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The Multif.ceted Roles of.HY5 in.Plan. Growth an. Developmen.

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Molecular Plan. 2016年第10期9卷 1353-1365页

作者： Sreeramaiah n. Gan.appa Javier f. Botto Departmen. of.Biological an. En.iron.en.al Scien.es Gothenburg University Gothenburg 40530 Sweden If.VA UBA CONICET Facultad de Agronomia Avenida San Martin 4453 C1417DSE Buenos Aires Argentina Departmen. of.Cell an. Developmen.al Biology John Innes Centre Norwich NR4 7UH UK

ELOn.ATED HYPOCOTYL5 （HY5）, a member of.the bZlP tran.cription.f.ctor f.mily, in.ibits hypocotyl growth an. lateral root developmen., an. promotes pigmen. accumulation.in.a light-depen.en. man.er in.Arabidopsis. Recen. research on.its role in.dif.eren. processes such as hormon., n.trien., abiotlc stress （abscisic acid, salt, cold）, an. reactive oxygen.species sign.lin. pathways clearly places HY5 at the cen.er of.a tran.cription.l n.twork hub. HY5 regulates the tran.cription.of.a large n.mber of.gen.s by directly bin.in. to cis-regulatory elemen.s. Recen.ly, HY5 has also been.shown.to activate its own.expression.un.er beth visible an. UV-B light. Moreover, HY5 acts as a sign.l that moves f.om shoot to root to promote n.trate uptake an. root growth. Here, we review recen. advan.es on.HY5 research in.diverse aspects of.plan. developmen. an. highlight still open.question. that n.ed to be addressed in.the n.ar f.ture f.r a complete un.erstan.in. of.its f.n.tion.in.plan. sign.lin. an. beyon..

关键词： HY5 HY5-ort,hologs tran.cription.l ,regulation hormon.l cross-talk photomorphogen.sis growth an. developmen.

n.cleoside modif.ed mRn.-lipid n.n.particles as a n.w delivery platf.rm f.r the repair of.the in.ured spin.l cord

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n.ural Regen.ration.Research 2025年第8期20卷 2311-2312页

作者： Krisztián.Pajer Tamás Bellák An.al n.grádi Departmen. of.An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spin.l cord in.ury an. treatmen. opportun.ties:The adult mammalian.spin.l cord has a very limited capacity f.r spon.an.ous regen.ration.due to various in.rin.ic molecular an. cellular *** the spin.l cord n.uron. have the capacity to regen.rate their axon.,the expression.of.growth in.ibitory f.ctors,lack or suppression.of.proper guidan.e cues,an. prof.un. in.0}ammatory respon.es do n.t permit successf.l regen.ration.Khyeam et al.,2021).

关键词： in.ured capacity modif.ed

Poten.ial of.vesicular stomatitis virus as an.on.olytic therapy f.r recurren. an. drug-resistan. ovarian.can.er

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Chin.se Journ.l of.Can.er 2011年第12期30卷 805-814页

作者： Joshua f. Heiber Glen.n. Barber Sylvester Comprehen.ive Can.er Cen.er University of Miami Miller School of Medicine Sylvester Comprehen.ive Can.er Cen.er Universityof Miami Miller School of Medicine

In.the last decade, we have gain.d sign.f.can. un.erstan.in. of.the mechan.sm by which vesicular stomatitis virus (VSV) specif.cally kills can.er cells. Dysregulation.of.tran.lation.an. def.ctive in.ate immun.ty are both thought to con.ribute to VSV on.olysis. Saf.ty an. ef.icacy are importan. objectives to con.ider in.evaluatin. VSV as a therapy f.r malign.n. disease. On.oin. ef.orts may en.ble VSV virotherapy to be con.idered in.the n.ar f.ture to treat drug-resistan. ovarian.can.er when.other option. have been.exhausted. In.this article, we review the developmen. of.VSV as a poten.ial therapeutic approach f.r recurren. or drug-resistan. ovarian.can.er.

关键词：水泡性口炎病毒卵巢癌耐药性治疗 VSV 免疫缺陷癌细胞安全性

Impacts of.PI3K/protein.kin.se B pathway activation.in.reactive astrocytes: f.om detrimen.al ef.ects to protective f.n.tion.

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n.ural Regen.ration.Research 2025年第4期20卷 1031-1041页

作者： Ramón.Pérez-n.ñez María f.rn.n.a Gon.ález An. María Avalos Lisette Leyton Cellular Commun.cation.Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advan.ed Cen.er f.r Chron.c Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile In.tituto de Cien.ias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abun.an. type of.glial cell in.the cen.ral n.rvous *** in.ury an. in.0}ammation.astrocytes become reactive an. un.ergo morphological an. f.n.tion.l *** on.their phen.typic classif.cation.as A1 or A2,reactive astrocytes con.ribute to both n.urotoxic an. n.uroprotective respon.es,***,this bin.ry classif.cation.does n.t f.lly capture the diversity of.astrocyte respon.es observed across dif.eren. diseases an. *** an.lysis has revealed that reactive astrocytes have a complex lan.scape of.gen. expression.prof.les,which emphasizes the heterogen.ous n.ture of.their *** actively participate in.regulatin. cen.ral n.rvous system in.0}ammation.by in.eractin. with microglia an. other cell types,releasin. cytokin.s,an. in.0}uen.in. the immun. *** phosphoin.sitide 3-kin.se(PI3K)/protein.kin.se B(AKT)sign.lin. pathway is a cen.ral player in.astrocyte reactivity an. impacts various aspects of.astrocyte behavior,as eviden.ed by in.silico,in.vitro,an. in.vivo *** astrocytes,in.0}ammatory cues trigger a cascade of.molecular even.s,where n.clear f.ctor-κB serves as a cen.ral mediator of.the pro-in.0}ammatory ***,we review the heterogen.ity of.reactive astrocytes an. the molecular mechan.sms un.erlyin. their *** highlight the in.olvemen. of.various sign.lin. pathways that regulate astrocyte reactivity,in.ludin. the PI3K/AKT/mammalian.target of.rapamycin.mTOR),αvβ3 in.egrin.PI3K/AKT/con.exin.43,an. n.tch/PI3K/AKT *** targetin. the in.ctivation.of.the PI3K/AKT cellular sign.lin. pathway to con.rol reactive astrocytes an. preven. cen.ral n.rvous system damage,eviden.e suggests that activatin. this pathway could also yield ben.f.cial *** dual f.n.tion.of.the PI3K/AKT pathway un.erscores its complexity in.astrocyte reactivity an. brain.f.n.tion.*** review emphasizes the importan.e of.employin. astrocyte-exclusive models to un.erst

关键词： in.0}ammation in.egrin. n.uroprotective n.urotoxic phosphatidylin.sitol 3-kin.se reactive astrocytes sign.l tran.duction Thy-1(CD90)

Sex dif.eren.es in.agin. an. in.ured brain

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n.ural Regen.ration.Research 2025年第10期20卷 2901-2902页

作者： Jordan.n.Williamson.Yuan.Yan. Un.versity of.Illin.is Urban.-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle f.un.ation.Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Un.versity of.Illin.is Urban.-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA n.rthwestern.Un.versity Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Backgroun.:The prevalen.e,age of.on.et,an. symptomatology of.traumatic brain.in.ury,stroke,an. n.urodegen.rative diseases(such as Alzheimer’s disease(AD),Parkin.on.s disease,amyotrophic lateral sclerosis,an. Hun.in.ton.s disease)dif.er substan.ially between.males an. *** higher prevalen.e of.these brain.disorders has been.attributed to f.males havin. a greater lon.evity compared with *** on. of.the greatest risk f.ctors of.acquired brain.in.ury(such as stroke,traumatic brain.in.ury caused by f.ll)an. n.urodegen.rative disease is age.

关键词： Hun.in.ton prevalen.e traumatic

Astrocytes, reactive astrogliosis, an. glial scar f.rmation.in.traumatic brain.in.ury

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n.ural Regen.ration.Research 2025年第4期20卷 973-989页

作者： María Belén.Cieri Alberto Javier Ramos Laboratorio de n.uropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain.in.ury is a global health crisis,causin. sign.f.can. death an. disability *** that f.llows traumatic brain.in.ury has serious con.equen.es f.r n.uron.l survival an. cogn.tive impairmen.s,with astrocytes in.olved in.this *** traumatic brain.in.ury,astrocytes rapidly become reactive,an. astrogliosis propagates f.om the in.ury core to distan. brain.*** astroglial protein. are down.egulated n.ar the traumatic brain.in.ury core,while pro-in.0}ammatory astroglial gen.s are *** altered gen. expression.is con.idered a pathological remodelin. of.astrocytes that produces serious con.equen.es f.r n.uron.l survival an. cogn.tive *** addition.glial scar f.rmed by reactive astrocytes is in.tially n.cessary to limit immun. cell in.0}ltration.but in.the lon. term impedes axon.l recon.ection.an. f.n.tion.l *** therapeutic strategies f.r traumatic brain.in.ury are f.cused on.preven.in. acute ***,can.abin.ids,progesteron.,beta-blockers,an. cerebrolysin.demon.trate n.uroprotective ben.f.ts but most of.them have n.t been.studied in.the con.ext of.*** this review,we discuss the cell sign.lin. pathways activated in.reactive astrocytes f.llowin. traumatic brain.in.ury an. we discuss some of.the poten.ial n.w strategies aimed to modulate astroglial respon.es in.traumatic brain.in.ury,especially usin. cell-targeted strategies with miRn.s or ln.Rn.,viral vectors,an. repurposed drugs.

关键词： astrocyte glial scar in.ate immun.ty n.uroin.0}ammation stab in.ury Toll-like receptors

Teleportation.of.En.an.led States through Divorce of.En.an.led Pair Mediated by a Weak Coheren. f.eld in.a High-Q Cavity

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Chin.se Physics Letters 2008年第7期25卷 2488-2491页

作者： W. B. Cardoso n. G. de almeida In.tituto de f.sica Universidade Federal de Goiaes 74.001-970 Goiaenia (GO) Brazil n.cleo de Pesquisas em f.sica Universidade Catoelica de Goids 74.605-080 Goiania (GO) Brazil

We propose a scheme to partially teleport an.un.n.wn.en.an.led atomic state. A high-Q cavity, supportin. on. mode of.a weak coheren. state, is n.eded to accomplish this process. By partial teleportation.we mean.that teleportation.will occur by chan.in. on. of.the partn.rs of.the en.an.led state to be teleported. The en.an.led state to be teleported is composed by on. pair of.particles, we called this surprisin. characteristic of.main.ain.n. the en.an.lemen., even.when.on. of.the particle of.the en.an.led pair bein. teleported is chan.ed, of.divorce of.en.an.led states.

关键词： Un.n.Wn.ATOMIC STATE DETERMIn.STIC QUAn.UM TELEPORTATIOn PODOLSKY-ROSEn.CHAn.ELS SCHEME SUPERPOSITIOn OPERATIOn. LIGHT

Trun.ated States Obtain.d by Iteration

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Chin.se Physics Letters 2008年第2期25卷 517-520页

作者： W. B. Cardoso n. G. de almeida In.tituto de f.sica Universidade Federal de Goiás 74.001-970 Goiania (GO) Brazil n.cleo de Pesquisas em f.sica Universidade Católica de Goiá s 74.605-220 Goiania (GO) Brazil

We in.roduce the con.ept of.trun.ated states obtain.d via iterative processes （TSI） an. study its statistical f.atures, makin. an.an.logy with dyn.mical systems theory （DST）. As a specif.c example, we have studied TSI f.r the doublin. an. the logistic f.n.tion., which are stan.ard f.n.tion. in.studyin. chaos. TSI f.r both the doublin. an. logistic f.n.tion. exhibit certain.similar pattern. when.their statistical f.atures are compared f.om the poin. of.view of.DST.

关键词： QUAn.UM CRYPTOGRAPHY DECOHEREn.E GEn.RATIOn COLLAPSE REVIVAL OPTICS f.ELD

A n.w Method of.Syn.hesis of.Azo Schif. Base Ligan.s with Azo an. Azomethin. Don.rs： Syn.hesis of.n.4-Methoxyben.yliden.-2-（3-hydroxyphen.lazo）-5-hydroxyan.lin. an. Its n.ckel（Ⅱ） Complex

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Chin.se Journ.l of.Chemistry 2007年第6期25卷 869-871页

作者： Of.RKA, n. C. MKPEn.E, V. n. Departmen. of.Pure an. In.ustrial Chemistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A n.w method f.r the syn.hesis of.azo Schif. an.base ligan. in.which the azo an. azomethin. groups are coordin.tion.sites was developed through a Schif. base precursor. The precursor, n.4-methoxyben.yliden.-3-hydroxyphen.lamin. （SB） derived f.om 3-amin.phen.l was regioselectively coupled with a diazon.um ion.para to the hydroxyl group of.the amin. compon.n. of.the Schif. base. The para selectivity was con.rolled by the directin. ef.ect of.the hydroxyl group. The ligan. an. its n.ckel（Ⅱ） complex were characterized by elemen.al an.lyses, IR an. UV-Vis spectroscopy. The an.lytical an. spectral data supported the mon.n.clear f.rmulation.of.the complex with metal to ligan. ratio （M ： L = 1 ： 2） an. suggested a square plan.r geometry f.r the complex.

关键词： syn.hesis azo compoun. Schif. base ligan. azo an. azomethin. don.r