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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers

Journal of Animal Science and Biotechnology 2024年第5期15卷 1918-1931页

作者： Xinrui Zhang Tong Xing Lin Zhang Liang Zhao feng gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNo.1 WeigangNanjingJiangsu 210095P.R.China

Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens *** examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)***,the underlying mechanisms responsible for the formation of WB in broilers have not been fully *** study aimed to investigate the potential role of hypoxia-mediated programmed cell death(PCD)in the formation of WB *** Histological examination and biochemical analysis were performed on the PM muscle of the control(CON)and WB groups.A significantly increased thickness of the breast muscle in the top,middle,and bottom portions(P<0.01)was found along with pathological structure damage of myofibers in the WB *** number of capillaries per fiber in PM muscle,and the levels of p O_(2) and s O_(2) in the blood,were significantly decreased(P<0.01),while the levels of p CO_(2) and TCO_(2) in the blood were significantly increased(P<0.05),suggesting hypoxic conditions in the PM muscle of the WB *** further evaluated the PCD-related pathways including autophagy,apoptosis,and necroptosis to understand the consequence response to enhanced hypoxic conditions in the PM muscle of birds with *** ratio of LC3 II to LC3 I,and the autophagy-related factors HIF-1α,BNIP3,Beclin1,AMPKα,and ULK1 at the m RNA and protein levels,were all significantly upregulated(P<0.05),showing that autophagy occurred in the PM muscle of the WB *** apoptotic index,as well as the expressions of Bax,Cytc,caspase 9,and caspase 3,were significantly increased(P<0.05),whereas Bcl-2 was significantly decreased(P<0.05)in the WB-affected PM muscle,indicating the occurrence of apoptosis mediated by the mitochondrial ***,the expressions of necroptosis-related factors RIP1,RIP3,and MLKL,as well as NF-κB and the pro-inflammatory cytokines TNF-α,IL-1β,and IL-6,were all significantly enhanced(P<0.05)in the WB-affected PM *** T

关键词： Apoptosis Autophagy Broiler chicken Hypoxia Necroptosis Wooden breast

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Highly reversible Zn anode enabled by anticatalytic carbon layer with suppressed hydrogen evolution

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Rare Metals 2024年第7期43卷 3044-3054页

作者： Wen-Duo Zhang Chuang Sun Yu-Xuan Zhu feng gao Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou221116China

Aqueous zinc-ion batteries(AZIBs)have emerged as a promising high-efficiency energy storage system due to the high energy density,low-cost and environmental ***,the practical application of AZIBs is severely restricted by the challenges faced by the Zn anode,which include uncontrollable dendrite growth,corrosion and hydrogen evolution ***,a simple and convenient physical vapor deposition(PVD)method is reported for fabricating uniform graphite as a protection layer on the surface of Zn *** high conductivity graphite layer on Zn anode(denoted as Zn@C)not only benefits the uniform distribution of the electric field,but also provides numerous Zn nucleation sites to regulate and navigate Zn-ion stripping/plating ***,the graphite layer with a poor catalytic activity endows the Zn@C anode with a highly suppressed hydrogen ***,a hydrogen and dendrite free anode is achieved with artificial anticatalytic carbon layer on Zn anode,exhibiting a high reversibility and excellent cycling stability over 2600 h at the current density of 5 mA·cm^(-2)with a capacity of 2.5 mAh·cm^(-2)and longtime cycling stability for assembled full *** work strategically designs the properties of the artificial interface layer to effectively address various challenges simultaneously,which presents insights for the future development of high-performance rechargeable AZIBs.

关键词： Zn metal anode Artificial anticatalytic layer Hydrogen suppression Dendrite free

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From germline genome to highly fragmented somatic genome:genome-wide DNA rearrangement during the sexual process in ciliated protists

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Marine Life Science & Technology 2024年第1期6卷 31-49页

作者： Liping Lyu Xue Zhang Yunyi gao Tengteng Zhang Jinyu Fu Naomi A.Stover feng gao Key Laboratory of Evolution&Marine Biodiversity(Ministry of Education) and Institute of Evolution&Marine BiodiversityOcean University of ChinaQingdao 266003China Department of Biology Bradley UniversityPeoriaIL 61625USA Laoshan Laboratory Qingdao 266237China

Genomes are incredibly dynamic within diverse eukaryotes and programmed genome rearrangements(PGR)play important roles in generating genomic ***,genomes and chromosomes in metazoans are usually large in size which prevents our understanding of the origin and evolution of *** expand our knowledge of genomic diversity and the evolutionary origin of complex genome rearrangements,we focus on ciliated protists(ciliates).Ciliates are single-celled eukaryotes with highly fragmented somatic chromosomes and massively scrambled germline *** in ciliates occurs extensively by removing massive amounts of repetitive and selfish DNA elements found in the silent germline genome dur-ing development of the somatic *** report the partial germline genomes of two spirotrich ciliate species,namely Strombidium *** and Halteria grandinella,along with the most compact and highly fragmented somatic genome for *** provide the first insights into the genome rearrangements of these two species and compare these features with those of other *** analyses reveal:(1)DNA sequence loss through evolution and during PGR in *** has combined to produce the most compact and efficient nanochromosomes observed to date;(2)the compact,transcriptome-like somatic genome in both species results from extensive removal of a relatively large number of shorter germline-specific DNA sequences;(3)long chromosome breakage site motifs are duplicated and retained in the somatic genome,revealing a complex model of chromosome fragmentation in spirotrichs;(4)gene scrambling and alternative pro-cessing are found throughout the core spirotrichs,offering unique opportunities to increase genetic diversity and regulation in this group.

关键词： Alternative processing Ciliates Gene scrambling Genome rearrangement Germline genome Somatic genome

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Investigation into the Methodology and Implementation of Life Cycle Engineering under China’s Carbon Reduction Target in the Process Industry

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Engineering 2024年第9期40卷 87-99页

作者： Mingyang Li feng gao Zuoren Nie Boxue Sun Yu Liu Xianzheng Gong National Engineering Laboratory for Industrial Big-data Application Technology College of Material Science and EngineeringBeijing University of TechnologyBeijing 100124China

The industrial sector is the primary source of carbon emissions in *** pursuit of meeting its carbon reduction targets,China aims to promote resource consumption sustainability,reduce energy consumption,and achieve carbon neutrality within its processing *** effective strategy to promote energy savings and carbon reduction throughout the life cycle of materials is by applying life cycle engineering *** strategy aims to attain an optimal solution for material performance,resource consumption,and environmental *** this study,five types of technologies were considered:raw material replacement,process reengineering,fuel replacement,energy recycling and reutilization,and material recycling and *** meaning,methodology,and development status of life cycle engineering technology abroad and domestically are discussed in detail.A multidimensional analysis of ecological design was conducted from the perspectives of resource and energy consumption,carbon emissions,product performance,and recycling of secondary resources in a manufacturing *** coupled with an integrated method to analyze carbon emissions in the entire life cycle of a material process industry was applied to the nonferrous industry,as an *** results provide effective ideas and solutions for achieving low or zero carbon emission production in the Chinese industry as recycled aluminum and primary aluminum based on advanced technologies had reduced resource consumption and emissions as compared to primary aluminum production.

关键词： Carbon neutrality Life cycle engineering Process Industry Carbon reduction technology Eco-design

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Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： gao Chen-yan QIN gao-feng ZHENG Ming-cui TIAN Mei-jing HE Yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

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Intestinal Behçet's disease: A review of clinical diagnosis and treatment

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1493-1500页

作者： Ying Liu feng gao Ding-Quan Yang Yan Jiao Department of General Surgery The Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Gastrointestinal and Colorectal Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Behçet's disease(BD)is a chronic inflammatory disorder prone to frequent re-currences,with a high predilection for intestinal ***,the ef-ficacy and long-term effects of surgical treatment for intestinal BD are *** the current issue of World J Gastrointest Surg,Park et al conducted a retrospec-tive analysis of 31 patients with intestinal BD who received surgical *** found that elevated C-reactive protein levels and emergency surgery were poor prognostic factors for postoperative recurrence,emphasizing the adverse impact of severe inflammation on the prognosis of patients with intestinal *** work has clinical significance for evaluating the postoperative condition of intestinal *** editorial attempts to summarize the clinical diagnosis and treatment of intestinal BD,focusing on the impact of adverse factors on surgical *** hope this review will facilitate more precise postoperative management of patients with intestinal BD by clinicians.

关键词： Intestinal Behçet's disease Diagnosis Treatment Surgery Recurrence

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Efficient second and third harmonic generation in dual-layer lithium niobate microdisk resonator

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 33-38页

作者： Zhenzhong Hao Xiao Wu Qiang Luo Zhang Li Rui Ma Fang Bo feng gao Guoquan Zhang Jingjun Xu MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China

Lithium niobate thin film frequency doubler has extensive applications in the preparation of classical and quantum *** this study,we successfully fabricated microdisk resonators with a quality factor of 2.2×10^(5) in reverse-polarization dual-layer x-cut lithium niobate for the first *** on the modal phase matching condition,efficient second harmonic generation with a record normalized conversion efficiency of~56000%W-1 and cascaded third harmonic generation with an efficiency of~6500%W-2 were obtained in the microdisk *** with the periodically poled lithium niobate microcavity,the complex domain structure preparation processes are *** work provides a scheme for achieving highly efficient second-order nonlinear effects in non-periodically poled microcavities.

关键词： harmonic lithium niobate

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Biomimetic leaf structures for ultra-thin electromagnetic wave absorption

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Nano Research 2024年第5期17卷 4507-4516页

作者： Shikun Hou Ying Wang feng gao Fei Jin Benfeng Zhu Qiong Wu Hongliang Ge Zhihai Cao Hua Yang Magnetism Key Laboratory of Zhejiang Province&College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Materials Science and Engineering Guangdong Technion-Israel Institute of TechnologyShantou 515063China Key Laboratory of Advanced Textile Materials and Manufacturing Technology and Engineering Research Center for Eco-Dyeing&Finishing of Textiles Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China

Ultra-thin electromagnetic wave(EMW)absorbers present challenging demands on EMW absorption *** inspiration from heather leaf structures,this study introduces an innovative design strategy for EMW absorbing material,proposing biomimetic leaf SnO_(2) structures(bio-SnO_(2))on carbon fabric(CF).By employing leaf-shaped SnS2 as precursors,biomimetic leaf SnO_(2) nanostructures are constructed on CF surface after a simple thermal treatment,resulting in bio-SnO_(2)@CF *** results indicate that bio-SnO_(2)@CF exhibits an exceptional minimum reflection loss of-54.8 dB at an incredibly thin thickness of 1.2 *** cross section(RCS)simulations further validate the outstanding EMW attenuation ability of bio-SnO_(2)@CF,attaining a maximum RCS reduction value of 16.9 dBm^(2) at an incident wave angle ofθ=0°.This novel research showcases the biomimetic structural design strategy and its remarkable function in enhancing the EMW absorbing performance at ultra-thin absorber thickness.

关键词： biomimetic leaf structures electromagnetic wave absorption ultra-thin thickness

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Zwitterionic additive for high-performance pure-blue perovskite light-emitting diodes

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Advanced Photonics 2024年第2期6卷 5-6页

作者： Hongling Yu feng gao Linköping University Department of PhysicsChemistry and Biology(IFM)LinköpingSweden

Metal halide perovskites have emerged as promising candidates for light-emitting diodes(LEDs)due to their cost effectiveness,solution processability,and impressive luminescence.1At present,the external quantum efficiencies(EQEs)of sky-blue,2green,3red,4and near-infrared perovskite LEDs(Pe LEDs)have exceeded 20%,5demonstrating significant potential for future display and communication ***,achieving high-performance pure-blue Pe LEDs with a peak wavelength of 460-470 nm,which is an indispensable color.

关键词： diodes performance light

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Precise separation and efficient recovery of Pd(Ⅱ) from high-level liquid waste by XAD-based adsorbents

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Rare Metals 2024年第10期43卷 5372-5390页

作者： Hao-Ran Dong Shun-Yan Ning Zeng-Yuan Li Si-Zhi Xu feng-Tao Hu feng gao You-Bin Wang Li-feng Chen Xiang-Biao Yin Toyohisa Fujita Mohammed F.Hamza Yue-Zhou Wei School of Resources Environment and MaterialsGuangxi University School of Nuclear Science and Technology University of South China

Efficient separation of palladium (Pd（II）) from high-level liquid waste （HLLW） not only helps the safe disposal of nuclear waste,but also is a vital importan supplement to Pd（II） ***,16 kinds of nove Amberlite XAD resins-based adsorbents were prepared by vacuum impregnation method for the separation of Pd（II）from simulated HLLW,and the MMBT/XAD7HP prepared using 4-methyl-2-mercaptobenzothiazole （MMBT） as ligand and Amberlite XAD7HP resin （XAD7HP） as the carrier was selected as the optimal research *** analysis experiments proved the successful preparation of MMBT/XAD7HP,which exhibited ultrahigh adsorption selectivity for Pd（II）(distribution coefficient （Kd）≥12584.5 ml·g-1,separation factor (SFPd/M)≥2818.4) and superior adsorption capacity(Q≥130.1 mg·g-1).The adsorption kinetics and adsorption isotherms for Pd（II） matched with pseudo-secondorder （PSO） kinetics model and Langmuir model,indicating that the adsorption mode for Pd（II） by MMBT/XAD7 HP was monolayer chemical *** dynamic column experiments showed that MMBT/XAD7 HP achieved efficiently separation of Pd（II） from simulated HLLW,and the recovery rate was nearly 100% The adsorption mechanism was analyzed by Fourier transform infrared spectroscopy （FTIR）,X-ray photoelectron spectroscopy （XPS） and density functional theory（DFT）,and the ultrahigh selectivity of MMBT/XAD7 HP is attributed to the preferred affinity of the soft-N,S donor atoms in MMBT for Pd（II）.MMBT has the shortest frontline molecular orbital energy band gap （HOMO–LUMO） among the four ligands,which makes it easier to become an electron donor to attract Pd2+to participate in ***3-participates in the adsorption to keep charge *** summary,MMBT/XAD7 HP has broad application prospects for the treatment of Pd（II） in HLLW

关键词： Adsorption Column experiments HLLW Palladium XAD

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