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Interactions of.Aurein with m.del m.m.ranes and Antim.larials

Am.rican Journal of.Analytical Chem.stry 2024年第2期15卷 72-98页

作者： Anaif.m. Alhewaitey Nsoki Pham.u Naif.m. Alhawiti Departm.nt of.Chem.stry Tennessee State University Nashville USA Departm.nt of.Chem.stry University of Tabuk Tabuk Saudi Arabia CAHf. University of California Davis Davis USA

Aurein is a cationic antim.crobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its m.chanism.of.action is not f.lly understood and has not been established. This project is f.cused on studying the interactions of.aurein with m.del biological m.m.ranes and antim.larials using f.urier Transf.rm.Inf.ared (f.IR), f.uorescence, dynam.c light scattering (DLS), atom.c f.rce m.croscopy (Af.), therm.gravim.tric analysis (TGA), and dif.erential scanning calorim.try (DSC) techniques. f.IR data revealed conf.rm.tional changes to the secondary structure of.the peptide in the presence of.the m.del m.m.ranes. The strongest interactions of.aurein were f.und with DOPC and lipid raf. system.. f.uorescence data revealed som. dif.erences in the m.chanism.of.interaction between aurein and lipid raf.s. Topographical analysis was perf.rm.d using atom.c f.rce m.croscopy (Af.). Af. im.ges of.the peptide with its lipid raf.s showed a change in surf.ce roughness suggesting a dif.erent m.chanism.of.interaction. DLS data in agreem.nt with f.IR conf.rm.d that aurein interacts dif.erently with the lipid raf.s. The results gathered f.om.this study provided new insights on the interaction of.aurein. On the other hand, drug-drug interaction issues continue to present a m.jor dilem.a f.r the clinician caring f.r com.lex patients such as those inf.cted with inf.ctious disease. This study has exam.ned the interaction of.aurein with quinine, prim.quine, and chloroquine. Signif.cant interactions between aurein and antim.larials occured at a higher concentration of.antim.larials. Interactions between aurein and anti-m.larials reveal a strong interaction between aurein and prim.quine. Interactions between aurein and quinine or chloroquine were f.und to be weak and negligible. f.IR, TGA, and DSC m.y be used in a com.lem.ntary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled

关键词： Aurein f.uorescence DPPC SPm cholesterol DPPC-SPm.CHOL Quinine Antim.larials

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Synthesis and Characterization of.Poly Styrene-Co-Poly 2-Hydroxyethylm.thacrylate (HEm.) Copolym.r and an Investigation of.f.ee-Radical Copolym.rization Propagation Kinetics by Solvent Ef.ects

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Open Journal of.Polym.r Chem.stry 2024年第1期14卷 63-93页

作者： Anaif.m. Alhewaitey Ishrat Khan Naif.m. Alhawiti Departm.nt of.Chem.stry Clark Atlanta University Atlanta USA Departm.nt of.Chem.stry University of Tabuk Tabuk Saudi Arabia CAHf. University of California Davis Davis California

A series of.hom. and copolym.rs of.styrene (ST) and 2-hydroxyethyl m.thacrylate (HEm.) in three dif.erent m.dia (bulk, tetrahydrof.ran, and benzene) have been investigated by f.ee radical polym.rization m.thod. The sam.les obtained f.om.the synthesis were characterized by f.urier Transf.rm.Inf.ared spectroscopy (f.-IR), proton nuclear m.gnetic resonance spectroscopy (1H Nm.), atom.c f.rce m.croscopy (Af.), and dif.erential scanning calorim.try (DSC). The results show that the synthesis of.the polym.rs is m.re f.asible under neat conditions rather than solvent directed reaction. m.reover, the DSC data shows that the polystyrene obtained is am.rphous in nature and theref.re displayed only a glass transition signal rather than crystallization and m.lting peaks. In addition, this study indicates that hom.lopolym.rization of.styrene via f.ee radical polym.rization tends to be pref.rable in less polar solvents like THf.than in non-polar solvents like benzene. Benzene m.ght destabilize the f.rm.tion of.the reactive radicals leading to the f.rm.tion of.the products. In sum.ary, the hom.lpolym.rization of.styrene is m.re f.asible than the hom.polym.rization 2-hydroxyethyl m.thacrylate under the experim.ntal setup used. Styrene is m.re reactive than 2-hydroxyethyl m.thacrylate than f.ee radical polym.rization reaction due in part of.the generation of.the benzylic radical interm.diate which is m.re stable leading to the f.rm.tion of.products than alkyl radical which are less stable. f.rtherm.re, polym.rization of.styrene under neat conditions is pref.rable in solvent-assisted environm.nts. The choice of.solvent f.r the synthesis of.these polym.rs is crucial and theref.re the selection of.solvent that leads to the f.rm.tion of.a m.re stable reaction interm.diate is m.re f.vorable. It is worth noting that the structure of.the proposed copolym.r consists of.a highly polar and hydrophilic m.nom.r, 2-hydroxyethyl m.thacrylate and a highly non-polar and hydrophobic m.nom.

关键词： 2-Hydroxyethyl m.thacrylate Polym.rization

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Assessm.nt of.CO_(2)storage prospect based on physical properties of.Rio Bonito f.rm.tion rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richardson m.Abraham.A Stephanie San m.rtín Cañas Isabella f.S.m.randa Colom.o C.G.Tassinari Institute of.Energy and Environm.nt(IEE) University of São Paulo(USP)Brazil Research Centre f.r Greenhouse Gas Innovation(RCGI) University of Sãao Paulo(USP)Brazil

The physical properties of.the rock units associated with the Rio Bonito f.rm.tion are presented in this study with the f.cus on m.delling reservoir quality based on petrophysics-derived param.ters to evaluate CO_(2)storage *** involves the m.delling of.the reservoir depths,thicknesses,f.ow zone indicators(f.I),and ef.ective perm.ability(Kef.)and presenting the CO_(2)storage ef.iciency f.ctors peculiar to the rock units of.the study *** results presented by this study f.r the stated objectives are not quite com.on in the *** values range f.om.200 m. to higher than 2000 m.,and f.I values are generally above 1.0 m. and up to 13.0 m. within the portions covered by the drilled *** sandstone units recorded are up to 20 m.thick in som. *** Kef. and f.I m.dels indicate the sandstone reservoirs as perm.able units to support the injection and circulation of.CO_(2)within the potential reservoir units of.the Rio Bonio f.rm.tion across São Paulo *** f.om.som. points in the southeastern part of.the study location,where the Rio Bonito are delineated at depths less than 800 m.m.nim.m.CO_(2)storage depth based on best practices),other portions are deeper,ranging f.om.950 m.to 3500 ***-bedded layers will af.ect the integrity of.the rocks as CO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m.in som. ***,hybrid CO_(2)reservoir units are f.asible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on CO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will signif.cantly control the CO_(2)storage ef.iciency of.the study *** studies f.aturing a detailed geophysical exploration of.the site to conf.rm.the availability and saturations of.preexisting f.uid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Ef.ective perm.ability f.uid transm.ssibility CO_(2)storage prospect Reservoir quality Overburden integrity f.ow zones

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Com.ining ability of.Egyptian cotton(Gossypium.barbadense L.)reveals genetic potential f.r im.roved yield and f.ber quality

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Journal of.Cotton Research 2024年第2期7卷 109-122页

作者： Abdelghany Ahm.d m. El-Banna Aly A.A. Lam.om.Sobhi f.El-Sorady Gawhara A. Salam. Ehab A.A. Ren Honglei Shaibu Abdulwahab S. Yehia Waleed m.B. Crop Science Departm.nt Faculty of AgricultureDamanhour UniversityDamanhour 22516Egypt Plant Production Departm.nt Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Agricultural Botany Departm.nt Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Heilongjiang Academ. of.Agricultural Sciences Soybean Research InstituteHarbin 150086China Departm.nt of.Agronom. Bayero University KanoKano 700001Nigeria Cotton Breeding Departm.nt Cotton Research InstituteAgriculture Research CenterGizaEgypt

Background As the m.st widely cultivated f.ber crop,cotton production depends on hybridization to unlock the yield potential of.current varieties.A deep understanding of.genetic dissection is crucial f.r the cultivation of.enhanced hybrid plants with desired traits,such as high yield and f.ne f.ber *** this study,the general com.ining ability(GCA)and specif.c com.ining ability(SCA)of.yield and f.ber quality of.nine cotton parents(six lines and three testers)and eighteen f. crosses produced using a line×tester m.ting design were *** The results revealed signif.cant ef.ects of.genotypes,parents,crosses,and interactions between parents and crosses f.r m.st of.the studied ***,the ef.ects of.both additive and non-additive gene actions played a notably signif.cant role in the inheritance of.m.st of.the yield and f.ber quality *** f. hybrids of.Giza 90×Aust)×Giza 86,Uzbekistan 1×Giza 97,and Giza 96×Giza 97 dem.nstrated superior perf.rm.nce due to their f.vorable integration of.high yield attributes and prem.um.f.ber quality *** analysis revealed that lint yield has the highest positive direct ef.ect on seed cotton yield,while lint percentage showed the highest negative direct ef.ect on seed cotton *** com.onent analysis identif.ed specif.c parents and hybrids associated with higher cotton yield,f.ber quality,and other agronom.c *** This study provides insights into identif.ing potential single-and three-way cross hybrids with superior cotton yield and f.ber quality characteristics,laying a f.undation f.r f.ture research on im.roving f.ber quality in cotton.

关键词： Gossypium.barbadense L. Com.ining ability Seed cotton yield f.ber quality Cluster analysis Path analysis

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覆盖UVA1的新型防晒剂m.E对色素和老化体征的影响:一项在两个不同遗传背景的人群进行的为期8周、随机、自身对照、前瞻性户外研究

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中华皮肤科杂志 2024年第6期57卷 579-580页

作者： f. f.am.nt D. G. m.rcurio B. m.ller J. Li C. Tricaud f. Bernerd A. Roudot D. Candau T. Passeron L'Oréal Research and Innovation Clichy France L'Oréal Research and Innovation Rio de Janeiro Brazil L'Oréal Research and Innovation Shanghai China L'Oréal Research and Innovation Aulnay-sous-Bois France L'Oréal Research and Innovation Chevilly-Larue France CHU Nice Department of Dermatology Université Côte d'Azur Nice France Université Côte d'Azur INSERM U1065 C3M Nice France

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm.具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如DNA、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多... 详细信息

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm.具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如DNA、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多地被发现与衰老、致癌作用、多种皮肤疾病和色素问题相关。

关键词： UVA1 真皮层自身对照致癌作用皮肤疾病防晒剂遗传背景氧化损伤

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Thirteen years to get f.om.b to a:one of.the neglected isof.rm. of.IL-37 enters the stage

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Cellular & m.lecular Im.unology 2024年第2期21卷 201-202页

作者： Steven X.Cho Ina Rudlof. Andrew m.Ellisdon Claudia A.Nold-Petry m.rcel f.Nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Departm.nt of.Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia m.nash Newborn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of.the f.w anti-inf.am.atory m.m.ers of.the predom.nantly pro-inf.am.atory IL-1 cytokine ***-37 possesses alarm.n-like properties[1]and exerts its activities via intracellular[2]as well as cell surf.ce receptor-dependent m.chanism.,and the latter involves IL-1R8 and IL-18Rα[3].Because of.its powerf.l and broad-spectrum.peacem.king”[4]f.nctions,considerable ef.orts have been invested in developing IL-37-based anti-inf.am.atory therapeutics[5,6].

关键词： Interleukin neglected cytokine

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Sports Prediction m.del through Cloud Com.uting and Big Data Based on Artif.cial Intelligence m.thod

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Journal of.Intelligent Learning System. and Applications 2024年第2期16卷 53-79页

作者： Aws I. Abu Eid Achraf.Ben m.led Ahlem.f.tnassi m.jid A. Nawaz Ashraf.f. A. m.hm.ud f.roug A. Abdalla Cham. Jabnoun Aida Dhibi f.ras m. Allan m.ham.ed Ahm.d Elhossiny Salem.Belhaj Im.n Ben m.ham.d f.culty of.Com.uting Studies Arab Open University Amman Jordan Com.uter Science Departm.nt Science College Northern Border University Arar Kingdom of Saudi Arabia Artif.cial Intelligence and Data Engineering Laboratory LR21ES23 Faculty of Sciences of Bizerte University of Carthage Tunis Tunisia Applied College Northern Border University Arar Kingdom of Saudi Arabia f.culty of.Specif.c Education Mansoura University Mansoura Egypt

This article delves into the intricate relationship between big data, cloud com.uting, and artif.cial intelligence, shedding light on their f.ndam.ntal attributes and interdependence. It explores the seam.ess am.lgam.tion of.AI m.thodologies within cloud com.uting and big data analytics, encom.assing the developm.nt of.a cloud com.uting f.am.work built on the robust f.undation of.the Hadoop platf.rm. enriched by AI learning algorithm.. Additionally, it exam.nes the creation of.a predictive m.del em.owered by tailored artif.cial intelligence techniques. Rigorous sim.lations are conducted to extract valuable insights, f.cilitating m.thod evaluation and perf.rm.nce assessm.nt, all within the dynam.c Hadoop environm.nt, thereby reaf.irm.ng the precision of.the proposed approach. The results and analysis section reveals com.elling f.ndings derived f.om.com.rehensive sim.lations within the Hadoop environm.nt. These outcom.s dem.nstrate the ef.icacy of.the Sport AI m.del (SAIm. f.am.work in enhancing the accuracy of.sports-related outcom. predictions. Through m.ticulous m.them.tical analyses and perf.rm.nce assessm.nts, integrating AI with big data em.rges as a powerf.l tool f.r optim.zing decision-m.king in sports. The discussion section extends the im.lications of.these results, highlighting the potential f.r SAIm.to revolutionize sports f.recasting, strategic planning, and perf.rm.nce optim.zation f.r players and coaches. The com.ination of.big data, cloud com.uting, and AI of.ers a prom.sing avenue f.r f.ture advancem.nts in sports analytics. This research underscores the synergy between these technologies and paves the way f.r innovative approaches to sports-related decision-m.king and perf.rm.nce enhancem.nt.

关键词： Artif.cial Intelligence m.chine Learning Spark Apache Big Data SAIm

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Volcanic Risk Perception and Coping Strategies f.om.m.unts Cam.roon and Nyiragongo Eruptions, Central Af.ica: A Com.arative Analysis

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Journal of.Geoscience and Environm.nt Protection 2024年第6期12卷 161-189页

作者： m.bel N. Wantim.Innocent Bradriyo Asong f. Zisuh Louis m. Balgawa m.ro Yannah Katcho Karum. Nde-f.n Peter Bih Am.an Nchini L. Wayih Em.anuel V. Yenshu Sam.el N. Ayonghe Unit of.Disaster Risk m.nagem.nt Department of Environmental Science University of Buea Buea Cameroon Observatoire Volcanologique de Gom. (OVG) Goma Democratic Republic of the Congo Institute of.Geological and m.ning Research (IRGm. Yaounde Cameroon f.culty of.Health Sciences University of Buea Buea Cameroon f.culty of.Social and m.nagem.nt Sciences University of Buea Buea Cameroon

Approxim.tely 2,000,000 people are exposed to volcanic risks in com.unities situated at the f.anks of.m.unts Cam.roon (m.) and Nyiragongo (m.) volcanoes in Central Af.ica. This study theref.re sought to investigate risk perception f.om.f.ur previous eruptions of.m., nam.ly the 1959, 1982, 1999, and 2000 eruptions;and two previous eruptions of.m.: 1977 and 2002. The study was initiated with co-design workshops held with m.jor stakeholders in the cities of.Buea and Gom. at the f.anks of.m. and m., respectively, in 2017, to develop the research objectives f.r the study. A non-random.questionnaire survey was later conducted within 14 and 15 com.unities in Buea and Gom. respectively, on the ef.ects, perceived risks, and coping strategies f.r the chosen eruptions. Three age groups (18 - 30, 31 - 45 and >45 years) and gender (m.le and f.m.le) were considered. The population at the f.anks of.both volcanoes cited scientif.c and indigenous f.ctors to be responsible f.r eruptions f.om.these volcanoes. At m. and m., ≥45% of.the sam.led participants (with a higher f.m.le population) perceived that the sam.led eruptions posed a very high risk to the population. In term. of.the ef.ects, the age group of.18 - 30 was the least knowledgeable. In term. of.direct ef.ect on persons, over 90% of.participants at m. and m. attested that they were overcom. by f.ar/panic. On m.asures to cope with any likely eruption, the f.llowing order was established at the f.anks of.both volcanoes: sensitization of.population, use of.religious (prayers) and of.traditional/indigenous strategies. In term. of.f.ture coping strategies, while the m.les at m. m.intained sensitization as the f.vourite option, 62% of.the m.les at m. opted f.r traditional/indigenous strategies. The f.m.le population at both m. and m. showed a higher pref.rence f.r religious strategies like prayers.

关键词： Risk Perception m.unt Cam.roon m.unt Nyiragongo Indigenous Buea Gom.

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一种评估非接触水下爆炸对海军复合船体影响的设计方法

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： f.m.nnacio f.Di m.rzo m.Gaiotti C.m.Rizzo m.Venturini Italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of.Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-contact underwater explosion phenom.na(UNDEX)have been studied f.r decades and several num.rical m.thods have been proposed in literature,its ef.ects on m.litary structures,especially com.osite ones,are even nowadays m.tter of.*** early design phases,it is not always possible to verif. the shock resistance of.hull structures m.delling the whole phenom.non,in which f.uid,gas and solid properties m.st be properly set in a f.lly coupled f.uid-structure interaction(f.I)num.rical *** ones are extrem.ly com.lex to set,com.utationally dem.nding and certainly not suitable f.r everyday design *** this paper,a sim.lif.ed f.nite elem.nt(f.)m.del,easy to use in an early design phase,is ***,the structure and the f.uid are *** this approxim.tion,the f.uid behaviour is sim.lif.ed,using special f.nite elem.nts,available in a com.ercial sof.ware *** choice reduces the com.utational tim. and num.rical ef.orts avoiding the problem.of.com.ining com.utational f.uid dynam.cs(Cf.)and f. dom.ins and equations in a f.lly coupled f.uid-structure interaction m.del.A typical parallel body block of.a m.nesweeper is m.delled,using two-dim.nsional m.lti-layered shell elem.nts to properly account f.r the com.osite m.terials *** the f.uid instead,three dim.nsional volum.tric elem.nts,directly coupled to the structural elem.nts,are *** addition,the sam. calculation is perf.rm.d,m.delling separately f.uid in the Cf. environm.nt and structures in the f.nite elem.nt ***,realizing a f.lly coupled f.uid-structure interaction *** results obtained by applying both num.rical m.dels are com.ared with the structural response m.asured on board of.a com.osite ship during a f.ll-scale shock *** sim.lif.ed proposed procedure provides results in satisf.ctory agreem.nt with experim.nts,allowing the validation of.the *** are discussed and dif.erences with the real phenom.non and f.lly coupled Cf.+

关键词： Underwater explosions Shock resistance Com.osites f.uid-structure interaction Experim.ntal analysis Num.rical sim.lation Vulnerability Prelim.nary design

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In vivo and in vitro study of.resorbable m.gnesium.wires f.r m.dical im.lants:m. purity,surf.ce quality,Zn alloying and polym.r coating

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Journal of.m.gnesium.and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková m.Jex m.Žaloudková R.Vrbová m.Bartoš P.Klein L.Vištejnová J.Dušková E.f.lová Z.Sucharda m.Steinerová S.Habr K.Balík A.Singh Departm.nt of.m.terials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of.Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of.Dental m.dicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Departm.nt of.Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Departm.nt of.Com.osites and Carbon m.terials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of.Anatom. First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biom.dical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Departm.nt of.Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Departm.nt of.Histology and Em.ryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of.Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Departm.nt of.Biom.terials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center f.r Structural m.terials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

m.gnesium.is an excellent m.terial in term. of.biocom.atibility and its corrosion products can serve as an active source f.r new bone ***,localized corrosion and H_(2)generation lim.t the potential of.m.-based *** low-alloyed m.-Zn wires can strongly reduce problem. with large H_(2)bubbles and im.rove the m.chanical properties considerably while m.intaining excellent long-term.*** pickling and a polym.r coating can be ef.ectively used to lower the rate of.in vivo *** this work,m.crostructural,m.chanical,and in vitro characterization of.250μm.and 300μm.extruded wires m.de f.om.ultra-pure m.,com.ercially pure m.,m.-0.15Zn,m.-0.4Zn and m.-1Zn was ***,m.-0.4Zn wires together with a variant coated with a copolym.r of.L-lactide andε-caprolactone were tested in vivo on artif.cially dam.ged Wistar rat *** on the observed m.-induced osteogenesis,polym.r-coated m. wires with a sm.ll addition of.Zn are a perspective m.terial f.r bone-support applications,such as cerclage and f.xation wires.

关键词： m.gnesium Resorbable m. wire m.-Zn im.lant degradation Biocom.atibility study Zn grain boundary segregation

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