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Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： Eric f. Tanlaka Torri Trojand faculty of Nursing University of Windsor Windsor Canada

Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer functional outcomes than those without impaired cognition. Differences in functional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of cognitive impairment, and severity of stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired from a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and functional gains, rehabilitation stays, and living settings after discharge from rehabilitation. Results: An aggregate sample of 393 males and 314 females subclassified as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were significantly (p 0.001) older, had (mostly) moderate to severe stroke with significantly (p = 0.012) more moderate cognitive impairment, had significantly (p 0.001) longer rehabilitation stays, and a high propensity for being discharged to longer-term care facilities compared to non-cognitively impaired patients. Conclusion: Presence of significant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of the patient, level of cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation functional Outcomes

Hydroxychloroquine in SARS-CoV-2 infection:Understanding the misadventure

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Journal of Acute Disease 2024年第2期13卷 45-52页

作者： David Banji Otilia J f Banji Department of Pharmacology&Toxicology College of PharmacyJazan UniversitySaudi Arabia Department of Clinical Pharmacy College of PharmacyJazan UniversitySaudi Arabia

The widespread outbreak of SARS-CoV-2 was declared a public health emergency by the World Health Organization and various governments *** prompted the implementation of stringent infection control measures to curb the spread of the *** this,the medical community faced the challenge of treating the virus without specific therapies or a vaccine,leading to reliance on empirical treatment *** this context,hydroxychloroquine,an antimalarial and antirheumatic drug,gained attention as a potential treatment *** its theoretical benefits,such as inhibiting viral entry,reducing inflammation,and modulating immune responses,empirical studies yielded inconsistent *** indicated a potential for symptom relief,while others showed no significant improvement in patient *** initial enthusiasm waned as the lack of substantial evidence led to revoking its Emergency Use Authorization,and several clinical trials were prematurely *** review in question critically examines the factors contributing to the ineffectiveness of hydroxychloroquine in treating SARS-CoV-2 infection,highlighting the complexities of drug repurposing during a rapidly evolving pandemic.

关键词： SARS-CoV-2 Hydroxychloroquine Pharmacogenomics TLR signaling Cardiotoxicity

On an Invariant of Tournament Digraphs

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2711-2722页

作者： Boris f. Melnikov Bowen Liu faculty of Computational Mathematics and Cybernetics Shenzhen MSU-BIT University Shenzhen China

To date, it is unknown whether it is possible to construct a complete graph invariant in polynomial time, so fast algorithms for checking non-isomorphism are important, including heuristic algorithms, and for successful implementations of such heuristics, both the tasks of some modification of previously described graph invariants and the description of new invariants remain relevant. Many of the described invariants make it possible to distinguish a larger number of graphs in the real time of a computer program. In this paper, we propose an invariant for a special kind of directed graphs, namely, for tournaments. The last ones, from our point of view, are interesting because when fixing the order of vertices, the number of different tournaments is exactly equal to the number of undirected graphs, also with fixing the order of vertices. In the invariant we are considering, all possible tournaments consisting of a subset of vertices of a given digraph with the same set of arcs are iterated over. for such subset tournaments, the places are calculated in the usual way, which are summed up to obtain the final values of the points of the vertices;these points form the proposed invariant. As we expected, calculations of the new invariant showed that it does not coincide with the most natural invariant for tournaments, in which the number of points is calculated for each participant. So far, we have conducted a small number of computational experiments, and the minimum value of the pair correlation between the sequences representing these two invariants that we found is for dimension 15.

关键词： Graph Directed Graph Tournament ?nvariant

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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Journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.fattahi Christopher Zaro Janice J.Chung Richard f.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA Jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

Thin-Shell Wormholes Admitting Conformal Motions in Spacetimes of Embedding Class One

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 162-171页

作者： Peter K. f. Kuhfittig Department of Mathematics Milwaukee School of Engineering Milwaukee USA

This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while the surface pressure is negative, resulting in , thereby signaling a violation of the null energy condition, a necessary condition for holding a wormhole open. for a Morris-Thorne wormhole, matter that violates the null energy condition is referred to as “exotic”. for the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of the embedding theory in conjunction with the assumption of conformal symmetry. These properties avoid the need to hypothesize the existence of the highly problematical exotic matter.

关键词： Thin-Shell Wormholes Conformal Symmetry Embedding Class One Exotic Matter

Silicon micromirrors with three-dimensional curvature enabling lensless efficient coupling of free-space light

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Light(Science & Applications) 2013年第1期2卷 98-106页

作者： Yasser M sabry Bassam Saadany Diaa Khalil Tarik Bourouina Universite Paris-Est ESYCOM(EA 2552)ESIEE ParisF-93162 Noisy-le-GrandFrance Si-Ware Systems 3 Khaled Ibn El-Waleed StreetHeliopolisCairo 11361Egypt Electron.and Comm.Eng.Dept. Faculty of Eng.Ain-Shams UniversityCairoEgypt

Miniaturized optical benches process free-space light propagating in-plane with respect to the substrate and have a large variety of applications,including the coupling of light through an optical *** coupling efficiency is usually obtained using assembled micro-optical parts,which considerably increase the system cost and integration *** this work,we report a high coupling efficiency,monolithically integrated silicon micromirror with controlled three-dimensional(3D)curvature that is capable of manipulating optical beams propagating in the plane of the silicon *** on our theoretical modeling,a spherical micromirror with a microscale radius of curvature as small as twice the Gaussian beam Rayleigh range provides a 100%coupling efficiency over a relatively long optical path *** dimensionless parameters facilitates the elucidation of the role of key design parameters,including the mirror’s radii of curvature,independent of the wavelength.A micromachining method is presented for fabricating the 3D micromirror using fluorinated gas *** measured coupling efficiency was greater than 50%over a 200-mm optical path,compared to less than 10%afforded by a conventional flat micromirror,which was in good agreement with the *** the 3D micromirror,an optical cavity was formed with a round-trip diffraction loss of less than 0.4%,resulting in one order of magnitude enhancement in the measured quality factor.A nearly 100%coupling was also estimated when matching the sagittal and tangential radii of curvature of the presented micromirror’s *** reported class of 3D micromirrors may be an advantageous replacement for the optical lenses usually assembled in silicon photonics and optical benches by transforming them into real 3D monolithic systems while achieving wideband high coupling efficiency over submillimeter distances.

关键词： coupling efficiency Gaussian beam coupling micro-optics monolithic chip optical cavity optical fabrication optical benches silicon photonics

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat Elabbasy Mohamed R.Atteya Mai A.Samak Mousa Abdelrahman Tahani AlMahmoud M.A.El-Morsy A.A.Menazea M.f.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),fourier transform infrared spectroscopy(fTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

Association between baseline levels of muscular strength and risk of stroke in later life:The Cooper Center Longitudinal Study

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Journal of Sport and Health Science 2024年第5期13卷 642-649页

作者： Stephen W.farrell David Leonard Qing Li Carolyn E.Barlow Kerem Shuval Jarett D.Berry Andjelka Pavlovic Laura f.Defina Research Division The Cooper InstituteDallasTX 75230USA Department of Internal Medicine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular strength is an important component of physical *** evaluated the relationship between baseline muscular strength and risk of stroke among adults who were aged≥65 years during ***:We included 7627 healthy adults(mean age=43.9 years,86.0%male)underwent a baseline physical examination between 1980 and *** strength was determined by 1-repetition maximum measures for bench press and leg press and categorized into age-and sex-specific tertiles for each *** fitness(CRf)was assessed via a maximal treadmill exercise *** enrolled in fee-for-service Medicare from 1999 to 2019 were included in the *** between baseline strength and stroke outcomes were estimated using a modified Cox proportional hazards *** a secondary analysis,we examined stroke risk by categories of CRf where Quintile 1=low,Quintiles 2-3=moderate,and Quintiles 4-5=high CRf based on age and ***:After 70,072 person-years of Medicare follow-up,there were 1211 earliest indications of incident *** multivariable analyses,the hazard ratio(95%confidence interval(95%CI))for stroke across bench press categories were 1.0(referent),0.96(0.83-1.11),and 0.89(0.77-1.04),respectively(p trend=0.14).The trend across categories of leg press was also non-significant(p trend=0.79).Adjusted hazard ratio(95%CI)for stroke across ordered CRf categories were 1.0(referent),0.90(0.71-1.13),and 0.72(0.57-0.92)(p trendfor muscular strengthening activities is likely to improve muscular strength as well as many health outcomes in older adults,performing such activities may not be helpful in preventing ***,meeting guidelines for aerobic activity is likely to improve CRf and lower stroke risk.

关键词： Cardiorespiratory fitness Medicare Muscular strength Stroke

Analysis of the Impact of the Blazhko Effect Both on the Van Hoof Effect and Radial Velocity Amplitude in the Star RR Lyr

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Research in Astronomy and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri f.L.Sefyani A.Benhida Z.Benkhaldoun K.Kolenberg K.Chafouai A.Habib M.Sabil Observatoire de l'Oukaimeden LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaimeden LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Département de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPM ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The Van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and metallic lines within the atmosphere of pulsating *** this article,we present a study of this phenomenon through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,france)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaimeden Observatory(Morocco)between 2015 and *** this study,we have detected information on atmospheric dynamics that had not previously been ***,the Van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the metallic lines has been observed and analyzed at different Blazhko phases.A correlation between the radial velocities of different metallic lines located in the lower atmosphere has been observed as *** the first time,we were able to show that the amplitude of the radial velocity curves deduced from the lines of hydrogen and that of feⅡ(λ4923.921?)increases toward the minimum of the Blazhko cycle and decreases toward the maximum of the same Blazhko ***,we found that the Van Hoof effect is also modulated by the Blazhko ***,toward the minimum of the Blazhko cycle the Van Hoof effect is more visible and at the maximum of the Blazhko cycle,this effect is *** also observed the temporal evolution of the amplitudes of the radial velocities of the lower and upper *** observed over a long time,we can interpret it as a function of the Blazhko phases.

关键词： stars:atmospheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)