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Mitochondrial proteomic analysis of ecdysterone protection against oxidative damage in human lens epithelial cells

International Journal of Ophthalmology(English edition) 2014年第1期7卷 38-43页

作者： Chun-Yan Feng Xiu-Rong Huang Ming-Xin Qi Song-Wen Tang Sheng Chen Yan-Hong Hu fa-jie ke Xin Wang Department of Ophthalmology Second Affiliated Peoples Hospital of Fujian University of Traditional Chinese Medicine Research Center of Pathophysiology Fujian University of Traditional Chinese Medicine Department of Laboratory Fujian University of Traditional Chinese Medicine subsidiary Rehabilitation Hospital

AIM: To investigate the protective effects of the natural medicinal monomer ecdysterone(ECR) with estrogenic activity against oxidative damage in human lens epithelial cells B3(HLE-B3) caused by hydrogen peroxide 21(H2 O2) and to pursue the possible mitochondrial proteomic regularity of the protective effects. · METHODS: HLE-B3 cells were treated with H2O2(300μmol/L),β-estuarial(E2; 10-8mol/L) and H2 O2,ECR(10-6mol/L) and H2 O2,or left untreated. Altered expression of all mitochondrial proteins was analyzed by protein array and surface-enhanced laser desorption ionization time of flight mass spectrometry(SELDI-TOF-MS). The mass/charge(M/Z) ratios of each peak were tested by the Kruskal-Wallis rank sum test,and the protein peak value of the M/Z ratio for each treatment by pair comparison was analyzed with the Nemenyi test. ·RESULTS: H2O2 up-regulated expression of two protein spots(with M/Z of 6 532 and 6 809). When E2 mitigated the oxidative damage,the expression of one protein spot(M/Z 6 532) was down-regulated. In contrast,ECR downregulated both of protein spots(M/Z 6 532 and 6 809). · CONCLUSION: ECR could effectively inhibite H2O2 induced oxidative damage in HLE-B3 cells. The protein spot at M/Z of 6 532 might be the target spot of ECR against oxidative damage induced by H2 O2.

关键词： ecdysterone mitochondrial proteomics lens epithelial cell senile cataract

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Effects of Dendrobium candidum polysaccharides on microRNA-125b and mitogen-activated protein kinase signaling pathways in diabetic cataract rats

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Traditional Medicine Research 2021年第5期6卷 43-48页

作者： Zi-Yang Chen Qian Lan Sheng Chen Yan-Hong Hu fa-jie ke Jun Hu Chun-Yan Feng Ming-Xin Qi Xiu-Rong Huang Comprehensive Clinic of Fujian Academy of Chinese Medicine Fuzhou 350003China Fujian University of Traditional Chinese Medicine Fuzhou 350122China Department of Opthalmology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003China

Background:Diabetic cataract is a common complication and a lens disorder in ***,Dendrobium officinale polysaccharide(DOP)is found to alleviate diabetes ***,microRNA-125b and mitogen-activated protein kinase signaling pathways play significant roles in ***,the mechanism and the effect of DOP on diabetic cataract remains ***:Wistar male rats were randomly assigned to the control,model,and DOP *** was induced with ***,DOP was orally given for 12 *** Lens Opacities Classification System III was used to evaluate lens opacity by slit-lamp *** lens was then harvested for testing the mRNA expression of microRNA-125b,ERK1,ERK2,Raf and Ras using reverse transcription-polymerase chain *** protein expression of ERK1,ERK2,Raf,and Ras was detected using the Western blot *** targets of microRNA-125b were predicted in miRWalk *** targets were obtained from the Kyoto Encyclopedia of Genes and Genomes ***:The lens opacities of the rats in the control group were almost at ***,the majority of the lens opacities in the model group were C3 to C4 and N1 to N2,and were mostly at C1 to C2 and N0 to N1 in the DOP *** difference was statistically significant(P<0.05).Furthermore,the microRNA-125b expression in the model group is significantly higher compared with the control ***,the microRNA-125b expression in the DOP group is significantly decreased(all P<0.05).The mRNA expression of ERK1,ERK2,Raf,and Ras in the model groups were upregulated compared with those of the control ***,the ERK1 and Raf mRNA expressions of the DOP group were lower compared with the model group(all P<0.05).The protein expression of ERK1,Raf,and Ras in the model group was significantly increased compared with those of the control *** protein expression of ERK1,Raf,and Ras in the DOP group was significantly lower compared with

关键词： Dendrobium officinale polysaccharide microRNA-125b mitogen-activated protein kinase diabetic cataract

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Mechanism of Liangxue Huayu decoction in treatment of age-related macular degeneration based on network pharmacology and clinical validation

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Drug Combination Therapy 2022年第3期4卷 1-7页

作者： Zi-Yang Chen Ying-Ying Lin Yi-Huang Zheng fa-jie ke Sheng Chen Yan-Hong Hu Eye Hospital of Chinese Academy of Traditional Chinese Medicine Beijing 100040China The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine Fujian 350001China

Background:This paper investigates the mechanism of Liangxue Huayu decoction treating age-related macular degeneration through network pharmacology and clinical ***:The potential targets of Liangxue Huayu decoction were retrieved by the BATMAN-TCM database,and age-related macular degeneration-related disease targets were collected using the OMIM,GeneCards,and CTD *** intersection of targets for Liangxue Huayu decoction for age-related macular degeneration was performed using the online tool ***-protein interaction network was drawn using the String *** core targets were obtained with the CytoNCA *** gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed using the Metascape ***,targets of Liangxue Huayu decoction for age-related macular degeneration were identified in clinical ***:In this study,832 potential action targets and 9,475 age-related macular degeneration-related disease targets were screened,and 575 intersection targets of Liangxue Huayu decoction and age-related macular degeneration were ***-protein interaction network analysis showed that 15 core targets include chemokine 8,interleukin 1,histone deacetylase 2,estrogen receptor 2,and glutamate ionotropic receptor NMDA type subunit 1,et *** ontology enrichment analysis included 2,727 biological processes,434 molecular functions,and 206 cellular *** Encyclopedia of Genes and Genomes enrichment analysis selected 107 signaling *** validation showed that peripheral blood chemokine 8 and interleukin 1 levels were significantly lower after age-related macular degeneration patients compared with before treatment,and the difference was statistically significant(t chemokine 8=12.684,t interleukin 1=11.405,all P<0.001).Conclusion:By treating age-related macular degeneration with multiple targets and multiple pathways,Liangxue Huayu decoction can down-re

关键词： Liangxue Huayu decoction age-related macular degeneration network pharmacology interleukin-1β chemokines 8

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OCTA定量分析补阳还五汤加味对非增殖型糖尿病视网膜病变患者视盘血流的影响

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国际眼科杂志 2023年第12期23卷 2040-2045页

作者：石颖陈子扬叶照达柯发杰胡艳红陈胜福建中医药大学附属第二人民医院眼科福建省福州市350003 福建省中医药科学院门诊部福建省福州市350003

目的:观察补阳还五汤加味治疗气阴两虚、络脉瘀阻型非增殖型糖尿病视网膜病变(NPDR)的临床疗效,并应用光学相干断层扫描血管成像(OCTA)定量分析治疗前后视盘旁血流密度的变化。方法:采用前瞻性随机对照试验。收集2022-06/11期间我院收... 详细信息

目的:观察补阳还五汤加味治疗气阴两虚、络脉瘀阻型非增殖型糖尿病视网膜病变(NPDR)的临床疗效,并应用光学相干断层扫描血管成像(OCTA)定量分析治疗前后视盘旁血流密度的变化。方法:采用前瞻性随机对照试验。收集2022-06/11期间我院收治的符合气阴两虚、络脉瘀阻型NPDR患者58例99眼,随机分为对照组29例48眼,采用2019年美国眼科学会发布的糖尿病视网膜病变推荐方案进行基础治疗(对于轻度NPDR患者进行控制血糖、糖尿病健康教育、定期随访;中度NPDR患者必要时增加局部或格栅样激光光凝治疗),观察组29例51眼在对照组的基础上加用补阳还五汤加味口服治疗1mo。比较两组患者治疗前后最佳矫正视力(BCVA)、中医证候疗效、视盘旁放射状毛细血管网血流密度(ppVD)及视盘旁视网膜神经纤维层(pRNFL)厚度变化。结果:治疗1mo后观察组BCVA(LogMAR)为0.20(0.10,0.30),较对照组0.30(0.20,0.40)明显改善(P<0.05)。治疗1mo后观察组中医证候疗效优于对照组(P<0.05)。观察组治疗1mo后各象限ppVD均较治疗前明显提高,且观察组各象限ppVD均高于对照组(P<0.05)。观察组治疗1mo后上方、颞侧象限及全周平均pRNFL厚度较治疗前升高,且观察组上方、颞侧、下方象限和全周平均pRNFL厚度均高于对照组(P<0.05)。结论:气阴两虚、络脉瘀阻型NPDR患者服用补阳还五汤加味后可改善视力、提高中医证候疗效,可能与其能提高视盘旁放射状毛细血管网血流密度和减少视盘旁神经纤维层的损伤有关。

关键词：非增殖型糖尿病视网膜病变补阳还五汤加味视盘血流光学相干断层扫描血管成像(OCTA)

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Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期100卷 369-376页

作者： Shiyao Shang Fuzhou Wang Zeyi Sun Chaofan Qiang ke Chu School of Materials Science and Engineering Lanzhou Jiaotong University

Electrochemical reduction of NO2-to NH3（NO2-RR） is recognized as an appealing approach for achieving renewable NH3synthesis and waste ***,we report isolated Bi alloyed Ru （Bi1Ru） as an efficient NO2-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO2-activation and suppress proton adsorption,while accelerating the NO2-RR protonation energetics to render a high NO2--to-NH3conversion ***,Bi1Ru assembled in a flow cell delivers an NH3yield rate of 1901.4μmol h-1cm-2and an NH3-faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA *** study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO2-RR catalysts toward the ammonia electrosynthesis.

关键词： Ammonia

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Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI ke XIE Meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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绝经后女性雌激素水平与老年性白内障的关系

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国际眼科杂志 2013年第6期13卷 1222-1223页

作者：冯春燕黄秀榕祁明信胡俊柯发杰胡艳红陈胜福建中医药大学附属第二人民医院眼科中国福建省福州市350003 福建中医药大学病理生理研究中心中国福建省福州市350003

目的:探讨绝经后女性雌激素水平与老年性白内障的关系。方法:实验分两组:对照(绝经后健康妇女)组、绝经后老年性白内障患者组。放射免疫检测法检测绝经后老年性白内障患者和对照组血清雌二醇(β-Estradiol,E2)的水平。结果:绝经后老年... 详细信息

目的:探讨绝经后女性雌激素水平与老年性白内障的关系。方法:实验分两组:对照(绝经后健康妇女)组、绝经后老年性白内障患者组。放射免疫检测法检测绝经后老年性白内障患者和对照组血清雌二醇(β-Estradiol,E2)的水平。结果:绝经后老年性白内障患者E2水平较绝经后健康妇女明显下降,与对照组比较差异有统计学意义(P<0.05)。结论:绝经后女性老年性白内障的发生与缺乏雌激素有关,雌激素对白内障有保护作用。

关键词：雌激素老年性白内障绝经后女性

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei HUANG Jin ZHU ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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中药单体榄香烯体外对人晶状体上皮细胞内胶原蛋白合成的影响

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国际眼科杂志 2009年第8期9卷 1456-1457页

作者：胡艳红黄秀榕祁明信侯补元冯春燕陈胜柯发杰福建中医学院附属第二人民医院眼科中国福建省福州市350003 福建中医学院病理生理研究中心中国福建省福州市350003

目的:探讨中药单体榄香烯(effects of elemene,Ele)对人晶状体上皮细胞系(human lens epithelial cells B3,HLE-B3)内Ⅰ型胶原蛋白和Ⅲ型胶原蛋白合成的影响。方法:利用10μg/L碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)诱导HLE-B3增殖,将80mg/L的Ele作用在处于增殖状态下的HLE-B3,24h后采用双抗体夹心ABC-酶联免疫吸附测定法(enzyme-linked immunosorbent assay,ELISA)检测Ele作用后HLE-B3内Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达。结果:rhbFGF作用后HLE-B3内Ⅰ型胶原蛋白浓度为53.5±5.4μg/L,较正常组(38.5±2.3μg/L)明显升高,Ele作用后HLE-B3内Ⅰ型胶原蛋白的浓度为29.5±2.9μg/L,较rhbFGF组明显下降(P<0.01)。rhbFGF作用后HLE-B3内Ⅲ型胶原蛋白浓度为1.27±0.29μg/L,较正常组(0.83±0.12μg/L)明显升高,Ele作用后HLE-B3内Ⅲ型胶原蛋白的浓度为0.69±0.11μg/L,较rhbFGF组明显下降(P<0.01)。结论:Ele抑制rhbFGF诱导的HLE-B3增殖的同时也能抑制HLE-B3内Ⅰ,Ⅲ型胶原蛋白合成,干扰HLE-B3纤维化,可望成为防治后囊膜混浊的理想药物。

关键词：榄香烯晶状体上皮细胞后囊膜混浊 Ⅰ型胶原蛋白 Ⅲ型胶原蛋白

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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long fan Chuan-ke Zhang Yong He the School of Automation China University of Geosciences the Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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