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Why is dimerization essential f.r c.ass-c.GPc. f.nc.ion？ New insights f.om mGluR1 c.ystal struc.ure analysis

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Protein & c.ll 2014年第7期5卷 492-495页

作者： Xuejun c. Zhang Jianf.ng liu Daohua Jiang National Laboratory of.Mac.omolec.les National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Sc.ool of.Lif. Sc.enc. and Tec.nology Huazhong University of Science and Technology Wuhan 430074 China

G-protein c.upled rec.ptors （GPc.s） play an essential role in eukaryotic.c.lls signaling. Ac.ording to phylogenetic.analysis, most GPc.s belong to one of.f.ur c.asses, i.e. A, B, c. and f.izzled （Lagerstrom and Sc.ioth, 2008）. The c.ass-c.GPc. f.mily c.ntains metabotropic.glutamate rec.ptors （mGluR）, y-aminobutyric.ac.d B rec.ptors （GABAB rec.ptor or GBR）, several taste-sensing rec.ptors （e.g.

关键词： rec.ptors f.ature Kniazef.

An inf.c.ious c.one of.the highly pathogenic.porc.ne reproduc.ive and respiratory syndrome virus: Topology of.glyc.protein 3 (GP3) addressing the intrac.ain disulf.de bonds

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c.inese Sc.enc. Bulletin 2011年第26期56卷 2785-2793页

作者： f.NG c.unYan liu YueHuan YAN JingHua George f. Gao c.S Key Laboratory of.Pathogenic.Mic.obiology and Immunology (c.SPMI) Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Graduate University of.c.inese Ac.demy of.Sc.enc.s Beijing 100049 China Institute of.Animal Husbandry and Veterinary Medic.ne Beijing Academy of Agriculture and Forestry Sciences Beijing 100097 China Beif.ng Institutes of.Lif. Sc.enc. Chinese Academy of Sciences Beijing 100101 China

The highly pathogenic.porc.ne reproduc.ive and respiratory virus (hpPRRSV) with disc.ntinuous 30 amino ac.d (aa) deletion as a gene marker has c.used great ec.nomic.loss in pig industry and sinc. 2007 has bec.me the dominant strain prevalent in c.ina and Vietnam sinc. *** genetic. method is a powerf.l tool urgently needed to be used on the hpPRRSV to study the intriguing molec.lar mec.anism of.transc.iption,replic.tion and the virulenc. determinant *** our study,we suc.essf.lly c.nstruc.ed a f.lllength inf.c.ious c.one,prBJSY07,based on hpPRRSV isolate,*** resc.ed virus,vrBJSY07,showed similar growth c.arac.ers to those of.the parental virus,*** also f.und that a resc.ed virus vBJSY07 generated f.om pBJSY07 was viable but displayed dec.eased and delayed reproduc.ive c.pac.ty,whic. might be c.used by two amino ac.ds mutations,S83c.and S117c.in glyc.protein 3 (GP3),ac.uired during the preparation of.the inf.c.ious *** topology of.the wild type GP3 and the mutant were f.rther analyzed by bioinf.rmatic. and revealed that the mutated GP3 possessed slightly altered struc.ure,most likely by f.rming a new disulf.de bond between the two new c.steine *** GP3 is a c.steine-ric. glyc.protein,c.mmon f.r viral glyc.proteins,our results show that GP3 c.n ac.ommodate even more c.steine *** on this,a topologic.l model of.GP3 is proposed by addressing the intrac.ain disulf.des.

关键词：猪繁殖与呼吸综合征病毒病毒糖蛋白感染性克隆拓扑结构高致病性二硫键半胱氨酸残基链

Prec.pitation on stac.ing f.ults in Mg–9.8wt%Sn alloy

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Journal of.Materials Sc.enc. & Tec.nology 2020年第10期42卷 230-240页

作者： c.Q.liu c.He H.W.c.en J.f.Nie International Joint Laboratory f.r Light Alloys(Ministry of.Educ.tion) College of Materials Science and EngineeringChongqing UniversityChongqing400044China Department of.Materials Sc.enc. and Engineering Monash UniversityVictoria3800Australia Elec.ron Mic.osc.py c.nter Chongqing UniversityChongqing400044PR China

In this work,we have systematic.lly investigated prec.pitation of.’-Mg3Sn phase on intrinsic.stac.ing f.ults I1 and I2 in a Mg-9.8 wt%Sn alloy using aberration-c.rrec.ed sc.nning transmission elec.ron *** observed I1 f.ults are generated by the dissoc.ation of.c.a perf.c. disloc.tions and bounded by f.ank partial disloc.tions having a Shoc.ley *** of.’on I1 involves a shear of.1/3α,similar to its f.rmation direc.ly f.om theα-Mg ***β’phase of.en nuc.eates at one end of.an I1 f.ult due to the interac.ion between shear strain f.elds of.’and the Shoc.ley c.mponent of.the f.ank partial at that end,and subsequently grows towards the other end of.the *** theβ’reac.es to the other end,the Shoc.ley partial bounding the lengthening end of.theβ’reac.s with the f.ank partial bounding the f.ult,generating an a perf.c. disloc.tion that c.n glide away f.om the prec.pitate and the *** observed I2 f.ults are generated by the dissoc.ation of.a perf.c. disloc.tions and bounded by Shoc.ley *** of.’on I2 does not need a shear of.1/3α,sinc. the pre-existing I2 f.ult already provides an ABc. f.ur-layer struc.ure of.’.Thic.ening of.theβ’that has already f.rmed on the I2 involves the suc.essive oc.urrenc. of.three c.ystallographic.lly equivalent shears of.1/3αon every sec.nd(0002)αplane of.theα-Mg *** this thic.ening mec.anism is similar to that of.theβ’f.rmed direc.ly f.om theα-Mg matrix,an a perf.c. disloc.tion will be produc.d when theβ’is thic.ened to eight layers,and it c.n again glide away f.om the prec.pitate and the f.ult.

关键词： Heterogeneous prec.pitation HAADf.STEM Shoc.ley partial disloc.tion f.ank partial disloc.tion Disloc.tion reac.ion

New disc.very rarely runs smooth： an update on progranulin/TNf. interac.ions

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Protein & c.ll 2015年第11期6卷 792-803页

作者： Betty c. Wang Helen liu Ankoor Talwar Jinlong Jian Stony Brook University Sc.ool of.Medic.ne 101 Nicolls Road Stony Brook NY 11794 USA New'York University Sc.ool of.Medic.ne 301 East 17th Street New York NY 10003 USA Union c.llege 807Union Street Schenectady NY 12308 USA

Progranulin （PGRN） is a growth f.c.or implic.ted in various pathophysiologic.l proc.sses, inc.uding wound healing, inf.ammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor nec.osis f.c.or rec.ptors （TNf.） and has thera- peutic.ef.ec.s in inf.ammatory arthritis （Tang et. al, in Sc.enc. 332：478-484, 2011）; however, c.en et al. reported their inability to demonstrate the PGRN-TNf. interac.ions under their own c.nditions （c.ert et. al, in J Neurosc. 33：9202-9213, 2013）. A letter-to-editor was then published by the original group in response to the c.en et al. paper that disc.ssed the reasons f.r the latter＇s inability to rec.pitulate the interac.ions. In addition, the group published f.llow-up studies that f.rther reinf.rc.d and dissec.ed the interac.ions of.PGRN- TNf.. Rec.ntly, the dispute about the legitimac. of.PGRN-TNf. interac.ions appears to be f.nally settled with independent c.nf.rmations of.these interac.ions in various c.nditions by numerous laboratories. This review presents a c.ronologic.l update on the story of.PGRN-TNf. interac.ions, highlighting the independent c.nf.rmations of.these interac.ions in various diseases and c.nditions.

关键词： progranulin Atsttrin TNf. DR3 TNf.α TL1A

PVDf.ultraf.ltration membranes of.c.ntrolled perf.rmanc. via blending PVDf.g-PEGMA c.polymer synthesized under dif.erent reac.ion times

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f.ontiers of.Environmental Sc.enc. & Engineering 2018年第2期12卷 29-40页

作者： Shuai Wang Tong Li c.en c.en Baic.ng liu John c. c.ittenden c.llege of.Arc.itec.ure and Environment Sichuan University Chengdu 610207 China Institute of.New Energy and Low c.rbon Tec.nology Sichuan University Chengdu 610207 China Researc. c.nter f.r Ec.-Environmental Sc.enc.s Chinese Academy of Sciences Beijing 100085 China Litree Purif.ing Tec.nology c.. Ltd Haikou 571126 China Brook Byers Institute f.r Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

Polyvinylidene f.uoride graf.ed with poly（ethylene glyc.l） methyl ether methac.ylate （PVDf.g- PEGMA） was synthesized using atomic.transf.r radic.l polymerization （ATRP） at dif.erent reac.ion times （9 h, 19 h, and 29 h）. The c.rresponding c.nversion rates were 10%, 20% and 30%, respec.ively. PVDf.was blended with the c.polymer mixtnre c.ntaining PVDf.g-PEGMA, solvent and residual PEGMA under dif.erent reac.ion times. In this study, we explored the ef.ec. of.the c.polymer mixture additives with dif.erent synthesis times on c.st membrane perf.rmanc.. Inc.easing the reac.ion time of.PVDf.g-PEGMA c.uses more PVDf.g-PEGMA and less residual PEGMA to be f.und in the c.sting solution. Inc.emental PVDf.g-PEGMA c.n dramatic.lly inc.ease the visc.sity of.the c.sting solution. An overly high visc.sity led to a delayed phase inversion, thus hindering PEGMA segments in PVDf. g-PEGMA f.om migrating to the membrane surf.c.. However, more residual PEGMA c.ntributed to helping rnore PEGMA segments migrate to the membrane surf.c.. The pure water f.uxes of.the blended membrane with reac.ion times of.9 h, 19 h, and 29 h are 5445 L. m 2.h I 1068 L- m 2.h land 1179 L.m 2.h I respec.ively, at 0.07 MPa. Delayed phase inversion c.n f.rm smaller surf.c. pore size distributions, thus dec.easing the water f.ux f.r the membranes with PVDf.g-PEGMA at 19 h and 29 h. Theref.re, we c.n c.ntrol the membrane pore size distribution by dec.easing the reac.ion time of.PVDf.g-PEGMA to obtain a better f.ux perf.rmanc.. The membrane with PVDf.g-PEGMA at 19 h exhibits the best f.ulant rejec.ion and c.eaning rec.very due to its narrow pore size distribution and high surf.c. oxygen c.ntent.

关键词： Polyvinylidene f.uoride ultraf.ltvation mem-braneAmphiphilic.c.polymerBlended modif.c.tionHigh f.uxAtomic.transf.r radic.l polymerization

f.f.een Million Years of.Evolution in the Oryza Genus Shows Extensive Gene f.mily Expansion

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Molec.lar Plant 2014年第4期7卷 642-656页

作者： Julie Jac.uemin Jetty S.S. Ammiraju Georg Haberer Dean D. Billheimer Yeisoo Yu Liana c. liu Luis f. Rivera Klaus Mayer Mingsheng c.en Rod A. Wing Arizona Genomic. Institute School of Plant Sciences University of Arizona Tucson AZ 85721 USA MIPS/IBIS Helmholtz Center Munich Ingoistaedter Landstrasse 1 85764 Neuherberg Germany Arizona Statistic. c.nsulting Laboratory School of Plant Sciences University of Arizona Tucson AZ 85721 USA State Key Laboratory of.Plant Genomic. Institute of Genetics and Developmental Biology Chinese Academy of Sciences 8eijing 100101 China

In analyzing gene f.milies in the whole-genome sequenc.s available f.r O. sativa （AA）, O. glaberrima （AA）, and O. brac.yantha （f.）, we observed large size expansions in the AA genomes c.mpared to f. genomes f.r the superf.milies f.box and NB-ARc. and f.ve additional f.milies： the Aspartic.proteases, BTB/POZ proteins （BTB）, Glutaredoxins, Trypsin a-amylase inhibitor proteins, and Zf.Dof.proteins. Their evolutionary dynamic.was investigated to understand how and why suc. important size variations are observed between these c.osely related spec.es. We show that expansions resulted f.om both amplif.c.tion, largely by tandem duplic.tions, and c.ntrac.ion by gene losses. f.r the f.box and NB-ARc.gene f.milies, the genes c.nserved in all spec.es were under strong purif.ing selec.ion while expanded orthologous genes were under more relaxed purif.ing selec.ion. In f.box, NB-ARc. and BTB, the expanded groups were enric.ed in genes with little evidenc. of.expression, in c.mparison with c.nserved groups. We also detec.ed 87 loc. under positive selec.ion in the expanded groups. These results show that most of.the duplic.ted c.pies in the expanded groups evolve neutrally af.er duplic.tion bec.use of.f.nc.ional redundanc. but a f.ac.ion of.these genes were preserved f.llowing neof.nc.ionalization. Henc., the lineage-spec.f.c.expansions observed between Oryza spec.es were partly driven by direc.ional selec.ion.

关键词： gene f.mily expansion Oryza tandem duplic.tion duplic.ted gene evolution.

Multi boron-doping ef.ec.s in hard c.rbon toward enhanc.d sodium ion storage

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Journal of.Energy c.emistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei liu c.llege of.Materials Sc.enc. and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute f.r Innovation Hunan University c.angsha Researc. Institute of.Mining & Metallurgy c.. LTD.

Hard c.rbon （Hc. has been c.nsidered as promising anode material f.r sodium-ion batteries （SIBs）.The optimization of.hard c.rbon’s mic.ostruc.ure and solid elec.rolyte interf.c. （SEI） property are demonstrated ef.ec.ive in enhanc.ng the Na+storage c.pability,however,a one-step regulation strategy to ac.ieve simultaneous multi-sc.le struc.ures optimization is highly ***,we have systematic.lly investigated the ef.ec.s of.boron doping on hard c.rbon’s mic.ostruc.ure and interf.c. c.emistry.A variety of.struc.ure c.arac.erizations show that appropriate amount of.boron doping c.n inc.ease the size of.c.osed pores via rearrangement of.c.rbon layers with improved graphitization degree,whic. provides more Na+storage ***-situ f.urier transf.rm inf.ared spec.rosc.py/elec.roc.emic.l impedanc. spec.rosc.py （f.IR/EIS） and X-ray photoelec.ron spec.rosc.py （XPS） analysis demonstrate the presenc. of.more Bc.and less B–c.O struc.ures that result in enhanc.d ion dif.usion kinetic. and the f.rmation of.inorganic.ric. and robust SEI,whic. leads to f.c.litated c.arge transf.r and exc.llent rate *** a result,the hard c.rbon anode with optimized boron doping c.ntent exhibits enhanc.d rate and c.c.ing *** general,this work unravels the c.itic.l role of.boron doping in optimizing the pore struc.ure,interf.c. c.emistry and dif.usion kinetic. of.hard c.rbon,whic. enables rational design of.sodium-ion battery anode with enhanc.d Na+storage perf.rmanc..

关键词： X ray photoelec.ron spec.rosc.py

Real-world evidenc. on the ef.ic.c. and saf.ty of.vonoprazanamoxic.llin dual therapy f.r Helic.bac.er pylori treatment in elderly patients

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World Journal of.Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang liu Hong c.eng Department of.Gastroenterology Peking University First HospitalBeijing 100034China Sc.ool of.Medic.ne Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of.Traditional c.inese Medic.ne and Integrative Medic.ne Peking University First HospitalBeijing 100034China

BAc.GROUND A dual therapy regimen c.ntaining amoxic.llin is a c.mmon treatment option f.r the eradic.tion of.Helic.bac.er pylori(***).While substantial researc. supports the ef.ic.c. and saf.ty of.vonoprazan and amoxic.llin(VA)dual therapy in the general population,there is still a lac. of.studies spec.f.c.lly f.c.sing on its saf.ty in elderly *** To evaluate ef.ic.c. and saf.ty of.VA dual therapy as f.rst-line or resc.e treatment f.r *** in elderly *** As a real-world retrospec.ive study,data were c.llec.ed f.om elderly patients aged 60 years and above who ac.epted VA dual therapy(vonoprazan 20 mg twic. daily+amoxic.llin 1000 mg thric. daily f.r 14 days)f.r *** eradic.tion in the Department of.Gastroenterology at Peking University f.rst Hospital between June 2020 and January *** status was evaluated by^(13)c.urease breath test 6 weeks af.er *** adverse events(AEs)during treatment were *** In total,401 c.ses were ***-one c.ses were exc.uded due to loss to f.llow-up,lac. of.re-examination,or unwillingness to take *** total of.380 inc.uded c.ses c.mprised 250 who rec.ived VA dual therapy as f.rst-line treatment and 130 who rec.ived VA dual therapy as resc.e *** was suc.essf.lly eradic.ted in 239 c.ses(95.6%)in the f.rst-line treatment group and 116 c.ses(89.2%)in the resc.e treatment *** overall inc.denc. of.AEs was 9.5%f.r both ***,9.2%of.patients experienc.d an AE in the f.rst-line treatment group and 10.0%in the resc.e treatment *** patients disc.ntinued treatment due to AE,with a disc.ntinuation rate of.1.3%.No serious AE *** The VA dual therapy regimen as a f.rst-line treatment and a resc.e therapy was ef.ec.ive and saf. f.r elderly patients aged 60 and older.

关键词： Helic.bac.er pylori Vonoprazan Amoxic.llin Dual therapy Elderly

Unsteady f.ow and heat transf.r of.porous media sandwic.ed between visc.us f.uids

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Applied Mathematic. and Mec.anic.(English Edition) 2010年第12期31卷 1497-1516页

作者： J. c. UMAVATHI I. c. liu J. PRATHAP-KUMAR D. SHAIK-MEERA Department of.Mathematic. Gulbarga University Gulbarga 585106 Karnaktaka India Department of.c.vil Engineering National Chi Nan University University Road Puli Nantou Hsien 54561 Taiwan China

The problem of.unsteady osc.llatory f.ow and heat transf.r of.porous medin sandwic.ed between visc.us f.uids has been c.nsidered through a horizontal c.annel with isothermal wall temperatures. The f.ow in the porous medium is modeled using the Brinkman equation. The governing partial dif.erential equations are transf.rmed to ordinary dif.erential equations by c.llec.ing the non-periodic.and periodic.terms. c.osed-f.rm solutions f.r eac. region are f.und af.er applying the boundary and interf.c. c.nditions. The inf.uenc. of.physic.l parameters, suc. as the porous parameter, the f.equenc. parameter, the periodic.f.equenc. parameter, the visc.sity ratios, the c.nduc.ivity ratios, and the Prandtl number, on the veloc.ty and temperature f.elds is c.mputed numeric.lly and presented graphic.lly. In addition, the numeric.l values of.the Nusselt number at the top and bottom walls are derived and tabulated.

关键词： unsteady porous medium immisc.ble f.uid horizontal c.annel analytic.lsolution