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Kelp Fucoidans Facilitate Vascular Recanalization via Inhibiting Excessive Activation of Platelet in Deep Venous Thrombosis Model of Mouse

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Journal of Ocean university of china 2024年第2期23卷 550-556页

作者： SUN Taohua LIU jie YAN Taishan CHEN Anjin ZHANG fang department of Clinical Drug Trials Qingdao Municipal HospitalQingdao 266100China department of Pharmacy Qingdao Municipal HospitalQingdao 266100China

This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)*** the control and sham mice,the walls of deep vein were regular and smooth with intact intima,myometrium and *** blood vessel was wrapped with the tissue and there was no thrombosis in the *** the DVT model,the wall was uneven with thicken intima,myometrium and *** treated with fucoidans LF1 and LF2,the thrombus was dissolved and the blood vessel was *** with the control group,the ROS content,ET-1 and VWF content and the expression of PKC-βand NF-κB in the model were significantly higher(P<0.05);these levels were significantly reduced following treatments with LF2 and *** with H_(2)O_(2)treated-HUVECs,combined LF1 and LF2 treatment resulted in significant decrease in the expression of PKC-β,NF-κB,VWF and TM protein(P<0.05).It is clear that LF1 and LF2 reduces DVT-induced ET-1,VWF and TM expressions and production of ROS,thus inhibiting the activation of PKC-β/NF-κB signal pathway and the activation of coagulation system and ultimately reducing the formation of venous thrombus.

关键词： kelp fucoidans LF1 LF2 deep vein thrombosis platelet

SO_(2)-Insertion induced enantioselective oxysulfonylation to access β-chiral sulfones with quaternary carbon stereocenters

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Science china Chemistry 2024年第3期67卷 908-913页

作者： Jun Zhang Xuefeng Wang Peiqi Wang Jiayuan fang Shaoyu Li jie Wu School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies Taizhou UniversityShanghai 200438China department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

β-Chiral sulfones are structural motifs widely found in natural products and bioactive molecules, while also serving as important intermediates for the synthesis of valuable chiral scaffolds. In contrast to the rapid growth of sulfur dioxide insertion chemistry over the last decade, enantioselective catalytic variants for accessing β-chiral sulfones, especially those bearing a quaternary carbon stereocenter, remain rare. Herein, we report an enantioselective copper/bisoxazoline catalyzed oxysulfonylation of alkenes to yield isoxazolinyl-containing β-chiral sulfones bearing quaternary carbon stereocenters with moderate to excellent yields and up to 96:4 er. The advantage and irreplaceability of this sulfur dioxide insertion catalytic system have been demonstrated by achieving transformations clearly unavailable with the previously reported sulfonyl chloride system. Additionally,the recoverability of the new-developed bisoxazoline ligand L9 and its reusability without any erosion of the catalytic activity and enantioselectivity further demonstrate the usefulness of the protocol.

关键词： β-chiral sulfones sulfur dioxide insertion oxysulfonylation copper catalysis enantioselectivity

Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-jie Wang Hong-Hua fang Zhen-Ze Li Dan Wang Hong-Bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size of<5 nm is *** underlying physics is that the uncertainty of local atom thermal motion dominates electron excitation,rather than the power density slope of the incident *** show that the colour centre yield in hexagonal boron nitride is transformed from stochastic to deterministic,and the emission from individual sites becomes polychromatic to *** a result,single colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

Flame Structure of Methane and Kerosene Combustion with a Compact Concave Flame-Holder using the LES-pdf Method

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Journal of Thermal Science 2024年第1期33卷 222-234页

作者： WANG fang WANG Yunfan WEI Guanyi LIU Denghuan JIN jie JONES P.William School of Energy and Power Engineering Beihang UniversityBeijingBeijing 100191China department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Compact flame-holders for afterburners are an increasing requirement for modern aero ***,flame-holder design is non-trivial since high inlet temperatures,velocities,and elaborate structures induce complex turbulence,combustion,and spray coupling in modern *** this work,the LES-pdf and stochastic fields-Lagrangian particle spray methods are used to investigate methane and aviation kerosene combustion structures formed by new-type concave *** flow pattern,combustion mode,and flame structure of gaseous and liquid fuel around a concave flame-holder are analyzed,discussed,and compared with experimental *** reveal that the flame stability of a concave flame-holder is better than that of the non-concave ***,when using liquid fuel,the concave flame-holder forms a stable and compact *** results suggest concave flame-holders are a promising design for compact afterburners.

关键词： concave structure flame-holder LES-pdf spray combustion flame structure AECSC

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science china Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi Yi-Ming Ou Hua-jie Jiang Yi-Jun fang Qi-Ming Wang Quan Gao jie Yu department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

SIMPLE OCKHAM ALGEBRAS

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Chinese Annals of mathematics,Series B 1996年第2期17卷 213-218页

作者： fang jie department of mathematics, Zhongshan university, Guangzhou 510271, china. department of mathematics Zhongshan University Guangzhou 510271 China

An algeber L is said to be simple, if its congruence lattice Con L reduces to the 2-elementchain {ω,v}. This paper describes the structure of finite simple Ockham algebras.

关键词： Ockham algebra Simple algebra Congruence lattic 2-element chain

Experimental study on wax deposition of highly paraffinic oil in intermittent gas-oil flow in pipelines

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Petroleum Science 2024年第3期21卷 2080-2088页

作者： Chuan-Shuo Wang Qian-Li Ma Xiao-fang Lv jie Zhang Yang Liu Shi-Dong Zhou Jiangsu Key Laboratory of Oil and Gas Storage and Transportation Technology Changzhou UniversityChangzhou213164JiangsuPR China Hade Oil and Gas Development department Tarim Oilfield BranchKorla841000XinjiangPR China

Oil-gas two phase wax deposition is a fairly common and open-ended question in flow assurance of multiphase transportation *** paper investigated the two main aspects of oil-gas two phase wax deposition layer:apparent thickness and crystal structure characteristics.A typical highly paraffinic oil in Bohai Sea,china,was used as the experimental material to investigate the wax deposition thickness in oil-gas two phase under the influence of different oil temperatures,superficial gas/liquid phase velocities and gas-oil ratios by using multiphase flow loop experimental *** as in the classical theory of wax molecular diffusion,it showed that wax deposition thickness of oil-gas two phase increased with increasing oil *** of the impact of different superficial phase velocities found that the actual liquid flow heat transfer and shear stripping was the gas phase dominant mechanisms determining wax deposit *** addition,the crystal structure of the wax deposition layer was characterized with the help of small-angle X-ray scattering(SAXS)for different circumferential positions,flow rates and gas-oil *** bottom deposition layer had a complex crystal structure and high hardness,which were subject to change over flow rate ***,the SAXS results provided evidence that the indirect effect of the actual liquid velocity modified by the gas phase was the main *** study of the effect of gas phase on the wax deposition of oil-gas two phase will help shed light onto the mechanism by which this important process *** findings address a very urgent need in the field of wax deposition of highly paraffinic oil to understand the flow security of oilgas two phase that occurs easily in multiphase field pipelines.

关键词： Oil-gas two phase Highly paraffinic oil Wax deposition SAXS

The Isotone Mappings on Ockham Algebras

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Acta Mathematica Sinica,English Series 1996年第1期12卷 43-48页

作者： fang jie department of mathematics Zhongshan university Guangzhou, 510275 china 中山大学数学系广东广州

In this paper we shall describe some algebraic concepts of Ockham algebras. We show that, if L, M∈K1,1 then H（S（L）,S（M））≌S（H（L,M））.

关键词： Isotone (Ockham) Isomorphism

Cuproptosis:A potential therapeutic target in clear cell renal cell carcinoma

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Chinese Medical Journal 2024年第11期137卷 1378-1380页

作者： Yuetong Zhao jie Li Xiaojie Lu Shuang Wu Yunze Xing Yaxuan fang Bo Yang department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China department of Nephrology National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological *** ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in *** studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in *** most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ***,cuproptosis induction may offer a new approach for ccRCC treatment.

关键词： metabolism chemotherapy potential