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Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

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Protein & Cell 2023年第2期14卷 137-142页

作者： Mingyue Ma Zhenxing Zhong yuwen Zhu yuan Gu Ruxin Jin Zhipeng Meng yu Wang fa-xing yu Institute of Pediatrics Children's Hospital of Fudan Universityand the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and Metabolismthe State Key Laboratory of Genetic EngineeringInstitutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Molecular and Cellular Pharmacology and Sylvester Comprehensive Cancer Center University of Miami Miller School of MedicineMiamiFL 33136USA

Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,2011).Thus,understanding the molecular mechanisms responsible for angiogenesis has important clinical implications and may guide strategies for drug development.

关键词： angiogenesis healing organs

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

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Protein & Cell 2020年第2期11卷 138-143页

作者： Beiqing Pan Yi Yang Jian Li yu Wang Chuantao fang fa-xing yu Yanhui Xu Fudan University Shanghai Cancer Center Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringKey Laboratory of Medical Epigenetics and MetabolismShanghai Medical College of Fudan UniversityShanghai 200032China Children's Hospital and Institutes of Biomedical Sciences Key Laboratory of Medical Epigenetics and MetabolismFudan UniversityShanghai 200032China Key Laboratory of Molecular Medicine Ministry of EducationDepartment of Systems Biology for MedicineSchool of Basic Medical SciencesShanghai Medical College of Fudan UniversityShanghai 200032China Collaborative Innovation Center of Genetics and Development School of Life SciencesFudan UniversityShanghai 200433China CAS Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031China

Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and ***-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;yu etal.,2015).

关键词： al. colorectal intestine

Immediate Glucose Response

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Immediate Glucose Response

Staurosporine targets the Hippo pathway to inhibit cell growth

中国生物化学与分子生物学会2016年全国学术会议

作者： fa-xing yu Yan Luo Children's Hospital and Institutes of Biomedical Sciences Fudan University School of Basic Medical Sciences Zhejiang University College of Medicine

Eukaryotic cells can sense glucose and evoke signaling pathways to regulate growth and *** immediate response to glucose is the expression of a set of genes mediated byciscarbohydrate response elements(Cho RE)and their associated transcription factors Mondo Aand Max-like protein X(MLX).Thioredoxin interacting protein(TXNIP),the product of an immediate glucose response gene TXNIP,

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来源： cnki会议评论

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Journal of Molecular Cell Biology 2018年第3期10卷 267-269页

作者： Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding yun Zhao fa-xing yu Xiangbing Qi Lei Zhang State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Innovation Center for Cell Signaling Network Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200031 China National Institute of Biological Sciences Beijing 102206 China National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201210 China School of Ufe Science and Technoloy ShanghaiTech University Shanghai 201210 China Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai 200032 China

The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis （yu et al., 2015）. Arising studies over the past two decades have defined the core c... 详细信息

关键词： Staurosporine 小径河马 apoptosis 生长房间指向核心部件

In Situ Loading and Delivery of Short Single- and Double-Stranded DNA by Supramolecular Organic Frameworks

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CCS Chemistry 2019年第2期1卷 156-165页

作者： Bo Yang Xiao-Dan Zhang Jian Li Jia Tian Yi-Peng Wu fa-xing yu Ruibing Wang Hui Wang Dan-Wei Zhang Yi Liu Lu Zhou Zhan-Ting Li Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200438China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Children’s Hospital and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacaoChina The Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Short DNA represents an important class of bioma-cromolecules that arewidely applied in gene therapy,editing,and ***,the development of simple and reliable methods for their intracellular delivery remains a ***,we describe that seven water-soluble,homogeneous supramole-cular organic frameworks(SOFs)with a well-defined pore size and high stability in water that can accom-plish in situ inclusion of single-stranded(ss)and double-stranded(ds)DNA(21,23,and 58 nt)and effective intracellular delivery(including two non-cancerous and six cancerous cell lines).

关键词： nucleic acid delivery homogeneous car-rier electrostatic interaction self-assembly porous polymer

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重构Hippo信号通路分子网络

Science Bulletin 2023年第20期68卷 2307-2310页

作者：钟振兴孟志鹏余发星 Institute of Pediatrics Children’s Hospital of Fudan Universityand Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and Metabolismthe State Key Laboratory of Genetic EngineeringInstitutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Molecular and Cellular Pharmacology&Sylvester Comprehensive Cancer Center University of Miami Miller School of MedicineMiami 33136USA

The mechanism by which organs perceive their size and regulate growth in accordance remains *** Hippo signaling pathway has been recognized as a master regulator for organ size,tissue regeneration,and tumorigenesis[1,2].In the last two decades or so,major components of the Hippo pathway have been uncovered,primarily in Drosophila and occasionally in mammals.A comprehensive understanding of the molecular framework and regulatory mechanisms of the Hippo pathway holds immense potential for advancements in cancer therapies and regenerative medicine.

关键词： organs 分子网络 Hippo信号通路

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

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Protein & Cell 2020年第4期11卷 292-298页

作者： Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang yun Liu Sanjun Cai Guoqiang Hua Junjie Peng fa-xing yu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Pediatrics Children's Hospital of Fudan UniversityShanghai 200032China Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Institute of Radiation Medicine Fudan UniversityShanghai 200032China MOE Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Radiation Medicine and Fudan University Shanghai Cancer Center Shanghai Medical schoolFudan UniversityShanghai 200032China

Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1).

关键词： al. colorectal adenocarcinoma

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： xing-Hui yu Yan Xie Jian yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng Xiao Hai-Yang Hu xing-yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control