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Asian pa.ific Journal of Tropical Medicine 2010年第1期3卷 25-28页

作者： Okoye TC Akah pa.Omeke CP Depa.tment of Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

Objective:To investigate the potentials of the root bark of Annona（A.） senegalensis in the control of seizure and related hypnotic and motor incoordination effects in mice using experimental ***:The methanol extract（ME） of the root bark of *** was studied in mice using pentylenetetrazole（PTZ） induced convulsions,phenobarbitone induced sleeping time and motor coordination test on rota-rod *** toxicity and lethality（LD50） lest as well as phytochemical analysis were also carried ***:The extract（200,400,800 mg/ kg） exhibited a non- dose dependent significant（P50 of 1 2%mg/kg,while the phytochemical studies showed the presence of alkaloids, resins,glycosides,carbohydrate,reducing sugar,flavonoids,terpenoids,saponins and tannins. Conclusion:The extract of A senegalensis possessed anticonvulsant activity with pronounced hypnotic and muscle relaxant effects.

关键词： Annona senegalensis Hypnosis Anticonvulsant Muscle relaxant

A New Compound from the Bud of Chrysanthemum indicum L.

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Chinese Chemical Letters 2005年第10期16卷 1341-1342页

作者： Wen Ming CHENG Tian pa.YOU Jun LI Depa.tment of Chemistry University of Science and Technology of China Hefei 230026 School of Pharmacy Anhui Medical University Hefei 230032

A new bicyclic spiroketone was isolated from the bud of Chrysanthemum indicum L. The chemical structure was elucidated as （1R, 9S, 10S）-10-hydroxyl-8 （2＇, 4＇-diynehexylidene）- 9-isovaleryloxy-2, 7-dioxaspiro [5,... 详细信息

关键词： Chrysanthemum indicum L. X-ray crystallography bicyclic spiroketone (1R 9S,10S)-10-hydroxyl-8 (2' 4'-diynehexylidene)-9-isovaleryloxy-2 7-dioxaspiro[5 4]decane.

Laryngopharyngeal reflux in pa.ients with reflux esophagitis

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World Journal of Gastroenterology 2008年第28期14卷 4523-4528页

作者： Yung-Chih Lai pa.Chun Wang Jun-Chen Lin Division of Gastroenterology Department of Internal Medicine Cathay General Hospital School of Medicine National Taiwan University School of Medicine Taipei Medical University Taipei 10630 Taiwan China Depa.tment of Otolaryngology Cathay General Hospital School of Medicine Fu Jen Catholic University Taipei 10630 School of Public Health China Medical University Taichung 40402 Taiwan China Depa.tment of Otolaryngology Cathay General Hospital Taipei 10630 Taiwan China

AIM: To assess the prevalence of laryngopharyngeal reflux (LPR) in pa.ients with reflux esophagitis and dis-close factors contributing to the development of LPR. METHODS: A total of 167 pa.ients who proved to have reflux esophagitis by endoscopy were enrolled. They received laryngoscopy to grade the reflux find-ings for the diagnosis of LPR. We used validated ques-tionnaires to identify the presence of laryngopharyn-geal symptoms, and stringent criteria of inclusion to increase the specificity of laryngoscopic findings. The data of pa.ients were analyzed statistically to find out factors related to LPR. RESULTS: The prevalence rate of LPR in studied sub-jects with reflux esophagitis was 23.9%. Age, hoarse- ness and hiatus hernia were factors significantly as-sociated with LPR. In 23 pa.ients with a hiatus hernia, the group with LPR was found to have a lower trend of esophagitis grading. CONCLUSION: Laryngopharyngeal reflux is present in pa.ients with reflux esophagitis, and three predicting factors were identified. However, the development of LPR might be different from that of reflux esophagi-tis. The importance of hiatus hernia deserves further study.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease Reflux esophagitis

瑞巴派特联合泮托拉唑治疗幽门螺杆菌阴性慢性糜烂性胃炎的临床疗效及药学分析

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中国医药科学 2024年第1期14卷 125-128页

作者：辛承益张劲王颖王法内蒙古自治区巴彦淖尔市医院药剂科内蒙古巴彦淖尔015000 内蒙古自治区包头市肿瘤医院药剂科内蒙古包头014000 海南医学院第一附属医院全科医学科海南海口570102 内蒙古自治区巴彦淖尔市医院手麻科内蒙古巴彦淖尔015000

目的研究瑞巴派特联合泮托拉唑治疗幽门螺杆菌(Hp)阴性慢性糜烂性胃炎的临床疗效。方法选取巴彦淖尔市医院2020年3月至2023年1月收治的85例Hp阴性慢性糜烂性胃炎患者开展试验。将其按照信封法随机分为试验组42例及参考组43例。试验组予... 详细信息

目的研究瑞巴派特联合泮托拉唑治疗幽门螺杆菌(Hp)阴性慢性糜烂性胃炎的临床疗效。方法选取巴彦淖尔市医院2020年3月至2023年1月收治的85例Hp阴性慢性糜烂性胃炎患者开展试验。将其按照信封法随机分为试验组42例及参考组43例。试验组予以瑞巴派特联合泮托拉唑治疗,参考组则予以瑞巴派特联合硫糖铝治疗。比较两组临床疗效,比较治疗前后胃黏膜丙二醛(MDA)及前列腺素E_(2)(PGE_(2))水平、血清学指标水平、不良反应。结果试验组治疗总有效率高于参考组(P0.05);治疗8周后,试验组MDA水平低于参考组,而PGE_(2)水平高于参考组,差异有统计学意义(P0.05);治疗8周后,试验组血清VIP水平低于参考组,而Ghrelin水平高于参考组(P<0.05)。试验组不良反应总发生率低于参考组(P<0.05)。结论瑞巴派特联合泮托拉唑治疗Hp阴性慢性糜烂性胃炎患者的疗效显著,可改善糜烂组织及血清VIP、Ghrelin水平,降低不良反应风险,值得推广应用。

关键词：慢性糜烂性胃炎幽门螺杆菌瑞巴派特泮托拉唑疗效

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印度文化中的形象(Rūpa.及其展开——从比较文化和比较文论的角度看Image(形象/意象/图像)(之三)

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河北学刊 2012年第3期32卷 24-30页

作者：张法浙江师范大学人文学院浙江金华321004

印度文化中的形象由多个概念体现出来:色与相是西方image的相似物,境是主客合一的形象,情呈现了艺术形象的三重结构,味体现了形象的印度型本质,韵呈现了文学形象的特质。

关键词：印度文论色相境情味韵

Novel aluminum-based fuel:facile prepa.ation to improve thermal reactions

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Defence Technology（防务技术） 2022年第10期18卷 1852-1862页

作者： fa-yang Guan Hui Ren Wan-jun Zhao Xin-zhou Wu Qing-jie Jiao State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

To improve the thermal properties of aluminum(Al)in the energetic system,a coated structure with ammonium perchlorate(AP)was prepa.ed by a facile *** N,N-Dimethylformamide(DMF)was chosen as an ideal solvent based on heterogeneous nucleation theory and molecular dynamics *** coated structure could enlarge the contact area and improve the reaction environment to enhance the thermal *** addition of AP could accelerate oxidation temperature of Al with around 17.5°*** the heat release of 85@15 composition rises to 26.13 k J/g and the reaction degree is97.6%with higher peak pressure(254.6 k pa.and rise rate(1.397 Mpa.s).An ideal ratio with 15 wt%AP was probed *** high energy laser-induced shockwave experiment was utilized to simulate the reaction behavior in hot *** the larger activated mixture of coated powder could release more energy to promote the growth of shockwave with higher speed up to 518.7±55.9 m/*** conclusion,85@15 composition is expected to be applied in energetic system as a novel metal fuel.

关键词： Aluminum-based fuel Heterogeneous nucleation Molecular dynamics simulation Thermal reaction High energy laser-induced shockwave experiment

Incidence and histopa.hology of encysted progenetic metacercaria of Clinostomum complanatum(Digenea:Clinostomidae) in Channa punctatus and its development in experimental host

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Asian pa.ific Journal of Tropical Biomedicine 2012年第6期2卷 421-426页

作者： pa.Ahammed Shareef SMA Abidi Section of pa.asitology Department of Zoology Aligarh Muslim University

Objective:To study the incidence of encysted progenetic metacercariae of Clinostomum complanatum(C. complanatum) in Channa punctatus(C. punctatus), associated histopa.hology and the experimental infection to laboratory chicken to obtain ovigerous adult ***:Live C. punctatus were brought from local fish market of Aligarh, India, dissected and examined on a monthly basis for the presence of C. complanatumcysts. For histochemistry, infected tissue sections with attached cysts were processed for haematoxylene and eosin staining. Cysts were aseptically fed to 4 day old leghorn chicken to obtain adult worms. Mechanically excysted metacercaria and the ovigerous adult worms were stained in carmine to prepa.e permanent ***:One year survey for the infection of encysted progenetic metacercaria of ***. punctatusrevealed the prevalence, intensity and abundance of 24.7%, 2.27and 0.608, respectively. Histopa.hology showed heavy infiltration of immune cells at the site of cyst attachment and some tissue damage was also evident. Following feeding to experimental chicken, about 41.07% of the encysted metacercariae were able to excyst and migrate back to bucco-pharyngeal region where they tenaciously attached and fed on blood, and transformed into ovigerous adult worms from 62 hours onwards of post ***:The pa.asite is potentially pa.hogenic to the host, and the availability of a suitable intermediate host can be a contributing factor for the occurrence of C. complanatummetacercaria either in the excysted or encysted form, indicating loose host specificity and zoonotic potential.

关键词： Clinostomum complanatum Encysted progenetic metacercaria Channa punctatus Histopa.hology Experimental infection Ovigerous adult worm Incidence Host-pa.asite interaction Metacercarial transformation

基于机器学习的核磁共振成像影像组学在舌鳞状细胞癌中应用研究进展

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中国实用口腔科杂志 2024年第1期17卷 97-101页

作者：刘盛张爱华刘法昱中国医科大学口腔医学院·附属口腔医院口腔颌面外科辽宁省口腔疾病重点实验室辽宁沈阳110002 中国医科大学口腔医学院·附属口腔医院口腔颌面-头颈外科辽宁省口腔疾病重点实验室辽宁沈阳110002

舌鳞状细胞癌(以下简称“舌癌”)是口腔鳞状细胞癌中发病率较高的亚型。由于此区域解剖结构复杂、淋巴回流丰富,因而舌癌具有颈淋巴结转移率高、预后差的特点。舌癌作为一种实体性肿瘤,常规的医学影像图像往往不能较好反映肿瘤内部异质... 详细信息

舌鳞状细胞癌(以下简称“舌癌”)是口腔鳞状细胞癌中发病率较高的亚型。由于此区域解剖结构复杂、淋巴回流丰富,因而舌癌具有颈淋巴结转移率高、预后差的特点。舌癌作为一种实体性肿瘤,常规的医学影像图像往往不能较好反映肿瘤内部异质性。影像组学可通过一种高通量方式提取高级定量图像特征,捕获肿瘤内部异质性,并结合机器学习算法进一步分析,用来建立与肿瘤表型或基因-蛋白质特点相关的图像特征分类或预测模型,辅助临床决策制定。文章就近年来基于机器学习的核磁共振成像(MRI)影像组学在预测舌癌病理分化程度、颈淋巴结转移、疗效及预后等方面应用的研究进展做一阐述,以期为舌癌患者精准医疗提供参考。

关键词：舌鳞状细胞癌核磁共振成像影像组学机器学习

New development of sets equipment technologies for coal mine longwall face in China

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Journal of Coal Science & Engineering(China) 2012年第1期18卷 1-9页

作者： Guo-fa Wang Huai-wei Ren Coal Mining and Designing Depa.tment Tiandi Science and Technology Co. Ltd. Beijing China

Background of the development and achievement on sets equipment technologies for coal mine longwall face in China was reviewed initially. On the theoretical side, a coupling model of hydraulic support and surrounding rock, support pa. rameters optimization and threedimensional （3D） dynamic design method were presented. On the practical side, this pa.er out lined some of practical issues and discussed some relative methods and technologies. In thin seam coal longwall mining, how to lower equipment height is the first problem that should be solved. Roof pressure regularity, control of rooffall and collapse, and hydraulic support stability were investigated preferentially in 5-7 m coal seam longwall mining. The application of equip- ment for longwall mining with 5-7 m cutting height in China was concluded. The characteristics of full-mechanized top coal caving for extra thick seam coal were presented. The automation of top-caving hydraulic support and relevant equipment have achieved important breakthrough. At the end of this pa.er, further development of China＇s coal industry and longwall mining technologies and equipment were prospected in brief. This pa.er gives readers a comprehensive understanding of China＇s coal mine longwall face equipment technologies. It will give help to other countries on its coal mining development.

关键词： sets equipment longwall mining coupling of hydraulic support and rock working face automation

Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine

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BIOCELL 2015年第2期39卷 1-3页

作者： Anna pa.CZYSZYN Anna KROP-WATOREK Maciej WIECZOREK University of Opole Department of Biotechnology and Molecular BiologyOpolePoland Ludwik Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of SciencesWroclawPoland

Carcinoembryonic antigen(CEA)is a surface glycoprotein expressed in human epithelial cells and is released from their surface,especially during colorectal ***,colorectal cancer is accompa.nied by inflammation,where tumor-infiltrating neutrophils play an important *** was also found to be a strong chemotactic agent for *** purpose of this study was to find out if CEA can enhance neutrophil priming and *** neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine(formyl-MLP)and the resulting oxidative burst was measured ***,in vitro priming of neutrophils by CEA,alone or preceded by LPS,inhibited subsequent activation of these cells by *** may have anti-inflammatory properties in vivo.

关键词： CEA oxidative burst formyl-MLP