Using biochemical knowledge of cytochrome P450 and other enzymes in prediction of drug metabolism and toxicity
作者单位：Department of Biochemistry Vanderbilt University School of Medicine
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：Cytochrome P450(P450,CYP)enzymes are remarkable in light of their great diversity of *** are the most versatile catalysts known,involved in95%of oxidations of chemicals(1).These oxidations are prominent in the metabolism of drugs,with P450s contributing in 75%of the enzymatic transformations of small molecule *** reactions are important in the inter-individual variability in drug metabolism