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Time-to-enrollment in clinical trials investigating neurological recovery in chronic spinal cord injury:observations from a systematic review and Clinical *** database

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Neural Regeneration Research 2022年第5期17卷 953-958页

作者： f m moinuddin Yagiz Ugur Yolcu Waseem Wahood Jad Zreik Sandy Goncalves Anthony John Windebank Wenchun Qu mohamad Bydon mayo Clinic Neuro-Informatics Laboratory Mayo ClinicRochesterMNUSA Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Dr.Kiran C.Patel College of Allopathic medicine Nova Southeastern UniversityDavieFLUSA Department of Neurology Mayo ClinicRochesterMNUSA Department of Physical medicine&Rehabilitation Mayo ClinicRochesterMNUSA

Currently,large numbers of clinical trials are performed to investigate different forms of experimental therapy for patients suffering from chronic spinal cord injury(SCI).However,for the enrollment process,there are different views on how the time period between injury and interventions should be ***,we sought to evaluate the impact of time-to-enrollment in chronic SCI clinical trials.A data set comprising 957 clinical studies from clinical *** was downloaded and analyzed focusing on the eligibility criteria for post-injury *** also aggregated individual patient data from nine clinical trials of regenerative interventions for chronic SCI selected by a systematic literature search from 1990 to *** of the studies were assessed and compared by dividing into three groups based on time-to-enrollment(group 1≤12 months,group 2=12-23 months and group 3≥24 months).In Clinical *** registry,445 trials were identified for chronic SCI where 87%(385)were unrestricted in the maximum post-injury time for trial *** systematic literature search,nine studies and 156 patients(group 1=30,group 2=55 and group 3=71)were *** range of time-to-enrollment was 0.5 to 321 months in those *** also observed various degrees of motor and sensory improvement in between three time-to-enrollment *** results indicate that enrolling wide ranges of time-to-enrollment in a group may present imprecise *** trial designs should consider appropriate postinjury time frames to evaluate therapeutic benefit.

关键词： chronic clinical trial spinal cord injury systematic review time-to-enrollment

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Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of methodology 2025年第2期15卷 27-43页

作者： Helal f Hetta Rehab Ahmed Yasmin N Ramadan Hayam fathy mohammed Khorshid mohamed m mabrouk mai Hashem Department of medical microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew f.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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EffECT Of GAmmA RAYS IN THE PREPARATION Of POLYmER AND HYDROGEL fROm ACRYLAmIDE mONOmER

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Chinese Journal of Polymer Science 2003年第4期21卷 437-442页

作者： m.m.Alam m.f.mina f.Akhtar NRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka Bangladesh

The formation of polymer and hydrogel from aqueous solutions having 20, 30 and 40% concentrations ofacrylamide monomer by γ-ray irradiation processing in the dose range 0.06-30 kGy using a Co-60 source and theircharacterization have been observed. Polymer conversion and gel fraction are found to depend on radiation doses. Polymerconversion increases with the increase of dose, depending on the solution concentration, where maximum conversion isachieved at 0.18, 0.16 and 0.10 kGy for 20%, 30% and 40% concentrations, respectively. On the other hand, gel fractionincreases with dose from the gel point (0.12 kGy) for all concentrations, where 100% conversion of gel occurs at doses≥5 kGy. Tensile strength, viscosity and molecular weight (m_w) of polymer samples increase with both the dose and theconcentration, showing a high value of m_w up to≈10~8. Swelling of hydrogels under water with respect to time varies due tothe variation of cross-linking density formed in the gels and the maximum swelling mainly occurs within 24 h. A remarkable change of surface morphology reveals characteristic features of monomer, polymer and hydrogel films.

关键词： Polymer Hydrogel γ-Radiation Cross-linking Swelling

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SWELLING BEHAVIOR Of ACRYLAmIDE HYDROGEL IN DIffERENT SOLVENTS AND pHs

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Chinese Journal of Polymer Science 2005年第3期23卷 269-274页

作者： m.f.mina m.m.Alam Institute of Nuclear Science and Technology Atomic Energy Research EstablishmentGPO Box-3787Dhaka-1000BangladeshInstitute of Nuclear Science and TechnologyAtomic Energy Research EstablishmentGPO Box-3787Dhaka-1000Bangladesh

Swelling property of acrylamide hydrogels,prepared from aqueous solutions of acrylamide monomer havingconcentrations in the range of 10-60 wt% by ray irradiation method using a Co-60 gamma radiation source at dosesranging 1-30.0 kGy,has been investigated under various swelling *** swelling media were basically solvents(solutions),produced by dissolving methanol,ethanol,glucose,sucrose,sodium chloride and sodium persulfate individuallywith distilled water,and solutions prepared with pHs=3,7 and *** investigation was performed in order to observe theeffect of these solvents and pHs as well as the influence of monomer concentrations,radiation doses and times on swellingbehavior of *** values were found higher for hydrogels prepared with lower monomer concentrations(ca.20 wt%)and radiation doses(ca.5 kGy)and showed a leveling off tendency within 24 *** glucose solvent and the buffersolution of pH=10 revealed significant increase of swelling of hydrogels as compared to other *** areexplained based on crosslinking density in hydrogel,polymer-solvent/polymer-polymer interactions in solutions,permeability of molecules in solutions and ionization capacity of hydrogel in pH.

关键词： Acrylamide Hydrogel Co-60 gamma radiation source Swelling.

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Photometric Investigation of Contact Binary DY Cet Based on TESS Data

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Research in Astronomy and Astrophysics 2022年第5期22卷 121-128页

作者： m.f.Yildirim Canakkale Onsekiz mart University Astrophysics Research Center and Ulupinar Observatory17020CanakkaleTurkey Canakkale Onsekiz mart University Department of Electricity and EnergyCan Vocational School17400CanakkaleTurkey

We present a photometric analysis of the Transiting Exoplanet Survey Satellite(TESS)light curve of contact binary system DY Cet and the behavior of its orbital period *** light curve and published radial velocity data analysis was performed using the Wilson-Devinney *** a result of simultaneous analysis of the light curve with radial velocity data,the masses and radii of the system’s components were determined as m_(1)=1.55±0.02 m_(⊙),m_(2)=0.55±0.01 m_(⊙) and R_(1)=1.51±0.02 R_(⊙),R_(2)=0.95±0.02 R_(⊙),*** degree of contact(f)and mass ratio(q)of the system were determined as 23%and 0.355±0.012,*** period analysis of DY Cet was conducted for the first time in this *** was observed that the orbital period has a sinusoidal change with decreasing *** explain the orbital period change,mass transfer between components is proposed with the assumption of conservative mass,and the transfer rate was calculated to be dm/dt=1.1×10^(-7) m_(⊙)yr^(-1).A possible third component is suggested for explaining the sinusoidal change,and the mass of the unseen component was determined as 0.13 m_(⊙).The age of the DY Cet system was estimated as 3.77 Gyr.

关键词： stars eclipsing binary stars-stars fundamental parameters of stars- stars individual (DY Cet)

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Control and vibration analyses of a sandwich doubly curved micro-composite shell with honeycomb,truss,and corrugated cores based on the fourth-order shear deformation theory

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Applied mathematics and mechanics(English Edition) 2024年第10期45卷 1773-1790页

作者： f.SHIRDELAN m.mOHAmmADImEHR f.BARGOZINI Department of Solid mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan 87317-53153Iran

Curved shells are increasingly utilized in applied engineering due to their shared characteristics with other sandwich structures,flexibility,and attractive ***,the inability of controlling and regulating vibrations and destroying them afterward is a challenge to *** this paper,the curve shell equations and a linear quadratic regulator are adopted for the state feedback design to manage the structure vibrations in state space forms.A five-layer sandwich doubly curved micro-composite shell,comprising two piezoelectric layers for the sensor and actuator,is modeled by the fourth-order shear deformation *** core(honeycomb,truss,and corrugated)is analyzed for the bearing of transverse shear *** results show that the honeycomb core has a greater effect on the *** the parameters related to the core and the weight percentage of graphene increase,the frequency *** uniform distribution of graphene platelets results in the lowest natural frequency while the natural frequency ***,without taking into account the piezoelectric layers,the third-order shear deformation theory(TSDT)and fourth-order shear deformation theory(fOSDT)align ***,when the piezoelectric layers are incorporated,these two theories diverge significantly,with the frequencies in the fOSDT being lower than those in the TSDT.

关键词： vibration and control doubly curved shell micro-composite honeycomb truss corrugate core

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Impact of wastewater reuse on cobalt status in Egyptian environment

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Journal of Environmental Sciences 2003年第3期15卷 388-395页

作者： m.f. Abdel-Sabour Soil and Water Research Department Nuclear Research Center Atomic Energy Authority

Cobalt is used in the manufacture of alloys, catalysts in the petroleum industry, catalytic converters, and paint pigments. Thus the potential for Co releases into the environment is highly increased. Use of waste sludges and sewage effluent to fertilize and irrigate soils has also increased soil Co concentrations. Total cobalt contents of alluvial delta soil of Egypt show considerable variation ranging from 13.1 to 64.7 ppm. The impact of either wastewater irrigation or industrial activities on soil total Co was obvious due to accumulation of organic matter and solid waste in the surface soil samples. food crops and vegetables should not be grown on soil highly contaminated by Co. It is noteworthy that the delayed neutron activation analysis(DNAA) technique could be used successfully for total Co determination due to its high sensitivity. It is quit clearly that dust samples of Cairo City contains higher Co level, as compared to Suez Canal Region(Ismailia, Port Said and El-Suez cities). The high values in Cairo City may be due to the existence of industries around the city and the intensive traffic. To minimize Co environmental hazards, waste effluents should be treated on site. Thus, levels of potentially toxic Co needs to be continuously monitored and should be removed during several treatment processes before the disposal of these wastes.

关键词： cobalt environment Egypt

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Surface morphology and impurity distribution of electron beam recrystallized silicon films on low cost substrates for solar cell absorber

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Rare metals 2006年第Z1期25卷 195-200页

作者： GROmBALL f müLLER J Department of mikrosystemtechnik Technische Universitt Hamburg-Harburg Hamburg 21073 Germany

A line shaped electron beam recrystallised polycrystalline silicon film on the low cost substrate was investigated for the use of the solar cell absorber. The applied EB energy density strongly influences the surface morphology of the film system. Lower EB energy density results in droplet morphology and the rougher SiO2 capping layer due to the low fluidity. With the energy increasing, the capping layer becomes smooth and continuous and less and small pinholes form in the silicon film. Tungstendisilicide (WSi2) is formed at the interface tungsten/silicon but also at the grain boundaries of the silicon. Because of the fast melting and cooling of the silicon film, the eutectic of silicon and tungstendisilicide mainly forms at the grain boundary of the primary silicon dendrites. The SEm-EDX analysis shows that there are no chlorine and hydrogen in the area surrounding a pinhole after recrystallization because of outgassing during the solidification.

关键词： polycrystalline silicon film solar cell recrystallization energy surface morphology outgassing

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Nonlinear continuous bi-inductance electrical line with dissipative elements:Dynamics of the low frequency modulated waves

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Chinese Physics B 2020年第4期29卷 179-189页

作者： S m Ngounou f B Pelap Unite de Recherche de mecanique et de modelisation des Systèmes Physiques(UR-2 mSP) Faculte des SciencesUniversite de DschangBP 69 DschangCameroun Unite de Recherche de matiere Condensee d'Electronique et de Traitement du Signal(UR-mACETS) Faculte des SciencesUniversite de DschangBP 67 DschangCameroun

The dynamics of modulated waves in a nonlinear bi-inductance transmission line with dissipative elements are *** show the existence of two frequency modes and carry out intensive investigations on the low frequency *** to the multiple scales method,the behavior of these waves is investigated and the dissipative effects are *** appears that the dissipation coefficient increases with the carrier wave *** the continuous approximation,we derive that the propagation of these waves is governed by the complex Ginzburg-Landau equation instead of the Korteweg-de-Vries equation as previously *** studies of the dynamics of plane waves in the line reveal the existence of three additional regions in the dispersion curve where the modulational phenomenon is *** the low frequency mode,we demonstrate that the network allows the propagation of dark and bright *** findings are in perfect agreement with the analytical predictions.

关键词： dissipative bi-inductance network low frequency mode continuous approximation complex Ginzburg-Landau equation

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