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Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： chen Pu ZHOU Jun RUAN An-min MA Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu min Guo Jianxin Zhao Hao Zhang Gang Wang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Used car price prediction based on XGBoost and retention rate

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 72-79页

作者： Shen Yutian chen Jian Dai min Zhang Sirui Xu Jing Wang Qing College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China College of Economics and Management Southeast University Chengxian CollegeNanjing 210088China Shandong Shuncheng Automobile Trade Co. LtdJinan 250000China

In order to improve the accuracy of used car price prediction,a machine learning prediction model based on the retention rate is proposed in this ***,a random forest algorithm is used to filter the variables in the *** main characteristic variables that affect used car prices,such as new car price,service time,mileage and so on,are filtered ***,the linear regression classification method is introduced to classify the test data into high and low retention rate *** that,the extreme gradient boosting(XGBoost)regression model is built for the two datasets *** prediction results show that the comprehensive evaluation index of the proposed model is 0.548,which is significantly improved compared to 0.488 of the original XGBoost ***,compared with other representative machine learning algorithms,this model shows certain advantages in terms of mean absolute percentage error(MAPE),5%accuracy rate and comprehensive evaluation *** a result,the retention rate-based machine learning model established in this paper has significant advantages in terms of the accuracy of used car price prediction.

关键词： random forest data dimensionality reduction extreme gradient boosting(XGBoost) retention rate price prediction

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Data-driven approach to predict the fatigue properties of ferrous metal materials using the cGAN and machine-learning algorithms

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Advances in Manufacturing 2024年第3期12卷 447-464页

作者： Si-Geng Li Qiu-Ren chen Li Huang min chen chen-Di Wei Zhong-Jie Yue Ru-Xue Liu Chao Tong Qing Liu School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuPeople’s Republic of China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Materials Bigdata and Application Division Material Academy JitriSuzhou215131JiangsuPeople’s Republic of China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China

The stress-life curve(S–N)and low-cycle strain-life curve(E–N)are the two primary representations used to characterize the fatigue behavior of a *** material fatigue curves are essential for structural fatigue ***,conducting material fatigue tests is expensive and *** address the challenge of data limitations on ferrous metal materials,we propose a novel method that utilizes the Random Forest Algorithm and transfer learning to predict the S–N and E–N curves of ferrous *** addition,a data-augmentation framework is introduced using a conditional generative adversarial network(cGAN)to overcome data *** incorporating the cGAN-generated data,the accuracy(R2)of the Random Forest Algorithm-trained model is improved by 0.3–*** is proven that the cGAN can significantly enhance the prediction accuracy of the machine-learning model and balance the cost of obtaining fatigue data from the experiment.

关键词： fatigue life curve Machine learning Transfer learning Conditional generative adversarial network(cGAN)

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The association and underlying mechanism of the digit ratio(2D:4D)in hypospadias

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Asian Journal of Andrology 2024年第4期26卷 356-365页

作者： Yu Ding Zu-Quan chen Wen-Feng Pan Hao-Jie chen min Wu Yi-Qing Lyu Hua Xie Yi-chen Huang Zhong-Zhong chen fang chen Department of Urology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Urogenital Development Research Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Clinical Research Center for Hypospadias Pediatric CollegeShanghai Jiao Tong University School of MedicineShanghai 200062China.

The second-to-fourth digit(2D:4D)ratio is thought to be associated with prenatal androgen ***,the relationship between the 2D:4D ratio and hypospadias is poorly understood,and its molecular mechanism is not *** this study,by analyzing the hand digit length of 142 boys with hypospadias(23 distal,68 middle,and 51 proximal)and 196 controls enrolled in Shanghai Children’s Hospital(Shanghai,China)from December 2020 to December 2021,we found that the 2D:4D ratio was significantly increased in boys with hypospadias(Pfamily member 5a(Wnt5a),Wnt5b,Smad family member 2(Smad2),and Smad3;mitochondrial function-related genes in cartilage such as AMP-activated protein kinase(AMPK)and nuclear respiratory factor 1(Nrf-1);and vascular development-related genes such as myosin light chain(MLC),notch receptor 3(Notch3),and sphingosine kinase 1(Sphk1),are responsible for the limitation of 4D growth,which results in a higher 2D:4D ratio in boys with hypospadias via decreased endochondral *** study indicates that the ratio of 2D:4D is a risk marker of hypospadias and provides a potential molecular mechanism.

关键词： androgen receptor digit ratio(2D:4D) endochondral ossification hypospadias testosterone level

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Ghrelin inhibits autophagy mediated by AKT/mTOR pathway to ameliorate retinal angiogenesis induced by high glucose stress

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 785-793页

作者： Jiang-Li fan Rong Li min Zhang Chao chen Guo-min Yao Ling-Xiao Zhou Department of Ophthalmology Gongshu District People’s Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310004Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of Endocrinology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of General Surgery the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina

AIM:To observe the effect of ghrelin,a growth hormonereleasing peptide,on retinal angiogenesis in vitro under high glucose(HG)stress and to explore the possible mechanism of ***:Human retinal microvascular endothelial cells(HRMECs)were treated with high concentration of glucose alone or in combination with *** cell migration,tube formation and the expression of the autophagy-related proteins LC3-II/I,Beclin-1,p62,phosphorylated AKT(p-AKT)/AKT and phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR were ***,to clarify the correlation between ghrelin effect and autophagy,AKT inhibitor VIII was adopted to treat HRMECs,and cell migration,tube formation as well as the protein expressions of LC3-II/I,Beclin-1 and p62 were ***:Under HG stress,ghrelin inhibited migration and tube formation of *** inhibited the increases in the protein levels of LC3-II/I,Beclin-1 and the decreases in the protein levels of p62,p-AKT/AKT and p-mTOR/mTOR induced by HG ***,under the action of AKT/mTOR pathway inhibitors,the effects of ghrelin on migration and tube formation were both *** addition,the expression of LC3-II/I and Beclin-1 were significantly up-regulated and the expression of p62 was ***:Retinal angiogenesis under in vitro HG stress can be inhibited by ghrelin through activating AKT/mTOR pathway to inhibit autophagy.

关键词： ghrelin retinal endothelial cell angiogenesis autophagy stress

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A defective iron-based perovskite cathode for high-performance IT-SOFCs:Tailoring the oxygen vacancies using Nb/Ta co-doping

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Journal of Energy Chemistry 2024年第1期88卷 306-316,I0008页

作者： Bayu Admasu Beshiwork Xinyu Wan min Xu Haoran Guo Birkneh Sirak Teketel Yu chen Jun Song chen Tingshuai Li Enrico Traversa School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina The Future Laboratory Tsinghua UniversityBeijing 100084China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Schoolof Environment and Energy South China University of Technlogy Guangzhou 50006GuangongChina Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina

The sluggish kinetics of the electrochemical oxygen reduction reaction(ORR)in intermediatetemperature solid oxide fuel cells(IT-SOFCs)greatly limits the overall cell *** this study,an efficient and durable cathode material for IT-SOFCs is designed based on density functional theory(DFT)calculations by co-doping with Nb and Ta the B-site of the SrFeO_(3-δ)perovskite *** DFT calculations suggest that Nb/Ta co-doping can regulate the energy band of the parent SrFeO_(3-δ)and help electron *** symmetrical cells,such cathode with a SrFe_(0.8)Nb_(0.1)Ta_(0.1)O_(3-δ)(SFNT)detailed formula achieves a low cathode polarization resistance of 0.147Ωcm^(2) at 650℃.Electron spin resonance(ESR)and X-ray photoelectron spectroscopy(XPS)analysis confirm that the co-doping of Nb/Ta in SrFeO_(3-δ)B-site increases the balanced concentration of oxygen vacancies,enhancing the electrochemical performance when compared to 20 mol%Nb single-doped perovskite *** cathode button cell with NiSDC|SDC|SFNT configuration achieves an outstanding peak power density of 1.3 W cm^(-2)at 650℃.Moreover,the button cell shows durability for 110 h under 0.65 V at 600℃ using wet H_(2) as fuel.

关键词： Solid oxide fuel cell Cathode Oxygen reduction reaction Power density DFT calculation

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Application of oblique photogrammetry technique in geological hazard identification and decision management

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Earthquake Research Advances 2024年第3期4卷 34-41页

作者： min Tang Xi Mei Yanna Li chen chen Xiuju Liu Heng Lu China Railway Eryuan Engineering Group CO.LTD Chengdu610031China School of Environment and Resource Southwest University of Science and TechnologyMianyang621000China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China College of Hydraulic and Hydroelectric Engineering Sichuan UniversityChengdu610065China chengdu Planning Information Technic Center Chengdu610042China

With the continuous development of the oblique photography technique, it has been used more and more widely in the field of geological disasters. It can quickly obtain the three-dimensional(3D) real scene model of dangerous mountainous areas under the premise of ensuring the safety of personnel while restoring the real geographic information as much as possible. However, geological disaster areas are often accompanied by many adverse factors such as cliffs and dense vegetation. Based on this, the paper introduced the flight line design of oblique photogrammetry, analyzed the multi-platform data fusion processing, studied the multi-period data dynamic evaluation technology and proposed the application methods of data acquisition, early warning, disaster assessment and decision management suitable for geological disaster identification through the analysis of actual cases, which will help geologists to plan and control geological work more scientifically and rationally, improve work efficiency and reduce the potential personnel safety hazards in the process of geological survey, to offer technical support to the application of oblique photogrammetry in geological disaster identification and decision making and provide the scientific basis for personal and property safety protection and later-stage geological disaster management in disaster areas.

关键词： Oblique photography technique Three-dimensional models Geological hazards Data integration Disaster assessment Decision management

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Salmonella Grumpensis Causing Diarrhea in Children—Shanghai Municipality,China,2023

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China CDC weekly 2024年第18期6卷 396-400,I0006,I0007页

作者： Yue Liu Xuebin Xu Wenqin Wang Wenjia Xiao Yi Hu Xin chen min chen Shanghai Municipal Center for Disease Control and Prevention ShanghaiChina Pudong New Area Center for Disease Control and Prevention ShanghaiChina Department of Epidemiology Key Laboratory of Public Health Safety of Ministry of EducationSchool of Public HealthFudan UniversityShanghaiChina

Summary What is already known about this topic?Foodborne diseases are a growing public health concern with a notable disease burden in *** is added by this report?Two children with diarrhea visited a healthcare facility within 24 hours on August 1 and 2,*** Grumpensis was detected in their stool samples by the public health *** genome sequencing(WGS)analysis revealed characteristics typical of outbreak *** the origin of the outbreak was unknown,the possibility of a hidden shared infection was deemed feasible.

关键词： diarrhea diseases Whole

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Adhesive hydrogel interface for enhanced epidermal signal

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Science China Technological Sciences 2024年第10期67卷 3136-3151页

作者： SHI XinLei YU Hui TANG ZiQing LU ShaoPing YOU min YIN HaiYan chen Qiang Wenzhou Institute University of Chinese Academy of Sciences Joint Research Centre on Medicine The Affiliated Xiangshan Hospital of Wenzhou Medical University

This paper presents a discussion on the method, mechanism, and application of adhesive hydrogel in enhancing epidermal signal,focusing on the interface between hydrogel and skin. Due to its excellent conductivity and high adaptability to the skin, the hydrogel is exceptionally suitable for detecting human-machine interfaces, particularly epidermal electromyographic ***, the detection of the high epidermal signal is hindered by the gap and low adhesion between hydrogel and skin. This paper addresses these challenges by introducing approaches to reduce the interface gap and increase interface adhesion, thereby enabling the development of hydrogel-based epidermal signal detection arrays with enhanced resolution and detection performance.

关键词： adhesive hydrogel hydrogel electrodes epidermal signal interfacial adhesion

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