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Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： fu-ming tsai PING-HSUN LU LU-KAI WANG CHAN-YEN KUO MAO-LIANG CHEN CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 Hair loss Cell cycle

Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant

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Chinese Journal of Chemistry 2024年第11期42卷 1203-1208页

作者： Wei Ge Jia-Xin Wang ming-Chen fu Yao fu Hefei National Research Center for Physical Sciences at the Microscale iChEMCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefeiAnhui230026 China Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering Hefei University of TechnologyHefeiAnhui230009 China

Herein,we report an efficient and practical protocol for the photoinduced dehalocyclization of ortho-halophenylacrylamides with formate by the engagement of a CO_(2) radical anion to access substituted *** method proceeds smoothly under mild conditions and exhibits a wide range of substrate as well as remarkable functional group compatibility.

关键词： Formate CO_(2)Radical ions Oxindole Photocatalysts Cyclization Organohalides

Grain size effect on the assembly quality of micro-scaled barrel formed by microforming

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Advances in Manufacturing 2024年第1期12卷 19-32页

作者： Dien Hu Jieyichen Fang Feng Zeng ming-Wang fu Department of Mechanical Engineering Research Institute of Advanced ManufacturingThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Xiamen Yulong Machinery Co.Ltd. Xiamen361023FujianPeople’s Republic of China

In this research,a method employing micro-extrusion was designed to produce the micro-scaled barrel-shaped parts with complex geometrical features to study the feasibility of the proposed microforming method and its grain size effect on the formability of the complicated internal features in terms of deformation behavior,material evolution,accuracy of dimensions and final components *** results reveal that the deformation behavior is highly affected by grain size and becomes unpredictable with increased grain *** addition,assembly parameters including feature dimension,tolerance and coaxiality also vary with grain size,and the variation of grain size needs to be accommodated by different assembly types,viz.,clearance fit or transition *** the microstructural evolution aspect,it was identified there were two dead zones and four shear bands,and the formation of these deformation zones was barely affected by the variation in grain *** bulges,cracks,and fracture induced voids were observed on the surface of the final components,tailoring the microstructure of the working material with finer grains could significantly avoid these *** study advances the understanding of forming microparts by extrusion processes and provides guidance for microforming of similar microparts.

关键词： Microformed part Size effect Extrusion Microstructural evolution Dimensions Assembly accuracy

Effect of Al content in molten steel on interaction between MgO-C refractory and SPHC steel

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Journal of Iron and Steel Research International 2024年第4期31卷 838-848页

作者： fu-bin Gao fu-ming Wang Xiang Zhang Tian-yu Du Xin-hua Wangg School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Handan Iron and Steel Company Hegang GroupHandan 056015HebeiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The effect of Al content in molten steel on the interaction between SPHC steel(0.005-0.068 wt.%Al,and 19×10^(-4)-58×10^(-4)wt.%O)and MgO-C refractory(11.63 wt.%C)was ***-metallic inclusions in the steel were examined at various periods(0,5,15,30,45,and 60 min)as well as the MgO-C interface after 60 min of corrosion at 1600℃.The results show that when MgO-C refractory comes into contact with SPHC steel,the refractory interface consists of three layers arranged from the innermost to the outermost,including the original refractory layer,the dense MgO layer,and the iron infiltration *** carbon in the MgO-C refractories and the Al content in the molten steel undergo a reaction with the MgO in the refractories,resulting in an increase in Mg concentration in the *** Al content in the molten steel from 0.005 to 0.068 wt.%causes a spinel layer to appear at the interface,and the disappearance time of Al_(2)O_(3) inclusions in the steel decreases from 60 to 30 min,while the average MgO content in inclusions ***,controlling the Al content in the molten steel and the smelting duration can help regulate the formation of spinel inclusionsinthe steel.

关键词： MgO-C refractory SPHC steel Inclusion-Spinel Al-killed steel Interfacial reaction

Investigation of Maxima Assumptions in Modelling Tropical Cyclone- Induced Hazards in the South China Sea

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China Ocean Engineering 2024年第3期38卷 491-504页

作者： WEN Ze-guo WANG fu-ming WAN Jing YANG Fan School of Civil Engineering Sun Yat-sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Guangdong Academy of Safety Science and Technology Guangzhou 510060China Guangdong Key Laboratory of Oceanic Civil Engineering Guangzhou 510275China Advanced Energy Science and Technology Guangdong Laboratory(Yangjiang Offshore Wind Energy Laboratory) Yangjiang 529500China

The present study aims to examine the suitability of two commonly used assumptions that simplify modelling metoceanconditions for designing offshore wind turbines in the South China Sea (SCS). The first assumption assumes thatjoint N-year extreme wind and wave events can be independently estimated and subsequently combined. The secondone assumes peak wind and waves can be modelled as occurring simultaneously during a tropical cyclone (TC) *** better understand the potential TC activity, a set of 10000 years synthetic TC events are generated. The wind fieldmodel and the Mike 21 spectral wave model are employed to model the TC-induced hazards. Subsequently, theeffect of the assumptions is evaluated by analyzing the peak structural response of both monopile and semisubmersibleoffshore wind turbines during TC events. The results demonstrate that the examined assumptions are generally *** assessing the implications of these assumptions, valuable insights are obtained, which can inform andimprove the modelling of TC-induced hazards in the SCS region.

关键词： tropical cyclone numerical wave modelling hazards offshore wind turbines structural response

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Androgens exert multifaceted functions in sex differences analyzed through single-cell transcriptome

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Science China Life Sciences 2024年第11期67卷 2530-2531页

作者： Xinxin Tang Yinkun fu Zhihui Zou Yue Li ming He Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases Department of Pathophysiology School of Medicine Shanghai Jiao Tong University Department of Pathology The Affiliated Hospital of Youjiang Medical University for Nationalities

Sex differences are ubiquitous in human development, aging and disease. For example, the overwhelming majority of non-reproductive system cancers are more common in males(Mauvais-Jarvis et al., 2020), while autoimmune diseases are more common in females. Hormones,especially androgens and oestrogens, contribute to sex-biased phenotypes(Khramtsova et al., 2019).

关键词： PROSTATE CASTRATION

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A particle-resolved heat-particle-fluid coupling model by DEM-IMB-LBM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： ming Xia Jinlong fu Y.T.Feng Fengqiang Gong Jin Yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary(IMB)scheme is used to couple the discrete element method(DEM)and lattice Boltzmann method(LBM),while a recently proposed Dirichlet-type thermal boundary condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IBM-LBM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant physical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKT)simulation with heat transfer,are carried out to validate the accuracy of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice Boltzmann method(LBM) Dirichlet-type thermal boundary Direct numerical simulation

Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation

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Neural Regeneration Research 2024年第9期19卷 2050-2056页

作者： Xigong Li Jing fu ming Guan Haifei Shi Wenming Pan Xianfeng Lou Department of Orthopedics The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang ProvinceChina Department of Stomatology Xixi HospitalHangzhouZhejiang ProvinceChina Department of Orthopedics and Spine Surgerythe Affiliated Hospital of Xuzhou Medical Schoolthe Second People’s Hospital of ChangshuChangshuJiangsu ProvinceChina

Previous studies have shown that Biochanin A,a flavonoid compound with estrogenic effects,can serve as a neuroprotective agent in the context of cerebral ischemia/reperfusion injury;howeve r,its effect on spinal cord injury is still unclea r. In this study,a rat model of spinal cord injury was established using the heavy o bject impact method,and the rats were then treated with Biochanin A(40 mg/kg) via intrape ritoneal injection for 14 consecutive *** res ults showed that Biochanin A effectively alleviated spinal cord neuronal injury and spinal co rd tissue injury,reduced inflammation and oxidative stress in spinal cord neuro ns,and reduced apoptosis and *** addition,Biochanin A inhibited the expression of inflammasome-related proteins(ASC,NLRP3,and GSDMD)and the Toll-like receptor 4/nuclear factor-κB pathway,activated the Nrf2/heme oxygenase 1 signaling pathway,and increased the expression of the autophagy markers LC3 Ⅱ,Beclin-1,and *** r,the therapeutic effects of Biochanin A on early post-s pinal cord injury were similar to those of *** findings suggest that Biochanin A protected neurons in the injured spinal cord through the Toll-like receptor 4/nuclear factor κB and Nrf2/heme oxygenase 1 signaling *** findings suggest that Biochanin A can alleviate post-spinal cord injury at an early stage.

关键词： apoptosis autophagy Biochanin A heme oxygenase 1 inflammation Nrf2 protein nuclear factor kappa-B oxidative stress spinal cord injury Toll-like receptor 4

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Pre-MASLD:Should it be defined separately?

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 1-3页

作者： Hang-Kai Huang You-ming Li Cheng-fu Xu Department of Gastroenterology Zhejiang Provincial Clinical Research Center for Digestive Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases,yet it has not received sufficient attention[1].Over the past two decades,the overall global prevalence of NAFLD has risen from 25%to 37%[2].The disease burden of NAFLD is fueled by the epidemic of obesity and diabetes[3].It is estimated that more than half of patients with diabetes have NAFLD.

关键词： NAFLD liver diseases

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