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A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics

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Nano-Micro Letters 2024年第5期16卷 120-133页

作者： Qian Wang Yanyan Li Yong Lin Yuping Sun chong Bai Haorun Guo Ting fang Gaohua Hu Yanqing Lu Desheng Kong College of Engineering and Applied Sciences National Laboratory of Solid State Microstructureand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023People’s Republic of China College of Chemical Engineering and Technology Engineering Research Center of Seawater Utilization Technology of Ministry of EducationState Key Laboratory of Reliability and Intelligence of Electrical EquipmentHebei University of TechnologyTianjin 300130People’s Republic of China Key Laboratory of Intelligent Optical Sensing and Manipulation Nanjing UniversityNanjing 210093People’s Republic of China

Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured skin.Hybrid electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device interfaces.However,chemical modifications are typically needed for reliable bonding,which can alter their original properties.To overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid electrodes.In this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the hydrogel.The microfoam-enabled bonding strategy is generally compatible with various polymers.The resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked hybrids.These electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive hydrogels.They have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle contractions.Interlocked nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.

关键词： Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites Hydrogel

Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording

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Nano-Micro Letters 2024年第7期16卷 244-264页

作者： Yuting Xiang Keda Shi Ying Li Jiajin Xue Zhicheng Tong Huiming Li Zhongjun Li chong Teng Jiaru fang Ning Hu Department of Chemistry Zhejiang-Israel Joint Laboratory of Self-Assembling Functional MaterialsZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 310058People’s Republic of China School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053People’s Republic of China General Surgery Department Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Children’s HealthHangzhou 310052People’s Republic of China Department of Lung Transplantation and General Thoracic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People’s Republic of China Department of Orthopedics The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322005People’s Republic of China School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhou 510006People’s Republic of China Department of Obstetrics and Gynecology The Tenth Affiliated HospitalSouthern Medical UniversityDongguan 523059People’s Republic of China Dongguan Key Laboratory of Major Diseases in Obstetrics and Gynecology Dongguan 523059People’s Republic of China

The development of precise and sensitive electrophysiological recording platforms holds the utmost importance for research in the fields of cardiology and neuroscience.In recent years,active micro/nano-bioelectronic devices have undergone significant advancements,thereby facilitating the study of electrophysiology.The distinctive configuration and exceptional functionality of these active micro-nano-collaborative bioelectronic devices offer the potential for the recording of high-fidelity action potential signals on a large scale.In this paper,we review three-dimensional active nano-transistors and planar active micro-transistors in terms of their applications in electroexcitable cells,focusing on the evaluation of the effects of active micro/nano-bioelectronic devices on electrophysiological signals.Looking forward to the possibilities,challenges,and wide prospects of active micro-nano-devices,we expect to advance their progress to satisfy the demands of theoretical investigations and medical implementations within the domains of cardiology and neuroscience research.

关键词： Active micro/nano collaborative bioelectronic device Three-dimensional active nano-transistor Planar active microtransistor Electrophysiology

Non-alcoholic fatty liver disease and sleep disorders

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World Journal of Hepatology 2024年第3期16卷 304-315页

作者： Lu-fang Bu chong-Yu Xiong Jie-Yi Zhong Yan Xiong Dong-Ming Li Fen-fang Hong Shu-Long Yang Department of Physiology Fuzhou Medical CollegeNanchang UniversityFuzhou 344000Jiangxi ProvinceChina Key Laboratory of Chronic Diseases Fuzhou Medical UniversityFuzhou 344000Jiangxi ProvinceChina Technology Innovation Center of Chronic Disease Research in Fuzhou City Fuzhou Science and Technology BureauFuzhou 344000Jiangxi ProvinceChina Experimental Center of Pathogen Biology College of MedicineNanchang UniversityNanchang 330006Jiangxi ProvinceChina

Studies have shown that non-alcoholic fatty liver disease(NAFLD)may be associated with sleep disorders.In order to explore the explicit relationship between the two,we systematically reviewed the effects of sleep disorders,especially obstructive sleep apnea(OSA),on the incidence of NAFLD,and analyzed the possible mechanisms after adjusting for confounding factors.NAFLD is independently associated with sleep disorders.Different sleep disorders may be the cause of the onset and aggravation of NAFLD.An excessive or insufficient sleep duration,poor sleep quality,insomnia,sleep-wake disorders,and OSA may increase the incidence of NAFLD.Despite that some research suggests a unidirectional causal link between the two,specifically,the onset of NAFLD is identified as a result of changes in sleep characteristics,and the reverse relationship does not hold true.Nevertheless,there is still a lack of specific research elucidating the reasons behind the higher risk of developing sleep disorders in individuals with NAFLD.Further research is needed to establish a clear relationship between NAFLD and sleep disorders.This will lay the groundwork for earlier identification of potential patients,which is crucial for earlier monitoring,diagnosis,effective prevention,and treatment of NAFLD.

关键词： Non-alcoholic fatty liver disease Sleep duration Sleep quality Sleep disorders Obstructive sleep apnea

Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-Yang Wu Hui-Hui fang Yan-Wu Xu Yan-Ling Zhang Shao-chong Zhang Wei-Hua Yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of myopia.METHODS:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics software.RESULTS:A total of 444 institutions in 87 countries published 4124 articles.Between 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related journals.Citations from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research frontiers.CONCLUSION:Myopia has become a hot research field.China and Chinese institutions have the strongest academic influence in the field from 2013 to 2022.The main driver of myopic research is still medical or ophthalmologists.This study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s health.At present,a unified theoretical system is still needed.Accurate surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive errors.In addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

Deciphering dynamic surface of PtRu alloy nanocatalysts to revisit their synergistic effects during the electrooxidation

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Science China Chemistry 2024年第7期67卷 2224-2233页

作者： Xiao-chong Li Bo Wang Zhou Yu Qiang Wan Ju-fang Zheng Emmanuel Maisonhaute Xiao-Shun Zhou Ya-Hao Wang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China Laboratoire Interface et Systèmes Electrochimiques CNRS UMR 8235Sorbonne UniversitéF-75252 Paris cedex 5France

Correlating dynamic structural transformation of catalysts with the surface intermediate species under operating conditions is critical for updating the understanding of structure–performance relationships.Here,we probe the electrochemical potentialdependent surface structures and adsorbed intermediates on PtRu binary alloy nanocatalysts to revisit its synergistic mechanisms for CO electrooxidation enhanced activity.In-situ spectral characteristics by using modified shell-isolated nanoparticle-enhanced Raman spectroscopy,show that in acidic solution,when the potential is positively scanned from 0.1 V to 1.5 V relative to reversible hydrogen electrode(RHE),the surface of the alloy catalyst evolves from metallic PtRu to adsorbed oxygen gradually covering and accumulating on Ru sites(denoted as PtRuO_(x),x≤2),forming segregated RuO_(2),and finally forming a threedimensional oxide layer(denoted as 3D PtRuO_(4)).Moreover,molecular evidence associated with periodic density functional theory calculations reveals that electronic effects promote ruthenium to become more oxidizable and oxophilic.In particular,we found here that*O and*OH at surface RuOxsites are highly efficient CO oxidation active species in comparison to the same entities adsorbed on metallic Ru sites.This work sheds light on the complex surface dynamic process of practical Pt-based binary nanocatalysts and improves the understanding of synergistic mechanism for the development of fuel cell devices.

关键词： in-situ Raman spectroscopy surface evolution bifunctional mechanism PtRu electrooxidation

Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-Ming Wang Yu-Tao Pan Chen-Song Yang Ming-chong Liu Sheng-Chao Ji Ning Han fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of survival.This study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical management.AIM To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly patients.METHODS The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical investigation.Patients with excellent and fair postoperative hip function had their clinical information and characteristics gathered and compared.Age,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate study.To further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression analysis.In addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two groups.RESULTS A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were female.The results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.020-4.498)and C1q>233 mg/L(OR 2.339,95%CI:1.094-

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice

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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming GUO Jiatian ZHAO Jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI fang CHEN chong HOU Mingzhuang LV Nanning XU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic Surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)development.Celastrol(CSL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain underexplored.This study aimed to substantiate CSL’s chondroprotective effects and unravel its underlying mechanisms.We investigated CSL’s impact on chondrocytes under both normal and inflammatory conditions.In vitro,CSL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)synthesis.In vivo,intra-articular injection of CSL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA mice.Mechanistically,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CSL-mediated antioxidative functions and exacerbated the progression of OA.This study is the first to elucidate the role of CSL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

Remote estimates of suspended particulate matter in global lakes using machine learning models

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International Soil and Water Conservation Research 2024年第1期12卷 200-216页

作者： Zhidan Wen Qiang Wang Yue Ma Pierre Andre Jacinthe Ge Liu Sijia Li Yingxin Shang Hui Tao chong fang Lili Lyu Baohua Zhang Kaishan Song Northeast Institute of Geography and Agroecology CASChangchunJilin130102China Department of Geology Indiana University∼Purdue UniversityIndianapolisIN44602USA University of Chinese Academy of Sciences Beijing100100China College of Geography and Urban Planning Liaocheng UniversityLiaochengChina

Suspended particulate matter(SPM)in lakes exerts strong impact on light propagation,aquatic ecosystem productivity,which co-varies with nutrients,heavy metal and micro-pollutant in waters.In lakes,SPM exerts strong absorption and backscattering,ultimately affects water leaving signals that can be detected by satellite sensors.Simple regression models based on specific band or hand ratios have been widely used for SPM estimate in the past with moderate accuracy.There are still rooms for model accuracy improvements,and machine learning models may solve the non-linear relationships between spectral variable and SPM in waters.We assembled more than 16,400 in situ measured SPM in lakes from six continents(excluding the Antarctica continent),of which 9640 samples were matched with Landsat overpasses within±7 days.Seven machine learning algorithms and two simple regression methods(linear and partial least squares models)were used to estimate SPM in lakes and the performance were compared.To overcome the problem of imbalance datasets in regression,a Synthetic Minority Over-Sampling technique for regression with Gaussian Noise(SMOGN)was adopted in this study.Through comparison,we found that gradient boosting decision tree(GBDT),random forest(RF),and extreme gradient boosting(XGBoost)models demonstrated good spatiotemporal transferability with SMOGN processed dataset,and has potential to map SPM at different year with good quality of Landsat land surface reflectance images.In all the tested modeling approaches,the GBDT model has accurate calibration(n=6428,R^(2)=0.95,MAPE=29.8%)from SPM collected in 2235 lakes across the world,and the validation(n=3214,R^(2)=0.84,MAPE=38.8%)also exhibited stable performance.Further,the good performances were also exhibited by RF model with calibration(R^(2)=0.93)and validation(R^(2)=0.86,MAPE=24.2%)datasets.We applied GBDT and RF models to map SPM of typical lakes,and satisfactory result was obtained.In addition,the GBDT model was evaluated by historical SPM measurements coincident with di

关键词： Landsat imagery Remote estimation SPM Transferability

Differentiation of Algal Blooms and Aquatic Vegetation in Chinese Lakes Using Modified Vegetation Presence Frequency Index Method

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Chinese Geographical Science 2022年第5期32卷 792-807页

作者： PU Jing SONG Kaishan LIU Ge WEN Zhidan fang chong HOU Junbing LV Yunfeng College of Geographical Sciences Changchun Normal UniversityChangchun 130032China Northeast Institute of Geography and Agro ecology Chinese Academy of ScienceChangchun 130102China

Algal blooms in lakes have become a common global environmental problem. Nowadays, remote sensing is widely used to monitor algal blooms in lakes due to the macroscopic, fast, real-time characteristics. However, it is often difficult to distinguish between algal blooms and aquatic vegetation due to their similar spectral characteristics. In this paper, we used modified vegetation presence frequency index(VPF) based on Moderate-resolution Imaging Spectroradiometer(MODIS) imagery to distinguish algal blooms from aquatic vegetation, and analyzed the spatial and temporal variations of algal blooms and aquatic vegetation from a phenological perspective for five large natural lakes with frequent algal bloom outbreaks in China from 2019 to 2020. We simplified the VPF method to make it with a higher spatial transferability so that it could be applied to other lakes in different climatic zones. Through accuracy validation, we found that the modified VPF method can effectively distinguish between algal blooms and aquatic vegetation, and the results vary from lake to lake. The highest accuracy of 97% was achieved in Hulun Lake, where the frequency of algal outbreaks is low and the extent of aquatic vegetation is stable, while the lowest accuracy of 76% was achieved in Dianchi Lake, which is rainy in summer and the lake is small. Analyses suggests that the time period when algal blooms occur most frequently might not coincide with that when they have the largest area. However, in most cases these two are close in terms of time period. The modified VPF method has a broad scope of application, is easy to implement, and has a high practical value. Furthermore, the method could be established using only a small amount of measured data, which is useful for water quality monitoring on large spatial scales.

关键词： algal blooms aquatic vegetation modified vegetation presence frequency index(VPF) phenology lake