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Journal of China University of Geosciences 2008年第1期19卷 85-92页

作者： J A Vargas-guzmán Saudi Aramco Dhahran 31311 KSA

An analysis of statistical expected values for transformations is performed in this study to quantify the effect of heterogeneity on spatial geological modeling and evaluations. Algebraic transformations are frequently applied to data from logging to allow for the modeling of geological properties. Transformations may be powers, products, and exponential operations which are commonly used in well-known relations （e.g., porosity-permeability transforms）. The results of this study show that correct computations must account for residual transformation terms which arise due to lack of independence among heterogeneous geological properties. In the case of an exponential porosity-permeability transform, the values may be positive. This proves that a simple exponential model back-transformed from linear regression underestimates permeability. In the case of transformations involving two or more properties, residual terms may represent the contribution of heterogeneous components which occur when properties vary together, regardless of a pair-wise linear independence. A consequence of power- and product-transform models is that regression equations within those transformations need corrections via residual cumulants. A generalization of this result is that transformations of multivariate spatial attributes require multiple-point random variable relations. This analysis provides practical solutions leading to a methodology for nonlinear modeling using correct back transformations in geology.

关键词： reservoir static model intrinsic permeability non-Gaussian nonlinear residual moment cumulant unbiased simulation parameter.

Changes in air pollution during COVID-19 lockdown in Spain:A multi-city study

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Journal of Environmental Sciences 2021年第3期33卷 16-26页

作者： Álvaro Briz-Redón Carolina Belenguer-Sapiña Ángel Serrano-aroca Statistics Office City Council of Valenciac/Arquebisbe Mayoral246002 ValenciaValenciaSpain Department of Analytical Chemistry Faculty of ChemistryUniversity of Valenciac/Doctor Moliner 5046100 BurjassotValenciaSpain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente Mártirc/Guillem de Castro 9446001 ValenciaValenciaSpain

The COVID-19 pandemic has escalated into one of the largest crises of the 21 st *** new SARS-CoV-2 coronavirus,responsible for COVID-19,has spread rapidly all around the *** Spanish Government was forced to declare a nationwide lockdown in view of the rapidly spreading virus and high mortality rate in the *** study investigated the impact of short-term lockdown during the period from March 15th to April 12th 2020 on the atmospheric levels of CO,SO_(2),PM_(10),O_(3),and nO_(2)over 11 representative Spanish *** possible influence of several meteorological factors(temperature,precipitation,wind,sunlight hours,minimum and maximum pressure)on the pollutants'levels were also *** results obtained show that the 4-week lockdown had significant impact on reducing the atmospheric levels of nO_(2)in all cities except for the small city of Santander as well as CO,SO_(2),and PM_(10)in some cities,but resulted in increase of O_(3)level.

关键词： COVID-19 Lockdown Air quality Pollution Meteorology

Leveraging ROTI map derived from Indonesian GnSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan n.Muafiry Teguh n.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo febrylian f.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GnSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GnSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GnSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GnSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GnSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GnSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

DnA repair deficiency in neuropathogenesis:when all roads lead to mitochondria

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Translational neurodegeneration 2019年第1期8卷 157-170页

作者： Luis Bermúdez-guzmán Alejandro Leal Section of Genetics and Biotechnology School of BiologyUniversidad de Costa RicaSan José11501Costa Rica neuroscience Research Center Universidad de Costa RicaSan JoséCosta Rica

Mutations in DnA repair enzymes can cause two neurological clinical manifestations:a developmental impairment and a degenerative *** kinase 3′-phosphatase(PnKP)is an enzyme that is actively involved in DnA repair in both single and double strand break repair *** in this protein or others in the same pathway are responsible for a complex group of diseases with a broad clinical ***,mitochondrial dysfunction also has been consolidated as a hallmark of brain *** we provide evidence that supports a shared role between mitochondrial dysfunction and DnA repair defects in the pathogenesis of the nervous *** models,we analyze PnKP-related disorders,focusing on Charcot-Marie-Tooth disease and ataxia.A better understanding of the molecular dynamics of this relationship could provide improved diagnosis and treatment for neurological diseases.

关键词： DnA repair Mitochondrial dysfunction neurodegeneration Ataxia PnKP

Effect of airflow on biodrying of gardening wastes in reactors

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Journal of Environmental Sciences 2013年第5期25卷 865-872页

作者： f.J.Colomer-Mendoza L.Herrera-Prats f.Robles-Martínez A.Gallardo-Izquierdo A.B.Pia-guzmn Department of Mechanical Engineering and Construction (Universidad Jaume I)Jaume 1st University.Ave.Sos Baynat s/nCastellón 12071Spain Biotechnology Multidisciplinary Professional Unit (Instituto Politcnico Nacional)National Politechnic Institute.Ave.Acueduct of Guadalupe s/n Barrio la Laguna TicomnGustavo A.Madero 07340Mxico DF.Mxico

Biodrying consists of reducing moisture by using the heat from aerobic *** parameters that control the process are：aeration,temperature during the process,initial moisture of biowaste,and temperature and relative humidity of the input *** mowing and garden waste from the gardens of the University Jaume I,Castellón（Spain）were used as a *** was performed in 10 reactors with known air volumes from 0.88 to 6.42 L/（min·kg dry weight）.To promote aeration,5 of the reactors had 15% of a bulking agent *** experiment lasted 20 *** the experiments it was found that the bulking agent led to greater weight ***,the increased airflow rate was not linearly proportional to the weight loss.

关键词： biodrying biowaste stabilization aerobic fermentation bulking agent

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Endophytes versus biotrophic and necrotrophic pathogens—are fungal lifestyles evolutionarily stable traits?

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fungal Diversity 2013年第3期60卷 125-135页

作者： Luis Delaye Graciela García-guzmán Martin Heil Departamento de Ingeniería Genética Centro de Investigación y de Estudios Avanzados(CINVESTAV)IrapuatoGuanajuatoMexico Departamento de Ecología Evolutiva Instituto de EcologíaUNAMMéxico CityMexico

Endophytes infect living plant tissues without causing symptoms of ***,many of them contribute to the resistance phenotype of their ***,fungal endophytes are generally closely related to plant pathogens,fungi that either develop within living host tissue(biotrophic fungi)or that kill the host cells and then live in the dead tissue(necrotrophic fungi).We adopted a phylogenetic approach to investigate whether these strategies represent evolutionarily stable lifestyles and to elucidate their general phylogenetic *** analysed 163 fungal strains for which we found information on the sequence of the 5.8S rRnA gene and the flanking internal transcribed spacer regions,the identity of the host plant and the concrete phenotypic outcome of the infection.A Maximum-Likelihood analysis combined with ancestral character mapping by maximum parsimony revealed that some fungal lineages had switched multiple times between a necrotrophic and an endophytic *** character mapping indicated a minimum of four changes from an endophytic to a necrotrophic lifestyle,four changes in the opposite direction and eight changes among these lifestyles for which the direction could not be determined *** contrast,biotrophs formed five clusters that did not contain necrotrophs or *** biotrophy evolves there is apparently no regression to one of the other two *** conclude that biotrophy usually represents a derived and evolutionarily stable trait,whereas fungi easily can switch between an endophytic and necrotrophic lifestyle at the evolutionary and even the ecological *** experimental studies should focus on the environmental or genetic changes that cause the rapid switches between these two phenotypically different lifestyles.

关键词： Disease expression fungi Plant pathogens Phylogenetic effects

Spatial variability of soil organic carbon stock in an olive orchard at catchment scale in Southern Spain

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International Soil and Water Conservation Research 2023年第2期11卷 311-326页

作者： Jose A.Gòmez Gema guzmán Tom Vanwalleghem Karl Vanderlinden Institute for Sustainable Agriculture.Spanish national Research Council(IAS-CSIC) Alameda del Obispo S/N14004CordobaSpain Department of Agronomy University of CordobaCampus de Rabanales14071CordobaSpain Centro IfAPA Alameda del Obispo 14004CordobaSpain

Orchards have a high potential for carbon ***,little research is available on the spatial variability at catchment scale and on the difference between the tree area and the *** analyzed theik spatial variability of soil organic carbon stock,SOCstock at 90 cm depth in an 8-ha catchment in Southern Spain with olives on a vertic *** showed higher soil organic carbon concentration,SOC,in the tree area as compared to the lane up to 60 cm depth,but its impact on SOCstock was negligible since it was compensated by the higher soil bulk density in the *** at different depths was correlated with that in the top 0-5 *** overall SOCstock of the orchard was 4.14 kg m^(-2),ranging between 1.8 and 6.0 kg m^(-2).This SOCstock is in the mid-lower range of values reported for olive orchards,measured at smaller scale,and similar to those other intensive field crops and agroforestry under comparable rainfall *** spatial variability in SOCstock was correlated to several geomorphological variables:elevation,cumulative upstream area,topographic wetness index,sediment transport index,and tillage *** in SOC and SOCstock are driven by the sediment redis-tribution downslope,mainly by tillage erosion,and higher soil water availability in lower areas allowing higher biomass *** topographic indexes and the correlation between SOC in the topsoil and SOCstock up to 90 cm should be further explored in other typology of olive orchards for facilitating the mapping of SOC_(stock).

关键词： Carbon sequestration Mediterraneancrops Catchment Spatial variability Vertic soils

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

factors affecting populations of the endemic Iberian hare(Lepus granatensis)after the first myxomatosis outbreaks in Central Spain

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Integrative Zoology 2023年第6期18卷 981-993页

作者： Carlos LÁZARO JoséLuis guzmÁn fabián CASAS Carlos SÁnCHEZ-GARCÍA Department of Research Fundación ArtemisanCiudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain

The Iberian hare(Lepus granatensis)is an endemic species distributed in Spain and *** outbreaks affecting this species were detected in 2018 in Central and Southern Spain,spreading *** to evaluate factors affecting the status of hare population after the arrival of myxomatosis,we conducted 108 nocturnal hare counts in Central Spain during two study periods(winter/spring and summer/autumn)in 54 different hunting grounds,covering 1071 km and observing 884 *** mean density in winter/spring was 7.66 hares/100 ha,(range 6.14-9.54/100 ha),while in summer/autumn,it was 3.4 hares/100 ha(range 2.6-4.4/100 ha).Densities of hares were not affected by the dominant habitat and the presence/absence of myxomatosis *** were more abundant at hunting grounds at a higher altitude and in those conducting targeted management,while detection of myxomatosis was related to lower altitude and higher levels of game management.A MaxEnt model used to generate a risk map for myxomatosis occurrence showed that the temperature annual range was the most important predictor,which suggests that environmental factors affecting myxomatosis vectors(mosquitoes,fleas,and ticks)could play a key role in disease *** myxomatosis in hares is becoming endemic,hare densities may be improved by game management and the monitoring and surveillance of this emerging *** surveillance programs could be the basis of effective collaborations between hunters,researchers,and environmental managers.

关键词： game management habitat Iberian hare MaxEnt monitoring myxomatosis