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1990—2019年中国儿童青少年1型糖尿病负担分析与模型预测

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中国儿童保健杂志 2024年第7期32卷 746-751,784页

作者：陈顺林雪梅袁乔英刘芳肖曙芳乐小婧张曼李仙云南省滇南中心医院(红河州第一人民医院)内分泌科云南红河651400 云南省儿童医院感染科

目的分析1990—2019年中国儿童青少年1型糖尿病疾病负担并对其未来的变化趋势进行预测,为预防和控制儿童青少年因1型糖尿病所致的疾病负担提供参考依据。方法利用2019年全球疾病负担(GBD)数据库提取1990—2019年20岁以下儿童青少年归因... 详细信息

目的分析1990—2019年中国儿童青少年1型糖尿病疾病负担并对其未来的变化趋势进行预测,为预防和控制儿童青少年因1型糖尿病所致的疾病负担提供参考依据。方法利用2019年全球疾病负担(GBD)数据库提取1990—2019年20岁以下儿童青少年归因于1型糖尿病的发病率、患病率、死亡率及伤残调整寿命年(DALYs)率,采用Joinpoint回归模型分析其变化趋势,通过灰色预测模型GM(1,1)预测未来20年的疾病负担。结果2019年,中国儿童青少年1型糖尿病发病率5.22/10^(5),患病率49.17/10^(5),死亡率0.07/10^(5),DALY率7.82/10^(5),均低于全球平均水平。2019年,中国男性儿童青少年1型糖尿病疾病发病率、死亡率均高于女性,而DALY率低于女性,其中5~9岁年龄组儿童青少年1型糖尿病疾病发病率最高,为7.30/10^(5),<1岁年龄组死亡率最高,为0.33/10^(5)。Joinpoint回归模型结果显示,1990—2019年发病率、患病率呈现上升趋势,平均年度变化百分比(AAPC)分别为1.44%、1.05%,而死亡率和DALY率呈现降低趋势,AAPC分别为-4.30%和-3.45%,差异均有统计学意义(P<0.05)。预测结果表明,2020—2039年中国儿童青少年1型糖尿病发病率和患病率均呈显著上升趋势。结论1990—2019年中国儿童青少年1型糖尿病发病率和患病率呈上升趋势,应继续采取积极的预防措施以减轻疾病负担。

关键词： 1型糖尿病疾病负担模型预测儿童青少年

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广西扶绥铝土矿区的地质特征与成矿分析

现代矿业 2024年第3期40卷 33-37,43页

作者：曹淑芳韦访廖江南张启连广西壮族自治区地质调查院

扶绥铝土矿区位于广西铝土矿成矿带南带的核心区,存在大量火山灰,为更深入地剖析火山灰及其对成矿作用的意义,通过野外地质调查、室内显微镜鉴定及X射线衍射分析法进行研究。结果表明,沉积型铝土矿分为块状、碎屑状和致密状3种类型,堆... 详细信息

扶绥铝土矿区位于广西铝土矿成矿带南带的核心区,存在大量火山灰,为更深入地剖析火山灰及其对成矿作用的意义,通过野外地质调查、室内显微镜鉴定及X射线衍射分析法进行研究。结果表明,沉积型铝土矿分为块状、碎屑状和致密状3种类型,堆积铝土矿为沉积铝土矿地表风化、堆积产物,继承了前者的矿石矿物、结构构造特征。铝土矿石中火山灰种类可分为岩屑、晶屑、玻屑和火山尘4种,为玄武岩、安山岩岩屑,长石、石英等基性-中性-酸性矿物。火山灰铝土矿化强烈,常生成水铝石、高岭石、赤铁矿等微细矿物,矿石中总含量大于50%,为铝土矿的重要物质来源。

关键词：铝土矿火山灰成矿分析地质特征

The clinical and genetic characteristics in children with mitochondrial disease in China

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Science China(Life Sciences) 2017年第7期60卷 746-757页

作者： fang fang Zhimei Liu Hezhi fang Jian Wu Danmin Shen Suzhen Sun Changhong Ding Tongli Han Yun Wu Junlan Lv Lei Yang shufang Li Jianxin Lv Ying Shen Department of Neurology Beijing Children 's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Inspection Medical School Wenzhou Medical College Wenzhou 325035 China Translational Medical Center The General Hospital of the Chinese People's Liberation Army Beijing 100853 China Department of Neurology Children's Hospital of Hebei Province Hebei Medical University Shijiazhuang 050030 China

Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of children with mitochondrial disease in China. We tested 141 candidate patients who have been suspected of mitochondrial disorders by using targeted next-generation sequencing(NGS), and summarized the clinical and genetic data of gene confirmed cases from Neurology Department, Beijing Children's Hospital, Capital Medical University from October 2012 to January 2015. In our study, 40 cases of gene confirmed mitochondrial disease including eight kinds of mitochondrial disease, among which Leigh syndrome was identified to be the most common type, followed by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes(MELAS). The age-of-onset varies among mitochondrial disease, but early onset was common. All of 40 cases were gene confirmed, among which 25 cases(62.5%)with mitochondrial DNA(mtDNA) mutation, and 15 cases(37.5%) with nuclear DNA(nDNA) mutation. M.3243A>G(n=7)accounts for a large proportion of mtDNA mutation. The nDNA mutations include SURF1(n=7),PDHA1(n=2),and NDUFV1,NDUFAF6, SUCLA2, SUCLG1, RRM2 B, and C12orf65, respectively.

关键词： mitochondrial disease targeted next generation sequencing clinical features gene

Regulations of m^(6)A methylation on tomato fruit chilling injury

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Horticultural Plant Journal 2021年第5期7卷 434-442页

作者： Chunmei Bai Minghuan fang Baiqiang Zhai Lili Ma Anzhen Fu Lipu Gao Xiaohong Kou Demei Meng Qing Wang shufang Zheng Jinhua Zuo State Key Laboratory of Food Nutrition and Safety College of Food Science and EngineeringTianjin University of Science&TechnologyTianjin 300457China Key Laboratory of Vegetable Postharvest Processing Ministry of AgricultureBeijing Key Laboratory of Fruit and Vegetable Storage and ProcessingKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)of Ministry of AgricultureKey Laboratory of Urban Agriculture(North)of Ministry of AgricultureBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Henan Railway Food Safety Management Engineering Technology Research Center Zhengzhou 451460China College of Food Science and Technology Hebei Agricultural UniversityBaoding 071001China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Tomato fruit are sensitive to chilling injury(CI)during cold *** factors have been discovered to be involved in chilling injury of tomato *** hormones play an important regulatory role,however,the relationship between chilling injury and N6-methyladenosine(m^(6)A)methylation of transcripts in plant hormone pathways has not been reported *** order to clarify the complex regulatory mechanism of m^(6)A methylation on chilling injury in tomato fruit,Nanopore direct RNA sequencing was employed.A large number of enzymes and transcription factors were found to be involved in the regulation process of fruit chilling injury,which were associated with plant hormone,such as 1-aminocyclopropane 1-carboxylate synthase(ACS),aspartate aminotransferase(AST),auxin response factor(ARF2),ethylene response factor 2(ERF2),gibberellin 20-oxidase-3(GA20ox)and jasmonic acid(JA).By conjoint analysis of the differential expression transcripts related to chilling injury andm^(6)Amethylation differential expression transcripts 41 differential expression transcripts were identified involved in chilling injury including 1-aminocyclopropane-1-carboxylate oxidase(ACO)and pectinesterase(PE)were down-regulated and heat shock cognate 70 kD protein 2(cpHSC70),HSP70-binding protein(HspBP)and salicylic acid-binding protein 2(SABP2)were *** results will provide a deeper understanding for chilling injury regulatory mechanism and post-harvest cold storage of tomato fruit.

关键词： m^(6)A methylation Chilling injury Plant hormone Nanopore direct RNA sequencing Tomato fruit

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不同含糖饮料摄入水平小学生肠道菌群差异

中国学校卫生 2024年第3期45卷 335-340,345页

作者：张琴刘雪婷张可馨田野何春雷王一迪徐裕杰单树方汪晓语熊静远成果何方四川大学华西公共卫生学院(四川大学华西第四医院) 成都610041 四川大学华西第二医院西部妇幼医学研究院妇儿营养中心四川大学华西护理学院

目的探讨不同含糖饮料摄入水平小学生肠道菌群的差异,为更好地识别儿童健康风险并制定有针对性的健康政策提供科学依据。方法于2022年6月,采用分层整群随机抽样方法选取成都市健康小学生192名,采用膳食频率问卷调查含糖饮料摄入量,依据... 详细信息

目的探讨不同含糖饮料摄入水平小学生肠道菌群的差异,为更好地识别儿童健康风险并制定有针对性的健康政策提供科学依据。方法于2022年6月,采用分层整群随机抽样方法选取成都市健康小学生192名,采用膳食频率问卷调查含糖饮料摄入量,依据小学生每日含糖饮料摄入量中位水平分为低摄入组(96名)和高摄入组(96名)。使用16S rRNA高通量测序对两组小学生新鲜粪便标本进行肠道菌群检测,比较两组肠道菌群的多样性和群落结构差异。结果低摄入组小学生含糖饮料摄入量为(21.3±1.6)mL/d,高摄入组摄入量为(269.6±37.3)mL/d。多样性分析结果显示,低摄入组与高摄入组肠道菌群α多样性的可观测的OTU(Observed_otus)指数[298.50(259.75,342.25),305.50(244.25,367.75)],测序深度(Goods_coverage)指数[1.00(1.00,1.00),1.00(1.00,1.00)],Chao指数[304.18(260.75,348.78),305.88(245.68,370.88)],香农(Shannon)指数[5.88(5.29,6.45),5.71(4.89,6.28)],辛普森(Simpson)指数[0.95(0.91,0.97),0.94(0.88,0.97)]差异均无统计学意义(Z值分别为-0.64,-0.76,-0.54,-1.76,-1.67,P值均>0.05);两组肠道菌群的β多样性差异无统计学意义(R^(2)=0.006,P>0.05)。在菌属水平,低摄入组中布劳特氏菌属[0.033(0.018,0.055)]、纺锤链杆属[0.009(0.005,0.015)]丰度均高于高摄入组[0.024(0.013,0.041),0.006(0.003,0.011)],差异均有统计学意义(Z值分别为-2.52,-2.81,P值均<0.05)。LEfSe分析显示两组菌群的组间差异主要体现在布劳特氏菌属、纺锤链杆属及八叠球菌属(LDA值分别为3.56,3.12,3.53,P值均<0.05)。结论不同含糖饮料摄入水平的小学生肠道菌群多样性和整体结构差异不大,但菌属水平存在物种差异,可为识别小学生的健康风险,制定健康对策提供科学依据。

关键词：碳水化合物饮料摄食行为胃肠道细菌儿童

宏基因组二代测序在食管气管瘘气道支架置入术后肺炎病原体检测中的价值

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中华实用诊断与治疗杂志 2024年第1期38卷 75-80页

作者：秦芳高永平王书方荆蕾王辉李小丽张洁莉周云芝应急总医院呼吸与危重症医学科北京100028

目的观察食管气管瘘气道支架置入术后肺炎患者支气管肺泡灌洗液(BALF)、防污染样本毛刷(PSB)采样分别行宏基因组二代测序(mNGS)和病原体培养的病原体检出情况,探讨mNGS在病原学诊断中的价值。方法 2020年8月—2021年8月应急总医院诊治... 详细信息

目的观察食管气管瘘气道支架置入术后肺炎患者支气管肺泡灌洗液(BALF)、防污染样本毛刷(PSB)采样分别行宏基因组二代测序(mNGS)和病原体培养的病原体检出情况,探讨mNGS在病原学诊断中的价值。方法 2020年8月—2021年8月应急总医院诊治食管气管瘘气道支架置入术后肺炎患者48例,抗感染治疗前行支气管镜检查,采集BALF和PSB采样,分别行mNGS及病原体培养检查;采集痰标本行病原体培养检查。比较5种方法病原体检出率;分析5种方法检出病原体种类及分布情况;比较BALF mNGS与PSB采样mNGS检出主要病原体序列数。结果 BALF mNGS病原体检出率(95.83%)与PSB采样mNGS(95.83%)比较差异无统计学意义(χ^(2)0.999);BALF培养(37.50%)、PSB采样培养(33.33%)、痰培养(33.33%)病原体检出率比较差异无统计学意义(χ^(2)=0.170,P>0.999),均低于BALF mNGS、PSB采样mNGS(P0.05)。结论食管气管瘘气道支架置入术后肺炎患者采用BALF和PSB采样结合mNGS的病原体检出率相近,均明显高于常规培养法;BALF和PSB采样结合mNGS检出病原体主要为纹带棒状杆菌、铜绿假单胞菌、嗜麦芽寡养单胞菌、白假丝酵母菌、热带假丝酵母菌、人疱疹病毒4型,有助于指导精准治疗。

关键词：食管气管瘘气道支架置入术肺炎支气管肺泡灌洗防污染样本毛刷宏基因组二代测序痰培养

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质量管理体系与标准体系的协调与转化

China Standardization 2024年第1期125卷 60-62页

作者：王丹杨磊王淑芳王雪方雷曹楠张帅东钟威任常菲 Changchun Standards Research Institute Jilin Provincial Institute of Standards Jilin Provincial Administration of Market Regulation Jilin Institute of Product Quality Supervision and Inspection

This paper elaborates on the differences and connections between the quality management system and standards system,as well as the principles and sequence of establishing the quality management system and standards *** provides suggestions on how to establish and integrate another system in the existing system and coordinate with it.

关键词： quality management system standards system

Structural Identification and Antioxidative Activity Evaluation of Flaxseed Lignan Macromolecules: Structure-activity Correlation

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Food Science and Human Wellness 2023年

作者： Chen Cheng Lei Wang Xiao Yu Fenghong Huang Jing Yang fang Geng Xiaoyang Xia Xia Xiang shufang Xu Qianchun Deng College of Food and Bioengineering， Zhengzhou University of Light Industry Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences， Hubei Key Laboratory of Lipid Chemistry and Nutrition， and Key Laboratory of Oilseeds Processing， Ministry of Agriculture， Oil crops and Lipids Process Technology National & Local Joint Engineering Laboratory Clinical Nutrition Department， The Central Hospital of Wuhan， Tongji Medical College， Huazhong University of Science and Technology Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs)， School of Food and Biological Engineering， Chengdu University

Flaxseed lignan macromolecules (FLM) are a class of important secondary metabolites in flaxseed， which have been widely concerned due to their biological and pharmacological properties， especially for their antioxidative activity. For the composition and structure of FLM， our results confirmed that ferulic acid glycoside (FerAG) was directly ester-linked with herbacetin diglucoside (HDG) or pinoresinol diglucoside (PDG)， which might determine the beginning of FLM biosynthesis. Additionally， p-coumaric acid glycoside (CouAG) might determine the end of chain extension during FLM synthesis in flaxseed. FLM exhibited higher antioxidative activity in polar systems， as shown by its superior DPPH free radical scavenging capacity compared to the ABTS free radical scavenging capacity in non-polar systems. Moreover， the antioxidative activity of FLM was found to be highly dependent on its composition and structure. In particular， it was positively correlated with the number of phenolic hydroxyl groups (longer FLM chains) and inversely related to the steric hindrance at the ends (lower levels of FerAG and CouAG). These findings verified the potential application of FLM in non-polar systems， particularly in functional food emulsions.

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AP番荔枝在广西崇左的引种表现及栽培技术

中国热带农业 2024年第2期 11-16页

作者：郑树芳陈海生谭秋锦周春衡潘贞珍宋海云樊灵丹方仁韦媛荣许鹏广西南亚热带农业科学研究所广西龙州532415 广西壮族自治区农业科学院园艺研究所广西南宁530007

为了调优热带水果品种比例,于2016年自湛江引入优良品种AP番荔枝进行试种。经过7年的引种栽培试验,AP番荔枝在广西崇左生长结果表现良好,果实大小中等、均匀。果实性状方面,AP番荔枝平均单果重297.8g,比普通番荔枝品种(CK)的181.6g增加6... 详细信息

为了调优热带水果品种比例,于2016年自湛江引入优良品种AP番荔枝进行试种。经过7年的引种栽培试验,AP番荔枝在广西崇左生长结果表现良好,果实大小中等、均匀。果实性状方面,AP番荔枝平均单果重297.8g,比普通番荔枝品种(CK)的181.6g增加64.0%,差异达极显著;可食率66%,比CK的57%增加15.8%,可溶性固形物24.5%,比CK的20.5%提高19.5%,这两项指标差异达显著;单果种子28粒,比CK的45粒减少37.8%,差异达极显著;可溶性糖18.3%,比CK的16.8%提高8.90%,平均株产量比CK高4.2%~10.5%,两项指标差异不显著。AP番荔枝具有早结丰产特性,其果实大、品质好、可食率高、可溶性固形物高,适合广西崇左发展种植。

关键词：番荔枝引种表现栽培技术