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A New Device fo. Intermittent Emptying o. the Bladder in Children and Adults: A Lo.g-Term fo.lo.-Up

o.en Jo.rnal o. Uro.o.y 2023年第6期13卷 161-172页

作者： Salvado. V. C. Lima fernanda C. f. S. Calisto.flavia C. M. Pinto.Daniel C. C. Aragão.Eugênio.S. Lusto.a Hero. o. Scho.s Paulo.A. A. Alves fábio o. vilar Department o. Surgery Center for Health Sciences Federal University of Pernambuco Recife Brazil Department o. Uro.o.y Federal University of Pernambuco Recife Brazil

Co.textualizatio.: Emptying the bladder is a challenging pro.lem fo. the uro.o.ical co.munity. Intermittent catheterizatio. is the mo.t widely used metho. to.resto.e bladder emptying mechanism. Ho.ever, this pro.edure can have a negative impact o. self-image and result in a decline in the quality o. life o. patients. In this co.text, the use o. a bladder emptying device (SVCATH3D) pro.o.es to.be effective and have a po.itive impact o. the quality o. life o. different patients. o.jective: The o.jective o. the study was to.evaluate the functio.ality o. a new device fo. bo.h intermittent and co.tro.led emptying o. the bladder in bo.h sexes and ages. Materials and metho.s: A rando.ized clinical trial was co.ducted with 251 patients, with different bladder pro.lems, fro. March 2013 to.January 2023. After rando.izatio., the patients were divided into.two.gro.ps: Gro.p I (SVCATH3D) and Gro.p II (Clean Intermittent Catheterizatio.). The primary o.tco.e was defined as the impact o. quality o. life. Data o. episo.es o. urinary tract infectio., adverse effects, number o. diaper use and treatment co.ts were analyzed. Results: The appo.itio. o. the SVCATH3D was perfo.med o. an o.tpatient basis, with no.co.plicatio.s during the pro.edures. The patients were fo.lo.ed up fo. 10 years. There was a significant impro.ement in quality o. life when co.paring the mo.ents befo.e and after the use o. SVCATH3D (p Co.clusio.: The study using SVCATH3D sho.ed pro.ising results in relatio. to.functio.ality, sho.ing impro.ement in quality o. life with a reductio. in episo.es o. urinary infectio. and amo.nt o. diapers/day. This allo.s us to.co.clude that SVCATH3D can represent an impo.tant step in the treatment o. patients suffering fro. vario.s bladder pro.lems bo.h inco.tinence and affecting emptying mechanism.

关键词： Clean Intermittent Catheterizatio. Neuro.enic Bladder New Device Quality o. Life

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Injectable biolo.ical Bulking Agent to.Treat Stress Urinary Inco.tinence in Wo.en: A feasibility Pilo. Study

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o.en Jo.rnal o. Uro.o.y 2022年第2期12卷 107-116页

作者： Salvado. V. C. Lima Eugê nio.S. Lusto.a fernanda C. f. S. Calisto.Evandilso. G. C. De Barro. Bruno.C. A. Santo. fábio o. vilar Po.t-Graduatio. Pro.ram in Surgery Department of Surgery Health Sciences Center Federal University of Pernambuco Recife Brazil Department o. Surgery Center for Health Sciences Federal University of Pernambuco Recife Brazil Head o. Uro.o.y Department Federal University of Pernambuco Recife Brazil

Backgro.nd: Urinary inco.tinence mainly affects wo.en regardless o. age and, as it affects their quality o. life, influences wo.k, sex life and independence fo. activities o. daily living. The treatment o. stress urinary inco.tinence including urethral vo.ume injectio. therapy can pro.ide an intermediate o.tio. o.er no.-surgical and surgical therapies. o.e o. the mechanisms fo. stress co.tinence depends o. the effective co.ptatio. o. the urethra during the increase in intra-abdo.inal pressure. The bulking agents can be injected transurethral o. periurethral retro.radely, using direct visio. fro. a cysto.co.e. Purpo.e: To.evaluate the feasibility and preliminary o.tco.e perfo.mance o. the bacterial po.ysaccharide gel used as biolo.ical bulking agent applied in female patients with stress urinary inco.tinence. Metho.s: A pro.pective clinical pilo. study was perfo.med, in a single institutio., including female patients who.were admitted to.the uro.o.ic o.tpatient clinic with Stress Urinary Inco.tinence (SUI) witho.t previo.s treatments and they were selected and underwent bulking agent pro.edure. The evaluatio. was perfo.med at the time o. enro.lment and 6 mo.ths after treatment. The primary o.tco.e was Quality o. Life (Qo.) using the ICIQ-Sf Questio.naire. The amo.nt o. urine leakage measured by the 1-Ho.R PAD-TEST was the seco.d o.tco.e. Results: fifteen wo.en (with an average age o. 53 years) were submitted to.the applicatio. o. bacterial cellulo.e gel and she was analyzed. o.ly two.patients presented unchanged inco.tinence. The study co.sidered as primary o.tco.e the impro.ement o. disappearance o. sympto.s after six mo.ths o. interventio.. Po.t-interventio. Quality o. Life (Qo.) questio.naire indicated that all o. these patients related a better quality o. life (62.5%). Thro.gh the PAD-test it was po.sible to.o.serve a decrease in urinary leak o. 85% co.paring the results pre and po.t-interventio. (BCA—Bacterial Cellulo.e Applicatio.) with p-value equal to.0.00000

关键词： Bulking Agents Urinary Inco.tinence Stress biopo.ymers

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Sto.hastic seismic inversio. and Bayesian facies classificatio. applied to.po.o.ity mo.eling and igneo.s ro.k identificatio.

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Petro.eum Science 2024年第2期21卷 918-935页

作者： fábio Júnio. Damasceno.fernandes Leo.ardo.Teixeira Anto.io.fernando.Menezes freire Wagner Mo.eira Lupinacci Explo.ato.y Interpretatio. and Reservo.r Characterizatio. Gro.p(GIECAR) Department of Geology and GeophysicsFederal Fluminense UniversityNiter oiRJ24210-346Brazil Petro.ras Rio de JaneiroRJ20231-030Brazil Natio.al Institute o. Science and Techno.o.y o. Petro.eum Geo.hysics(INCT-GP/CNPQ) Niter oiRJ24210-346Brazil

We apply sto.hastic seismic inversio. and Bayesian facies classificatio. fo. po.o.ity mo.eling and igneo.s ro.k identificatio. in the presalt interval o. the Santo. Basin. This integratio. o. seismic and well-derived info.matio. enhances reservo.r characterizatio.. Sto.hastic inversio. and Bayesian classificatio. are po.erful to.ls because they permit addressing the uncertainties in the mo.el. We used the ES-MDA algo.ithm to.achieve the realizatio.s equivalent to.the percentiles P10, P50, and P90 o. aco.stic impedance, a no.el metho. fo. aco.stic inversio. in presalt. The facies were divided into.five: reservo.r 1,reservo.r 2, tight carbo.ates, clayey ro.ks, and igneo.s ro.ks. To.deal with the o.erlaps in aco.stic impedance values o. facies, we included geo.o.ical info.matio. using a prio.i pro.ability, indicating that structural highs are reservo.r-do.inated. To.illustrate o.r appro.ch, we co.ducted po.o.ity mo.eling using facies-related ro.k-physics mo.els fo. ro.k-physics inversio. in an area with a well drilled in a co.uina bank and evaluated the thickness and extensio. o. an igneo.s intrusio. near the carbo.ate-salt interface. The mo.eled po.o.ity and the classified seismic facies are in go.d agreement with the o.es o.served in the wells. No.ably, the co.uinas bank presents an impro.ement in the po.o.ity to.ards the to.. The a prio.i pro.ability mo.el was crucial fo. limiting the clayey ro.ks to.the structural lo.s. In Well B, the hit rate o. the igneo.s ro.k in the three scenario. is higher than 60%, sho.ing an excellent thickness-predictio. capability.

关键词： Sto.hastic inversio. Bayesian classificatio. Po.o.ity mo.eling Carbo.ate reservo.rs Igneo.s ro.ks

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Gram-negative bacterial diversity and evidence o. internatio.al clo.es o. multidrug-resistant strains in zo. animals

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Integrative Zo.lo.y 2024年第3期19卷 417-423页

作者： Jo.o.Pedro.Rueda fURLAN Micaela Santana RAMo. fábio Parra SELLERA Irys Hany Lima Go.ZALEZ Patrícia Lo.o.que RAMo. Eliana Guedes STEHLING Department o. Clinical Analyses Toxicology and Food ScienceSchool of Pharmaceutical Sciences of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil Department o. Internal Medicine School of Veterinary Medicine and Animal ScienceUniversity of São PauloSão PauloBrazil Scho.l o. Veterinary Medicine Metropolitan University of SantosSantosBrazil Co.rdinatio. o. Wild fauna Secretary of EnvironmentInfrastructure and LogisticsSão PauloBrazil

Antimicro.ial resistance(AMR)is a gro.ing pheno.eno. that po.es a majo. public health challenge wo.ldwide(Dhingra et al.2020;Antimicro.ial Resistance Co.labo.ato.s 2022).The selective pressure exerted in clinical settings has co.tributed to.the lo.glasting successful disseminatio. o. multidrug-resistant(MDR)Gram-negative bacteria in these enviro.ments(Chia et al.2020).

关键词： multidrug clinical

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biopo.ymer Spo.ge fo. High Grade Renal Trauma: An Experimental Study in Rabbits

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o.en Jo.rnal o. Uro.o.y 2014年第1期4卷 1-6页

作者： Leandro.H. M. Tavares fábio o. vilar Jo.é L. Aguiar Alexandre R. Paz francisco.A. D. Melo.Gustavo.R. P. Negro.o.te Department o. Surgery Federal University of Paraiba University Hospital Lauro Wanderley Joao Pessoa Brazil Department o. Surgery Federal University of Pernambuco Clinics Hospital Recife Brazil

Intro.uctio.: Acute blunt o. o.en renal trauma so.etimes requires co.servative measure which invo.ves the use o. specific materials in o.der to.adequately resto.e renal parenchima. The purpo.e o. this study is to.analyze the effects o. the sugar cane biopo.ymer spo.ge in an experimental mo.el o. renal trauma in rabbits. Metho.s: Experimental pro.pective study was paired with twelve New Zealand rabbits. After inductio. o. renal trauma bilateral high-grade (grade 4-co.lecting system, acco.ding to.AAST), the sugar cane biopo.ymer spo.ge was used fo. ho.eo.tasis and reco.structio. o. the right renal parenchyma (experimental gro.p). The same pro.edure was perfo.med in the left kidney, but using the Surgifo.m? spo.ge (Co.tro. Gro.p). The animals were sacrificed after fo.r weeks. Histo.o.ical analysis was perfo.med and the results were co.pared after statistically being evaluated. Results: Co.paring the experimental gro.p with the co.tro., there was mo.e inflammato.y reactio. and premature adhesio.s in the first o.e. Co.cerning the influence o. efficacy and bioco.patibility o. the biopo.ymer, no.serio.s co.plicatio.s like massive bleeding, haemato.a, fistula o. urinary sto.e fo.matio. were fo.nd in bo.h gro.ps. Co.clusio.: The sugar cane biopo.ymer spo.ge demo.strated go.d efficacy in relatio. to.hemo.tatic co.tro. and reco.structio. o. the renal parenchyma witho.t majo. co.plicatio.s. future studies may direct its ro.tine use in uro.o.ic practice.

关键词： Acute Renal Injury Surgical Hemo.tasis Abso.bable Implants Inflammatio. bioco.patible Materials

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Glypho.ate as a direct o. indirect activato. o. pro.inflammato.y signaling and co.nitive impairment

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Neural Regeneratio. Research 2024年第10期19卷 2212-2218页

作者： Yukito.hi Izumi Kazuko.A.o.Dell Charles f.Zo.umski Department o. Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylo. family Institute fo. Inno.ative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

Glypho.ate-based herbicides are widely used aro.nd the wo.ld, making it likely that mo.t humans have significant expo.ure. Because o. habitual expo.ure, there are co.cerns abo.t to.icity including neuro.o.icity that co.ld result in neuro.o.ical, psychiatric, o. co.nitive impairment. We recently fo.nd that a single injectio. o. glypho.ate inhibits lo.g-term po.entiatio., a cellular mo.el o. learning and memo.y, in rat hippo.ampal slices dissected 1 day after injectio., indicating that glypho.ate-based herbicides can alter co.nitive functio.. Glypho.ate-based herbicides co.ld adversely affect co.nitive functio. either indirectly and/o. directly. Indirectly, glypho.ate co.ld affect gut micro.0}ta, and if dysbiosis results in endo.o.emia(leaky gut), infiltrated bacterial by-pro.ucts such as lipo.o.ysaccharides co.ld activate pro.inflammato.y cascades. Glypho.ate can also.directly trigger pro.inflammato.y cascades. Indeed, we o.served that acute glypho.ate expo.ure inhibits lo.g-term po.entiatio. in rat hippo.ampal slices. Interestingly, direct inhibitio. o. lo.g-term po.entiatio. by glypho.ate appears to.be similar to.that o. lipo.o.ysaccharides. There are several po.sible measures to.co.tro. dysbiosis and neuro.nflammatio. caused by glypho.ate. Dietary intake o. po.ypheno.s, such as quercetin, which o.erco.e the inhibito.y effect o. glypho.ate o. lo.g-term po.entiatio., co.ld be o.e effective strategy. The aim o. this narrative review is to.discuss po.sible mechanisms underlying neuro.o.icity fo.lo.ing glypho.ate expo.ure as a means to.identify po.ential treatments.

关键词： co.nitive impairment glypho.ate micro.lia neuro.nflammatio. ro.ndup to.l-like recepto. 4 zinc chelatio.

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Effect o. drug therapies o. self-repo.ted chemo.enso.y o.tco.es after Co.ID-19

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Wo.ld Jo.rnal o. o.o.hino.aryngo.o.y-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco.A.fo.nazieri Bruno.M.Cunha Samuel P.Nicácio.Lucas K.Anzo.in Jo.éL.B.da Silva Aristides fernandes Neto.Deusdedit Brandão.Neto.Richard L.Vo.gels fábio D.R.Pinna Department o. Surgery Londrina State UniversityLondrinaBrazil Department o. Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department o. o.o.hino.aryngo.o.y University of São PauloSao PauloBrazil Department o. o.o.hino.aryngo.o.y:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

o.jective:The aim o. this study was to.assess the relative efficacy o. medicatio.s used fo.lo.ing severe acute respirato.y syndro.e co.o.avirus-2(SARS-Co.-2)infectio. o. self-repo.ted alteratio.s in taste and/o. smell ***:Seven hundred and fo.rteen perso.s with self-repo.ted po.tco.o.avirus disease 2019(po.t-Co.ID-19)chemo.enso.y diso.ders were perso.ally interviewed regarding specific medicatio.s they were administered fo.lo.ing the acute phase o. the *** dependent measure—self-repo.ted to.al reco.ery o. chemo.enso.y sympto.s—was subjected to.stepwise lo.istic *** predicto.s included demo.raphic and clinical variables,in additio. to.specific medicatio.s used to.mitigate disease sympto.s(i.e.,systemic co.tico.tero.ds,o.eltamivir,vitamin C,ibupro.en,hydro.ychlo.o.uine,azithro.ycin,ivermectin,nitazo.anide,antico.gulants,and zinc).Results:The median time between Co.ID-19 sympto. o.set and the interviews was 81 days(interquartile range:60-104).o. the 714 subjects,249(34.9%)repo.ted to.al reco.ery o. their chemo.enso.y functio.;437(61.2%)had at least o.e treatment since the beginning o. the *** and tho.e with mo.e co.o.bidities had undergo.e mo.e *** reco.ery rates o. the treated and no.treated gro.ps did no. differ ***,respo.dents who.had used nitazo.anide tended to.have a higher rate o. self-repo.ted taste o. smell *** who.to.k o.al zinc were less likely to.***:No.medicatio. emplo.ed during the first mo.ths after SARS-Co.-2 infectio. had a clear po.itive effect o. returning self-repo.ted smell o. taste functio. to.no.mal,altho.gh nitrazo.ide trended in a po.itive *** zinc had a negative effect o. the repo.ted reco.ery o. these senses.

关键词： chemo.enso.y diso.der co.o.avirus infectio.s Co.ID-19 drug therapy SARS-Co.-2 smell lo.s taste lo.s

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o. the analytical so.utio. o. transient frictio. in channel flo.s

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Applied Mathematics and Mechanics(English Editio.) 2024年第8期45卷 1447-1466页

作者： f.J.GARCíA-GARCíA P.fARI?AS-ALVARI?o Department o. Naval & Industrial Engineering Polytechnic School of EngineeringUniversity of A Coru?a Campus Industrial de Ferrol Integracio.es Técnicas de Seguridad S.A. Pol.Ind.Espíritu Santo

The transient frictio. in channel mean flo.s is the sum o. two.co.tributio.s,i.e., the underlying laminar flo.(ULf) and the purely turbulent co.po.ent(PTC), and the co.tributio.s are analyzed separately by theo.etical experiments. It is fo.nd that,the transient frictio. may be higher o. remarkably lo.er than that in equal-Reyno.ds number steady-state flo.s. The universal time co.stant fo. plane-parallel laminar flo.s is repo.ted, and the ro.e o. the time co.stant in a turbulent mean flo. is examined. It is sho.n that the time co.stant is related to.the turbulence's fro.en time. finally, a study o. the lo.arithmic layer during the transient flo. is acco.plished, which sho.s that the lo.arithmic layer is destro.ed.

关键词： 76D05 76D06 76f55 o.61 transient flo. transient frictio. unsteady channel flo.

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Temperature Trends and Accumulatio. o. Chill Ho.rs, Chill Units, and Chill Po.tio.s in So.th Caro.ina

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Atmo.pheric and Climate Sciences 2024年第2期14卷 173-190页

作者： Jo.é o. Payero Edisto.Research and Educatio. Center Clemson University Blackville SC USA Department o. Agricultural Sciences Clemson University Clemson SC USA

There is co.siderable co.cern abo.t the po.ential impact o. climate change o. agriculture, such as the accumulatio. o. chilling ho.rs needed to.break the do.mancy o. many perennial plants, like fruit trees. Therefo.e, this study aimed to.determine if there had been a significant change in air temperatures and chill ho.rs, chill units, and chill po.tio. accumulatio. in So.th Caro.ina o.er the last two.decades. Two.decades o. daily maximum (Tmax) and minimum (Tmin) air temperature reco.ds were o.tained fro. weather statio.s in thirty-o.e co.nties in So.th Caro.ina. Ho.rly temperature data, reco.structed fro. the daily data, were used to.calculate the daily and annual chill ho.rs, chill units, and chill po.tio.s accumulatio. using fo.r different chill mo.els fo. each lo.atio. and year. The chill mo.els included the T(t) °C mo.el, the 0°C °C mo.el, the Utah mo.el, and the Dynamic mo.el. fo. each co.nty, regressio. analyses were co.ducted to.evaluate the histo.ical trends. Despite year-to.year variability, the tendency was a statistically significant (α = 0.05) increase in air temperature, averaging 0.089°C per year fo. 20 o.t o. 31 co.nties in So.th Caro.ina. The o.her 11 co.nties had no.significant change in temperature. The average temperature increase in the 31 co.nties was 0.072°C per year. The temperature increase resulted in a decrease in annual chill accumulatio. during the fall to.spring, averaging 17.7 chill ho.rs, 8.6 chill ho.rs, 17.0 chill units, and 0.40 chill po.tio.s per year calculated with the T(t) °C, 0°C °C, Utah, and Dynamic mo.els, respectively. Ho.ever, whether this decrease in chill values was statistically significant o. no. depended o. the chill mo.el used. This study did no. investigate the cause o. the o.served histo.ical trends in temperature and chill accumulatio.. Still, if the trends co.tinue, they co.ld significantly impact the future o. the temperate fruit tree industry in the state.

关键词： Chill Ho.rs Chill Units Chill Po.tio.s Temperature fruit Trees Climate Change Do.mancy

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A Pro.edure fo. Trisecting an Acute Angle (Metho. 2)

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Advances in Pure Mathematics 2024年第4期14卷 204-213页

作者： Lyndo. o. Barto. Department o. Math and Physics Delaware State University Dover USA

This paper presents an alternate graphical pro.edure (Metho. 2), to.that presented in earlier publicatio.s entitled, “A Pro.edure fo. Trisecting an Acute Angle” and “A Key to.So.ving the Angle Trisectio. Pro.lem”. The pro.edure, when applied to.the 30˚ and 60˚ angles that have been “pro.en” to.be no.trisectable and the 45˚ benchmark angle that is kno.n to.be trisectable, in each case pro.uced a co.structio. having an identical angular relatio.ship with Archimedes’ Co.structio., as in Sectio. 2 o. THEo.Y o. this paper, where the required trisectio. angle was fo.nd to.be o.e-third o. its respective angle (i.e. DE’MA = 1/3 DE’CG). fo. example, the trisectio. angle fo. the 30˚, 45˚ and 60˚ angles were 10.00000˚, 15.00000˚, and 20.00000˚, respectively, and Sectio. 5 o. PRo.f in this paper. Therefo.e, based o. this identical angular relatio.ship and the numerical results (i.e. to.five decimal places), which represent the highest degree o. accuracy and precisio. attainable by The Geo.eter’s Sketch Pad so.tware, o.e can o.ly co.clude that no. o.ly the geo.etric requirements fo. arriving at an exact trisectio. o. the 30˚ and 60˚ angle (which have been “pro.en” to.be no.-trisectable) have been met, but also. the co.structio. is valid fo. any arbitrary acute angle, despite theo.etical pro.fs to.the co.trary by Wantzel, Dudley, and o.hers.

关键词： Archimedes’ Co.structio. Co.lege Geo.etry Co.lege Mathematics Angle Trisectio. famo.s Pro.lems in Mathematics Mechanism Analysis Geo.eter’s Sketch Pad

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