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Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： Yu-fa Luo Shu-Qiang Li School of Life and Environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using DNA data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to East Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and East/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an East-West direction from the middle Eocene.

关键词： Geological event Climate change Ballooning organism faunal exchange Species distribution

Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： Peter Göttle Michael dietrich Patrick Küry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(Kuhlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

Analytical Solution for the Reissner-Sagoci Problem of a Piezoelectric Half-Space

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Acta Mechanica Solida Sinica 2024年第3期37卷 363-370页

作者： Keqiang Hu Cun-fa Gao Zengtao Chen Zheng Zhong State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Mechanical Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Science Harbin Institute of TechnologyShenzhen518055China

In this paper,a transversely isotropic piezoelectric half-space with the isotropy axis parallel to the z-axis is considered under rotation on a rigid circular disk bonded to the surface of the piezoelectric *** is a type of Reissner-Sagoci mixed boundary value *** utilizing the Hankel transform,the mixed boundary value problem is simplified into solving a pair of dual integral ***-field analytical expressions for displacement,stresses,and electric displacement inside the half-space are *** shear stresses and electric displacement on the surface are found to be singular at the edge of the rigid circular disk,and the stress intensity factors and electric displacement intensity factor are *** results show that material properties and geometric size have significant effects on displacement,shear stresses,and electric displacement.

关键词： Piezoelectric half-space Circular disk Reissner-Sagoci problem Stress intensity factor Electric displacement intensity factor

NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： Zi-fa Zhang Shu-Ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPia database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:GEPia database showed that NUDT5 expression was significantly increased in GBM *** the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM ***,TRIM47 was highly expressed in GBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for GMB treatment.

关键词： Glioblastoma multiforme NUDT5 TRIM47 Growth Metastasis Warburg effect

Area Operators on Bergman Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1161-1176页

作者： Xiao Fen LV Jordi PAU Mao fa WANG Department of Mathematics Huzhou UniversityHuzhou 313000P.R.China Departament de Matemàtiques i Informàtica Universitat de Barcelona08007 BarcelonaCataloniaSpain School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0ial results were previously obtained by ... 详细信息

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0ial results were previously obtained by Wu in[Wu,Z.:Volterra operator,area integral and Carleson measures,*** Math.,54,2487–2500(2011)].Especially,in the case q

关键词： Area operator Bergman space tent space area formula

Effects of diamond particle size on microstructure and properties of diamond/Al-12Si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou Guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

Intelligent casting:Empowering the future foundry industry

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China Foundry 2024年第5期21卷 409-426页

作者： Jin-wu Kang Bao-lin Liu Tao Jing Hou-fa Shen School of Materials Science and Engineering Key Laboratory for Advanced Materials Processing TechnologyTsinghua UniversityBeijing 100084China

Emerging technological advances are reshaping the casting sector in latest *** technology is evolving towards intelligent casting paradigm that involves automation,greenization and intelligentization,which attracts more and more attention from the academic and industry *** this paper,the main features of casting technology were briefly summarized and forecasted,and the recent developments of key technologies and the innovative efforts made in promoting intelligent casting process were ***,the technical visions of intelligent casting process were also put *** key technologies for intelligent casting process comprise 3D printing technologies,intelligent mold technologies and intelligent process control *** future,the intelligent mold that derived from mold with sensors,control devices and actuators will probably incorporate the Internet of Things,online inspection,embedded simulation,decision-making and control system,and other technologies to form intelligent cyber-physical casting system,which may pave the way to realize intelligent *** is promising that the intelligent casting process will eventually achieve the goal of real-time process optimization and full-scale control,with the defects,microstructure,performance,and service life of the fabricated castings can be accurately predicted and tailored.

关键词： intelligent casting 3D printing intelligent mold process control cyber-physical casting system embedded simulation

Knowledge Graph Enhanced Transformers for Diagnosis Generation of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第3期30卷 267-276页

作者： WANG Xin-yu YANG Tao GAO Xiao-yuan HU Kong-fa School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing210023China School of Information Management Nanjing UniversityNanjing210023China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing210023China Jiangsu Province Engineering Research Center of TCM Intelligence Health Service Nanjing210023China

Chinese medicine(CM)diagnosis intellectualization is one of the hotspots in the research of CM *** traditional CM intelligent diagnosis models transform the CM diagnosis issues into classification issues,however,it is difficult to solve the problems such as excessive or similar *** the development of natural language processing techniques,text generation technique has become increasingly *** this study,we aimed to establish the CM diagnosis generation model by transforming the CM diagnosis issues into text generation *** semantic context characteristic learning capacity was enhanced referring to Bidirectional Long Short-Term Memory(BILSTM)with Transformer as the backbone ***,the CM diagnosis generation model Knowledge Graph Enhanced Transformer(KGET)was established by introducing the knowledge in medical field to enhance the inferential *** KGET model was established based on 566 CM case texts,and was compared with the classic text generation models including Long Short-Term Memory sequence-to-sequence(LSTM-seq2seq),Bidirectional and Auto-Regression Transformer(BART),and Chinese Pre-trained Unbalanced Transformer(CPT),so as to analyze the model ***,the ablation experiments were performed to explore the influence of the optimized part on the KGET *** results of Bilingual Evaluation Understudy(BLEU),Recall-Oriented Understudy for Gisting Evaluation 1(ROUGE1),ROUGE2 and Edit distance of KGET model were 45.85,73.93,54.59 and 7.12,respectively in this *** with LSTM-seq2seq,BART and CPT models,the KGET model was higher in BLEU,ROUGE1 and ROUGE2 by 6.00–17.09,1.65–9.39 and 0.51–17.62,respectively,and lower in Edit distance by 0.47–*** ablation experiment results revealed that introduction of BILSTM model and prior knowledge could significantly increase the model ***,the manual assessment indicated that the CM diagnosis results of the KGET model used

关键词： Chinese medicine diagnosis knowledge graph enhanced transformer text generation

Numerical Study on the Effect of Gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： BiaN Xiang-qian JI Chun-yan XU Sheng GUO Jian-ting HUO fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation