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Protein arginine methyltransf.rase-6 regulates heterogeneous nuclear ribonucleoprotein-f.expression and is a potential target f.r the treatment of.neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu z.ang Yuqi Liu fangxia Xu Chengcheng z.ou Kaimei Lu Bin fang Lijuan Wang Lina Huang z.f.ng Xu Department of.Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of.Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of.Embryo Original Diseases ShanghaiChina

Protein arginine methyltransf.rase-6 participates in a range of.biological f.nctions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transf.rase-6 modif.es neuropathic pain and,if.so,what the mechanisms of.this *** this study,protein arginine methyltransf.rase-6 expression levels and its ef.ect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-f.ee proteomic *** results showed that protein arginine methyltransf.rase-6 mostly co-localiz.d withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased f.llowing spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of.spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransf.rase-6 ***,when protein arginine methyltransf.rase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of.phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransf.rase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of.heterogeneous nuclear ***,protein arginine methyltransf. rase-6-mediated modulation of.hete rogeneous nuclear ribonucleoprotein-f.expression required amino atids 319 to 388,but not classical H3R2 *** f.ndings indicated that protein arginine methyltransf.rase-6 is a potential therapeutic target f. r the treatment of.peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein f neuropathic pain protein arginine methyltransf.rase-6 sensory neurons

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Targeting CXCR4 and EDN1 f.r the treatment of.recurrent miscarriage using stearic acid f.om traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： fang Liu Dong-Mei Shi Wen-Ye Ma Da-Wei Tang Gang Bai Xin-You Yu Reproductive Center of.Yinchuan Maternal and Child Health Hospital Yinchuan 750001China Prenatal Diagnosis Center of.Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)af.ects an estimated 1-3%of.couples attempting to conceive,and its molecular components stay inef.ectively caught *** study aims to explore potential therapeutic targets f.r RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utiliz.d the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine dif.erentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the af.inity of.TCM components f.r key ***:In the mouse model,genes such as Ly6f. and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identif.ed key pathways,including the tumor necrosis f.ctor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identif.ed C-X-C motif.chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking conf.rmed that stearic acid f.om TCM appears to regulate these ***:This study presents a comprehensive analysis of.the genetic and cellular underpinnings of.RM,identif.ing CXCR4 and EDN1 as promising therapeutic *** acid f.om TCM could provide targeted treatment by modulating these key proteins,paving the way f.r new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

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Seismogenic model of.the 2023 M_(W)5.5 Pingyuan earthquake in North China Plain and its tectonic implications

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Earthquake Science 2024年第6期37卷 499-513页

作者： Shiguang Wang Libo Han Junju Xie Liping f.n Xiang Huang Jinmeng Bi Hongf.ng Yang Lihua fang Institute of.Geophysics China Earthquake AdministrationBeijing 10081China Tianjin Earthquake Agency Tianjin 300201China Earth System Science Programme The Chinese University of Hong KongShatinHong Kong 999077China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 100095China

The 6 August 2023 M_(W)5.5 Pingyuan earthquake is the largest earthquake in the central North China Plain(NCP)over the past two *** to the thick sedimentary cover,no corresponding active f.ults have been reported yet in the epicenter ***,this earthquake presents a unique opportunity to delve into the buried active f.ults beneath the *** integrating strong ground motion records,high-precision af.ershock sequence relocation,and f.cal mechanism solutions,we gain insights into the seismotectonics of.the Pingyuan *** af.ershocks are clustered at depths ranging f.om 15 to 20 km and delineate a NE-SW trend,consistent with the distribution of.ground motion records.A NE-SW nodal plane(226°)of.the f.cal mechanism solutions is also derived f.om regional wavef.rm inversion,suggesting that the mainshock was dominated by strike-slip motion with minor normal f.ulting *** regional geological data,we propose that an unrecogniz.d f.ult between the NE-SW trending Gaotang and Lingxian-Yangxin f.ults is the seismogenic f.ult of.this *** on the S-wave velocity structure beneath the NCP,this f.ult probably extends into the lower crust with a high *** the tectonic regime and stress state,we speculate that the interplay of.shear strain between the Amurian and South China blocks and the hot upwelling magma f.om the subducted paleo Pacif.c f.at slab signif.cantly contributed to the generation of.the Pingyuan earthquake.

关键词： Pingyuan earthquake af.ershock relocation f.cal mechanism S-wave velocity structure North China Plain

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A mitochondria-targeted H_(2)S-activatable f.uorogenic probe f.r tracking hepatic ischemia-reperf.sion injury

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Chinese Chemical Letters 2024年第6期35卷 370-375页

作者： Bin fang Jiaqi Yang Limin Wang Haoqin Li Jiaying Guo Jiaxin z.ang Qingyuan Guo Bo Peng Kedi Liu Miaomiao Xi Hua Bai Li f. Lin Li School of.Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China f.ontiers Science Center f.r f.exible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key laboratory of.f.exible Electronics of.z.ejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China The Institute of.f.exible Electronics(If. Future Technologies)Xiamen UniversityXiamen 361005China Wuhan National Laboratory f.r Optoelectronics-Advanced Biomedical Imaging f.cility Huazhong University of Science and TechnologyWuhan 430074China TANK Medicinal Biology Institute of.Xi’an Xi’an 710032China

Hepatic ischemia-reperf.sion injury(HIRI)is the cause of.postoperative hepatic dysf.nction and f.ilure,and even *** an important biological ef.ector molecule,hydrogen sulf.de(H_(2)S)of.mitochondria as a gasotransmitter that is usually used to protect against acute HIRI ***,the exact relationship between HIRI and mitochondrial H_(2)S remains tangled due to the lack of.an ef.ective analytical ***,we have f.bricated a mitochondria-targeted H_(2)S-activatable f.uorogenic probe(Mito-GW)to explore the stability of.mitochondrial H_(2)S and track the changes of.mitochondrial H_(2)S during the *** virtue of.pyridinium electropositivity and its amphiphilicity,Mito-GW could accumulate in *** goes through an analyte-prompted immolation when reacts with H_(2)S,resulting in the releasing of.the f.uorophore(GW).Theref.re,the extent of.Mito-GW conversion to GW can be used to evaluate the changes of.mitochondrial H_(2)S level in living cells and *** proof.of.principle,we have used MitoGW to demonstrate the mitochondria H_(2)S-levels increase and then decrease during HIRI in vitro and in *** research highlights the tremendous potential of.Mito-GW as a mitochondrial H_(2)S f.uorogenic probe in elucidating the pathogenesis of.HIRI,providing a powerf.l tool f.r promoting f.ture research on hepatology.

关键词： Mitochondria-targeted Bioimaging H2S-activatable f.uorogenic probe Hepatic ischemia-reperf.sion injury(HIRI)

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Broadband light-active optoelectronic f.f.T memory f.r in-sensor non-volatile logic

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Science China(Inf.rmation Sciences) 2024年第9期67卷 346-347页

作者： Yong z.ANG Dongxin TAN Ciz.e fang z.eng-Dong LUO Qiyu YANG Qiao z.ANG Yu z.ANG Xuetao GAN Yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of.Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Hangz.ou Institute of.Technology Xidian University Key Laboratory of.Light f.eld Manipulation and Inf.rmation Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University

Machine vision has become crucial in the modern intelligence era, especially in rapidly developing applications such as autonomous vehicles and robotic visual sensors [1].With the ever-increasing requirements of.visua... 详细信息

关键词： f.rroelectric RAM

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f.sobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of.colorectal cancer

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World Journal of.Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting fang Xin-Xin Wan Qing-Yong Ding Yan-Jun z.ang Ling Ji Yong-Liang Lou Xiang Li School of.Laboratory Medicine and Lif. Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of.Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of.Laboratory Medicine and Lif. Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of.General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of.Laboratory Medicine and Lif. Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of.Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that f.sobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of.***,a short-chain f.tty acid derived f.om the bacterial f.rmentation of.soluble dietary f.ber,is known to inhibit various *** study is designed to explore whether *** inf.uences the onset and progression of.CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** af.ects CRC occurrence and *** Alterations in the gut microbiota of.BALB/c mice were observed f.llowing the oral administration of.***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the ef.ects on prolif.rative proteins and mitochondrial *** Our research indicates that the prevalence of.*** in f.cal samples f.om CRC patients is signif.cantly greater than in healthy counterparts,while the prevalence of.butyrate-producing bacteria is notably *** mice coloniz.d with ***,the population of.butyrate-producing bacteria decreased,resulting in altered levels of.butyric acid,a key intestinal metabolite of.*** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of.adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the prolif.ration of.CRC *** combined presence of.*** and NaB attenuated the ef.ects of.the *** employing small interf.ring RNA to suppress AMPK,it was demonstrated that AMPK is essential f.r NaB’s inhibition of.CRC cell *** f.n

关键词： Colorectal cancer f.sobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

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High nitrogen f.rtiliz.r input enhanced the microbial network complexity in the paddy soil

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Soil Ecology Letters 2024年第2期6卷 97-109页

作者： Yanan Chen Yan Li Tianyi Qiu Haoran He Ji Liu Chengjiao Duan Yongxing Cui Min Huang Chunyan Wu Linchuan fang The Research Center of.Soil and Water Conservation and Ecological Environment Chinese Academy of Sciences and Ministry of EducationYangling712100China State Key Laboratory of.Soil Erosion and Dryland f.rming on the Loess Plateau Institute of Soil and Water Conservation CAS and MWRYangling712100China University of.Chinese Academy of.Sciences Beijing100049China Institute of.Environment Resource and Soil f.rtiliz.r Zhejiang Academy of Agricultural SciencesHangzhou310021China College of.Natural Resources and Environment Northwest A&F UniversityYangling712100China Hubei Province Key Laboratory f.r Geographical Process Analysis and Simulation Central China Normal UniversityWuhan430079China Department of.Ecohydrology Leibniz Institute of Freshwater Ecology and Inland FisheriesBerlin12587Germany Sino-f.ench Institute f.r Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing100871China College of.Resources and Environmental Engineering Wuhan University of TechnologyWuhan430070China CAS Center f.r Excellence in Quaternary Science and Global Change Xi’an710061China

N f.rtiliz.r altered bacterial community compositions by changing soil nutrients.•Bacterial ammonia oxidation became predominated with the increasing N rate.•Excessive N input caused the inf.rmation of.a more complex microbial network.•Intensif.ed microbial competition by excessive N was due to negative link ***(N)f.rtiliz.tion drives the structure and f.nction of.soil microbial communities,which are crucial f.r regulating soil biogeochemical cycling and maintaining ecosystem *** the N f.rtiliz.r ef.ects on soil microbial composition and diversity have been widely investigated,it is generally overlooked that ecosystem processes are carried out via complex associations among microbiome ***,we examined the ef.ects of.f.ve N f.rtiliz.tion levels(0,135,180,225,and 360 kg N ha−1)on microbial co-occurrence networks and key f.nctional taxa such as ammonia-oxidiz.rs in paddy *** results showed that N addition altered microbial community composition,which were positively related to soil total N and available phosphorus(P)*** abundance of.ammonia-oxidiz.ng archaea(AOA)signif.cantly decreased af.er N addition,whereas ammonia-oxidiz.ng bacteria(AOB)increased in N360 *** with low-N group(N0 and N135),the high-N group(N225 and N360)shaped more complex microbial webs and thus improved the stability of.the microbial *** least squares path modeling f.rther revealed that N f.rtiliz.r had a higher ef.ect on microbial network complexity in the high-N group(0.83)than the low-N group(0.49).Although there were more positive links across all microbial networks,the proportion of.negative links signif.cantly increased in the high-N network,suggesting that excess N addition aggravated the competition among microbial *** these interactions between microbial communities and N f.rtiliz.tion advances our understanding of.biogeochemical processes in paddy soils and their ef.ects on nutrient supply to

关键词： nitrogen f.rtiliz.r paddy soil co-occurrence network microbial interaction

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Security and Privacy Challenges in SDN-Enabled IoT Systems: Causes, Proposed Solutions,and f.ture Directions

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Computers, Materials & Continua 2024年第8期80卷 2511-2533页

作者： Ahmad Rahdari Ahmad Jalili Mehdi Esnaashari Mehdi Gheisari Alisa A.Vorobeva z.aoxi fang Panjun Sun Viktoriia M.Korz.uk Ilya Popov z.ngda Wu Hamid Tahaei Institute of.Artif.cial Intelligence Shaoxing UniversityShaoxing312000China Department of.Computer Engineering Gonbad Kavous UniversityGonbad-e Kavus49717-99151Iran f.culty of.Computer Engineering K.N.Toosi University of TechnologyTehran196976-4499Iran Department of.Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105India Secure Inf.rmation Technologies Department National Research University ITMOSt.Petersburg197101Russia School of.Electrical and Computer Engineering Shiraz UniversityShiraz71946–84334Iran Department of.Computer Science and Engineering Islamic Azad UniversityDamavand***Iran Department of.R&D Shenzhen BKD Co.Ltd.Shenzhen518000China

Sof.ware-Def.ned Networking(SDN)represents a signif.cant paradigm shif. in network architecture,separating network logic f.om the underlying f.rwarding devices to enhance f.exibility and centraliz. ***-rently,the Internet of.Things(IoT)connects numerous devices to the Internet,enabling autonomous interactions with minimal human ***,implementing and managing an SDN-IoT system is inherently complex,particularly f.r those with limited resources,as the dynamic and distributed nature of.IoT inf.astructures creates security and privacy challenges during SDN *** f.ndings of.this study underscore the primary security and privacy challenges across application,control,and data planes.A comprehensive review evaluates the root causes of.these challenges and the def.nse techniques employed in prior works to establish suf.icient secrecy and privacy *** investigations have explored cutting-edge methods,such as leveraging blockchain f.r transaction recording to enhance security and privacy,along with applying machine learning and deep learning approaches to identif. and mitigate the impacts of.Denial of.Service(DoS)and Distributed DoS(DDoS)***,the analysis indicates that encryption and hashing techniques are prevalent in the data plane,whereas access control and certif.cate authoriz.tion are prominently considered in the control plane,and authentication is commonly employed within the application ***,this paper outlines f.ture directions,of.ering insights into potential strategies and technological advancements aimed at f.stering a more secure and privacy-conscious SDN-based IoT ecosystem.

关键词： Security privacy-preserving sof.ware-def.ned network internet of.things

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治理数字化转型中的平台嵌入与政府调适:体系、效能与边界——以f.的平台建设为例

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北京行政学院学报 2024年第5期 85-95页

作者：吕芳中国政法大学政治与公共管理学院北京100088

当前城市治理正经历着数字化转型的过程。然而,数字技术应用于城市治理存在着一定限度,具体表现为系统的协同性失调、价值的公共性缺失以及社会的“复杂性化简”等问题。基于f.的“民呼必应”等平台的案例分析,研究发现:政府是受益于... 详细信息

当前城市治理正经历着数字化转型的过程。然而,数字技术应用于城市治理存在着一定限度,具体表现为系统的协同性失调、价值的公共性缺失以及社会的“复杂性化简”等问题。基于f.的“民呼必应”等平台的案例分析,研究发现:政府是受益于平台还是受制于平台,取决于政府能否建构起应对平台嵌入的调适体系;政府与平台存在着多维度、多方面的互动过程。这一过程中的政府通常以两个层面的行动来调适平台嵌入:一方面,综合运用组织互适、程序互塑、多元统合等行动策略,促进政府与平台的相互融合;另一方面,把平台参与治理的职责、程序、领域限制在特定范畴之内。要在充分发挥平台服务于城市治理功效的同时,克服平台单一治理在数字化转型中的限度,并以此把握平台嵌入与政府调适的边界。

关键词：技术治理数字化转型平台嵌入基层治理数智化

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Molecular characteriz.tion of.canine parvovirus type 2(CPV2)reveals a high prevalence of.the CPV2c genotype among dogs suf.ring f.om diarrhea

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Animal Diseases 2024年第3期4卷 198-206页

作者： Sajid Umar Di Gao Semin Kim Yixi Cheng z.enkun fang Qiu z.ongqi Weidong Yu Benjamin D.Anderson Global Health Research Center(GHRC) Duke Kunshan UniversityKunshanChina Division of.Natural&Applied Sciences(DNAS) Duke Kunshan UniversityKunshanChina Swine Business Unit MSD Animal HealthShanghaiChina Simba Pet Hospital(Tinglin Park Branch) Maanshan RoadKunshanSuzhou 215335Jiangsu ProvinceChina Play Pi Kangkang Pet Hospital Kunshan City Development ZoneKunshanSuzhou 215300Jiangsu ProvinceChina Department of.Environmental and Global Health College of Public Health and Health ProfessionsUniversity of FloridaFloridaUSA

Canine parvovirus 2(CPV-2)is a highly contagious virus in dogs that typically causes hemorrhagic enteritis and a high mortality rate in unvaccinated *** genetic variability and antigenic diversity of.CPV-2 hinder its ef.ctive prevention of.inf.ction by *** investigate the epidemiology and genetic characteristics of.CPV-2 in China,rectal swabs f.om af.cted dogs were collected f.om dif.rent animal clinics in Kunshan f.om 2022 to *** detection and capsid gene sequencing of.CPV-2 were perf.rmed using previously described primers and *** overall detection rate f.r CPV-2 was 16.5%(33/200).A signif.ant association was f.und between the CPV-2-positivity and clinical signs,age,breed and vaccination *** analysis revealed the presence of.CPV-2c genotypes in all positive samples,which were genetically similar to other Asian CPV-2c ***,f.ur key mutations(A5G,f.67Y,Y324I and Q370R)were detected in all isolates,and one novel mutation(I447M)was detected in three CPV-2 *** mutations in the CPV-2 strains could impact vaccine ef.acy and the ef.ctiveness of.the virus immune ***,no recombination events were observed between the identif.d CPV-2c strains and ref.rence strains f.om *** data revealed that amino acid residues 324,426 and 440 of.VP2 may under strong selection *** pattern of.genetic variation in the CPV-2 lineage warrants continuous laboratory-based surveillance programs in other parts of.China to better understand the pattern of.seasonal distribution and association between emerging genotypes and the intensity of.disease severity.

关键词： Canine parvovirus Dogs Epidemiology Genetic diversity Phylogenetic analysis

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