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On implications of somatostatin in diabetic retinopathy

Neural Regeneration Research 2024年第9期19卷 1984-1990页

作者： yanhong fang Qionghua Wang youjian Li Li Zeng Jian Liu Kepeng Ou Department of Ophthalmology Chongqing University Jiangjin HospitalChongqingChina College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsIATTIChongqing University of Arts and SciencesChongqingChina Shandong Provincial Hospital Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong ProvinceChina Academic Unit of Ophthalmology Bristol Medical SchoolUniversity of BristolBristolUK

Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the *** this review,we summarize the progress of somatostatin treatment of diabetic retinopathy through analysis of relevant studies published from February 2019 to February 2023 extracted from the PubMed and Google Scholar *** neuroprotection,which occurs as a consequence of declined expression or dysregulation of retinal somatostatin in the very early stages of diabetic retinopathy,triggers retinal neurovascular unit impairment and microvascular *** replacement is a promising treatment for retinal neurodegeneration in diabetic *** pre-clinical and clinical trials of somatostatin analog treatment for early diabetic retinopathy have been *** one such trial(EUROCONDOR),topical administration of somatostatin was found to exert neuroprotective effects in patients with pre-existing retinal neurodysfunction,but had no impact on the onset of diabetic ***,we concluded that somatostatin restoration may be especially beneficial for the growing population of patients with early-stage *** order to achieve early prevention of diabetic retinopathy initiation,and thereby salvage visual function before the appearance of moderate non-proliferative diabetic retinopathy,several issues need to be *** include the needs to:a)update and standardize the retinal screening scheme to incorporate the detection of early neurodegeneration,b)identify patient subgroups who would benefit from somatostatin analog supplementation,c)elucidate the interactions of somatostatin,particularly exogenously-delivered somatostatin analogs,with other retinal peptides in the context of hyperglycemia,and d)design safe,feasible,low cost,and effective administration routes.

关键词： diabetes retinopathy excitotoxicity growth hormone insulin like growth factor irisin neurodegeneration neuroinflammation neuroprotection neurovascular unit octreotide oxidative stress somatostatin

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5G工业互联网下的轻量级数据使用安全方案

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东南大学学报（自然科学版） 2024年第3期54卷 772-780页

作者：张晗陈立全杨波方瑞琦东南大学网络空间安全学院南京211189

针对5G工业互联网环境下数据分析所面临的隐私和安全问题,提出了一种结合隐私计算技术与逻辑回归技术的轻量级解决方案.运用隐私计算技术来保护敏感数据,并通过数据加密和数字签名来确保数据传输的隐私性和完整性,以达到不暴露原始训练... 详细信息

针对5G工业互联网环境下数据分析所面临的隐私和安全问题,提出了一种结合隐私计算技术与逻辑回归技术的轻量级解决方案.运用隐私计算技术来保护敏感数据,并通过数据加密和数字签名来确保数据传输的隐私性和完整性,以达到不暴露原始训练数据和模型参数的目标.采用轻量级的密码算法来实现隐私计算功能,以适应大量数据的训练和调参.结果表明,该方案模型的预测精确度高达98.62%,且具有较小的计算量和通信开销.数据使用者在无需获取原始数据的情况下,便可进行逻辑回归模型训练,从而实现数据的可用性和不可见性,同时还确保了模型参数的私密性,适用于5G工业互联网环境中的低功耗设备.

关键词：工业互联网数据使用安全隐私计算逻辑回归

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The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei Shi yang yan Chun-sheng Shao Kun yu bo Zhang Liang-jian Chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5y-2.5Nd was as a *** then investigated the effect of additions of y and Mn on alloys'*** results show that Mn and y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility bone regeneration bone defect repair

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Electroluminodynamic therapy for the treatment of drug-resistant pathogen infection

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Biomedical Engineering Communications 2024年第1期3卷 21-22页

作者： Si-Wen Du Jin-Gai Jiang bo-Han Li Hui-Juan Cheng yan-Ni Song fang-fang Wang Dong-Liang yang Key Laboratory of Flexible Electronics and Institute of Advanced Materials School of Physical and Mathematical SciencesNanjing Tech UniversityNanjing 211816China

The administration of antibiotics has been the primary strategy for combating bacterial infections[1,2].However,the widespread and excessive use of antibiotics has resulted in the alarming rise of bacterial resistance,posing a significant threat to human health[3–5].Therefore,it is imperative to exploit innovative treatment strategy.

关键词： treatment infection dynamic

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Stacking集成策略下的径向基函数曲面复杂矿体三维建模方法

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地球科学 2024年第3期49卷 1165-1176页

作者：扶金铭胡茂胜方芳储德平李红万波中国地质大学计算机学院湖北武汉430074 中国地质大学地理与信息工程学院湖北武汉430078 国家地理信息系统工程技术研究中心湖北武汉430078

建立三维矿体模型是数字矿山、智慧矿山的基础.针对经典径向基函数曲面重建算法在原始数据稀疏时出现曲面边界自拟合及模型不连续现象,提出了一种集成多种机器学习模型的径向基函数曲面复杂矿体三维建模方法.该方法利用Stacking模型学... 详细信息

建立三维矿体模型是数字矿山、智慧矿山的基础.针对经典径向基函数曲面重建算法在原始数据稀疏时出现曲面边界自拟合及模型不连续现象,提出了一种集成多种机器学习模型的径向基函数曲面复杂矿体三维建模方法.该方法利用Stacking模型学习矿体轮廓线离散化点云数据的分布特征,建立表征矿体模型几何信息的有向点集;在此基础上提取边界点及法向量,通过Hermite型径向基函数建立隐式场,最后基于行进四面体算法建立三维矿体模型.与轮廓线拼接法、经典径向基函数曲面重建算法、简单克里金插值法相比,该方法能够有效减少曲面边界自拟合现象,减少模型多余孔洞,提高模型的连续性;建立的模型所切轮廓线与原始轮廓线相似度达75.14%,与人工干预程度较高的显式模型相当;在体积表征上与显式模型的差距达到最低.

关键词：复杂矿体建模隐式建模 Stacking集成策略机器学习径向基函数三维建模

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LoRa扩频信道干扰与扩展性分析

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应用科学学报 2024年第2期42卷 211-221页

作者：雷芳陈博吕京昭重庆邮电大学通信与信息工程学院重庆400065

为了提高LoRa通信系统节点的接入量,对LoRa通信系统的干扰及扩展性进行了详细分析。首先分析了LoRa相同扩频信道间和不同扩频信道间的干扰,得出相同扩频信道干扰严重的原因,以及不同扩频信道存在一定的干扰的情况,进而发现扩频信道间的... 详细信息

为了提高LoRa通信系统节点的接入量,对LoRa通信系统的干扰及扩展性进行了详细分析。首先分析了LoRa相同扩频信道间和不同扩频信道间的干扰,得出相同扩频信道干扰严重的原因,以及不同扩频信道存在一定的干扰的情况,进而发现扩频信道间的码片间距越近干扰越严重;其次提出了一种LoRa不同扩频信道间的干扰消除算法,通过仿真验证了该算法能有效消除低扩频信道干扰的可行性;最后从理论上对LoRa原有调制解调算法进行了扩展性分析,结合LoRa技术的特点及干扰仿真结果得到LoRa技术新增扩频信道与相邻扩频信道的码片数之差大于等于128,并仿真验证了4条典型新增扩频信道的抗噪声性能、可行性,系统节点的可接入量能增加36.94%。

关键词： LoRa 扩频信道干扰码片数扩展性

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China Survey Report on High Schools'Online Learning Status During the Pandemic

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ECNU Review of Education 2024年第1期7卷 182-194页

作者：郭丛斌徐柱柱方晨晨秦博 Peking University

●We examined the results of a large-scale national survey of online secondary education in *** online survey of 33,194 high school students and 5,667 teachers has provided comprehensive and representative data regarding the quality of online education and its implementation during the pandemic.●Questionnaire surveys administered to students and teachers in different grades and comparative analysis of different cohorts revealed group heterogeneity of the online learning effect.●The findings have elucidated the emergency teaching situation in China during the pandemic,yielding targeted suggestions for school education following the resumption of classes.

关键词： China high school online learning pandemic survey report

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Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

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World Journal of Stem Cells 2024年第1期16卷 33-53页

作者： Hong-Shuo Shi Xin yuan fang-fang Wu Xiao-yu Li Wei-Jing Fan Xiao yang Xiao-Ming Hu Guo-Bin Liu Department of Peripheral Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 250021China

BACKGROUND Stem cell therapy has shown great potential for treating diabetic foot(DF).AIM To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades,with the aim of depicting the current global research landscape,identifying the most influential research hotspots,and providing insights for future research *** We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in *** analysis was carried out using CiteSpace,VOSviewer,and R(4.3.1)to identify the most notable *** A search was conducted to identify publications related to the use of stem cells for DF treatment.A total of 542 articles published from 2000 to 2023 were *** United States had published the most papers on this *** this field,Iran’s Shahid Beheshti University Medical Sciences demonstrated the highest ***,*** from the same university has been an outstanding researcher in this *** Cell Research&Therapy is the journal with the highest number of publications in this *** main keywords were“diabetic foot ulcers,”“wound healing,”and“angiogenesis.”CONCLUSION This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 *** research findings suggested that the hotspots in this field include stem cell dressings,exosomes,wound healing,and adipose-derived stem *** research should also focus on the clinical translation of stem cell therapies for DF.

关键词： Stem cells Diabetic foot Bibliometric CiteSpace VOSviewer R-bibliometrix

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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin yuan Tian Wenlong Xia yongwen Song Shulian Wang Hui fang yu Tang Hao Jing yueping Liu yuan Tang Shunan Qi bo Chen yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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Progressive meristem and single-cell transcriptomes reveal the regulatory mechanisms underlying maize inflorescence development and sex differentiation

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Molecular Plant 2024年第7期17卷 1019-1037页

作者： yonghao Sun Liang Dong Lu Kang Wanshun Zhong David Jackson fang yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA School of Agriculture Sun Yat-Sen UniversityShenzhen 518107China

Maize develops separate ear and tassel inflorescences with initially similar morphology but ultimately different architecture and *** detailed regulatory mechanisms underlying these changes still remain largely *** this study,through analyzing the time-course meristem transcriptomes and floret single-cell transcriptomes of ear and tassel,we revealed the regulatory dynamics and pathways underlying inflorescence development and sex *** identified 16 diverse gene clusters with differential spatiotemporal expression patterns and revealed biased regulation of redox,programmed cell death,and hormone signals during meristem differentiation between ear and ***,based on their dynamic expression patterns,we revealed the roles of two RNA-binding proteins in regulating inflorescence meristem activity and axillary meristem ***,using the transcriptional profiles of 53910 single cells,we uncovered the cellular heterogeneity between ear and tassel *** found that multiple signals associatedwith either enhancedcell death or reduced growth are responsiblefortassel pistil suppression,while part of the gibberellic acid signal may act non-cell-autonomously to regulate ear stamen arrest during sex *** further showed that the pistil-protection gene SILKLESS 1(SK1)functions antagonistically to the known pistil-suppression genes through regulating common molecular pathways,and constructed a regulatory network for pistil-fate ***,our study provides a deep understanding of the regulatory mechanisms underlying inflorescence development and sex differentiation in maize,laying the foundation for identifying new regulators and pathways for maize hybrid breeding and improvement.

关键词： maize inflorescence floral organ sex differentiation single-cell RNA sequencing RNA-binding protein

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