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Bilateral oophorectomy combined with exemestane treating advanced refractory breast cancer

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The Chinese-German Journal of Clinical Oncology 2011年第1期10卷 43-46页

作者： Xinhong Wu Yaojun feng juan xu Yiping Gong Biao Ma Department of Breast Cancer Hubei Cancer Hospital Wuhan 430079 China

Objective： Taking tamoxifen orally is the main endocrine therapy of the premenopausal breast cancer with positive hormone receptor, but numerous patients developed to be advanced refractory breast cancer because of drug resistance. Our study investigated a role of the combination of bilateral oophorectomy and exemestane in the management of advanced refractory breast cancer. Methods： The bilateral oophorectomy was carried out in 17 patients. One week after the operation, exemestane was taken orally （25 mg/d）. The median time to progression （TTP）, the median survival time and the survival rate were calculated using Kaplan-Meier methods. Results： Seventeen patients age ranged from 26 to 44 years （median, 36 years） were treated with an overall response rate of 64.70%, TTP was 8 months and the median survival time was 31 months. The survival rate of 1-year, 3 years and 5 years was 88.24%, 64.71%, 29.41%, respectively. There have no grade Ⅲ/Ⅳ side effects appeared. Conclusion： Bilateral oophorectomy combined with exemestane is safe and effective for advanced refractory premenopausal breast cancer with positive hormone receptor and it is well-torerated.

关键词： advanced breast cancer exemestane oophorectomy

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng xu xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei xu Guoqing Wang feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

2011年～2015年辽宁水稻育成品种品质性状分析

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北方水稻 2017年第5期47卷 12-15页

作者：韩锋徐娟辽宁省盐碱地利用研究所辽宁盘锦124010 辽宁省农业技术推广总站沈阳110034

以辽宁省2011年~2015年育成的72个水稻品种为分析材料,对辽宁水稻品质性状现状进行分析。结果表明:辽宁省近年来育成的水稻品种碾磨品质较好,透明度、垩白性状上品种间差异明显。垩白度、透明度是决定品种品质等级表现的主要性状。品质... 详细信息

以辽宁省2011年~2015年育成的72个水稻品种为分析材料,对辽宁水稻品质性状现状进行分析。结果表明:辽宁省近年来育成的水稻品种碾磨品质较好,透明度、垩白性状上品种间差异明显。垩白度、透明度是决定品种品质等级表现的主要性状。品质性状间存在着不同程度的相关性。对加工品质、外观品质进行综合选择是优质水稻品种选育的主要途径。

关键词：水稻品质性状优质分析相关分析

水稻种质资源主要农艺性状遗传多样性及多元分析

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北方水稻 2017年第4期47卷 6-8,16页

作者：韩锋徐娟辽宁省盐碱地利用研究所辽宁盘锦124010 辽宁省农业技术推广总站沈阳110034

采用多样性指数、主成份分析、聚类分析等方法,对437份水稻品种进行研究。结果表明:株高、穗长、穗粒数、着粒密度、有效穗数、结实率、千粒重、谷粒长度、谷粒宽度的变异系数为8.16%~32.26%,各性状Shannon-Wiener多样性指数为1.756~2.... 详细信息

采用多样性指数、主成份分析、聚类分析等方法,对437份水稻品种进行研究。结果表明:株高、穗长、穗粒数、着粒密度、有效穗数、结实率、千粒重、谷粒长度、谷粒宽度的变异系数为8.16%~32.26%,各性状Shannon-Wiener多样性指数为1.756~2.046。穗长因子、穗粒因子、谷粒因子、粒重因子是影响性状综合表现的主要因子,437份水稻品种可划分具有不同形态的3个类群。

关键词：水稻性状多样性主成份分析聚类分析

cPKCbetaⅡ-CRMP-2 pathway was involved in hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury

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cPKCbetaⅡ-CRMP-2 pathway was involved in hypoxic preconditi...

Changes of cPKCgamma signaling molecules in the hippocampus of hypoxic preconditioned mice

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Cai-Yan ZHANG,Su-juan feng,xu LIU,Nan ZHANG,Xiang-Ning BU,Jun-Fa LI~* Department of Neurobiology and Beijing Institute for Neuroscience,Capital Medical University,Beijing 100069, China

＜正＞Objective To identify the classical protein kinase CbetaⅡ（cPKCbetaⅡ）- interacting proteins involved in hypoxic preconditioning（HPC） and explore its changes in middle cerebral artery occlusion（MCAO） induced brain injuries of *** Using our established HPC and MCAO mouse models,we applied the techniques of immunoprecipitation, two-dimensional electrophoresis and mass spectrometry to identify cPKCbetaⅡ-interacting ***-PAGE and Western blot were used to analyze the changes in protein phosphorylation and expression levels in HPC and MCAO. Results We found that collapsin response mediator protein-2（CRMP-2） could be coimmunoprecipitated with cPKCbetaⅡ,and the protein expression of CRMP-2 interacting with cPKCbetaⅡincreased significantly in the cortex of mice after *** phosphorylation level,not protein expression,of CRMP-2 decreased significantly after cerebral ischemia and partially be turned over by *** These results suggested that cPKCbetaⅡ-CRMP-2 pathway was involved in the neuroprotective effects of hypoxic preconditioning on cerebral ischemia.

关键词： hypoxic preconditioning(HPC) middle cerebral artery occlusion(MCAO) classical protein kinase CbetaⅡ(cPKCbetaⅡ) proteomics neuroprotection

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Changes of cPKCgamma signaling molecules in the hippocampus ...

Recent Advances in Fibrous Materials for Hydroelectricity Generation

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Nan ZHANG,Xiang-Ning BU,Su-juan feng,xu LIU,Cai-Yan ZHANG,Jing LIANG,Jian-Li DU,Jun-Fa LI~* Department of Neurobiology,Capital Medical University,Beijing 100069,China

＜正＞Objective Previously,we have demonstrated that the translocation activation of conventional protein kinase Cgamma（cPKCgamma） is involved in the development of hypoxic *** present study was designed to indentify the cPKCgamma signaling molecules and further explore the mechanisms of hypoxic *** Using our established "auto-hypoxia"-induced HPC model,healthy male BALB/c mice were randomly divided into norrnoxic control and HPC *** extracted from the cytosolic and particulate fraction of mice hippocampus were coimmunoprecipitated with cPKCgamma and separated by 2-dimensional electrophoresis（2DE）.Differential expressed proteins were identified by matrix-assisted laser desorption/ionization time of flight mass spectrometer（MALDI-TOF MS）. Reverse immunoprecipitation and Western blot were applied to validate the interactions between the identified proteins and *** Totally,23 cPKCgamma-interacting proteins were successfully identified by MALDI-TOF MS in the cytosolic fraction of mice hippocampus,among which 13 proteins increased and 8 decreased more than 2 times. While in the particulate fraction,47 cPKCgamma-interacting proteins were identified including 25 increased and 14 decreased. Heat shock protein 60（HSP60）,HSP70,14-3-3gamma,synapsin and collapsin response mediator protein 2（CRMP2） can be precipitated by cPKCgamma and vice versa in both cytosolic and particulate fractions of *** Changes of cPKCgamma signaling molecules are involved in the development of hypoxic preconditioning.

关键词： Hypoxic preconditioning(HPC) conventional protein kinase Cgamma(cPKCgamma) Proteomics co-immunoprecipitation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo xu Xiao feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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影响压疮愈合的危险因素分析

中国实用护理杂志 2017年第22期33卷 1720-1723页

作者：冯娟徐美娟张静山东省泰安市中心医院肿瘤外科 271000 上海市第二人民医院老年病科

目的探讨影响压疮患者治疗30 d后创面愈合的危险因素.方法选取2015年1月至2016年10月住院的压疮患者245例,治疗30 d时根据是否愈合分组,压疮愈合的84例为愈合组,压疮未愈合的161例为未愈合组.观察患者年龄、性别、卧床、水肿、多病并... 详细信息

目的探讨影响压疮患者治疗30 d后创面愈合的危险因素.方法选取2015年1月至2016年10月住院的压疮患者245例,治疗30 d时根据是否愈合分组,压疮愈合的84例为愈合组,压疮未愈合的161例为未愈合组.观察患者年龄、性别、卧床、水肿、多病并存、压疮个数、压疮面积、压疮愈合评价量表（PUSH）、Hb、血清白蛋白（Alb）、LDL-C及血同型半胱氨酸（Hcy）12项指标,进行单因素及多因素回归分析.结果对12项指标进行单因素分析,影响压疮愈合的危险因素有年龄、Hb、Alb、Hcy、压疮面积、PUSH评分6项指标进入回归方程（Z=3.11~6.63,均P〈0.01）,性别也进入回归方程（χ2=0.19,P〈0.01）;进一步经多因素回归分析发现PUSH评分指标的差异有统计学意义（χ2=10.47,P〈0.01,OR=0.001,95%可信区间为0.001~0.037）.结论对于压疮治疗30 d后创面愈合而言,影响压疮愈合的危险因素有年龄、性别、Hb、Alb、Hcy、压疮面积等指标.

关键词：压力性溃疡压疮愈合评价量表创面愈合回归分析