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Synthesis of.Silver Nanoparticles f.om Honeybees and Its Antibacterial Potential

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Open Journal of.Medical Microbiology 2024年第1期14卷 77-92页

作者： Akamu J. Ewunkem Niore’s Johnson A’lyiha f. Beard Ilunga Tshimanga Brittany Justice Jef.ery Meixner Department of.Biological Sciences Winston Salem State University Winston Salem NC USA Department of.Clinical Science and Laboratory Science Winston Salem State University Winston Salem NC USA

Honeybees (Apis mellif.ra) are important pollinators of.f.owering plants and agricultural crops contributing annually to billions of.dollars in revenues to crop production. Honeybees have an average lif.span between 8 weeks to 5 years. Dead honeybees are abundantly available in beehives and can be utilized as an alternative source to synthesize nanoparticles. In recent years, biologically synthesized nanoparticles have been pref.rred over their chemical counterparts. However, honeybee-based-green synthesis of.nanoparticles has not been explored yet. Herein, we report the biosynthesis of.silver nanoparticles f.om honeybees and its antibacterial activity. The synthesis of.silver nanoparticles was monitored visually through a gradual change in color. f.rthermore, the biosynthesized nanoparticles were conf.rmed and characterized by UV-visible spectroscopy. Scanning Electron Microscope was utilized to analyze the average size and morphologies of.the biosynthesized nanoparticles. Subsequently, the antibacterial potential of.the biosynthesized silver nanoparticles was tested against selected Gram-positive and Gram-negative bacterial strains. It was f.und that a distinct color change f.om yellow to brown in the reaction solution suggested the f.rmation of.silver nanoparticles. The biosynthesized nanoparticles exhibited absorption maxima at 430 nm. The SEM analysis conf.rmed the spherical and cuboidal shape of.the biosynthesized silver nanoparticles with a size range between 10 - 40 nm. f.rthermore, the biosynthesized silver nanoparticles exhibited strong antimicrobial potential against tested Gram-positive and Gram-negative bacteria strains by aggregating on the cell surf.ce. This study showcases the biomedical and agricultural applications of.biosynthesized silver nanoparticles f.om honeybee wings. .

关键词： Honeybee Bacteria Green Synthesis Nanoparticles Antimicrobial

f.rmation of.dif.use and spark discharges between two needle electrodes with the scattering of.particles

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Plasma Science and Technology 2024年第9期26卷 32-39页

作者： Victor f.TARASENKO Dmitry V BELOPLOTOV Alexei N PANCHENKO Dmitry A SOROKIN Institute of.High Current Electronics Siberian BranchRussian Academy of SciencesTomsk 634055Russia National Research Tomsk State University Tomsk 634050Russia

The development of.a nanosecond discharge in a pin-to-pin gap f.lled with air at atmospheric pressure has been studied with high temporal and spatial resolutions f.om a breakdown start to the spark *** and negative nanosecond voltage pulses with an amplitude of.tens of.kilovolts were ***-resolved images of.the discharge development were taken with a f.urchannel Intensif.ed Charge Coupled Device(ICCD)*** minimum delay between the camera channels could be as short as≈0.1 *** made it possible to study the gap breakdown process with subnanosecond *** was observed that a wide-diameter streamer develops f.om the high-voltage pointed *** ionization processes near the grounded pin electrode started when the streamer crossed half.of.the *** bridging the gap by the streamer,a dif.use discharge was *** development of.spark leaders f.om bright spots on the surf.ce of.the pointed electrodes was observed at the next *** was f.und that the rate of.development of.the spark leader is an order of.magnitude lower than that of.the wide-diameter *** thin luminous tracks were observed against the background of.a discharge plasma *** has been established that the tracks are adjacent to brightly glowing spots on the electrodes and are associated with the f.ight of.small particles.

关键词： needle electrodes short voltage pulses atmospheric air streamer breakdown dif.use and spark discharges scattering metal particles

New evidence f.r the epigenetic regulation of.skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao Charles K.f.Chan Institute f.r Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of.Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of.Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial f.r skeletal development and regeneration,yet the epigenetic regulation of.these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of.SSCs,highlighting the involvement of.Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to f.ster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

Artif.cial ground f.eezing of.underground mines in cold regions using thermosyphons with air insulation

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International Journal of.Mining Science and Technology 2024年第5期34卷 643-654页

作者： Ahmad f.Zueter Mohammad Zolf.gharroshan Navid Bahrani Agus P.Sasmito Department of.Civil and Resource Engineering Dalhousie UniversityHalifax B3H4R2Canada Department of.Mining Engineering McGill UniversityMontreal H3A0E8Canada

Current practice of.underground artif.cial ground f.eezing(AGf.typically involves huge ref.igeration systems of.large economic and environmental *** this study,a novel AGf.technique is proposed deploying available cold wind in cold *** is achieved by a static heat transf.r device called thermosyphon equipped with an air insulation layer.A ref.igeration unit can be optionally integrated to meet additional cooling *** introduction of.air insulation isolates the thermosyphon f.om ground zones where f.eezing is not needed,resulting in:(1)steering the cooling resources(cold wind or ref.igeration)towards zones of.interest;and(2)minimizing ref.igeration *** design is demonstrated using well-validated mathematical models f.om our previous work based on two-phase enthalpy method of.the ground coupled with a thermal resistance network f.r the *** Canadian mines are considered:the Cigar Lake Mine and the Giant *** results show that our proposed design can speed the f.eezing time by 30%at the Giant Mine and by two months at the Cigar Lake ***,a cooling load of.2.4 GWh can be saved at the Cigar Lake ***,this study provides mining practitioners with sustainable solutions of.underground AGf.

关键词： Artif.cial ground f.eezing Underground mining Sustainable mining Thermosyphon Air insulation Cold regions

Glyphosate as a direct or indirect activator of.pro-inf.ammatory signaling and cognitive impairment

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Neural Regeneration Research 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi Kazuko A.O'Dell Charles f.Zorumski Department of.Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor f.mily Institute f.r Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have signif.cant exposure. Because of.habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently f.und that a single injection of.glyphosate inhibits long-term potentiation, a cellular model of.learning and memory, in rat hippocampal slices dissected 1 day af.er injection, indicating that glyphosate-based herbicides can alter cognitive f.nction. Glyphosate-based herbicides could adversely af.ect cognitive f.nction either indirectly and/or directly. Indirectly, glyphosate could af.ect gut microbiota, and if.dysbiosis results in endotoxemia(leaky gut), inf.ltrated bacterial by-products such as lipopolysaccharides could activate pro-inf.ammatory cascades. Glyphosate can also directly trigger pro-inf.ammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of.long-term potentiation by glyphosate appears to be similar to that of.lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinf.ammation caused by glyphosate. Dietary intake of.polyphenols, such as quercetin, which overcome the inhibitory ef.ect of.glyphosate on long-term potentiation, could be one ef.ective strategy. The aim of.this narrative review is to discuss possible mechanisms underlying neurotoxicity f.llowing glyphosate exposure as a means to identif. potential treatments.

关键词： cognitive impairment glyphosate microglia neuroinf.ammation roundup toll-like receptor 4 zinc chelation

Resource management at the network edge f.r f.derated learning

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Digital Communications and Networks 2024年第3期10卷 765-782页

作者： Silvana Trindade Luiz f.Bittencourt Nelson L.S.da f.nseca Institute of.Computing State University of CampinasCampinasBrazil

f.derated learning has been explored as a promising solution f.r training machine learning models at the network edge,without sharing private user *** limited resources at the edge,new solutions must be developed to leverage the sof.ware and hardware resources as the existing solutions did not f.cus on resource management f.r network edge,specially f.r f.derated *** this paper,we describe the recent work on resource manage-ment at the edge and explore the challenges and f.ture directions to allow the execution of.f.derated learning at the *** such as the discovery of.resources,deployment,load balancing,migration,and energy ef.i-ciency are discussed in the paper.

关键词： Resource management Edge computing f.derated learning Machine learning

Digital twin-and extended reality-based telepresence f.r collaborative robot programming in the 6G perspective

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Digital Communications and Networks 2024年第2期10卷 315-327页

作者： Davide Calandra f.Gabriele Pratticò Alberto Cannavò Claudio Casetti f.brizio Lamberti Politecnico di Torino Department of Control and Computer EngineeringCorso Duca Degli Abruzzi2410129TurinItaly

In the context of.Industry 4.0,a paradigm shif. f.om traditional industrial manipulators to Collaborative Robots(CRs)is ongoing,with the latter serving ever more closely humans as auxiliary tools in many production *** this scenario,continuous technological advancements of.er new opportunities f.r f.rther innovating robotics and other areas of.next-generation *** example,6G could play a prominent role due to its human-centric view of.the industrial *** particular,its expected dependability f.atures will pave the way f.r new applications exploiting highly ef.ective Digital Twin(DT)-and eXtended Reality(XR)-based *** this work,a novel application f.r the above technologies allowing two distant users to collaborate in the programming of.a CR is *** approach encompasses demanding data f.ows(e.g.,point cloud-based streaming of.collaborating users and robotic environment),with network latency and bandwidth *** obtained by analyzing this approach f.om the viewpoint of.network requirements in a setup designed to emulate 6G connectivity indicate that the expected perf.rmance of.f.rthcoming mobile networks will make it f.lly f.asible in principle.

关键词： 6G Digital twin Telepresence Collaborative robots Industry 4.0 Augmented reality Virtual reality Point cloud streaming

The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.f.Matthees Carsten Hof.mann Institut f.r Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany f.iedrich-Schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)f.mily C,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanf.rd gained Skin

Evaluation of.sodium borocaptate(BSH)and boronophenylalanine(BPA)as boron delivery agents f.r neutron capture therapy(NCT)of.cancer:an update and a guide f.r the f.ture clinical evaluation of.new boron delivery agents f.r NCT

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Cancer Communications 2024年第8期44卷 893-909页

作者： Rolf.f.Barth Nilendu Gupta Shinji Kawabata Department of.Pathology The Ohio State UniversityColumbusOhioUSA Department of.Radiation Oncology The Ohio State UniversityColumbusOhioUSA Department of.Neurosurgery Osaka Medical and Pharmaceutical UniversityTakatsukiOsakaJapan

Boron neutron capture therapy(BNCT)is a cancer treatment modality based on the nuclear capture and f.ssion reactions that occur when boron-10,a stable isotope,is irradiated with neutrons of.the appropriate energy to produce boron-11 in an unstable f.rm,which undergoes instantaneous nuclear f.ssion to produce high-energy,tumoricidal alpha *** primary purpose of.this review is to provide an update on the f.rst drug used clinically,sodium borocaptate(BSH),by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug,boronophenylalanine(BPA),which f.rst was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous ***,BPA has become the primary drug used as a boron delivery agent to treat patients with several types of.cancers,specif.cally brain tumors and recurrent tumors of.the head and neck *** f.cus of.this review will be on the initial studies that were carried out to def.ne the pharmacokinetics and pharmacodynamics of.BSH and BPA and their biodistribution in tumor and normal tissues f.llowing administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with highgrade ***,wewill summarize the studies thatwere carried out in Japan with BSH and subsequently at our own institution,The Ohio State University,and those of.several other ***,we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically f.r ***,although there have been intense ef.orts to develop new and better boron delivery agents f.r BNCT,none of.these have yet been evaluated *** present reportwill provide a guide to the f.ture clinical evaluation of.new boron delivery agents prior to their clinical use f.r BNCT.

关键词： Boron neutron capture therapy(BNCT) boronophenylalanine(BPA) brain tumors head and neck cancer sodium borocaptate(BSH)