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Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection

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Asian Pacific journal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat Bağırova Murat Ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey V.Akhundov National Scientific Research Medical Prophylactic Institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Objective:To prepare and characterize polycaprolactone(PCL)nanoparticles loaded with sonicator fragmented(SLA)and freeze-thaw Leishmania antigens(fTLA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCL *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in j774 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and ELISA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with Leishmania ***:Compared to the control group,SLA PCL and fTLA PCL nanoparticles with calcium phosphate adjuvant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of IfN-γand *** PCL and fTLA PCL nanoparticles combined with calcium phosphate adjuvant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCL nanoparticles and the formulations with calcium phosphate adjuvant show strong in vitro immune stimulating ***,PCL-based antigen delivery systems and calcium phosphate adjuvant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： Leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adjuvant Vaccine design

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汉语与土耳其语定语类型比较与习得研究

汉语与土耳其语定语类型比较与习得研究

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作者：伊培芸（Kübra DEM(?)R j(?)ANG）上海师范大学

学位级别：硕士

定语是汉语学习中的一个重要的语法点。近年来,许多专家研究了汉语和韩语的定语,汉语和泰语的定语,汉语和越南语的定语,汉语和俄语的定语,汉语和英语的定语等,但是迄今为止,中国的学者鲜有对汉语和土耳其的定语进行深入系统的对比研究... 详细信息

定语是汉语学习中的一个重要的语法点。近年来,许多专家研究了汉语和韩语的定语,汉语和泰语的定语,汉语和越南语的定语,汉语和俄语的定语,汉语和英语的定语等,但是迄今为止,中国的学者鲜有对汉语和土耳其的定语进行深入系统的对比研究。随着中国“一带一路”的提出,中国和土耳其在经济、文化上的交往越来越密切,土耳其学生学汉语的热情也越来越高,到中国留学的土耳其学生也越来越多。但是由于土耳其语和汉语语言类型并不相同,土耳其语是黏着语,汉语是孤立语,土耳其语里面很少专门讲定语的,但是汉语的定语是汉语句法的一个很重要的句法成分,汉语的定语研究是汉语的语法的一个研究热点。土耳其学生在学习汉语的定语时候遇到很多困难,所以汉语和土耳其定语的比较研究非常有现实意义。本文在考察汉语与土耳其语定语基本类型基础上,运用结构主义语言学的方法进行对比分析,对土耳其语和汉语定语的结构类型及其特征进行比较分析研究。本文对下列内容进行对比分析:汉语定语的成分类型;土耳其语定语类型、土耳其语定语与汉语定语共同点与区别的对比分析。尽管土耳其语定语和汉语定语在句法、语义等方面存在不少差异,但是也有共性,比如两种语言的多项定语与中心语都遵循距离象似性原则,即越能说明中心沿所指的稳定而恒久的本质属性的词语充当定语,其位置越靠近中心语;反之,则离中心语越远。换言之,多项定语与中心语之间线性距离的远近反映了二者之间语义关系的远近。本文的最终目的就是希望把所研究的成果运用到对土耳其人学习汉语上,为中国老师教授土耳其学生提供一定借鉴,提高汉语教学的效果和质量。希望本文所得出的结论能够对土耳其学生学习汉语、教师教学和中土语言文化交流起到积极的促进作用。

关键词：土耳其语汉语定语对比分析

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评估复杂混合物(以柴油为例)对水体毒性的多面试验方法

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黑龙江环境通报 1991年第1期15卷 32-38页

作者： B.Thomas j.hnson Vitaly I Romaentko 李思维

柴油是一种对水体有毒害的复杂混合物,现以它为典型,用传统单一的毒性试验与多组分实验室微观分析相结合的方法评估其在水体中产生的毒害影响。我们用了14天的时间,研究了柴油的剂量对典型微观池塘内淡水生物群体的直接影响。多组分的... 详细信息

柴油是一种对水体有毒害的复杂混合物,现以它为典型,用传统单一的毒性试验与多组分实验室微观分析相结合的方法评估其在水体中产生的毒害影响。我们用了14天的时间,研究了柴油的剂量对典型微观池塘内淡水生物群体的直接影响。多组分的实验室微观分析主要是测试柴油的剂量(1mg/l)对水、底泥(土壤与微生物群)。

关键词：水体污染水生大型植物复杂混合物微观分析淡水生物微观体系生物群异养试验方法生物检验

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When a general morphology allows many habitat uses

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Integrative Zoology 2016年第6期11卷 483-499页

作者： María j.TULLI félix B.CRUZ Tiana KOHLSDORf Virginia ABDALA Unidad Ejecutora Lillo(CONICET)Instituto de Herpetología Fundación Miguel LilloTucumánArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA)CONICET-UNCOMA BarilocheRío NegroArgentina Departamento de Biologia-ffCLRP Universidade de São PauloRibeirão PretoBrazil Instituto de Biodiversidad Neotropical UNT-CONICETCátedra de Biología GeneralFacultad de Ciencias Naturales e IMLTucumánArgentina

During the last decades the study of functional morphology received more attention incorporating more detailed data corresponding to the internal anatomy that together contribute for a better understanding of the functional basis in *** we focus on 2 lizard families,Tropiduridae and Liolaemidae,and use information related to muscle-tendinous and external morphology traits of hind *** investigate whether the value of the traits analyzed tend to exhibit a reduced phenotypic variation produced by stabilizing selection,and whether species showing specialization in their habitat use will also exhibit special morphological features related to *** a result,we identified that evolution of hind limb traits is mainly explained by the Ornstein-Uhlenbeck model,suggesting stabilizing *** and tropidurids show clear ecomorphological trends in the variables considered,with sand lizards presenting the most specialized morphological *** ecomorphological trends differ between the 2 lineages,and traits of internal morphology tend to be more flexible than those of external morphology,restricting the ability to identify ecomorphs shared between these 2 *** traits of external morphology likely explain such restriction,as ecomorphs have been historically defined in other lizard clades based on variation of external morphology.

关键词： external morphology Lioalemidae muscles tendon Tropiduridae

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On s-Reflexive Spaces and Continuous Selections

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Chinese Annals of Mathematics,Series B 2015年第2期36卷 181-194页

作者： Rongxin SHEN Heikki j K jUNNILA Department of Mathematics Taizhou University Department of Mathematics and Statistics University of Helsinki

This paper deals with the s-reflexive spaces introduced by Yang and Zhao. The authors prove that every s-reflexive Hausdorff space is zero-dimensional, and indicate a close relationship between the theory of s-reflexi... 详细信息

关键词： s-Reflexive Continuous selection Zero-Dimensional Retractifiable

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New method for oblique impact dynamics research of a flexible beam with large overall motion considering impact friction force

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Acta Mechanica Sinica 2016年第4期32卷 720-730页

作者： W.Yuan L.Li D.G.Zhang j.Z.Hong School of Science Nanjing University of Science and Technology Department of Engineering Mechanics Shanghai Jiao Tong University

A flexible beam with large overall rotating motion impacting with a rigid slope is studied in this paper. The tangential friction force caused by the oblique impact is analyzed. The tangential motion of the system is divided into a stick state and a slip state. The contact constraint model and Coulomb friction model are used respectively to deal with the two states. Based on this hybrid modeling method, dynamic equations of the system, which include all states（before, during, and after the collision）are obtained. Simulation results of a concrete example are compared with the results obtained from two other models： a nontangential friction model and a modified Coulomb model. Differences in the results from the three models are discussed. The tangential friction force cannot be ignored when an oblique impact occurs. In addition, the results obtained from the model proposed in this paper are more consistent with real movement.

关键词： collision oblique friction stick tangential considering Coulomb constraint coordinate rotating

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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： f.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio f.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett j.Baudot A.Beaulieu j.Becker P.K.Behera j.V.Bennett E.Bernieri f.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj f.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.bračko P.branchini N.braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank f.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez f.Di Capua S.Di Carlo j.Dingfelder Z.Doležal I.Domínguez jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.ferber D.ferlewicz G.finocchiaro S.fiore A.fodor f.forti A.frey B.G.fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich j.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia j.Irakkathil jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.jackson W.W.jacobs D.E.jaffe E.-j.jang H.B.jeon S.jia Y.jin C.joo j.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger j.f.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-j.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri j.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 forschungszentrum jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 j-PARC branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de fisica Corpuscular Paterna 46980 INfN Laboratori Nazionali di frascati I-00044 Frascati INfN Sezione di Napoli I-80126 Napoli INfN Sezione di Padova I-35131 Padova INfN Sezione di Perugia I-06123 Perugia

from April to july 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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一种新型植酸酶对保育猪和肥育猪的生长性能、骨胳灰分及矿物质消化率的影响

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饲料与畜牧（新饲料） 2007年第7期 50-50页

作者：卢寿锋 D.V.braa M.Ellis E.O.Castaeda j.S.Sands D.H.Bake 伊利诺斯大学动物科学系墨西哥国家农林牧研究所丹尼斯克动物营养公司

为了比较两种植酸酶（Phyzyme和Natuphos）的效果，进行了4个试验，评价它们对生产性能、腓骨灰分、Ca和P的消化率的影响。在前3个试验中，选择832只猪进行试验，包括保育猪288只，初始体重为8．1kg；生长猪288只，初始体重为24．2kg；... 详细信息

为了比较两种植酸酶（Phyzyme和Natuphos）的效果，进行了4个试验，评价它们对生产性能、腓骨灰分、Ca和P的消化率的影响。在前3个试验中，选择832只猪进行试验，包括保育猪288只，初始体重为8．1kg；生长猪288只，初始体重为24．2kg；肥育猪256只，初始体重为57．8kg，分别进行为期28d，42d和60d的试验。

关键词：骨胳灰分生长磷植酸酶猪

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fUNDAMENTALS Of CORPORATE fINANCE / 4th ed.

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丛书名： McGraw-Hill/Irwin series in finance, insurance, and real estate

2004年

作者： RICHARD A. BREALEY STEWART C. MYERS ALAN j. MARC

来源：畅想之星图书光盘版（南... 评论

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巴西儿童期疾病的综合管理:母亲对卫生工作者建议的反应

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 25-26页

作者： Cunha A.j.L.A. Dos Santos S.R. Martines j. 郭战宏 Rua Rodrigo de Brito 46 apt. 503-22280-100 Rio de Janeiro RJ Brazil

Aim: To describe the process of follow-up in primary care facilities where the Integrated Management of Childhood Illness (IMCI) strategy was implemented. IMCI was developed by WHO and UNICEf as an integrated approach to manage sick children under 5 y of age and aims to reducemortality and morbidity. Methods: from August 2001 to february 2002, 229 sick children who had a health condition included in the IMCI case management guidelines were seen in six family health care facilities in brazil. We analysed the care provided to 153 children who were recommended for a 2-or 5-d follow-up visit. Children who did not return were visited and assessed at home. Results: Only 87 children (56.9%) timely returned for follow-up: 70 had improved, eight presented the same health conditions, five were worse and four had a new problem. The main reasons given for not returning for follow-up were: the child had improved (35.1 %) and other family priorities (47.4%). Home visits showed that, although most children had improved (n = 49), some had a new health problem and one child was sick enough to be referred. Prescription of antibiotics was associated with increased probability of returning for a follow-up visit (RR = 1.64 1.22-2.20 ,p = 0.001). Conclusion: Adherence to followup was just over 50%, mostly because the condition had already resolved, but some children were still sick and needed intervention. Training on counselling on the recognition of danger signs and when to return for a follow-up visit must be reinforced.

关键词：卫生工作者综合管理初级保健随访过程卫生保健机构管理指南保健措施综合方法

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