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雌性骆驼生殖组织β-防御素-1基因的克隆及其组织表达量的检测

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中国兽医科学 2007年第6期37卷 515-518页

作者：唐博曹贵方锡林高娃任秀娟内蒙古农业大学动物科学与医学学院内蒙古呼和浩特010018

从雌性骆驼输卵管、子宫、子宫颈、阴道组织中提取总RNA,根据已发表的骆驼β-防御素-1基因的cDNA序列设计合成引物,采用RT-PCR扩增出了骆驼β-防御素-1基因;将扩增产物克隆于pBlueselectT载体后进行了序列分析。以β-肌动蛋白(β-actin... 详细信息

从雌性骆驼输卵管、子宫、子宫颈、阴道组织中提取总RNA,根据已发表的骆驼β-防御素-1基因的cDNA序列设计合成引物,采用RT-PCR扩增出了骆驼β-防御素-1基因;将扩增产物克隆于pBlueselectT载体后进行了序列分析。以β-肌动蛋白(β-actin)基因作为内参,对扩增的β-防御素-1基因进行琼脂糖凝胶电泳后,应用凝胶成像分析系统,推断出了不同组织中β-防御素-1基因的表达量。结果,从雌性骆驼生殖各组织上皮均获得了203 bp的β-防御素-1基因的扩增片段,且β-防御素-1基因在雌性骆驼生殖道各组织内的表达量不同。结果表明,β-防御素-1在雌性骆驼生殖组织的先天免疫中起重要作用。

关键词： β-防御素-1基因骆驼 β-肌动蛋白基因基因组织表达

wang Tao, a distinguished scholar in medical classic systematization

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Journal of Traditional Chinese Medical Sciences 2017年第4期4卷 315-316页

作者： Yinghua Huang Yongxuan Liang Tingyu fang School of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Chinese Medicine Confucius Institute Hyogo College of MedicineNishinomiyaHyōgoJapan 不详

wang Tao (circa 690-756) was from today's Mei County,Shaanxi Province in the Tang Dynasty,and born into an official *** father,grandfather and brothers served the imperial government for many years and he himself was put in charge of the imperial library for about 20 *** compiled the Arcane Essentials from the Imperial Library (Wài Tái Mì Yào),a well-known miscellaneous medical masterpiece,which has been honored with a 'treasure handed down from ancient times'.

关键词： wang Tao a distinguished scholar medical classic systematization

降钙素原与单纯脑外伤患者病情严重程度和并发症以及预后的关系

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中华急诊医学杂志 2012年第9期21卷 1032-1036页

作者：邓水香曹同瓦祝禾辰王昆仑方勇复旦大学附属华山医院重症医学科上海200040

目的探讨血清降钙素原（PCT）与单纯脑外伤患者病情严重程度、并发症以及预后的关系。方法采用前瞻性观察研究，入选120例单纯性脑外伤患者。分别于患者入院后第1、2、3、5、7、10天早上采集血标本检测血降钙素原和C反应蛋白（CRP）水... 详细信息

目的探讨血清降钙素原（PCT）与单纯脑外伤患者病情严重程度、并发症以及预后的关系。方法采用前瞻性观察研究，入选120例单纯性脑外伤患者。分别于患者入院后第1、2、3、5、7、10天早上采集血标本检测血降钙素原和C反应蛋白（CRP）水平，收集患者入院10d内的临床资料并随访患者28d后的生存情况。另选30例健康人群（正常组）作为对照。结果轻、重度脑外伤患者各时段血PCT水平比较差异均具有统计学意义（P〈0．05）。感染组与非感染组PCT水平第1、2天比较，差异无统计学意义，但第3、5、7、10天比较差异具有统计学意义（P〈0．05）。Kaplan-Meier生存分析显示入院高PCT水平组与低PCT水平组患者28d生存率差异具有统计学意义（P〈0．05）。结论入院高PCT水平的患者病情更严重且更容易出现各种并发症包括感染且预后不良。动态监测血PCT水平可以作为判断单纯脑外伤患者病情、感染控制及预后的有效指标之一。

关键词：降钙素原颅脑外伤感染预后

THE HYDROLOGICAL EFFECT UNDER HUMAN ACTIVITIESIN THE INLAND waTERSHEDS OF XINJIANG, CHINA

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Chinese Geographical Science 2001年第1期11卷 27-34页

作者： LI Xin, JI fang, ZHOU Hong-fei (Xinjiang Institute of Ecology and Geography, the Chinese Academy of Sciences, Urumqi 830011, P. K China) Xinjiang Institute of Ecology and Geography the Chinese Academy of Sciences Urumqi P. R. China

Natural environment, inland water distribution and water circulation has been changed greatly affected by human activities in Xinjiang, China. Human activities developed quickly in the inland watersheds in Xinjiang after 1950. More than 50% of river water is drawn into irrigation area, and all water in parts of little river is drawn to canal or reservoirs. However, there is evident hydrological effect caused by human activities. 1) water distribution in arid land has changed. A lot of river water is drawn into oasis and water table inside of oasis has risen but declined out of oasis. However, water table has declined in some cities because of over pumping for groundwater. 2) Stream process has changed after water drawing and drainage for irrigation. Runoff in the lower reaches of river has generally decreased, and the lower reaches of some rivers are even disappeared for stream. 3) Large watersheds have been divided into several small watersheds. In some tributaries, most of the river water has drawn to irrigation area so that stream in the lower reaches has disappeared for years. 4) Evaporation at oasis has increased from 50–200mm/a to 800–1300mm/a after reclamation. But it decreased to 50mm/a or less out of oasis. Some lakes have reduced or dried. water-system with canals and reservoirs has appeared in the oases. 5) water quality of inland rivers and lakes has generally deteriorated because it accepts drainage water from farmland and factories. 6) Effective scale of human activities on hydrological process in arid land has expanded from separate rivers to all watersheds; from surface water to groundwater; from drought season to flood season; and from single year to several years. Scale of the effect of human activities to hydrological process is going larger and larger. Along with the effective usage of water resources in the inland watershed in Xinjiang, the hydrological effect of human activities will be mainly change to: 1) river in pain area will be canalized;

关键词： Xinjiang inland rivers human activities hydrological effects

喉罩置入和视可尼喉镜气管插管在全麻诱导期对循环和BIS影响的比较

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北京医学 2012年第8期34卷 674-676页

作者：纪方陈磊舒洛娃首都医科大学附属北京同仁医院麻醉科 100730

目的比较全麻诱导期喉罩置入和视可尼气管内插管对患者心血管反应和脑电双频指数(BIS)的影响。方法选择择期行鼻内窥镜全麻手术的患者60例,ASAⅠ～Ⅱ级,随机分为喉罩置入组(Ⅰ组)和视可尼气管插管组(Ⅱ组),每组30例。麻醉诱导和维持采... 详细信息

目的比较全麻诱导期喉罩置入和视可尼气管内插管对患者心血管反应和脑电双频指数(BIS)的影响。方法选择择期行鼻内窥镜全麻手术的患者60例,ASAⅠ～Ⅱ级,随机分为喉罩置入组(Ⅰ组)和视可尼气管插管组(Ⅱ组),每组30例。麻醉诱导和维持采用靶控输注丙泊酚和瑞芬太尼全静脉麻醉。比较各组患者诱导前(T1),诱导后(T2),喉罩置入或视可尼气管插管后即刻(T3)、1min(T4)、3min(T5)、5min(T6)时平均动脉压(MAP)、心率(HR)、BIS值的变化。结果Ⅰ组喉罩置入前后MAP、HR、BIS值组内比较差异无统计学意义(P>0.05);Ⅱ组T3、T4、T5的MAP、HR较T2时点差异无统计学意义(P>0.05),但BIS值明显升高(P<0.05),且在T3、T4、T5时明显高于Ⅰ组(P<0.05)。结论在相同麻醉深度下,全麻诱导期使用喉罩置入或视可尼气管内插管均可保持患者循环系统稳定,但视可尼气管内插管可使中枢神经兴奋性增高。

关键词：视可尼喉镜喉罩全麻血流动力学脑电双频指数

不同入渗水质对天津滨海吹填土淋洗脱盐的影响

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节水灌溉 2014年第5期 55-58页

作者：赖羽寒赵秀芳傅瓦利侯颖臻西南大学重庆400700 天津市泰达盐碱地绿化研究中心天津300457

为研究不同矿化度入渗水质对天津滨海吹填土淋洗脱盐的影响,通过室内土柱模拟试验,分析了海水、中咸水和淡水3种水质入渗条件下天津滨海吹填土水分、盐分以及pH的变化特征。结果表明:3种不同矿化度入渗水作用下,湿润峰均与入渗时间呈显... 详细信息

为研究不同矿化度入渗水质对天津滨海吹填土淋洗脱盐的影响,通过室内土柱模拟试验,分析了海水、中咸水和淡水3种水质入渗条件下天津滨海吹填土水分、盐分以及pH的变化特征。结果表明:3种不同矿化度入渗水作用下,湿润峰均与入渗时间呈显著的幂函数关系(R2>0.99),且随矿化度升高,入渗速率增大,即海水>中咸水>淡水;入渗结束后,海水、中咸水和淡水处理吹填土盐分分别为3.90、2.93、1.36dS/m,脱盐率为67.01%、75.21%、88.49%,脱盐效果显著;土壤pH均由淋洗前的7.65升为8.74、8.66和9.00,随盐分降低土壤碱化有所增强。

关键词：吹填土淋洗脱盐咸水灌溉

The competition and equilibrium in power markets under decar-bonization and decentralization

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iEnergy 2022年第2期1卷 188-203页

作者： Qixin Chen Xichen fang Hongye Guo Kedi Zheng Qinghu Tang Ruike Lyu Kaikai Pan Peter Palensky Daniel SKirschen Chongqing Kang Department of Electrical Engineering Tsinghua UniversityBeijing 100084China College of Electrical Engineering Zhejiang UniversityHangzhou 310058China Department of Electrical Sustainable Energy Delft University of Technology2600 AA DelftThe Netherlands Department of Electrical and Computer Engineering University of WashingtonSeattleWA 98195USA

Equilibrium analysis has been widely studied as an effective tool to model gaming interactions and predict market ***,as competition modes are fundamentally changed by the decarbonization and decentralization of power systems,analysis techniques must *** article comprehensively reviews recent developments in modelling methods,practical settings and solution tech-niques in equilibrium ***,we review equilibrium in the evolving wholesale power markets which feature new entrants,novel trading products and multi-stage ***,the competition modes in the emerging distribution market and distributed resource aggregation are reviewed,and we compare peer-to-peer clearing,cooperative games and Stackelberg ***-more,we summarize the methods to treat various information acquisition degrees,risk preferences and rationalities of market *** deal with increasingly complex market settings,this review also covers refined analytical techniques and agent-based models used to compute the ***,based on this review,this paper summarizes key issues in the gaming and equilibrium analysis in power markets under decarbonization and decentralization.

关键词： Power markets high renewable penetration equilibrium analysis modelling methods solution techniques recent develop-ments

Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG

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Neuroscience Bulletin 2019年第5期35卷 853-866页

作者： Ling fang Xinmei Kang Zhen wang Shisi wang Jingqi wang Yifan Zhou Chen Chen Xiaobo Sun Yaping Yan Allan G. Kermode Lisheng Peng Wei Qiu Department of Neurology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510000 China Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China College of Life Sciences Shaanxi Normal University Xi’an 710119 China Department of Neurology Centre for Neuromuscular and Neurological Disorders Queen Elizabeth II Medical Centre Sir Charles Gairdner Hospital University of Western Australia Perth WA 6009 Australia

Immunoglobulin G against myelin oligodendrocyte glycoprotein(MOG-Ig G) is detectable in neuromyelitis optica spectrum disorder(NMOSD) without aquaporin-4 Ig G(AQP4-Ig G), but its pathogenicity remains *** this study, we explored the pathogenic mechanisms of MOG-Ig G in vitro and in vivo and compared them with those of AQP4-Ig G. MOG-Ig G-positive serum induced complement activation and cell death in human embryonic kidney(HEK)-293 T cells transfected with human MOG. In C57 BL/6 mice and Sprague-Dawley rats, MOG-Ig G only caused lesions in the presence of complement. Interestingly, AQP4-Ig G induced astroglial damage, while MOGIg G mainly caused myelin loss. MOG-Ig G also induced astrocyte damage in mouse brains in the presence ofcomplement. Importantly, we also observed ultrastructural changes induced by MOG-Ig G and AQP4-Ig G. These findings suggest that MOG-Ig G directly mediates cell death by activating complement in vitro and producing NMOSDlike lesions in vivo. AQP4-Ig G directly targets astrocytes,while MOG-Ig G mainly damages oligodendrocytes.

关键词： Neuromyelitis optica spectrum disorder Aquaporin-4 immunoglobulin G Myelin oligodendrocyte glycoprotein immunoglobulin G Complement-dependent cytotoxicity Transmission electron microscopy

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早期使用三七总皂苷对大鼠脑出血炎症的影响

中国实验方剂学杂志 2009年第9期15卷 77-80页

作者：徐枝芳唐璐陈志刚朱陵群扎娃高芳钟伟森陈路北京中医药大学东方医院神经内科北京100078 北京中医药大学东直门医院中医脑病研究室北京100700

目的:早期使用三七总皂苷对大鼠脑出血(ICH)神经功能缺损和炎症介质IL-6(白细胞介素-6)、MMP-9(基质金属蛋白酶-9)的影响。方法:将SD大鼠随机分为假手术组、模型组和三七总皂苷组,采用胶原酶注射尾状核法制作脑出血模型,观察Zea Longa... 详细信息

目的:早期使用三七总皂苷对大鼠脑出血(ICH)神经功能缺损和炎症介质IL-6(白细胞介素-6)、MMP-9(基质金属蛋白酶-9)的影响。方法:将SD大鼠随机分为假手术组、模型组和三七总皂苷组,采用胶原酶注射尾状核法制作脑出血模型,观察Zea Longa评分和脑出血死亡率;免疫组织化学染色法观察血肿周围IL-6和MMP-9的表达。结果:三七总皂苷组造模5 d时Zea Longa评分优于模型组(P<0.05),造模24 h和5 d的减分值亦优于模型组(P<0.01),且未增加脑出血死亡率;模型组48h和7 d时脑组织IL-6和MMP-9明显升高,三七总皂苷用药7 d可下调IL-6(P<0.05)和MMP-9(P<0.05)。结论:三七总皂苷可减轻大鼠脑出血后神经功能缺损,抑制IL-6和MMP-9的释放以改善神经元损伤可能是其作用机制之一。

关键词：脑出血白细胞介素-6 基质金属蛋白酶-9 三七总皂苷神经功能缺损