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International Journal of Disaster Risk Science 2012年第1期3卷 11-22页

作者： Lorenzo fabian Department of Urbanism University IUAV of Venice(Istituto Universitario di Architettura di Venezia)30125 VeniceItaly

In Italy extreme cities and territories occur at the extremities of lagoons,coastlines,and river deltas,in hydraulically reclaimed and hydrogeologically instable areas,and those where the water supply network has been placed underground,channeled into piping,or removed altogether. These areas are now increasingly subject to natural calamities and extreme weather conditions,and the consequences of climate change and the fragility of the more and more impermeable and urbanized land surface are clearly evident. Isotropic territories are characterized by weak hierarchization of infrastructure and settlement. The metropolitan area of Venice,aptly described as a diffuse city(città diffusa),and other diffusely organized territories characterized by settlement dispersion are good examples of this phenomenon. This article reviews recent research at the University IUAV of Venice in a study on climate change and water forms,a project in which the profound relations between water networks,the geological nature of the terrain,forms of urbanization,and energy saving are tested out. The study of the territories of the Venetian metropolitan area provides a series of initial working hypotheses as to how the ongoing environmental emergency can become an opportunity for a development project of the city and the territory,capable of structuring its various parts differently.

关键词： extreme consequences underground

Influence of the number of flights on the dilute phase ratio in flighted rotating drums by PTV measurements and DEM simulations

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Particuology 2021年第3期19卷 171-182页

作者： Lanyue Zhang Zhaochen Jiang Jochen Mellmann fabian Weigler fabian Herz Andreas Bück Evangelos Tsotsas Department of Postharvest Technology Leibniz Institute for Agricultural Engineering and BioeconomyMax-Eyth-Allee 100Potsdam 14469Germany Thermal Process Engineering Otto von Guericke University MagdeburgUniversitaetsplatz 239106 MagdeburgGermany Institute of Particle Technology(LFG) FAU Erlangen-NurembergCauerstr.491058 ErlangenGermany Department of Applied Biosciences and Process Engineering Anhalt University of Applied SciencesBernburgerStr.5506366 KoethenGermany

Particle distribution in the cross-section of the flighted rotating drum(FRD)is critical to the analysis of heat and mass transfer between gas and *** this work,the particle tracking velocimetry(PTV)method is applied to study the influence of the number of flights on the particle motion in *** drum,installed with 1,4,8,or 12 rectangular flights,is filled with plastic balls to 15%and operated at various rotating speeds ranging from 10 rpm to 30 *** results show that the number of flights has different effects on the holdup ratio and cascading rate of single flight and active *** 8 and 12 flights,the FRD produces a larger and more stable particle ratio of the dilute ***,DEM simulations agree with PTV measurements,whereas literature models show significant deviations.

关键词： Flighted rotating drum Number of flights Dilute phase PTV DEM

Simulating orthokinetic heterocoagulation and cluster growth in destabilizing suspensions

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Particuology 2017年第2期15卷 117-128页

作者： fabian Billow Hermann Nirschl Willy Dorfler Institute of Mechanical Process Engineering and Mechanics Karlsruhe Institute of Technology 76131 Karlsruhe Germany Institute for Applied and Numerical Mathematics Karlsruhe Institute of Technology 76131 Karlsruhe Germany

Using direct numerical simulation, we investigate the coagulation behavior of non-Brownian colloidal particles as exemplified by Al2O3 particles. This yields the so-called capture efficiency, for which we give an analytical expression, as well as other time-dependent variables such as the cluster growth rate. Instead of neglecting or strongly approximating the hydrodynamic interactions between particles, we include hydrodynamic and non-hydrodynamic interactions in a Stokesian dynamics approach and a comprehensive modeling of the interparticle forces. The resulting parallelized simulation framework enables us to investigate the dynamics of polydisperse particle systems composed of several hundred particles at the same high level of modeling we used for a close investigation of the coagulation behavior of two unequal particles in shear flow. Appropriate cluster detection yields all the information about large destabilizing systems, which is needed for models used in flow-sheet simulations. After non-dimensionalization, the results can be generalized and applied to other systems tending to secondary coagulation

关键词： Destabilization Coagulation Capture efficiency Al2O3 Cluster detection Stokesian dynamics

Using multispectral landsat and sentinel-2 satellite data to investigate vegetation change at Mount St. Helens since the great volcanic eruption in 1980

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Journal of Mountain Science 2018年第9期15卷 1851-1867页

作者： Katharina TELTSCHER fabian Ewald FASSNACHT Institute of Geography and Geoecology Karlsruhe Institute of Technology

Long-term analyses of vegetation succession after catastrophic events are of high interest for an improved understanding of succession dynamics. However, in many studies such analyses were restricted to plot-based measurements. Contrarily, spatially continuous observations of succession dynamics over extended areas and timeperiods are sparse. Here, we applied a change vector analysis(CVA) to investigate vegetation succession dynamics at Mount St. Helens after the great volcanic eruption in 1980 using Landsat. We additionally applied a supervised random forest classification using Sentinel-2 data to map the currently prevailing vegetation types. Change vector analysis was performed with the normalized difference vegetation index(NDVI) and the urban index(UI) for three subsequent decades after the eruption as well as for the whole observation time between 1984 and 2016. The influence of topography on the current vegetation distribution was examined by comparing altitude, slope angles and aspect values of vegetation classes derived by the random forest classification. WilcoxRank-Sum test was applied to test for significant differences between topographic properties of the vegetation classes inside and outside of the areas affected by the eruption. For the full time period, a total area of 516 km2 was identified as re-vegetated, whereas the area and magnitude of re-growing vegetation decreased during the three decades and migrated closer to the volcanic crater. Vegetation losses were mainly observed in regions unaffected by the eruption and related mostly to timber harvesting. The vegetation type classification reached a high overall accuracy of approximately 90%. 36 years after the eruption, coniferous and deciduous trees have established at formerly devastated areas dominating with a proportion of 66%, whereas shrubs are more abundant in riparian zones. Sparse vegetation dominates at regions very close to the crater. Elevation was found to have a great influence on th

关键词： Mount St. Helens Vegetation change Remote sensing Change vector analysis (CVA) Supervised classification Topography Density-plots

Focus on LPA signaling:a promising therapeutic target to foster regeneration in immune-mediated neuropathies

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Neural Regeneration Research 2023年第12期18卷 2651-2652页

作者： fabian Szepanowski Mark Stettner Department of Neurology and Center for Translational and Behavioral Neurosciences(C-TNBS) University Medicine EssenUniversity Duisburg EssenEssenGermany

Lysophospholipids are metabolites of glycerophospholipids and sphingolipids that are commonly found as lipid constituents of cell *** addition to their function as structural membrane components,certain members of the lysophospholipid family have considera ble cell signaling pro ***-1-phosphate(S1P) and lysophosphatidic acid(LPA)represent the two major bioactive members of the lysophospholipid family that address specific G-protein cou pled receptors.

关键词： lipids therapeutic Focus

Interactive map reports summarizing bivariate geographic data

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Visual Informatics 2019年第1期3卷 27-37页

作者： Shahid Latif fabian Beck University of Duisburg–Essen paluno–The Ruhr Institute of Software TechnologyGermany

Bivariate map visualizations use different encodings to visualize two variables but comparison across multiple encodings is *** to a univariate visualization,it is significantly harder to read regional differences and spot geographical *** targeting inexperienced users of visualizations,we advocate the use of natural language text for augmenting map visualizations and understanding the relationship between two geo-statistical *** propose an approach that selects interesting findings from data analysis,generates a respective text and visualization,and integrates both into a single *** generated reports interactively link the visualization with the textual *** can get additional explanations and have the ability to compare different *** text generation process is flexible and adapts to various geographical and contextual settings based on small sets of *** showcase this flexibility through a number of application examples.

关键词： Geographic visualization Natural language generation Interactive documents

Histopathological assessment of the microscopic activity in inflammatory bowel diseases:What are we looking for?

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World Journal of Gastroenterology 2022年第36期28卷 5300-5312页

作者： Ondrej fabian Lukas Bajer Clinical and Transplant Pathology Centre Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Pathology and Molecular Medicine 3rd Faculty of MedicineCharles University and Thomayer HospitalPrague 14059Czech Republic Hepatogastroenterology Department Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Institute of Microbiology Czech Academy of SciencesPrague 14220Czech Republic

Advances in diagnostics of inflammatory bowel diseases(IBD)and improved treatment strategies allowed the establishment of new therapeutic ***,it is desirable not only to cease clinical symptoms,but mainly to achieve endoscopic remission,a macroscopic normalization of the bowel ***,up to one-third of IBD patients in remission exhibit persisting microscopic activity of the *** evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse,surgical intervention,need for therapy escalation,or development of colorectal *** proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been ***,a majority of them have not been validated and no scoring index became a part of the routine bioptic *** review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD,describes the most commonly used scoring indices for Crohn's disease and ulcerative colitis,and comments on current limitations and unresolved issues.

关键词： Crohn’s disease Microscopy Predictor Score Ulcerative colitis

District heating system operation in power systems with high share of wind power

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Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 850-862页

作者： Ilias DIMOULKAS Mikael AMELIN fabian LEVIHN School of Electrical Engineering Electric Power and Energy SystemsKTH Royal Institute of TechnologyStockholmSweden Fortum Va¨rme StockholmSweden School of Industrial Engineering and Management Industrial Economics and ManagementKTH Royal Institute of TechnologyStockholmSweden

The integration of continuously varying and not easily predictable wind power generation is affecting the stability of the power system and leads to increasing demand for balancing *** this study,a short-term operation model of a district heating system is proposed to optimally schedule the production of both heat and power in a system with high wind power *** application of the model in a case study system shows the increased flexibility offered by the coordination of power generation,consumption and heat storage units which are available in district heating systems.

关键词： District heating systems Combined heat and power(CHP) Flexible power system operation Heat storage

Retinal pigment epithelium–Bruch’s membrane volume in grading of age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1827-1831页

作者： fabian Kananen Ilkka Immonen Department of Ophthalmology Örebro University HospitalÖrebro 70185Sweden Department of Ophthalmology and Otorhinolaryngology Helsinki UniversityHelsinki 00014Finland Department of Ophthalmology Helsinki University Central HospitalHelsinki 00014Finland

AIM:To assess the agreement of optical coherence tomography(OCT)algorithm-based retinal pigment epithelium–Bruch’s membrane complex volume(RBV)with fundus photograph-based age-related macular degeneration(AMD)***:Digital color fundus photographs(CFPs)and spectral domain OCT images were acquired from 96 elderly *** were graded according to Age-Related Eye Disease Study(AREDS)*** image segmentation and RBV data calculation were done with OrionTM *** and multivariate analyses were performed to find out whether AMD lesion features associated with higher ***:RBV correlated with AMD grading(rs=0.338,P=0.001),the correlation was slightly stronger in early AMD(n=52;rs=0.432,P=0.001).RBV was higher in subjects with early AMD compared with those with no AMD lesions evident in fundus photographs(1.05±0.20 vs 0.96±0.13 mm3,P=0.023).In multivariate analysis higher RBVs were associated significantly with higher total drusen(β=0.388,P=0.027)and pigmentation areas(β=0.319,P=0.020)in fundus photographs,whereas depigmentation area(β=-0.295,P=0.015)associated with lower ***:RBV correlate with AMD grading status,with a stronger association in patients with moderate,non-late AMD *** effect is driven mostly by lesions with drusen or *** with depigmentation tend to have lower *** is more comprehensive measurement of the key area of AMD pathogenesis,compared to sole drusen volume *** measurements are independent on grader variations and offer a possibility to quantify early and middle grade AMD lesions in a research setting,but may not substitute fundus photograph-based grading in the whole range of AMD spectrum.

关键词： age-related macular degeneration drusen optical coherence tomography Bruch’s membrane

Four-wheel-drive immune protection

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3637-3638页

作者： fabian Heinrich Susanne Krasemann Institute of Legal Medicine University Medical Center Hamburg Eppendorf20251 HamburgGermany Institute of Neuropathology University Medical Center Hamburg Eppendorf20251 HamburgGermany

In a recent study published in Cell,Zhang and colleagues provide the first longitudinal study comparing four different COVID-19 vaccines head-to-head for binding and neutralizing antibodies,spike-specific CD4+or CD8+T... 详细信息

关键词： antibodies immune vaccines