检索结果-南通市图书馆

检索条件"作者=F.Peter Guengerich"

共 2 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Using biochemical knowledge of cytochrome P450 and other enzymes in prediction of drug metabolism and toxicity

Using biochemical knowledge of cytochrome P450 and other enz...

引用

中国生物化学与分子生物学会2016年全国学术会议

作者： f.peter guengerich Department of Biochemistry Vanderbilt University School of Medicine

Cytochrome P450(P450,CYP)enzymes are remarkable in light of their great diversity of *** are the most versatile catalysts known,involved in>95%of oxidations of chemicals(1).These oxidations are prominent in the metabolism of drugs,with P450s contributing in 75%of the enzymatic transformations of small molecule *** reactions are important in the inter-individual variability in drug metabolism

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Regulation of Cytochrome P450 Enzymes by Reversible Oxidation of Thiols to Sulfenic Acids

Regulation of Cytochrome P450 Enzymes by Reversible Oxidatio...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： f.peter guengerich Matthew E.Albertolle Department of Biochemistry Vanderbilt University School of Medicine

Cytochrome P450(P450) enzymes are the major catalysts involved in the metabolism of drugs,steroids,chemical carcinogens,and fat-soluble *** they are involved in >95% of oxidation/reduction reactions of *** signature spectroscopic properties and the catalytic activities are related to a conserved cysteine thiolate ligand binding to the proximal side of the heme *** found that the activity of one human P450 enzyme,P450 4 A11,was stimulated by the addition of mild reducing agents,***,and attenuated by H2 *** analyzed the enzyme and did not find disulfides but did find that the cysteine sulfur was oxidized to a sulfenic acid(-SOH),a reversible *** then found numerous drug metabolizing enzymes that contained sulfenic acids,including several mouse and human P450 s with the heme-cysteinyl sulfenic *** sulfenic acid was found in mouse and human liver and kidney samples in situ,suggesting physiological *** dynamics simulations suggest roles for specific amino acids in modulating the oxidation of the *** part of our continuing efforts in characterization of these systems in cells,we have synthesized new heavy isotope-labeled reagents with much faster kinetics than dimedone and iodoacetamide,which can be used to label sulfenic acids and disulfides,using liquid chromatography-mass *** phenomenon represents a potential new means of post-transcriptionally regulating the activities of P450 enzymes,although more in vivo evidence is in order.

关键词： Cytochrome P450 redox control sulfenic acid drug metabolism steroidogenesis heme ligands

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：