between the sessions.CONClUSION： Results of this study suggest that 20 min of im of the head and spine is effective in reducing HR and improving HRV through vagal dominance in healthy volunteers.

关键词： heart rate variability hydrotherapy massage therapy

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中国全科医学 2018年第27期 3284-3284页

作者： IWAGAM im CAPlIN B SMEETH l 本刊编辑部

背景虽然慢性肾脏病可引起多种不良后果,但是其引起的何种疾病/症状导致了患者住院,还未为人知。目的定量研究慢性肾脏病和病因别住院之间的相关性。设计与场所本研究为配对队列研究。使用的数据来自英国临床研究数据库（CPRD）及其链... 详细信息

背景虽然慢性肾脏病可引起多种不良后果,但是其引起的何种疾病/症状导致了患者住院,还未为人知。目的定量研究慢性肾脏病和病因别住院之间的相关性。设计与场所本研究为配对队列研究。使用的数据来自英国临床研究数据库（CPRD）及其链接到的医院住院患者统计数据库（HES）。方法研究对象为2004—2014年间诊治的慢性肾脏病患者[连续3个月或者3个月以上估算肾小球滤过率l·min-1·（1.73 m2）-1,慢性肾脏病组]和年龄、性别、经治疗的全科医生素质和治疗日期相匹配的非慢性肾脏病患者（对照组）。首次住院时诊断的疾病被认定为入院原因,主要包括10种常见病:心力衰竭、尿路感染、肺炎、急性肾损伤、心肌梗死、脑梗死、消化道出血、髋部骨折、静脉血栓栓塞、颅内出血。对慢性肾脏病组和对照组首次住院时每一种疾病的发生率进行了对比。对每一种疾病的相对患病风险进行多因素Cox回归分析。结果共纳入了242 349对研究对象。慢性肾脏病组（9.7‰）和对照组（3.1‰）因为心力衰竭发病而住院的人年比例差值最大（6.6‰）,其次为尿路感染（5.2‰）、肺炎（4.4‰）、急性肾损伤（4.1‰）。急性肾损伤的相对发病风险最高,调整HR值为4.90[95%CI（4.47,5.38）],其次为心力衰竭,调整HR值为1.66[95%CI（1.59,1.75）]。结论慢性肾脏病患者同时患有心力衰竭、尿路感染或急性肾损伤有更高的绝对和/或相对住院风险,建议对此类人群加强预防性护理。

关键词：慢性肾脏病对照组肾损伤队列研究相关性

An Assessment of Eco Driving System for Agricultural Tractor

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Journal of Agricultural Science and Technology(B) 2011年第6期1卷 906-912页

作者： S. H. Park Y. J. Kim D. H. im C. K. Kim National Academy of Agricultural Science Rural Development Administration Suwon 441857 Republic of Korea

In this study, tractor power output, fuel consumption rate and work performance were indirectly predicted in order to develop an eco driving system. Firstly, equations were developed which could foretell tractor power output and fuel consumption rate using characteristic curves of tractor power output. Secondly, with actual engine revolution per minute (rpm) determined by initial engine rpm and work load, tractor power output and fuel consumption rate were forecasted. Thirdly, it was possible to foresee tractor work performance and fuel consumption rate by the speed signals of Global Positioning System (GPS). lastly, precision of the eco driving system was evaluated through tractor Power Take-Off (PTO) test, and effects of the eco driving system were investigated in the plowing and rotary tilling operations. Engine rpm, power output, fuel consumption rate, work performance and fuel consumption rate per plot area were displayed on the eco driving system. Predicted tractor power outputs in the full load curve were well coincided with the actual power output of prototype, but small differences, 1 to 6 kW were found in the part load curve. Error of the fuel consumption rate was 0.5 to 3 l/h at the part load curve. It was shown that 69% and 53% of fuel consumption rates could be reduced in plowing and rotary tilling operations, respectively, when the eco driving system was installed in tractor.

关键词：农用拖拉机驾驶系统测试评估生态燃油消耗率最大功率输出发动机转速输出功率

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英国大学董事会制度的变迁

清华大学教育研究 2013年第2期34卷 29-35页

作者：郭春发孙霄兵中国人民大学教育学院北京100872 教育部政策法规司北京100816

本文以大学治理的权力结构为标准,分析了英国大学董事会制度从牛桥模式、92前模式到92后模式发展变化的内在动因,并揭示了不同模式中董事会内部的组成和相应的功能,以此揭示以董事会为权力核心的大学治理变革所起的作用。我国的大学治... 详细信息

本文以大学治理的权力结构为标准,分析了英国大学董事会制度从牛桥模式、92前模式到92后模式发展变化的内在动因,并揭示了不同模式中董事会内部的组成和相应的功能,以此揭示以董事会为权力核心的大学治理变革所起的作用。我国的大学治理可以借鉴英国董事会制度的有益经验,提高大学的治理水平,实现从多种决策力量的动态制衡到决策多元的变革,从而实现真正意义上的大学治理的法治化、效率化和科学化。

关键词：大学治理董事会牛桥模式 92前模式 92后模式

Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

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World Journal of Gastroenterology 2014年第45期20卷 17084-17091页

作者： Mi Na Kim Seong-Joon Koh Jung Mogg Kim Jong Pil im Hyun Chae Jung Joo Sung Kim Seoul National University Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Microbiology Hanyang University College of Medicine Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Aim:To investigate the effect of Clostridium difficile(***)infection in an interleukin 10-deficient(Il-10-/-)mouse model of inflammatory bowel ***:Bone marrow-derived dendritic cells isolated from wild type(WT)and Il-10-/-mice were stimulated for 4 h with *** toxin A(200μg/m l),and gene expression of interferon(IFN)-γ,Il-12 and Il-23was determined by real-time reverse transcription polymerase chain *** and Il-10-/-mice(n=20each)were exposed to an antibiotic cocktail for three days and then were injected with clindamycin(i.p.).Mice(n=10 WT,10 Il-10-/-)were then challenged with oral administration of ***(1×105 colony forming units of strain VPI 10463).Animals were monitored daily for 7 d for signs of *** tissue samples were evaluated for cytokine gene expression and histopathologic ***:*** toxin A treatment induced IFN-γgene expression to a level that was significantly higher in BDMCs from Il-10-/-compared to those from WT mice(Pl-12 and Il-23 was not different among the *** *** administration,mice developed diarrhea and lost weight within 2-3 *** loss was significantly greater in Il-10-/-compared to WT mice(Plogic features typical of colitis in both Il-10-/-and WT *** histopathologic severity score was significantly higher in the Il-10-/-than in WT mice(mean±standard error;5.50±0.53 vs 2.44±0.46;Ply greater increase in IFN-γgene expression in colonic tissues from Il-10-/-than from WT mice challenged with ***(PlUSION:These results indicate that colitis is more severe after *** infection in Il-10-/-mice,and that IFN-γexpression is involved in this process.

关键词： Clostridium difficile Inflammatory bowel disease I

基于自适应隐马尔可夫模型的石油领域文档分词

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计算机科学 2018年第B6期45卷 97-100页

作者：宫法明朱朋海中国石油大学(华东)计算机与通信工程学院山东青岛266580

中文分词技术是把没有分割标志的汉字串转换为符合语言应用特点的词串的过程,是构建石油领域本体的第一步。石油领域的文档有其独有的特点,分词更加困难,目前仍然没有有效的分词算法。通过引入术语集,在隐马尔可夫分词模型的基础上,提... 详细信息

中文分词技术是把没有分割标志的汉字串转换为符合语言应用特点的词串的过程,是构建石油领域本体的第一步。石油领域的文档有其独有的特点,分词更加困难,目前仍然没有有效的分词算法。通过引入术语集,在隐马尔可夫分词模型的基础上,提出了一种基于自适应隐马尔可夫模型的分词算法。该算法以自适应隐马尔可夫模型为基础,结合领域词典和互信息,以语义约束和词义约束校准分词,实现对石油领域专业术语和组合词的精确识别。通过与中科院的NlPIR汉语分词系统进行对比,证明了所提算法进行分词时的准确率和召回率有显著提高。

关键词：中文分词隐马尔可夫模型组合词石油

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大气相干长度的稳定测量

光学精密工程 2013年第4期21卷 911-918页

作者：陈浩宣丽胡立发曹召良穆全全中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室吉林长春130033 中国科学院大学北京100049

采用传统的一对差分星点像运动法(DimM)测量大气相干长度r0时,受统计星点对数的限制很难得到稳定的r0数值。因此,本文提出将对波面上一对星点像运动的统计增加为对正方形分布的十二对星点像运动的统计,并利用Shack-Hartmann波前探测器... 详细信息

采用传统的一对差分星点像运动法(DimM)测量大气相干长度r0时,受统计星点对数的限制很难得到稳定的r0数值。因此,本文提出将对波面上一对星点像运动的统计增加为对正方形分布的十二对星点像运动的统计,并利用Shack-Hartmann波前探测器采集的光点阵列实现了这种统计。畸变波面上十二对点的差分运动统计方法从空间角度上增加了大气相干长度r0采样的统计数量,从空间群的概念来说增加了中心对称统计,因此大幅降低了统计时间。实验显示:仅使用300ms采样300幅畸变波面即可完成对大气相干长度r0的统计,得出稳定而准确的r0值,而波动只有±3%。该方法解决了长期以来大气相干长度r0的统计量不确定、测定误差无法分析的问题,有助于提高地基望远镜自适应光学系统成像的精度。

关键词：大气光学自适应光学大气相干长度 Shack—Hartmann