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Biological characteristics and clinical management of uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA KAŠTELAN ANA DIDOVIĆpa.IČIĆ DARIA pa.ALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Depa.tment of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Depa.tment of Ophthalmology Zadar General HospitalZadar23000Croatia Depa.tment of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Depa.tment of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Depa.tment of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pa.hogenesis of melanoma at different sites is very similar,however,the prognosis for pa.ients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pa.hogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for pa.ients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

高校竞技健美操运动员落地偏侧性和稳定性的生物力学研究

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中国运动医学杂志 2024年第4期43卷 266-274页

作者：王莉莉 Wan Ahmad Munsif Bin Wan pa.王宇轩李风雷颉梦宁许春莲马来西亚国立大学教育学院吉隆坡43600 东华理工大学体育学院南昌330032 南昌交通学院体育学院南昌330100

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和... 详细信息

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和动力学数据,比较优势侧和非优势侧的触地时刻关节角度、关节活动度(ROM)、地面反作用力(GRF)、负载率、压力中心(COP)位移和包络面积的差异,计算对称指数(代表偏侧性),并采用多元逐步回归方法分析指标偏侧性和COP包络面积的关系。结果:与非优势侧相比,优势侧在触地时刻具有更大的膝外旋和髋外展角(P<0.05),在落地过程中具有较大的踝屈伸、髋屈伸、髋内收-外展及较小的踝旋转ROM(P<0.05);优势侧的伸膝力矩峰值大于非优势侧(P<0.01);垂直方向负载率和伸膝力矩峰值的对称指数与COP包络面积呈显著正相关(P<0.05);垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以解释COP包络面积差异的83.6%。结论:竞技健美操运动员落地动作存在肢体间的偏侧性,垂直方向负载率和伸膝力矩峰值的偏侧性越大,则落地稳定性越差。此外,垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以作为落地稳定性的预测因子。

关键词：健美操落地生物力学偏侧性稳定性

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翻译在藏传佛教中国化进程中的重要作用

攀登（藏文版） 2024年第2期 148-155页

作者：交巴草中国民族语文翻译中心(局)

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持... 详细信息

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持藏传佛教中国化方向进程中,加强汉藏翻译,一方面使藏传佛教教义教规的翻译呈现社会主义发展内涵,适应社会主义社会的时代要求。另一方面引进宗教中国化的理论,以社会主义核心价值观为引领,使藏传佛教浸润中国特色,弘扬先进思想。

关键词：翻译藏传佛教新时代中国化

RE-EXAMINATION OF THE DNA-MEDIATED TRANSFORMATION IN GOLDFISH

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Science in China,Ser.B 1983年第7期26卷 700-707页

作者： LILLIAN C.NIU Depa.tment of Biology Temple University Philadelphia pa. 19112 USA

DNAs were isolated from goldfish, and the balancer bearing species of newt. They were injected sepa.ately into fertilized goldfish eggs. A balancer developed in some newt-DNA injected *** injected goldfish eggs occasionally developed a non-balancer process. These results demonstrated the newt DNA-mediated transfer of the species character from newt to goldfish. The injected DNA was localized by the method of autoradiography using H3-cDNA. Silver grains were found in areas over the colchicine induced metaphase. The incorporation of foreign DNA into chromosomes provides a material basis for genetic transformation.

关键词： DNA RE-EXAMINATION OF THE DNA-MEDIATED TRANSFORMATION IN GOLDFISH

Design of Slant-Form Tool in Precision Reuse of Digital pa.er Display

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Journal of Materials Science & Technology 2011年第9期27卷 846-850页

作者： pa.-Shan pa Depa.tment of Digital Content Design Graduate School of Toy and Game Design National Taipei University of Education Taipei 10667 Taiwan China

A reuse fabrication module using micro electroetching as a precision machining process with a new design of a slant-form tool to remove the defective indium-tin-oxide （ITO） nanostructure from the optical polyethyleneterephthalate （PET） surfaces of digital pa.er display is presented in current studies. The low yield of ITO thin film deposition is an important factor in optoelectronic semiconductor production. The adopted precision reuse process requires only a short period of time to remove the ITO nanostructure easily and cleanly, which is based on technical and economical considerations and is highly efficient. In the current experiment, a large inclined angle of the cathode and a small end radius of the anode take less time for the same amount of ITO removal. A higher feed rate of the optical PET diaphragm combines with enough electric power to drive fast micro electroetching. A small rotational diameter of the anode accompa.ied by a small width of the cathode corresponds to a higher removal rate for the ITO nanostructure. A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the workpiece. This improvement is associated with an increase in current rating. High rotational speed of the slant-form tool can improve the effect of dregs discharge and is advantageous to associate with the fast feed rate of the workpiece （optical PET diaphragm）.

关键词： Reuse fabrication Slant-Form Digital pa.er display Optical polyethyleneterephthalate (PET) diaphragm Indium-tin-oxide (ITO) nanostructure Micro electroetching

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实体瘤治疗所致急性毒性反应的处理

国外医学（儿科学分册） 1992年第2期19卷 92-94页

作者： Gootenberg JE Pizzo pa. 张力群

目前由于应用放疗与化疗联合治疗,儿科实体肿瘤的治疗已取得了很大进展,然而,这种疗法常因其毒性反应而严重地阻碍了疾病的恢复,所以尽早地预测、预防毒性反应并及时进行有效的处理是至关重要的。

关键词：实体肿瘤毒性反应

Selective removal technology using chemical etching and excimer assistance in precision recycle of color filter

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 210-214页

作者： pa.-shan pa Digital Content Design Graduate School of Toy and Game Design National Taipei University of Education Taipei City 10671 China

Color filters are produced using semiconductor production techniques although problems with low yield remain to be addressed. This study presents a new means of selective removal using excimer irradiation, chemical etching, or electrochemical machining on the fifth generation TFT LCDs. The selective removal of microstructure layers from the color filter surface of an optoelectronic flat pa.el display, as well as complete removal of the ITO thin-films, RGB layer, or resin black matrix (BM) layer from the substrate is possible. Individual defective film layers can be removed, or all films down to the Cr layer or bare glass can be completely eliminated. Experimental results demonstrate that defective ITO thin-films, RGB layers, or the resin BM layer can now be recycled with a great precision. When the ITO or RGB layer proves difficult to remove, excimer light can be used to help with removal. During this recycling process, the use of 225 nm excimer irradiation before chemical etching, or electrochemical machining, makes removal of stubborn film residues easy, effectively improving the quality of recycled color filters and reducing fabrication cost.

关键词： chemical etching excimer light selective removal technology display color filter

An effective round ball tool in electrochemistry process as novel reuse fabrication technology

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中国有色金属学会会刊：英文版 2012年第S3期22卷 825-830页

作者： P.S.pa Depa.tment of Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A reuse fabrication module using micro electrochemistry (MECM) with a round-ball tool to remove the defective In2O3 SnO2 thin film from the surfaces of digital pa.er display was *** etching effect improves that the number of the round-balls decreases for promoting the concentration of electric power and increasing discharge *** a small size of the round-ball tool takes less time for the same amount of In2O3 SnO 2 layer removal since the effect of MECM is easily developed for supplying of sufficient electrochemical power.A higher feed rate of the poly ethylene terephthalate (PET) diaphragm combines with enough electric power to drive fast etching rate.A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the *** the ultra-precise etching of In2O 3 SnO2,the optoelectronic semiconductor industry can effectively reuse the defective products,reducing production *** precision etching process is of high efficiency and requires only a short period of time to remove the In2O3 SnO2 nanostructures.

关键词： thin film round-ball tool In2O3SnO2 micro electrochemistry digital pa.er display

Effective tool design of three-rank form as precision removal-process of ITO thin-films

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中国有色金属学会会刊：英文版 2009年第B9期19卷 232-237页

作者： pa.-shan pa Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A new effective tool design of three-rank form of electroremoval was present using a precision recycle system offering faster performance in removing the indium-tin-oxide(ITO) thin-films on color filter surface of displays. Higher electric power is not required since the three-rank form tool is adopted as a feeding mode to reduce the response area. The low yield of ITO persists throughout the entire semiconductor production process. By establishing a recycle process of ultra-precise removal of the thin-film nanostructure, defective products in the optoelectronic semiconductors industry can be effectively recycled, decreasing both production costs and pollution. A 5th generation TFT-LCD was used. The design features of the removal processes for the thin-films and the tool design of three-rank form were of major interest. For the precision removal processes, a pulsed current can improve the effect of dreg discharge and contributes to the achievement of a fast workpiece (displays' color filter) feed rate, but raises the current rating. High flow velocity of the electrolyte with a high rotational speed of the tool electrodes elevates the ITO removal effect. A displays' color filter with a fast feed rate is combined with enough electric power to provide highly effective removal. A small thickness of the rank and a small arc angle of the negative-electrode correspond to a higher removal rate for ITO-film. An effective three-rank form negative-electrode provides larger discharge mobility and better removal effect. It only needs a short period of time to remove the ITO easily and cleanly.

关键词：工具设计薄膜材料 ITO