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Microstructural morphology and visual acuity outcome in eyes with epiretinal membrane before,during,and after membrane peeling in intraoperative optical coherence tomography assisted macular surgery

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 748-754页

作者： Melanie Weschta Moritz Pettenkofer Julian EKlaas nikolaus feucht Chris PLohmann Mathias Maier Department of Ophthalmology Klinikum rechts der IsarTechnische Universität MünchenIsmaninger Str.22Munich 81675Germany Jules Stein Eye Institute University of California Los Angeles100 Stein Plaza DrivewayLos AngelesCalifornia 90095USA Department of Ophthalmology Ludwig-Maximilians-Universität MünchenMathildenstr.8Munich 80336Germany Smile Eyes Augenklinik Munich Airport Terminalstraße Mitte 18Munich 85356Germany

AIM:To measure the difference of intraoperative central macular thickness(CMT)before,during,and after membrane peeling and investigate the influence of intraoperative macular stretching on postoperative best corrected visual acuity(BCVA)outcome and postoperative CMT ***:A total of 59 eyes of 59 patients who underwent vitreoretinal surgery for epiretinal membrane was *** with intraoperative optical coherence tomography(OCT)were *** of intraoperative CMT before,during,and after peeling was ***-and postoperatively obtained BCVA and spectral-domain OCT images were ***:Mean age of the patients was 70±8.13y(range 46-86y).Mean baseline BCVA was 0.49±0.27 log MAR(range 0.1-1.3).Three and six months postoperatively the mean BCVA was 0.36±0.25(P=0.01 vs baseline)and 0.38±0.35(P=0.08 vs baseline)log MAR *** stretch of the macula during surgery was 29%from baseline(range 2%-159%).Intraoperative findings of macular stretching did not correlate with visual acuity outcome within 6mo after surgery(r=-0.06,P=0.72).However,extent of macular stretching during surgery significantly correlated with less reduction of CMT at the fovea centralis(r=-0.43,Pfrom the fovea(r=-0.37,P=0.02 and r=-0.50,Pf retinal stretching during membrane peeling may predict the development of postoperative central retinal thickness,though there is no correlation with visual acuity development within the first 6mo postoperatively.

关键词： retinal imaging treatment surgery intraoperative optical coherence tomography epiretinal membrane

Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C

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World Journal of Gastroenterology 2011年第44期17卷 4883-4889页

作者： Elke Kaemmerer Anne Peuscher Andrea Reinartz Christian Liedtke Ralf Weiskirchen Jürgen Kopitz nikolaus Gassler Department of Pediatrics RWTH Aachen UniversityAachenGermany Institute of Pathology RWTH Aachen University Department of Plant Biotechnology Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Institute of Pathology RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Institute of Clinical Chemistry and Pathobiochemistry RWTH Aachen University Institute of Pathology University of Heidelberg

AIM:To investigate whether human acyl-CoA synthetase 5(ACSL5) is sensitive to the ACSL inhibitor triacsin ***:The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly expressed as 6xHis-tagged *** 2+-affinity purified recombinant enzymes were assayed at pH 7.5 or pH 9.5 in the presence or absence of triacsin *** addition,ACSL5 transfected CaCo2 cells and intestinal human mucosa were ***5 expression in cellular systems was verified using Western blot and *** ACSL assay mix included TrisHCl(pH 7.4),ATP,CoA,EDTA,DTT,MgCl 2,[9,103 H] palmitic acid,and triton *** 200 μL reaction was initiated with the addition of solubilized,purified recombinant proteins or cellular *** were terminated after 10,30 or 60 min of incubation with Doles ***:Expression of soluble recombinant ACSL proteins was found after incubation with isopropyl betaD-1-thiogalactopyranoside and after ultracentrifugation these were further purified to near homogeneity with Ni 2+-affinity *** C selectively and strongly inhibited recombinant human ACSL5 protein at pH 7.5 and pH 9.5,as well as recombinant rat ACSL1(sensitive control),but not recombinant rat ACSL5(insensitive control).The IC50 for human ACSL5 was about 10 μmol/*** inhibitory triacsin C effect was similar for different incubation times(10,30 and 60 min) and was not modified by the N-or C-terminal location of the *** order to evaluate ACSL5 sensitivity to triacsin C in a cellular environment,stable human ACSL5 CaCo2 transfectants and mechanically dissected normal human intestinal mucosa with high physiological expression of ACSL5 were *** both models,ACSL5 peak activity was found at pH 7.5 and pH 9.5,corresponding to the properties of recombinant human ACSL5 *** the presence of triacsin C(25 μmol/L),total ACSL activity was dramatically diminished in human ACSL5 transfectants as well as in AC

关键词： Acyl-CoA synthetase 5 fatty acid metabolism Mitochondria Triacsin C

Prevalence of Bicuspid Aortic Valve in Turner Syndrome Patients Receiving Cardiac MRI and CT: A Meta-Analysis

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Congenital Heart Disease 2022年第2期17卷 129-140页

作者： Pengzhu Li Martina Bacova Robert Dalla-Pozza nikolaus Alexander Haas felix Sebastian Oberhoffer Department of Pediatric Cardiology and Intensive Care Medical Hospital of the University of MunichLudwig Maximilians University MunichMunichGermany

Turner syndrome(TS)is a rare disorder affecting 25–50 in 100000 female *** aortic valve(BAV)is assumed to be the most common congenital heart defect(CHD)in *** literature,reported BAV prevalence in TS ranges between 14%and 34%.The specific BAV prevalence in TS is still *** aim of this study was to give a more precise estimation of BAV prevalence in TS by conducting a meta-analysis of TS-studies,which detected BAV by either cardiac magnetic resonance imaging(MRI)or cardiac computed tomography(CT).We searched PubMed,Cochrane Library,and Web of Science databases to collect observational studies including the prevalence of BAV identified by cardiac MRI or cardiac CT in TS patients up to June 4th,*** screening for inclusion,data extraction,and quality assessment by two independent reviewers,the meta-analysis was performed with R 4.1.1 *** are shown as proportion and weighted mean difference with 95%confidence intervals(95%CI).In total,11 studies involving 1177 patients were *** data showed that the prevalence of BAV in TS patients was 23.7%(95%CI:21.3%to 26.1%).No high heterogeneity was found between the included *** current meta-analysis reveals that BAVcan be detected in 23.7%of TS patients receiving cardiac MRI or cardiac ***,BAV can be considered as the most common CHD in *** to TTE,cardiac MRI and cardiac CT might represent superior imaging modalities in BAV assessment of adult TS patients.

关键词： Turner syndrome bicuspid aortic valve magnetic resonance imaging(MRI) tomography X-ray computed(CT)

Coincidence of active Crohn's disease and florid endometriosis in the terminal ileum: A case report

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World Journal of Gastroenterology 2013年第27期19卷 4413-4417页

作者： Elke Kaemmerer Maren Westerkamp Reinhard Kasperk Gerhard Niepmann Axel Scherer nikolaus Gassler Department of Pediatrics and Institute of Pathology RWTH Aachen University Department of Surgery Luisenhospital Aachen Department of Radiology Luisenhospital Aachen Institute of Pathology RWTH Aachen University

Crohn's disease (CD), a variant of chronic inflammatory bowel disease, frequently affects the terminal ileum and coecal region. The clinical symptoms are often subtle and depend on the inflammatory activity of disease. In women of child-bearing age, florid intestinal endometriosis can simulate CD. Moreover, current pathophysiological concepts include intestinal endometriosis as a putative founder lesion for consecutive CD establishment. The report summarizes clinical and histomorphological data of a 35-year-old woman with the rare coincidence of florid intestinal endometriosis and CD both affecting the terminal ileum. The patient was suffering over 10 years from strong abdominal disorders including constipation, diarrhea, weight loss, and diffuse abdominal pain. In magnetic resonance imaging-Sellink, strong inflammation and intestinal obstruction of the terminal ileum were found. The laparoscopy revealed further evidence for existence of an inflammatory disease like CD, but brownish spots on the peritoneum were found indicative for endometriosis. Surgical resection of the terminal ileum and the coecal segment was performed followed by histopathological investigations. In transmural sections of the terminal ileum, histomorphological features of florid endometriosis intermingled with florid CD was found. The diagnostic findings were substantiated with a panel of immunohistological stainings. In conclusion, the findings demonstrate that florid endometriosis persists in florid CD lesions and the putative link between intestinal endometriosis and CD is more complex than previously assumed.

关键词： Crohn’s diseases Intestinal endometriosis Pathogenesis

TBSSvis:Visual analytics for Temporal Blind Source Separation

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Visual Informatics 2022年第4期6卷 51-66页

作者： nikolaus Piccolotto Markus Bögl Theresia Gschwandtner Christoph Muehlmann Klaus Nordhausen Peter filzmoser Silvia Miksch TU Wien Institute of Visual Computing&Human-Centered TechnologyFavoritenstrasse 9–11A-1040 ViennaAustria Erste Group Bank AG Am Belvedere 1A-1100 ViennaAustria TU Wien Institute of Statistics and Mathematical Methods in EconomicsWiedner Hauptstrasse 8–10A-1040 ViennaAustria University of Jyväskylä Department of Mathematics and StatisticsFI40014 JyväskyläFinland

Temporal Blind Source Separation(TBSS)is used to obtain the true underlying processes from noisy temporal multivariate data,such as *** has similarities to Principal Component Analysis(PCA)as it separates the input data into univariate components and is applicable to suitable datasets from various domains,such as medicine,finance,or civil *** TBSS’s broad applicability,the involved tasks are not well supported in current tools,which offer only text-based interactions and single static *** are limited in analyzing and comparing obtained results,which consist of diverse data such as matrices and sets of time ***,parameter settings have a big impact on separation performance,but as a consequence of improper tooling,analysts currently do not consider the whole parameter *** propose to solve these problems by applying visual analytics(VA)*** primary contribution is a design study for TBSS,which so far has not been explored by the visualization *** developed a task abstraction and visualization design in a user-centered design ***-specific assembling of well-established visualization techniques and algorithms to gain insights in the TBSS processes is our secondary *** present TBSSvis,an interactive web-based VA prototype,which we evaluated extensively in two interviews with five TBSS *** and observations from these interviews show that TBSSvis supports the actual workflow and combination of interactive visualizations that facilitate the tasks involved in analyzing TBSS results.

关键词： Blind source separation Ensemble visualization Visual analytics Parameter space exploration

PEComa of the colon resistant to sirolimus but responsive to doxorubicin/ifosfamide

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World Journal of Gastroenterology 2013年第10期19卷 1657-1660页

作者： Wolfgang Scheppach nikolaus Reissmann Thomas Sprinz Ekkehard Schippers Bjoern Schoettker Justus G Mueller Department of Medicine Juliusspital WuerzburgD-97070 WuerzburgGermany Department of Surgery Juliusspital WuerzburgD-97070 WuerzburgGermany Onkologische Schwerpunktpraxis D-97070 WuerzburgGermany Department of Pathology University of Wuerzburg97070 WürzburgGermany

A 23-year-old male presented with a three-week-history of crampy abdominal pain and *** revealed a friable mass filling the entire lumen of the cecum;histologically,it was classified as perivascular epithelioid cell tumor(PEComa).An magnetic resonance imaging scan showed,in addition to the primary tumor,two large mesenteric lymph node metastases and four metastatic lesions in the *** patient underwent right hemicolectomy and left hemihepatectomy combined with wedge resections of metastases in the right lobe of the liver,the resection status was ***,the patient was treated with *** 4 mo of adjuvant mammalian target of rapamycin inhibition he developed two new liver metastases and a local pelvic *** visible tumor formations were again excised surgically,this time the resection status was R2 with regard to the pelvic *** patient was treated with 12 cycles of doxorubicin and ifosfamide under which the disease was stable for 9 *** clinical course was then determined by rapid tumor growth in the pelvic *** line chemotherapy with gemcitabine and docetaxel was ineffective,and the patient died 23 mo after the onset of *** case report adds evidence that,in malignant PEComa,the mainstay of treatment is curative *** not achievable,the effects of adjuvant or palliative chemotherapy are unpredictable.

关键词： Perivascular epithelioid cell tumor Colon Liver metastases Mammalian target of rapamycin inhibitor Sirolimus Chemotherapy Doxorubicin Ifosfamide

Calcium isotope fractionation and its controlling factors over authigenic carbonates in the cold seeps of the northern South China Sea

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Chinese Science Bulletin 2012年第11期57卷 1325-1332页

作者： WANG ShuHong YAN Wen MAGALHAES H Vitor CHEN Zhong PINHEIRO M Luis GUSSONE nikolaus CAS Key Laboratory of Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Centre for Environmental and Marine Studies(CESAM)and Geosciences Department University of AveiroAveiro 3810-193Portugal Institut fiir Mineralogie Universitgit MiinsterMiinster 48149Germany

In this study, we analyzed stable calcium isotope results of authigenic carbonates from two cold seep areas of the Dongsha area and the Baiyun Sag in the northern South China Sea. The stable isotopes of carbon and oxygen as well as the mineral composition of authigenic carbonates were used to investigate control calcium isotope fractionation. The δ44/40Ca ratios of the southwestern Dongsha area samples ranged from 1.21‰ to 1.52‰ and the ratio of the Baiyun Sag sample was 1.55‰ of the SRM915a isotope standard. X-ray diffraction analysis showed that the carbonate samples consisted of dolomite, calcite and aragonite, with small amounts of high-Mg calcite and siderite. The δ13C values of the carbonates of the southwestern Dongsha area varied between δ49.21‰ and δ16.86‰ of the Vienna PeeDee Belemnite (VPDB) standard and the δ18O values ranged from 2.25‰ to 3.72‰ VPDB. The δ13C value of the Baiyun Sag sample was 2.36‰ VPDB and the δ18O value was 0.44‰ VPDB. The δ13C values of the carbonates of the southwestern Dongsha area revealed there is methane seeping into this area, with a variable contribution of methane-derived carbon. The sampled carbonates covered a range of δ13C values suggesting a dominant methane carbon source for the light samples and mixtures of δ13C values for the heavier samples, with possibly an organic or seawater carbon source. The δ18O values indicated that there is enrichment in 18O, which is related to the larger oxygen isotope fractionation in dolomite compared to calcite. The results of the Baiyun Sag sample exhibited normal seawater carbon and oxygen isotopic values, indicating that this sample is not related to methane seepage but instead to precipitation from seawater. The relatively high δ44/40Ca values indicated either precipitation at comparatively high rates in pore-water regimes with high alkalinity, or precipitation from an evolved heavy fluid with high degrees of Ca consumption (Raleigh type fractionation). The dolomite samples from the

关键词：氧同位素分馏碳酸盐岩控制因素南海北部冷泉中国碳稳定同位素 X射线衍射分析

Paneth cells in intestinal physiology and pathophysiology

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World Journal of Gastrointestinal Pathophysiology 2017年第4期8卷 150-160页

作者： nikolaus Gassler Institute of Pathology RWTH Aachen University38114 BraunschweigGermany

Small intestinal mucosa is characterised by villus forming connective tissues with highly specialised surface lining epithelial cells essentially contributing to the establishment of the intestinal *** order to perform these diverse functions,spatially distinct compartments of epithelial differentiation are found along the crypt-villus axis,including Paneth cells as a highly specialised cell *** cells locate in crypts and assist undifferentiated columnar cells,called crypt base columnar cells,and rapidly amplifying cells in the regeneration of absorptive and secretory cell *** is some evidence that Paneth cells are involved in the configuration and function of the stem cell zone as well as intestinal morphogenesis and crypt ***,the flow of Paneth cells to crypt bottoms requires strong Wnt signalling guided by EphB3 and partially antagonised by *** addition,mature Paneth cells are essential for the production and secretion of antimicrobial peptides including α-defensins/*** antimicrobials are physiologically involved in shaping the composition of the *** autophagy related 16-like 1(ATG16L1) is a genetic risk factor and is involved in the exocytosis pathway of Paneth cells as well as a linker molecule to PPAR signalling and lipid *** is evidence that injuries of Paneth cells are involved in the etiopathogenesis of different intestinal *** review provides an overview of the key points of Paneth cell activities in intestinal physiology and pathophysiology.

关键词： Antimicrobial peptide Paneth cell Crohn’s disease Microbiome Small intestine

Transcatheter mitral valve repair is feasible and effective in oldest-old patients:results from real-world cohort

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Journal of Geriatric Cardiology 2022年第10期19卷 761-767页

作者： Mhd Nawar Alachkar Annemarie Kirschfink Anas Alnaimi Jörg Schröder felix Vogt nikolaus Marx Ertunc Altiok Mohammad Almalla Department of Cardiology and Angiology REGIOMED Hospital CoburgCoburgGermany Department of Cardiology Angiology and Intensive CareMedical Clinic ⅠUniversity Hospital RWTH AachenAachenGermany

OBJECTIVE To evaluate the safety and efficacy of transcatheter mitral valve repair(TMVR)using MitraClip^(■)devices in oldest-old patients compared to younger *** The study retrospectively included 340 consecutive patients who underwent *** were classified according to age into the oldest-old(age≥85 years)patient group or the younger(agef the procedure,intrahospital outcomes and one-year outcomes were *** Oldest-old patients represented 15.9%(n=54)of all *** success was comparable for the oldest-old patient group and the younger patient group(92.6%vs.95.8%,P=0.30),and there was no difference in intrahospital mortality(9.2%vs.4.2%,P=0.12).At a one-year follow-up(interquartile range:6–16 months),there was no significant difference in rehospitalization due to decompensated heart failure(25.5%vs.34.3%,P=0.24)or all-cause mortality(29.8%vs.22.2%,P=0.26)between the oldest-old patient group and the younger patient *** patients with available echocardiographic follow-up,severity of residual mitral regurgitation was also comparable between the oldest-old patient group and the younger patient *** TMVR seems to be feasible and effective in oldest-old patients and should be considered for oldest-old patients presenting with symptomatic severe mitral regurgitation and high surgical risk.

关键词： patients mitral mortality