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Effect of viral hepatitis on type 2 diabetes:A Mendelian randomization study

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World Journal of Diabetes 2024年第2期15卷 220-231页

作者： yun-feng Yu Gang Hu Ke-Ke Tong Xin-Yu Yang Jing-Yi Wu Rong Yu The First Hospital of Hunan University of Chinese Medicine Changsha 410007Hunan ProvinceChina The Hospital of Hunan University of Traditional Chinese Medicine Changde 415213Hunan ProvinceChina College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital of Zhejiang Chinese Medical University Hangzhou 310005Zhejiang ProvinceChina

BACKGROUND The effects of viral hepatitis(VH)on type 2 diabetes(T2D)remain *** To analyze the causal correlation between different types of VH and T2D using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms of VH,chronic hepatitis B(CHB),chronic hepatitis C(CHC)and T2D were obtained from the BioBank Japan Project,European Bioinformatics Institute,and *** variance weighted,MREgger,and weighted median were used to test exposure-outcome *** MR-Egger intercept analysis and Cochran’s Q test were used to assess horizontal pleiotropy and heterogeneity,***-one-out sensitivity analysis was used to evaluate the robustness of the MR analysis *** The MR analysis showed no significant causal relationship between VH and T2D in Europeans[odds ratio(OR)=1.028;95%confidence interval(CI):0.995-1.062,P=0.101].There was a negative causal association between CHB and T2D among East Asians(OR=0.949;95%CI:0.931-0.968,P0.05).Sensitivity analysis showed that the results were *** Among East Asians,CHB is associated with a reduced T2D risk,but this association is limited by HBV load and *** VH among Europeans and CHC among East Asians are not associated with the risk of T2D,focusing on blood glucose in patients with CHC is still relevant for the early detection of T2D induced by CHCmediated pathways of hepatic steatosis,liver fibrosis,and cirrhosis.

关键词： Viral hepatitis Chronic hepatitis B Chronic hepatitis C Type 2 diabetes Mendelian randomization

Severe acute pancreatitis complicated with intra-abdominal infection secondary to trauma:A case report

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World Journal of Clinical Cases 2024年第25期12卷 5821-5831页

作者： Yu Zhang yun-feng Cui Department of Surgery Tianjin Nankai HospitalTianjin Medical UniversityTianjin 300070China Department of Hepatobiliary and Pancreatic Surgery Department of SurgeryTianjin Nankai HospitalNankai Clinical School of MedicineTianjin Medical UniversityTianjin 300100China

BACKGROUND Pancreatic trauma(PT)is rare among traumatic injuries and has a low incidence,but it can still lead to severe infectious complications,resulting in a high mortality *** pancreatitis(AP)is a common complication after PT,and when combined with organ dysfunction and sepsis,it will result in a poorer *** SUMMARY We report a 25-year-old patient with multiple organ injuries,including the pancreas,due to abdominal trauma,who developed necrotising pancreatitis secondary to emergency caesarean section,combined with intra-abdominal infection(IAI).The patient underwent performed percutaneous drainage,pancreatic necrotic tissue debridement,and abdominal infection foci debridement on the *** We report a case of severe AP and IAI secondary to *** patient was managed by a combination of conservative treatment such as antibiotic therapy and fluid support with surgery,and a better outcome was obtained.

关键词： Abdominal trauma Pancreatic trauma Severe acute pancreatitis Management Intra-abdominal infection Case report

Does type 1 diabetes serve as a protective factor against inflammatory bowel disease:A Mendelian randomization study

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World Journal of Diabetes 2024年第7期15卷 1551-1561页

作者： Ke-Ke Tong yun-feng Yu Xin-Yu Yang Jing-Yi Wu Rong Yu Chuan-Chuan Tan The First Hospital of Hunan University of Chinese Medicine Changsha 410007Hunan ProvinceChina School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND The impact of type 1 diabetes(T1D)on inflammatory bowel disease(IBD)remains *** To analyze the causal relationship between T1D and IBD using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms were sourced from FinnGen for T1D,IBD,ulcerative colitis(UC)and Crohn’s disease(CD).Inverse variance-weighted,MREgger,and weighted median tests were used to assess exposure-outcome *** MR-Egger intercept was used to assess horizontal ***’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity,*** Our MR analysis indicated that T1D was associated with a reduced risk of IBD[odds ratio(OR):0.959;95%confidence interval(CI):0.938-0.980;P0.05).Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous(P>0.05)and were *** This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.

关键词： Type 1 diabetes Inflammatory bowel disease Ulcerative colitis Crohn’s disease Mendelian randomization

Engineered plasmonic resonances with Fabry-Perot optical microcavities

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 172-172页

作者： Xiaoxiu Zhu Xiao Xiong yun-feng Xiao State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Optical cavities play a crucial role in confining light in both the time and frequency domains,serving as essential components in fundamental and applied *** quality factor(Q)and smaller mode volume(V)are sought-after characteristics,as the Purcell factor is directly proportional to Q/*** microcavities possess an ultra-high Q but a relatively large V,whereas plasmonic nanocavities have an ultra-small V but suffer from significant Ohmic loss.

关键词： Engine optical Ohmic

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A Post-Quantum Cross-Domain Authentication Scheme Based on Multi-Chain Architecture

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Computers, Materials & Continua 2024年第2期78卷 2813-2827页

作者： Yi-Bo Cao Xiu-Bo Chen yun-feng He Lu-Xi Liu Yin-Mei Che Xiao Wang Ke Xiao Gang Xu Si-Yi Chen Information Security Center State Key Laboratory ofNetworking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Information Center of China North Industries Group Corporation Beijing100089China School of Information Science and Technology North China University of TechnologyBeijing100144China

Due to the rapid advancements in network technology,blockchain is being employed for distributed data *** the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication ***,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication schemes based on traditional cryptography,posing a significant security *** response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication scheme to negotiate the session key used in the cross-chain asset exchange ***,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication ***,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust ***,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(SIS)assumption,respectively,indicating that our scheme has post-quantum *** but not least,through comparison analysis,we display that our scheme is efficient compared with the cross-domain authentication scheme based on traditional cryptography.

关键词： Cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract

西藏公共文化服务体系铸牢中华民族共同体意识的现实问题与路径选择

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中国藏学 2024年第1期 144-152,217页

作者：冯云西藏民族大学图书馆咸阳712082

公共文化服务是保障人民群众基本文化权益的重要制度性安排,有利于促进文化认同,增强文化自信,是铸牢中华民族共同体意识的重要载体与纽带。近年来,西藏公共文化服务体系建设得到较快发展,但还存在经费投入相对不足、公共文化服务供给... 详细信息

公共文化服务是保障人民群众基本文化权益的重要制度性安排,有利于促进文化认同,增强文化自信,是铸牢中华民族共同体意识的重要载体与纽带。近年来,西藏公共文化服务体系建设得到较快发展,但还存在经费投入相对不足、公共文化服务供给不均衡、服务功能较为单一等问题,这在一定程度上限制了公共文化服务体系在铸牢中华民族共同体意识方面作用的发挥。按照铸牢中华民族共同体意识的要求,结合当前西藏公共文化服务体系建设的现实问题,亟需通过进一步加大公共文化财政投入力度、着力提高基本公共文化服务均等化水平、拓展公共文化服务职能、促进公共文化资源共建共享、充分挖掘和发挥公共文化空间凝聚功能等措施,积极探索新时代西藏公共文化服务体系铸牢中华民族共同体意识的新路径。

关键词：西藏中华民族共同体意识公共文化服务现实问题路径选择

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二维过渡金属碳/氮化物在肿瘤治疗中的应用

生物化学与生物物理进展 2024年第2期51卷 328-344页

作者：刘美青赵璐白云峰冯锋山西大同大学化学与化工学院化学生物传感山西省重点实验室大同037009 山西能源学院能源化学与材料工程系太原030600

二维过渡金属碳/氮化物(MXenes)具有优异的光热转换性能,丰富的表面基团,良好的生物相容性、亲水性和粒径可调性,这使得应用MXenes作为肿瘤诊疗过程中的治疗剂和造影剂具有巨大潜力。本文综述了基于MXenes的肿瘤单一治疗和联合治疗的相... 详细信息

二维过渡金属碳/氮化物(MXenes)具有优异的光热转换性能,丰富的表面基团,良好的生物相容性、亲水性和粒径可调性,这使得应用MXenes作为肿瘤诊疗过程中的治疗剂和造影剂具有巨大潜力。本文综述了基于MXenes的肿瘤单一治疗和联合治疗的相关研究,同时介绍了MXenes在肿瘤主动靶向治疗领域的研究,最后阐述了目前MXenes在制备和肿瘤治疗研究中存在的挑战和对未来的展望。

关键词：二维过渡金属碳/氮化物肿瘤治疗靶向光热疗法

面向无人机自主着陆的视觉感知与位姿估计方法综述

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自动化学报 2024年第7期50卷 1284-1304页

作者：马宁曹云峰南京航空航天大学航天学院南京211106

自主着陆技术是制约无人机(Unmanned aerial vehicle,UAV)自主性等级提升中极具挑战性的一项技术.立足于未来基于视觉的无人机自主着陆技术的发展需求,围绕其中的核心问题——着陆场检测与位姿估计,对近十年来国内外无人机自主着陆领域... 详细信息

自主着陆技术是制约无人机(Unmanned aerial vehicle,UAV)自主性等级提升中极具挑战性的一项技术.立足于未来基于视觉的无人机自主着陆技术的发展需求,围绕其中的核心问题——着陆场检测与位姿估计,对近十年来国内外无人机自主着陆领域中基于视觉的着陆场检测与位姿估计方法研究进展进行总结.首先,在分析无人机自主着陆应用需求的基础上,指出机器视觉在无人机自主着陆领域的应用优势,并凝练出存在的科学问题;其次,按不同应用场景划分对着陆场检测算法进行梳理;然后,分别对纯视觉、多源信息融合的位姿估计技术研究成果进行归纳;最后,总结该领域有待进一步解决的难点,并对未来的技术发展趋势进行展望.

关键词：自主着陆无人机机器视觉着陆场检测位姿估计信息融合

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两种咔唑基-吡啶-N-氧化物内盐荧光极性探针研究

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光谱学与光谱分析 2024年第6期44卷 1600-1606页

作者：梁文娟王慧敏白云峰冯锋山西大同大学化学与化工学院山西大同037009

合成了4-(9H-咔唑-9-基)吡啶1-氧化物(CPNO)和4-(4-(9H-咔唑-9-基)苯基)吡啶1-氧化物(CPPNO)两种咔唑基-吡啶-N-氧化物内盐,测定了它们在不同溶剂中的紫外-可见吸收和荧光光谱,均表现出对溶剂极性较好的敏感性。计算表明,两个化合物都... 详细信息

合成了4-(9H-咔唑-9-基)吡啶1-氧化物(CPNO)和4-(4-(9H-咔唑-9-基)苯基)吡啶1-氧化物(CPPNO)两种咔唑基-吡啶-N-氧化物内盐,测定了它们在不同溶剂中的紫外-可见吸收和荧光光谱,均表现出对溶剂极性较好的敏感性。计算表明,两个化合物都具有较大的激发态偶极矩,是化合物溶剂极性敏感性的原因。研究为开发新型的荧光极性探针提供了一种新思路。

关键词：咔唑基吡啶 N氧化物内盐溶剂效应荧光极性探针