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Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination

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Neural Regeneration Research 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita Singh Matthew c.Banton School of Traditional chinese Medicine Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Faculty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea ***,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann ***,using Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were *** observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block in macrophage clearance in the late stage of *** together,our findings indicate that Runx2 is a key regulator of Schwann cell plasticity,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury.

关键词： macrophage clearance migration peripheral nerve injury regeneration re-myelination Runx2 Schwann cells

Semi-analytical investigation of heat transfer in a porous conv.c.ive radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAvITHRA B.J.GIREESHA M.L.KEERTHI Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： conv.c.ion radiation moving longitudinal fin Adomian decomposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic field

SUv39H1-driven NFATc1 methylation is essential for the c-cbl-mediated degradation of NFATc1 in an osteoclast lineage

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Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene c.Yi Nacksung Kime Yang-Sook chun Department of Biomedical Sciences Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Ischemic/Hypoxic Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmacology Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associated with the progression of ***,the specific epigenetic modifiers are incompletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUv39H1)in osteoclast formation.

关键词： osteoclast remodeling incomplete

Peculiarities of Ethylene Polymerization Reactions with Bis(imino)pyridyl complexes of cocl_(2) and Fecl_(2)

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chinese Journal of Polymer Science 2024年第4期42卷 492-500页

作者： Laura A.Rishina Yury v.Kissin Svetlana S.Lalayan Artem A.Antonov vadim G.Krasheninnikov Alexander A.Gulin N.N.Semenov Federal Research center for chemical Physics Russian Academy of Sciences4 Kosygin St.Moscow119991Russia Department of chemistry and chemical Biology RutgersThe State University of New Jersey123 Bevier Rd.PiscatawayNJ08854USA Boreskov Institute of catalysis Russian Academy of Sciences5 Lavrentieva Prosp.Novosibirsk630090Russia

The article describes ethylene polymerization reactions with transition metal catalysts based on complexes of cocl_(2) and Fecl_(2) with an N,N,N-tridentate ligand 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine. The complexes are converted into polymerization catalysts by reacting them either with polymethylalumoxane (MAO) or with a combination of Al(c2H5)2cl and Mg(c4H9)2 at an [Al]:[Mg] ratio of ~3. Both MAO-activated complexes readily polymerize ethylene at 35 ℃ with the formation of linear, low molecular weight polymers with a narrow molecular weight distribution. The same complexes, when activated with the Al(c2H5)2cl-Mg(c4H9)2 combination, form multi-center catalysts and generate polyethylenes with a broad molecular weight distribution.

关键词： Ethylene polymerization Bis(imino)pyridyl complexes of cocl_(2)and Fecl_(2) Molecular-weight distribution Polymer chain structure

Highly Defective Dark TiO_(2) Modified with Pt: Effects of Precursor Nature and Preparation Method on Photocatalytic Properties

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Transactions of Tianjin University 2024年第2期30卷 198-209页

作者： E.D.Fakhrutdinova O.A.Reutova T.A.Bugrova I.Yu.Ovsyuk L.S.Kibis O.A.Stonkus D.B.vasilchenko O.v.vodyankina v.A.Svetlychnyi National Research Tomsk State University TomskRussia 634050 Novosibirsk State University NovosibirskRussia 630090 Boreskov Institute of catalysis NovosibirskRussia 630090 Nikolaev Institute of Inorganic chemistry NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. Both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed cO adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (Me _(4) N) _(2) [Pt _(2) (OH) _(2) (NO _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the TiO _(2) surface to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(c)/TiO_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： Dark(black)TiO_(2) Pulsed laser ablation Platinum reduction method Precursor type Photocatalysis Hydrogen evolution reaction

Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier chirag P.Doshi Shalin c.Desai Petar Bajic Michelle van Kuiken Mark Khemmani Ahmer v.Farooq Larissa Bresler Thomas M.T.Turk Alan J.Wolfe Kristin G.Baldea Loyola University Medical center Department of UrologyMaywoodILUSA Loyola University chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUc)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demographics and non-MetS *** controls had uric acid stone *** EQUc,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** validate our EQUc results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUc reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

用于抵抗扭转采取边缘弹性约束下的单轴压缩下板材极限强度:一种新的综合方法

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 443-459页

作者： v.Piscopo The University of Naples“Parthenope” Department of Science and TechnologyCentro Direzionale Isola C480143 NaplesItaly

The ultimate strength of platings under compression is one of the most important factors to be addressed in the ship *** Rules for ship structural design generally provide explicit strength check criteria against buckling for simply supported and clamped ***,ship platings generally exhibit an intermediate behaviour between the simple support and the clamped conditions,which implies that the torsional stiffness of supporting members should be duly ***,the main aim of this study is the development of new design formulas for the ultimate strength of platings under uniaxial compression,with short and/or long edges elastically restrained against *** this respect,two benchmark studies are *** former is devoted to the development of new equations for the elastic buckling coefficients of platings with edges elastically restrained against torsion,based on the results of the eigenvalue buckling analysis,performed by Ansys Mechanical *** latter investigates the ultimate strength of platings with elastically restrained edges,by systematically varying the plate slenderness ratio and the torsional stiffness of supporting ***,the effectiveness of the new formulation is checked against a wide number of finite element(FE)simulations,to cover the entire design space of ship platings.

关键词： Platings under compression Edges elastically restrained against torsion Torsional stiffness Supporting members Eigenvalue buckling analysis Nonlinear ultimate strength analysis FE simulations

Impact of v.c.ination on the dynamics of cOvID-19:A mathematical study using fractional derivatives

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International Journal of Biomathematics 2024年第2期17卷 201-232页

作者： Shraddha Ramdas Bandekar Mini Ghosh c.Rajivganthi Division of Mathematics School of Advanced Sciences Vellore Institute of TechnologyChennaiIndia

Arrival of a new disease marks a yearlong destruction of human lives and economy in general,and if the disease turns out to be a pandemic the loss is ***-19 is one such pandemic that has claimed millions of lives till *** is a suffering throughout the world due to various factors associated with the pandemic,be it loss of livelihoods because of sudden shutdown of companies and lockdown,or loss of lives due to lack of medical aid and inadequate v.c.ination *** this study,we develop a six-compartmental epidemiological model incorporating *** motivation behind the study is to analyze the significance of higher v.c.ination efficacy and higher rate of population getting v.c.inated in controlling the rise in infectives and thereby the untimely demise of various *** work begins with an ordinary differential equation model followed by stability analysis of the same,after which a fractional-order derivative model of the same is formulated and the existence of uniformly stable solution for the system is *** addition to this,we present the stability of the equilibria in general for the fractional model *** sensitivity analysis of the basic reproduction number along with its correlation with various parameters is *** addition to this,sensitivity of certain state variables in the fractional model with respect to *** orders as well with respect to different infection rate is exhibited in this *** related to lockdown and usage of face shields are incorporated in the entire study,and importance of these is highlighted in the study as *** major takeaway from the study is that mere v.c.ination will not sufice in eradication of the *** v.c.ine efficacy plays a major role along with other intervention included in the *** numerical simulations are carried out in MATLAB software using ode45 and fdel2.

关键词： caputo fractional derivative basic reproduction number stability analysis sensitivityanalysis v.c.ination

Prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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chinese Physics c 2024年第6期48卷 112-117页

作者： R.S.Mukhin A.v.Isaev A.v.Andreev M.L.chelnokov v.I.chepigin H.M.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad B.Sailaubekov T.M.Shneidman E.A.Sokol A.I.Svirikhin M.S.Tezekbayeva M.A.Bychkov A.v.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-Martens Joint Institute for Nuclear Research Dubna141980Russia Dubna State University Dubna141982Russia Institute of Nuclear Physics Almaty050032Kazakhstan L.N.Gumilyov Eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJcLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)Pb(^(48)ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the SFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide