Molecular classification of colorectal carcinomas:The genotype-to-phenotype relation
Molecular classification of colorectal carcinomas:The genotype-to-phenotype relation作者机构：Institute of Pathology RWTH Aachen University 52074 Aachen Germany
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第45期
页 面：8163-8167页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Carcinogenesis Colorectal cancer Molecular pathology
摘 要：Colorectal carcinomas(CRCs)are frequently found in industrialized countries and lead to a high incidence of malignancy-related *** by histomorphological features,CRCs and their pre-invasive lesions are quite *** underlying molecular mechanisms include genomic instability,genomic mutation of tumor suppressor genes or oncogenes,epigenetic changes,and the microRNA *** molecular mechanisms are guided by repeated clonal *** genotype-to-phenotype relation is assumed to be the great challenge of cancer research and the development of effective targeted *** present a strong genotype-to-phenotype relation is characterized only for a minority of ***,the molecular characterization of CRCs is essential to interpret histological patterns and to identify prognostic groups as well as patients for targeted therapy.
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