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Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression

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Journal of Integrative Medicine 2022年第4期20卷 355-364页

作者： Shang-jin Song Xuan Liu Qing Ji Da-zhi Sun Li-juan xiu Jing-yu Xu Xiao-qiang Yue Department of Traditional Chinese Medicine Changzheng HospitalNaval Medical UniversityShanghai 200003China Strategic Support Force Xingcheng Special Duty Sanatorium Xingcheng 125100Liaoning ProvinceChina Cancer Institute Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objectives: Ziyin Huatan Recipe(ZYHT), a traditional Chinese medicine comprised of Lilii Bulbus, Pinelliae Rhizoma, and Hedyotis Diffusa, has shown promise in treating gastric cancer(GC). However, its potential mechanism has not yet been clearly addressed. This study aimed to predict targets and molecular mechanisms of ZYHT in treating GC by network pharmacology analysis and to explore the role of ZYHT in GC both in vitro and in ***: Targets and molecular mechanisms of ZYHT were predicted via network pharmacology analysis. The effects of ZYHT on the expression of metastasis-associated targets were further validated by Western blot and quantitative real-time polymerase chain reaction. To explore the specific molecular mechanisms of the effects of ZYHT on migration and invasion, the runt-related transcription factor 3(RUNX3) gene was knocked out by clustered regularly interspaced short palindromic repeats/Cas9, and lentiviral vectors were transfected into SGC-7901 cells. Then lung metastasis model of GC in nude mice was established to explore the anti-metastasis effect of ZYHT. Western blot and immunohistochemistry were used to explore the impact of ZYHT on the expression of metastasis-related proteins with or without RUNX3 ***: The network pharmacology analysis showed that ZYHT might inhibit focal adhesion, migration,invasion and metastasis of GC. ZYHT inhibited the proliferation, migration and invasion of GC cells in vitro via regulating the expression of metastasis-associated targets. Knocking out RUNX3 almost completely reversed the cell phenotypes(migration and invasion) and protein expression levels elicited by *** vivo studies showed that ZYHT inhibited the metastasis of GC cells to the lung and prolonged the survival time of the nude mice. Knocking out RUNX3 partly reversed the metastasis of GC cells to the lung and the protein expression levels elicited by ***: ZYHT can effectively inhibit the invasion and migration of GC in

关键词： Ziyin Huatan Recipe Gastric cancer Traditional Chinese medicine Metastasis Runt-related transcription factor 3

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冷弯薄壁C型钢组合桁架梁受力性能试验研究

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华北理工大学学报（自然科学版） 2024年第1期46卷 97-102页

作者：雷超张佳琪韩建强付秀艳唐江明华北理工大学建筑工程学院河北唐山063210 河北省地震工程研究中心河北唐山063210 邯郸建工集团有限公司河北邯郸056001

随着我国绿色建筑发展的不断推进,轻钢结构开始展露头角。冷弯薄壁型钢作为新型建筑材料,在轻钢建筑中仍有较大的发展空间,因此对冷弯薄壁型钢的受力性能进行分析具有一定程度的工程价值。首先开展C型钢组合桁架梁承载力和变形实验,在... 详细信息

随着我国绿色建筑发展的不断推进,轻钢结构开始展露头角。冷弯薄壁型钢作为新型建筑材料,在轻钢建筑中仍有较大的发展空间,因此对冷弯薄壁型钢的受力性能进行分析具有一定程度的工程价值。首先开展C型钢组合桁架梁承载力和变形实验,在此基础之上利用ABAQUS建立C型钢组合桁架梁有限元模型,分析有无缀板、自攻螺钉等因素对于组合桁架梁承载力的影响。本文的实验结果表明裸露的骨架梁由于自攻螺钉的剪切而损坏,最终的承载能力取决于螺钉的抗剪能力;缀板的加固对提高梁的承载能力有着显著的影响。

关键词：冷弯薄壁型钢组合桁架梁承载力缀板自攻螺钉

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Effect of Iodine Additive on Thermostability of Bulk Amorphous Sulfur Prepared by Rapid Compression

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Chinese Physics Letters 2011年第8期28卷 206-208页

作者： LIN Sheng-Xiong LIU xiu-Ru SHAO Chun-Guang SHEN Ru HONG Shi-Ming Laboratory of High Pressure Physics Southwest Jiaotong UniversityChengdu 610031 National Engineering Research Center for Advanced Polymer Processing Technology Zhengzhou UniversityZhengzhou 450002 Analysis and Test Center Southwest Jiaotong UniversityChengdu 610031

Bulk amorphous sulfur(a-S)with 1 mol%of phosphorus,selenium and iodine additives and bulk amorphous pure sulfur samples were prepared by rapidly compressing the melts to 2 GPa within 20 *** results of x-ray diffraction,differential scanning calorimetry and in situ wide angle x-ray scattering of the recovered samples are presented and *** the iodine doping case,obvious inhibiting effects on the crystallization and the melting process under high temperatures occurred,as well as on the structure relaxation of a-S at room temperature,suggesting that the thermal stability of amorphous sulfur is remarkably improved by the introduction of iodine additives.

关键词： amorphous iodine Bulk

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Changes in HIV-1 Subtypes/Sub-Subtypes,and Transmitted Drug Resistance Among ART-Naïve HIV-Infected Individuals—China,2004–2022

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China CDC weekly 2023年第30期5卷 664-671,I0010-I0012页

作者： xiu Liu Dong Wang Jing Hu Chang Song Lingjie Liao Yi Feng Dan Li Hui Xing Yuhua Ruan State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:The efficacy of treatment and clinical outcomes may be jeopardized by factors such as transmitted drug resistance(TDR)and the genetic diversity of the human immunodeficiency virus type 1(HIV-1).This comprehensive study aims to examine the alterations in HIV-1 subtypes or sub-subtypes and TDR among Chinese individuals,who have been diagnosed with HIV infection and are previously untreated with antiretroviral therapy(ART),across the span of 2004 to ***:Sequences of the HIV-1 pol gene region were obtained from ART-naïve HIV-positive individuals across 31 provincial-level administrative divisions between 2004 and *** predict susceptibility to 12 antiretroviral drugs,the research utilized the Stanford HIV Drug Resistance *** Cochran-Armitage trend test facilitated the analysis of changes in HIV-1 subtype/sub-subtype prevalence and *** analysis was conducted in alignment with the progression of the National Free Antiretroviral Treatment Program’s stages between 2004 and ***:Among the 57,902 ART-naïve individuals infected with HIV,there was a notable decline in the prevalence of CRF01_AE,B,and C from 37.3%,24.1%,and 1.3%respectively in 2004–2007 to 29.4%,7.3%,and 0.2%respectively in 2020–***,a significant increase was observed in the proportions of CRF07_BC,CRF08_BC,CRF55_01B,other CRFs,and URFs,from 24.1%,11.5%,0.1%,0.4%,and 0.9%respectively in 2004–2007 to 40.8%,11.5%,3.8%,3.7%,and 2.8%respectively in 2020–2022(all Pfavirenz,and nevirapine also significantly increased from 2.6%,1.8%,1.6%,and 1.8%respectively in 2004–2007 to 7.8%,6.7%,6.3%,and 6.7%respectively in 2020–2022(all P<0.001 for trend).However,there were no meaningful changes in the TDR prevalence of nucleoside reverse transcriptase inhibitor and protease ***,in 2020–2022,the overall TDR prevalence exceeded 15%in ***

关键词： prevalence alterations drugs

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Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer

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Journal of Pharmaceutical Analysis 2022年第2期12卷 232-242页

作者： Yang-Yang Wang Liang Li xiu-Jun Liu Qing-fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin300060China NHC Key Laboratory of Biotechnology of Antibiotics Department of OncologyInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic *** addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic ***,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic *** this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer *** uptake in wild-type cells was more extensive than in K-Ras mutant-type *** in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 *** the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell *** also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic *** well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.

关键词： Pancreatic cancer Folate receptor Multi-functional Macropinocytosis-enhanced Bioconjugate K-Ras PEGylation

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Competition Ability Dependence on Uniqueness in General Cooperation-Competition Systems

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Chinese Physics Letters 2011年第2期28卷 243-246页

作者： LIU Ai-Fen XU xiu-Lian FU Chun-Hua WANG Jian HE Da-Ren College of Physics Science and Technology Yangzhou UniversityYangzhou 225002

We discuss the dependence of competition ability on uniqueness for the general cooperation-competition *** empirical investigation of the 15 real world systems is *** find that the dependence varies with the change of *** most of the systems show positive tendency,we find that a special system shows negative *** relationship between the heterogeneity indexes for the distributions of competition ability and uniqueness is also discussed analytically and empirically.

关键词： uniqueness empirical system

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Inversion tillage with straw incorporation affects the patterns of soil microbial co-occurrence and multi-nutrient cycling in a Hapli-Udic Cambisol

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Journal of Integrative Agriculture 2023年第5期22卷 1546-1559页

作者： CHEN Xu HAN Xiao-zeng WANG Xiao-hui GUO Zhen-xi YAN Jun LU Xin-chun ZOU Wen-xiu Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081P.R.China Agricultural Technology Extension Center of Wafangdian City Wafangdian 116300P.R.China Modern Agricultural Development Service Center of Tieling County Tieling 112600P.R.China

Inversion tillage with straw amendment is widely applied in northeastern China, and it can substantially increase the storage of carbon and improve multiple subsoil functions. Soil microorganisms are believed to be the key to this process,but research into their role in subsoil amelioration is limited. Therefore, a field experiment was conducted in 2018 in a region in northeastern China with Hapli-Udic Cambisol using four treatments: conventional tillage(CT, tillage to a depth of 15 cm with no straw incorporation), straw incorporation with conventional tillage(SCT, tillage to a depth of 15 cm),inversion tillage(IT, tillage to a depth of 35 cm) and straw incorporation with inversion tillage(SIT, tillage to a depth of 35 cm). The soils were managed by inversion to a depth of 15 or 35 cm every year after harvest. The results indicated that SIT improved soil multi-nutrient cycling variables and increased the availability of key nutrients such as soil organic carbon, total nitrogen, available nitrogen, available phosphorus and available potassium in both the topsoil and *** contrast to CT and SCT, SIT created a looser microbial network structure but with highly centralized clusters by reducing the topological properties of average connectivity and node number, and by increasing the average path length and the modularity. A Random Forest analysis found that the average path length and the clustering coefficient were the main determinants of soil multi-nutrient cycling. These findings suggested that SIT can be an effective option for improving soil multi-nutrient cycling and the structure of microbial networks, and they provide crucial information about the microbial strategies that drive the decomposition of straw in Hapli-Udic Cambisol.

关键词： soil microbiome microbial co-occurrence networks straw amendment soil nutrient

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Soil microbial properties under different vegetation types on Mountain Han

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Science China(Life Sciences) 2013年第6期56卷 561-570页

作者： WANG Miao QU LaiYe MA KeMing YUAN xiu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-environmental ScienceChinese Academy of Sciences University of Chinese Academy of Sciences

This study investigated the influence of broadleaf and conifer vegetation on soil microbial communities in a distinct vertical distribution belt in Northeast *** samples were taken at 0-5,5-10 and 10-20 cm depths from four vegetation types at different altitudes,which were characterized by poplar(Populus davidiana)(1250-1300 m),poplar(***) mixed with birch(Betula platyphylla)(1370-1550 m),birch(***)(1550-1720 m),and larch(Larix principis-rupprechtii)(1840-1890 m).Microbial biomass and community structure were determined using the fumigation-extraction method and phospholipid fatty acid(PLfa) analysis,and soil fungal community level physiological profiles(CLPP) were characterized using Biolog FF *** was found that soil properties,especially soil organic carbon and water content,contributed significantly to the variations in soil *** increasing soil depth,the soil microbial biomass,fungal biomass,and fungal catabolic ability diminished;however,the ratio of fungi to bacteria *** fungal ratio was higher under larch forests compared to that under poplar,birch,and their mixed forests,although the soil microbial biomass was *** direct contribution of vegetation types to the soil microbial community variation was 12%.If the indirect contribution through soil organic carbon was included,variations in the vegetation type had substantial influences on soil microbial composition and diversity.

关键词： vegetation types soil organic carbon soil microbial composition fungal catabolic diversity

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Propofol protects against blood-spinal cord barrier disruption induced by ischemia/reperfusion injury

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Neural Regeneration Research 2017年第1期12卷 125-132页

作者： Li-jie Xie Jin-xiu Huang Jian Yang Fen Yuan Shuang-shuang Zhang Qi-jing Yu Ji Hu Department of Anesthesiology Liyuan Hospital of Tongji Medical CollegeHuazhong University of Science & Technology Department of Anesthesiology Renmin Hospital of Wuhan University

Propofol has been shown to exert neuroprotective effects on the injured spinal ***,the effect of propofol on the blood-spinal cord barrier（BSCB） after ischemia/reperfusion injury（IRI） is poorly ***,we investigated whether propofol could maintain the integrity of the *** cord IRI（SCIRI） was induced in rabbits by infrarenal aortic occlusion for 30 ***,30 mg/kg,was intravenously infused 10 minutes before aortic clamping as well as at the onset of ***,48 hours later,we performed histological and m RNA/protein analyses of the spinal *** decreased histological damage to the spinal cord,attenuated the reduction in BSCB permeability,downregulated the m RNA and protein expression levels of matrix metalloprotease-9（MMP-9） and nuclear factor-κB（NF-κB）,and upregulated the protein expression levels of occludin and *** findings suggest that propofol helps maintain BSCB integrity after SCIRI by reducing MMP-9 expression,by inhibiting the NF-κB signaling pathway,and by maintaining expression of tight junction proteins.

关键词： nerve regeneration spinal cord ischemia reperfusion injury blood–spinal cord barrier propofol matrix metalloprotease-9 nuclear factor-κB tight junction proteins neural regeneration

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Microstructure and mechanical properties of VAlN/Si_(3)N_(4) nano-multilayer coatings

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Journal of Central South University 2022年第5期29卷 1403-1411页

作者： TAO xian-cheng LOU Yu-min LI Miao-lei ZHAO Ning-ning TANG xiu-zhi HU Hai-long HUANG Xiao-zhong YUE Jian-ling State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Advanced Fibers and Composites Central South UniversityChangsha 410083China Zhejiang Energy Group R&D Institute Co. Ltd.Hangzhou 310000China Institute of Aeronautics and Astronautics Central South UniversityChangsha 410012China

VAlN coating is of particular interest for dry cutting applications owing to its low-friction and excellent ***-multilayer structure is designed to tailor the properties of VAlN *** this work,a series of VAlN/Si_(3)N_(4) nano-multilayer coatings with varied Si_(3)N_(4) layer thicknesses were prepared by reactive sputtering *** microstructure and mechanical properties of the coatings were both *** is revealed that Si_(3)N_(4) with a shallow thickness(~0.4 nm)was crystallized and grown coherently with VAlN,showing a remarkable increase in hardness compared to VAlN monolayer *** hardness of coherently VAlN/Si_(3)N_(4) nano-multilayer coatings reached to 48.7 *** further increase of Si_(3)N_(4) layer thickness,the coherent growth of nano-multilayers was terminated,showing amorphous structure formed in nano-multilayers and the hardness was *** the other hand,when Si_(3)N_(4) layer thickness was 0.4 nm,the friction coefficient of VAlN/Si_(3)N_(4) nano-multilayer coating was almost equal to that of VAlN monolayer coating,which was attributed to the crystallization of Si_(3)N_(4) and the produced coherent interfaces between VAlN and Si_(3)N_(4) for the hardening effect of nano-multilayer *** further increase of Si_(3)N_(4) layer thickness,pronounced improvement of friction coefficient in VAlN/Si_(3)N_(4) nano-multilayer coating was observed.

关键词： VAlN/Si_(3)N_(4) nano-multilayer coatings mechanical properties microstructure superhardness effect

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