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The immunomodulating effect of bifidobacteria is modified by the anticoagulant acenocoumarol

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food Bioscience 2023年第2期52卷 1166-1174页

作者： Sabrina E.Assad Melisa fragomeno Martin Rumbo Jessica Minnaard Pablo f.perez Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos-UNLP-CONICET CCT La PlataArgentina Catedra de Microbiologia FCEUNLPCalle 47 y 116CP 1900La PlataBs.AsArgentina Instituto de Estudios Inmunologicos y fisiopatologicos-UNLP-CONICET-CCT La PlataArgentina

Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host *** study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial *** bifidum CIDCA 5310 and *** CIDCA 5317 were grown in MRS broth in anaerobic *** experiments were done in the presence of ***-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,***,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow *** using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by *** decreased phagocytosis of bifidobacteria but intracellular routing was not ***,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 ***,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 *** increased CCL20 expression and it was partially abrogated by strain CIDCA *** of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.

关键词： Bifidobacterium Acenocoumarol THP-1 cells Caco-2 ccl20:luc reporter system Immune response Anticoagulant

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复合材料在阿里安上的应用

国外导弹与航天运载器 1989年第11期 48-53页

作者： f.perez 文隆枝

本文提出复合材料在阿里安运载器上扩大应用范围的问题。这包括在阿里安运载器第一代到第四代和阿里安5上的应用,所用的材料包括碳纤维增强塑料和玻璃纤维增强塑料。文章阐明了在这方面所取得的进展并提到一些诸如重量、刚度和成本等参... 详细信息

本文提出复合材料在阿里安运载器上扩大应用范围的问题。这包括在阿里安运载器第一代到第四代和阿里安5上的应用,所用的材料包括碳纤维增强塑料和玻璃纤维增强塑料。文章阐明了在这方面所取得的进展并提到一些诸如重量、刚度和成本等参数。使用这些材料是对技术的和工业的挑战,这些是值得讨论的。文中给出的精确实例包括:断裂准则、正交各向异性影响、热效应和单位成本与质量控制。文章叙述了在这些方面所做的工作并列举了其结果,但有些问题仍然未能解决;作者建议进一步作短期和长期的工作。

关键词：复合材料运载火箭航天器

用10MHz参考源产生一个9.997925MHz信号

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电子产品世界 1997年第8期4卷 79-79,78页

作者： M.Pereira f.perez-fontan 冰西班牙Vigo大学

很多的应用都需要相对于给定的参考源合成一个略有偏移的频率.本设计思路是利用10MHz基准源用一个电路来产生9.997925MHz信号.其频率偏移是很低的(只有2kHz),这对于混频器和滤波器的设计造成严格的约束.本电路利用一个锁相环基方案(图1)... 详细信息

很多的应用都需要相对于给定的参考源合成一个略有偏移的频率.本设计思路是利用10MHz基准源用一个电路来产生9.997925MHz信号.其频率偏移是很低的(只有2kHz),这对于混频器和滤波器的设计造成严格的约束.本电路利用一个锁相环基方案(图1).图2描述所建议的电路的详细设计图.在频域中,相位传递函数是:(Φo(S))/(Φi(S))=(Kmp)/(nq) (f(S))/(mpS+Kf(S))(1)式中Φi(S)和Φo(S)是输入和输出相位的拉普拉斯变换,f(S)是环的频率响应.

关键词：电子电路混频器参考源滤波器设计

Post-compression of high-energy,sub-picosecond laser pulses

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High Power Laser Science and Engineering 2023年第2期11卷 117-126页

作者： P.-G.Bleotu J.Wheeler S.Yu.Mironov V.Ginzburg M.Masruri A.Naziru R.Secareanu D.Ursescu f.perez J.De Sousa D.Badarau E.Veuillot P.Audebert E.Khazanov G.Mourou LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Doctoral School of Physics University of BucharestBucharest-MagureleRomania Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IfIN-HH) MagureleRomania IZEST Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Independent Researcher Bourg-La-ReineFrance federal Research Center Institute of Applied Physics of the Russian Academy of Sciences(IAP RAS) Nizhny NovgorodRussia

The post-compression technique based on self-phase modulation of high-energy pulses leads to an increase in achievable peak power and ***,the pulses considered in experiments have been less than 100 fs in ***,the method is applied to the ELfIE laser system at the LULI facility,for a pulse of 7 J energy and an initial measured duration of 350 fs.A 5-mm-thick fused silica window and a 2 mm cyclic-olefin polymer were used as optical nonlinear *** 9 cm diameter beam was spectrally broadened to a bandwidth corresponding to 124 fs fourier-limited pulse duration,and then it was partly post-compressed to 200 *** measuring the spatial spectra of the beam fluence,a uniform gain factor of 4 increase in the fluctuations over the studied range of frequencies is observed,due to small-scale self-focusing.

关键词： high-power laser nonlinear pulse interaction post-compression self-phase modulation

Characterization and performance of the Apollon short-focal-area facility following its commissioning at 1 PW level

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Matter and Radiation at Extremes 2021年第6期6卷 12-25页

作者： K.Burdonov A.fazzini V.Lelasseux J.Albrecht P.Antici Y.Ayoul A.Beluze D.Cavanna T.Ceccotti M.Chabanis A.Chaleil S.N.Chen Z.Chen f.Consoli M.Cuciuc X.Davoine J.P.Delaneau E.d’Humieres J.-L.Dubois C.Evrard E.filippov A.freneaux P.forestier-Colleoni L.Gremillet V.Horny L.Lancia L.Lecherbourg N.Lebas A.Leblanc W.Ma L.Martin f.Negoita J.-L.Paillard D.Papadopoulos f.perez S.Pikuz G.Qi f.Quere L.Ranc P.-A.Soderstrom M.Sciscio S.Sun S.Vallieres P.Wang W.Yao f.Mathieu P.Audebert J.fuchs LULI–CNRS CEASorbonne UniversiteEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Universite Observatoire de ParisUniversite PSLCNRSLERMAF-75005 ParisFrance IAP Russian Academy of Sciences603155 Nizhny NovgorodRussia INRS-EMT 1650Boulevard Lionel-BouletVarennesQuebec J3X 1S2Canada Universite Paris-Saclay CEACNRSLIDYL91191Gif-sur-YvetteFrance Universite Paris-Saclay CEALMCE91680 Bruy`eres-le-ChˆatelFrance “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania ENEA Fusion and Technologies for Nuclear Safety DepartmentC.R.FrascatiVia E.Fermi 4500044 FrascatiItaly University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance Joint Institute for High Temperatures RAS125412 MoscowRussia Laboratoire d’Optique Appliquee Ecole Polytechnique–ENSTA–CNRS–Institut Polytechnique de ParisPalaiseauFrance State Key Laboratory of Nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China Laboratoire Charles fabry Institut d’Optique Graduate SchoolCNRSUniversite Paris-Saclay91127 Palaiseau CedexFrance

We present the results of the first commissioning phase of the short-focal-length area of the Apollon laser facility(located in Saclay,france),which was performed with the first available laser beam(f2),scaled to a nominal power of 1 *** the conditions that were tested,this beam delivered on-target pulses of 10 J average energy and 24 fs *** diagnostics were fielded to assess the performance of the *** on-target focal spot and its spatial stability,the temporal intensity profile prior to the main pulse,and the resulting density gradient formed at the irradiated side of solid targets have been thoroughly characterized,with the goal of helping users design future *** of energetic electrons,ions,and electromagnetic radiation were recorded,showing good laser-to-target coupling efficiency and an overall performance comparable to that of similar international *** will be followed in 2022 by a further commissioning stage at the multipetawatt level.

关键词： performance beam nominal

Oxidation and Coatings for Power Generation： New Super Ultra Critical Steam Turbines

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中国腐蚀与防护学报 2009年第4期29卷 318-319页

作者： f. J. perez Grupo de Investigacion de Ingenieria de Superficies y Materiales Nanoestructurados U. C. M. N°910627 facultad de Ciencias Quimicas Universidad Complutense de Madrid. 28040 Madrid Spain

The steels with chromium contents between 9%and 12%wt are used for power plants with advanced steam oxidation *** present good creep properties as 9%Cr steels and good oxidation resistance,at the temperatures range between 500℃～600℃.In the last years numerous investigation in development of coatings has been realized with the aim the protected them against the oxidation in order to allow operation of steam turbines at 650℃.In this study,Al-Hf protective coatings were deposited by CVD-fBR on ferritic steel HCM-12A followed by a diffusion heat treatment,have shown to be protective at 650℃under steam for at least 3000 hours of laboratory steam exposure under atmospheric *** and composition of coatings were characterized by different techniques, such as scanning electron microscopy(SEM),electron probe microanalysis,and X-ray diffraction(XRD). On the other hand,volatile species by mass spectrometry(MS) and thermogravimetric measurements (TG) during the initial stages oxidation of the P92 ferritic steel without and of Al and Al/Si coating by chemical vapour deposition in fluidized bed reactors(CVD-fBR) at 650℃in Ar+20%H_2O for 150 h were *** order to go forward to coatings design the Thermocalc code is used as base for the MSdata. TG-MS experiments were conducted in a closed steam loop in order to obtain information about the oxyhydroxides formation as reaction between coatings and *** those results the role of the different coating element could be established and optimized for the coating *** oxidation mechanism based on the TG-MS results is *** morphology/composition and structure of the oxidized samples were also studied using SEM/EDS and XRD techniques.

关键词：氧化金属腐蚀防护

Instability and sensitivity analysis of flows using OpenfOAM~

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Chinese Journal of Aeronautics 2016年第2期29卷 316-325页

作者： Liu Qiong f. Gomez J.M. perez V. Theofilis School of Aeronautics Universidad PolitOcnica de Madrid Plaza Cardinal Cisneros 3 Madrid E-28040 Spain Department of Mechanical and Aerospace Engineering Monash University Victoria 3800 Australia

The present contributions deal with the development and implementation of the direct and adjoint incompressible Navie-Stokes equations in a matrix-free time-stepping context making use of the open-source OpenfOAM~ （open source field operation and manipulation） C ＋＋ tool- box. It is shown that a few minor modifications in the source code can enable these multi-purpose computational fluid dynamics （CfD） solvers to carry out global instability analysis of three- dimensional flows of engineering interest, exploiting all additional capabilities of such codes. The strength of this methodology is demonstrated through the analysis of an interesting selection of ooen and wall-bounded flows.

关键词： Adjoint-based analysis Computational fluid dynam-ics flow instability OpenfOAM Time-stepping method

L^1→L^q Poincare Inequalities for 0formulas

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Acta Mathematica Sinica,English Series 2002年第1期18卷 1-20页

作者： perez Carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of homogeneous type. let B_0 S be a given ball. It has been a well-known result bv now (see)[1 4])theat the validity of an L^1→L^1 Poincaré inequality of the following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of the main results of this paper shows that an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply the above representation formula. As an immediate corollary, we can show that the weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies the same formula. Analogous theorems related to high-order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas High-order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

Increasing the performance of anaerobic digestion:Pilot scale experimental study for thermal hydrolysis of mixed sludge

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frontiers of Environmental Science & Engineering 2010年第2期4卷 135-141页

作者： S.I.perez-ELVIRA M.fDZ-POLANCO f.fDZ-POLANCO Department of Chemical Engineering and Environmental Technology University of ValladolidValladolid 47011Spain

The performance of a pilot plant operation combining thermal hydrolysis(170℃,30 min)and anaerobic digestion(AD)was studied,determining the main properties for samples of fresh mixed sludge,hydrolyzed sludge,and digested sludge,in order to quantify the thermal pretreatment performance(disintegration,solubilisation,and dewaterability)and its impact on the anaerobic digestion performance(biodegradability,volatile solids reduction,and digester rheology)and end product characteristics(dewaterability,sanitation,organic and nitrogen content).The disintegration achieved during the thermal treatment enhances the sludge centrifugation,allowing a 70%higher total solids concentration in the feed to anaerobic *** digestion of this sludge generates 40%more biogas in half the time,due to the higher solids removal compared to a conventional *** waste generated can be dewatered by centrifugation to 7%dry solids without polymer addition,and is pathogen free.

关键词： anaerobic digestion(AD) biogas performance sludge thermal hydrolysis