检索结果-南通市图书馆

Hereditary cancer syndromes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2023年第2期14卷 40-68页

作者： evgeny N Imyanitov Ekaterina S Kuligina Anna P Sokolenko evgeny N Suspitsin Grigoriy A Yanus Aglaya G Iyevleva Alexandr O Ivantsov Svetlana N Aleksakhina Department of Tumor Growth Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Clinical Genetics St.-Petersburg Pediatric Medical UniversitySt.-Petersburg 194100Russia

Hereditary cancer syndromes(HCSs)are arguably the most frequent category of Mendelian genetic diseases,as at least 2%of presumably healthy subjects carry highly-penetrant tumor-predisposing pathogenic variants(PVs).Hereditary breast-ovarian cancer and Lynch syndrome make the highest contribution to cancer morbidity;in addition,there are several dozen less frequent types of familial *** development of the majority albeit not all hereditary malignancies involves two-hit mechanism,*** somatic inactivation of the remaining copy of the affected *** studies on cancer families suggested nearly fatal penetrance for the majority of HCS genes;however,population-based investigations and especially large-scale next-generation sequencing data sets demonstrate that the presence of some highly-penetrant PVs is often compatible with healthy *** cancer research initially focused mainly on cancer detection and *** studies identified multiple HCS-specific drug vulnerabilities,which translated into the development of highly efficient therapeutic options.

关键词： Hereditary cancer syndromes Germline pathogenic variants Cancer predisposition Cancer treatment Next-generation sequencing

Evaluation of embankment foundation creep in conditions of deep bedding of roof in permafrost soils

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Cold and Arid Regions 2013年第5期5卷 534-539页

作者： evgeny Ashpiz Lev Khrustalev Department of Track and Track Facilities Moscow State University of Railway Department of Geology Lenynskie goryLomonosow Moscow State University

Railroad operating experience in permafrost conditions has shown that deformations of embankments on thawing foun- dations last for a long time. After an initial period of heat settlement due to permafrost degradation, the determining factor is the plastic flow of seasonal thawed soils of the foundation upper layer under the embankment. This paper provides a method to evaluate these deformations, and calculation examples using data from line sections of the Chum-Labytnangi Railway in northwestern Russia. It also discusses several methods of embankment stabilization, including the use of ver- tical thermosiphons.

关键词： permafrost railway plastic flow embankment stabilization methods thermosiphons

Additive manufacturing of high entropy alloys:A practical review

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第18期77卷 131-162页

作者： Ahmad Ostovari Moghaddam Nataliya A.Shaburova Marina N.Samodurova Amin Abdollahzadeh evgeny A.Trofimov Department of Materials Science.Physical and Chemical Properties of Materials.South Ural State University 76 Lenin AveChelyabinsk454080Russian Federation Department of Metal Forming South Ural State University76 Lenin AveChelyabinsk.454080Russian Federation Department of Materials Science and Engineering Faculty of EngineeringShahid Chamran University ofAhvazAhvazIran

The novel idea of alloying,which is based on the utilization of multiple principal elements in high concentrations,has created a novel class of promising materials called high entropy alloys(HEAs).So far,several HEAs with outstanding properties beyond those of conventional alloys have been discovered,and new superior high-entropy alloys are still expected to be developed in the ***,the fabrication process of HEAs through conventional manufacturing techniques suffers from significant limitations due to the intrinsic requirements of *** manufacturing(AM),on the other hand,has provided new opportunities for fabricating geometrically complex HEAs with the possibility of in situ tailoring of their microstructure *** the growing interest in AM of HEAs during most recent years,this review article aims at providing the state of the art in AM of *** describes the feedstock requirements for laser based AM ***,a comprehensive picture of the current state of nearly all HEAs processed by laser metal deposition(LMD),selective laser melting(SLM)and selective electron beam melting(SEBM)is *** attention is paid to the features of AM derived microstructures along with their outstanding properties and underlying mechanisms for various material processing *** AM of interstitial solute hardening HEAs,HEA matrix composites as well as non-beam based AM of HEAs will also be *** post-AM treatments and the strategies to fabricate defect-free HEAs are ***,a conclusion of current state and future prospects of additive manufacturing of HEAs will be presented.

关键词： High entropy alloys Additive manufacturing Microstructure Mechanical properties

Tunable order in colloids of hard magnetic hexaferrite nanoplatelets

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第2期15卷 898-906页

作者： Artem A.Eliseev Lev A.Trusov evgeny O.Anokhin Andrei P.Chumakov Vladimir V.Korolev Anastasia E.Sleptsova Peter Boesecke Vladimir Ya.Shur Vladimir YaShur Pavel E.Kazin Andrei A.Eliseev Faculty of Chemistry Moscow State UniversityLeninskie Gory lb3Moscow 119991Russia Department of Materials Science MSU-BIT UniversityShenzhen 517182China Faculty of Materials Science Moscow State UniversityLeninskie Gory lb73Moscow 119991Russia European Synchrotron Radiation Facility Avenue des Martyrs 71Grenoble 38043France School of Natural Sciences and Mathematics Ural Federal UniversityLenin Ave 51Ekaterinburg 620000Russia

Structural ordering in the concentrated magnetic colloids containing 50×5 nm hard magnetic disc-like SrFe_(12)O_(19) nanoparticles was investigated by cryogenic scanning electron microscopy,optical microscopy,magnetic measurements,and small-angle X-ray *** was revealed that macroscopically homogeneous magnetic liquid consists of dynamic threads of stacked *** threads align into quasiperiodic arrays with the distances between individual threads of a few *** also can form pseudodomain structures with -90°domain boundaries realized through T-type thread *** effects of magnetic attraction and electrostatic repulsion on the equilibrium interplatelet distance in the threads were *** was demonstrated that this distance can be tuned by the control of the particles charge and electric double layer screening from Stern layer thickness(-1 nm)to tens of *** was shown that the permanent magnetic field is not able to cause any structural changes in the ordered magnetic liquid phase,while alternating field draws particles apart by their *** variation of interparticle distance up to 6%was achieved using an alternating magnetic field of low *** data were complemented by the theoretical models of screened electrostatic interactions between spherical and platelike magnetic *** last model provides good predictive power and correlates with the experimental *** stabilization energy of the condensed phase in the order of 1-10 kBT was derived from the *** approach allows controlling of an equilibrium interparticle distance and interparticle distance distribution by adjusting the magnetization and surface charge of the particles as well as the ionic strength of the solvent.

关键词： hexaferrite ferrofluid self-assembly colloidal solution

Predictive modelling of ferroelectric tunnel junctions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2016年第1期2卷 150-162页

作者： Julian P Velev John D Burton Mikhail Ye Zhuravlev evgeny Y Tsymbal Department of Physics and Astronomy University of NebraskaLincolnNEUSA Department of Physics and Astronomy University of Puerto RicoSan JuanPuerto RicoUSA Nebraska Center for Materials and Nanoscience University of NebraskaLincolnNEUSA Kurnakov Institute for General and Inorganic Chemistry Russian Academy of SciencesMoscowRussia Faculty of Liberal Arts and Sciences St Petersburg State UniversitySt PetersburgRussia

Ferroelectric tunnel junctions combine the phenomena of quantum-mechanical tunnelling and switchable spontaneous polarisation of a nanometre-thick ferroelectric film into novel device *** the ferroelectric barrier polarisation direction produces a sizable change in resistance of the junction—a phenomenon known as the tunnelling electroresistance *** a fundamental perspective,ferroelectric tunnel junctions and their version with ferromagnetic electrodes,i.e.,multiferroic tunnel junctions,are testbeds for studying the underlying mechanisms of tunnelling electroresistance as well as the interplay between electric and magnetic degrees of freedom and their effect on *** a practical perspective,ferroelectric tunnel junctions hold promise for disruptive device *** a very short time,they have traversed the path from basic model predictions to prototypes for novel non-volatile ferroelectric random access memories with non-destructive *** remarkable progress is to a large extent driven by a productive cycle of predictive modelling and innovative experimental *** this review article,we outline the development of the ferroelectric tunnel junction concept and the role of theoretical modelling in guiding experimental *** discuss a wide range of physical phenomena that control the functional properties of ferroelectric tunnel junctions and summarise the state-of-the-art achievements in the field.

关键词： ferroelectric tunnel resistance

Predicting the propensity for thermally activated β events in metallic glasses via interpretable machine learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2020年第1期6卷 46-57页

作者： Qi Wang Jun Ding Longfei Zhang evgeny Podryabinkin Alexander Shapeev Evan Ma Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Department of Computer Science Johns Hopkins UniversityBaltimoreMD 21218USA Center for Energy Science and Technology Skolkovo Institute of Science and Technology3 Nobel StreetMoscow 143026Russia

The elementary excitations in metallic glasses(MGs),i.e.,β processes that involve hopping between nearby sub-basins,underlie many unusual properties of the amorphous alloys.A high-efficacy prediction of the propensity for those activated processes from solely the atomic positions,however,has remained a daunting ***,employing well-designed site environment descriptors and machine learning(ML),notable progress has been made in predicting the propensity for stress-activated β processes(i.e.,shear transformations)from the static structure.

关键词： structure glasses metallic

On increasing of integration rate of elements in a multi-level inverter

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Intelligent Computing and Cybernetics 2017年第3期10卷 272-286页

作者： evgeny L.Pankratov Volga-Vyatka Branch Elena Alexeevna Bulaeva Mathematical Department Radiophysical FacultyNizhny Novgorod State UniversityNizhny NovgorodRussia Moscow Technical University of Communication and Informatics(MTUSI) Nizhny NovgorodRussia

Purpose–The purpose of this paper is to analyze the redistribution of dopant and radiation defects to determine conditions which correspond to decreasing of elements in the considered inverter and at the same time to increase their ***/methodology/approach–In this paper,the authors introduce an approach to increase integration rate of elements in a three-level *** approach is based on decrease in the dimension of elements of the inverter(diodes and bipolar transistors)due to manufacturing of these elements by diffusion or ion implantation in a heterostructure with specific configuration and optimization of annealing of dopant and radiation ***–The authors formulate recommendations to increase density of elements of the inverter with a decrease in their *** implications–Optimization of manufacturing of integrated circuits and their ***/value–The results of this paper are based on original analysis of transport of dopant with account transport and interaction of radiation defects.

关键词： Function approximation Mathematical optimization

Laser metal deposition of refractory high-entropy alloys for high-throughput synthesis and structure-property characterization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2021年第1期3卷 98-120页

作者： Henrik Dobbelstein Easo P George evgeny L Gurevich Aleksander Kostka Andreas Ostendorf Guillaume Laplanche Applied Laser Technologies Ruhr-University BochumUniversitätsstr.15044801 BochumGermany Material Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831-6115United States of America Materials Science and Engineering Department University of TennesseeKnoxvilleTN 37996-2100United States of America Center for Interface-Dominated High Performance Materials Ruhr-University BochumUniversitätsstr.15044801 BochumGermany Institute for Materials Ruhr-University BochumUniversitätsstr.15044801 BochumGermany

Progress in materials development is often paced by the time required to produce and evaluate a large number of alloys with different chemical *** applies especially to refractory high-entropy alloys(RHEAs),which are difficult to synthesize and process by conventional *** evaluate a possible way to accelerate the process,high-throughput laser metal deposition was used in this work to prepare a quinary RHEA,TiZrNbHfTa,as well as its quaternary and ternary subsystems by in-situ alloying of elemental *** graded variants of the quinary RHEA were also *** results show that the influence of various parameters such as powder shape and purity,alloy composition,and especially the solidification range,on the processability,microstructure,porosity,and mechanical properties can be investigated *** strength of these alloys was mainly affected by the oxygen and nitrogen contents of the starting powders,while substitutional solid solution strengthening played a minor role.

关键词： high-entropy alloy HfNbTaTiZr refractory powder blend laser metal deposition additive manufacturing high-throughput synthesis

Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第1期18卷 47-66页

作者： Ekaterina A Polyakova evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza Almazov National Medical Research Centre Saint-PetersburgRussia

Heart failure is common in adult population,accounting for substantial morbidity and mortality *** main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic *** main factor associated with poor outcome of these patients is constant progression of heart *** the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management ***,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the *** authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection *** could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse *** article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.

关键词： cardiac and inflammatory markers in the evaluation of heart failure severity and progression Neurohumoral