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Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias

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World Journal of Meta-Analysis 2023年第5期11卷 181-195页

作者： Ana Clara Carvalho Cardoso Brito everton oliveira carneiro ribeiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Haploidentical hematopoietic stem cell transplantation(Haplo-HSCT)is often performed in children with hematologic *** with the gap in the literature regarding the approach to experiences related to Haplo-HSCT with pediatric patients with leukemias and myelodysplasias aged up to 18 years,there was an interest in exploring the clinical outcomes of patients undergoing this *** To identify and summarize the scientific contributions available on Haplo-HSCT performed in the last 10 years in children and adolescents with myeloid and lymphoid leukemias and myelodysplasias,aged up to 18 *** This is a descriptive systematic *** extracted data including characteristics of participants,health condition,characteristics of the donation,conditioning regimen,recurrent clinical complications and clinical *** Virtual Health Library Brazil,PubMed,EMBASE,and SciELO platforms were used,finding a total of 1052 *** the eligibility criteria and complete reading of the texts,18 articles were included for *** The total sample of all study cohorts was 1825 patients,mostly male,the highest reported median age was 15.0 years and the lowest was 1.2 *** graftversus-host disease and chronic graft-versus-host disease were observed in almost all ***,graft rejection and delayed immune recovery were identified as major clinical ***-transplant minimal positive residual disease was identified in 288 *** are also among the main clinical complications,viral,bacterial and fungal infections being *** is observed that in the 5-year interval,the lowest rates of EFS and overall survival(OS)were 29.5%and 68.0%,***,the highest rates of EFS and OS,in the same interval,were 80.1%and 81.0%.CONCLUSION Haplo-HSCT represents a promising therapy,considering the potential number of possible donors and the conditioning and treatment platforms that can be *** res

关键词： Haploidentical Stem cell transplantation Children Cancer Treatment outcome Prognosis

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes Pamela Castro-e-Souza Anselmo Alves de oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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Influence of broken kernels content on soybean quality during storage

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Grain & Oil Science and Technology 2024年第2期7卷 105-112页

作者： Lazaro da Costa Correa Canizares Cesar Augusto Gaioso Newiton da Silva Timm Silvia Leticia Rivero Meza Adriano Hirsch Ramos Maurício de oliveira everton Lutz Moacir Cardoso Elias Department of Agroindustry Science and Technology Federal University of PelotasPelotasRio Grande do Sul 96010-900Brazil Information and Communication Technological Axis Federal Institute of EducationScienceand Technology FarroupilhaCampus PanambiPanambiRio Grande do Sul 98280-000Brazil

Although it is recognized that the post-harvest system is most responsible for the loss of soybean quality,the real impact of this loss is still *** regulation allows 15%and 30%of broken soybean for group I and group II(quality groups),***,the industry is not informed about the loss in the quality parameters of soybeans and its impacts during long-term ***,the objective was to evaluate the effect of the breakage kernel percentage of soybean stored for 12 *** of 15% of breakage kernels did not affect soybean ***,content of 30% of breakage kernels affected significantly soybean quality,which was evidenced by the increase of up to 75% in moldy soybeans,72% in acidity,50% in leached solids,27% in electrical conductivity,and the decrease of up to 12% in soluble protein,6.4% in germination and 3.5% in thousand kernel weight after 8 months of *** the legislation establishes a percentage limit,it is recommended to store soybeans with up to 15% breakage *** the contrary,values higher than that can cause a significant reduction in soybean quality,resulting in commercial losses.

关键词： Soybean quality Breakage kernels Storage problems Grain defects Quality parameters

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Combined Oxidative Phosphorylation Deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto Matos-Neto Lucas Antonissen Lima Verde Airton Ferreira da Ponte-Filho Luís Eduardo oliveira Matos Amandha Espavier Trés Paulo Roberto Lacerda Leal Gerardo Cristino-Filho Regina Coeli de Carvalho Porto carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil Department of Neurosurgery Federal University of Cear Sobral Cear Brazil Department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial Defect VARS2

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Night and day at the beach: Relating social life to location and infrastructure in a Brazilian city

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Frontiers of Architectural Research 2022年第6期11卷 1177-1192页

作者： Lucy Donegan Gabriel de oliveira Madruga Natália Vale carneiro Departamento de Arquitetura e Urbanismo Federal University of ParaíbaJoão PessoaParaíbaBrazil

Brazilian city beaches are public spaces favoring citizens *** studies relate built form and infrastructure with urban vitality and coastal studies underline uses as important for beach management,yet few researches relate form and infrastructure with beach *** daily life as essential for public spaces and that spatial form relates with uses,this paper assesses time-based relationships between built and natural physical attributes and social life on the beaches of João Pessoa,a coastal city in North-east *** attributes are investigated at city scale-beach type,street network centrality and topography-and seafront scale-land uses,public/private interfaces,public infrastructure,beach sections and water *** social life was surveyed online,enquiring peoples’beach choice,visiting time and place,activities and *** and street network follow topography and help configure shore and promenade for different *** central beaches have diverse land uses,well-equipped promenades and lighting and were popular night and day,while less central beaches had less infrastructure and were visited only by *** highlight how physical attributes facilitate uses and,together with peoples’evaluation,can inform urban beach design and planning.

关键词： Public space Social life Built environment Beaches Public infrastructure

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Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 643-654页

作者： Lucas Eiki Kawakami Pedro Barzan Bonomi Marina Alessandra Pereira Fabrício oliveira Carvalho Ulysses ribeiro Jr Bruno Zilberstein Luciana ribeiro Sampaio Luiz Augusto carneiro-D'Albuquerque Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil Blood Transfusion Unit Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil

BACKGROUND Gastric cancer(GC)is still a prevalent neoplasm around the world and its main treatment modality is surgical *** need for perioperative blood transfusions is frequent,and there is a long-lasting debate regarding its impact on *** To evaluate the factors related to the risk of receiving red blood cell(RBC)transfusion and its influence on surgical and survival outcomes of patients with *** Patients who underwent curative resection for primary gastric adenocarcinoma at our Institute between 2009 and 2021 were retrospectively *** and surgical characteristics data were *** patients were divided into transfusion and non-transfusion groups for *** A total of 718 patients were included,and 189(26.3%)patients received perioperative RBC transfusion(23 intraoperatively,133 postoperatively,and 33 in both periods).Patients in the RBC transfusions group were older(P<0.001),and had morecomorbidities(P=0.014),American Society of Anesthesiologists classification III/IV(P<0.001),and lower preoperative hemoglobin(P<0.001)and albumin levels(P<0.001).Larger tumors(P<0.001)and advanced tumor node metastasis stage(P<0.001)were also associated with the RBCtransfusion *** rates of postoperative complications(POC)and 30-d and 90-d mortalitywere significantly higher in the RBC transfusion group than in the non-transfusion *** and albumin levels,total gastrectomy,open surgery,and the occurrence of POC werefactors associated with the RBC *** analysis demonstrated that the RBCtransfusions group had worse disease-free survival(DFS)and overall survival(OS)compared withpatients who did not receive transfusion(P<0.001 for both).In multivariate analysis,RBCtransfusion,major POC,pT3/T4 category,pN+,D1 lymphadenectomy,and total gastrectomywere independent risk factors related to worse DFS and *** RBC transfusion is associated with worse clinical condition

关键词： Stomach neoplasms Blood transfusion Red blood cells Postoperative complications Survival Prognosis

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Flight performance and wing morphology in the bat Carollia perspicillata:biophysical models and energetics

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Integrative Zoology 2023年第5期18卷 876-890页

作者： Lucas de oliveira carneiro Breno MELLADO Marcelo Rodrigues NOGUEIRA Ariovaldo Pereira da CRUZ-NETO Leandro Rabello MONTEIRO Laboratório de Ciências Ambientais Centro de Biociências e BiotecnologiaUniversidade Estadual do Norte FluminenseCampos dos GoytacazesRio de JaneiroBrasil Departamento de Biodiversidade Universidade Estadual PaulistaRio ClaroSão PauloBrasil

Studies on functional performance are important to understand the processes responsible for the evolution of *** trait variation within species influences the energetic cost of locomotion and impacts life history traits,with ecological and evolutionary *** study examined wing morphology correlates of flight performance measured by energetic expenditure in the Seba’s short-tailed bat,Carollia *** the flight experiments,nature caught bats(59 females,57 males)were allowed to fly for 3 min in a *** each flight,thermographic images were taken to measure body temperature,and biophysical models were used to calculate sensible heat loss as a measure of energetic *** morphological traits were measured for each individual and associated with heat loss and power required to fly on performance *** morphological traits explained 7-10%of flight energetic cost,and morphologies with the best performance would save the energy equivalent to 9-30%of total daily *** optimal performance areas within the *** morphospace were consistent with predicted selection trends from the literature.A trade-off between demands for flight speed and maneuverability was *** loading and camber presented sexual *** morphological differences are likely associated with more economical but less maneuverable flight in females,leading them to fly more often in open areas along the forest *** findings demonstrate how small scale changes in wing morphology can affect life history strategies and fitness.

关键词： aerodynamics Chiroptera infrared thermography performance surfaces Phyllostomidae wing morphometrics

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Assessment of Genetic Stability Among In Vitro Plants of Arachis retusa Using RAPD and AFLP Markers for Germplasm Preservation

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Journal of Integrative Plant Biology 2007年第3期49卷 307-312页

作者： Rachel Fatima Gagliardi Luiz Ricardo Hanai Georgia Pacheco Carlos Alberto oliveira Leonardo Alves carneiro José Francisco Montenegro Valls Elisabeth Mansur Maria Lucia carneiro Vieira Laboratório de Micropropagacao e Transformacao de Plantas Universidade do Estado do Rio de Janeiro postal code 20550-013 Maracana Rio de Janeiro Brazil Departamento de Genética - Escola Superior de Agricultura Luiz de Queiroz Universidade de Sao Paulo postal code 13418-900 Piracicaba Brazil Embrapa Recursos Genéticos e Biotecnologia postal code 70770-901 Brasilia Brazil

Arachis retusa Krapov. et W. C. Gregory et Valls is endemic in the West-central region of Brazil, occurring In areas endangered by human actions. The establishment of in vitro preservation methods for wild species of Arachis is an alternative to seed banks for germplasm storage, multiplication and distribution. The risk of genetic changes Induced by tissue culture and the monitoring of the genetic stability of the biological material before, during and after storage must be considered In the context of conservation. Random amplified polymorphlc ONA （RAPO） and amplified fragment length polymorphism （AFLP） fingerprinting were used to evaluate the genetic stability of in vitro plants originated from cotyledons and embryo axes of A. retusa. Cotyledons originated shoots through direct organogenesls and embryo axes displayed muItishoot formation Induced by 110 mmol/L and 8.8 mmol/L BAP, respectively. Ninety genomlc regions （loci） generated from RAPO and 372 from AFLP analyses were evaluated. All amplified fragments detected by both techniques in plants derived from the two explant types were monomorphic. The results Indicate that the recovered shoots are genetically stable at the assessed genomic regions.

关键词： amplified fragment length polymorphism Arachis retusa in vitro preservation micropropagation random amplifiedpolymorphic DNA somaclonal variation

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Stepped machine learning for the development of mineral models: Concepts and applications in the pre-salt reservoir carbonate rocks

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能源与人工智能(英文) 2021年第1期3卷 167-179页

作者： Lucas Abreu Blanes de oliveira Luiz Felipe Niedermaier Custodio Thais Bortotti Fagundes Carina Ulsen Cleyton de Carvalho carneiro Petrobras–Petroleo Brasileiro S.A. Avenida Henrique Valadares 28CentroRio de Janeiro20231-030 Rio de JaneiroBrazil Universidade de Sao Paulo USPEscola PolitecnicaPraça Narciso de AndradeVila MathiasSantosSão Paulo 11013-560Brazil

Understanding rock mineralogy is essential for formation evaluation,improving the calculation of porosity and hydrocarbon *** primary method to obtain the mineralogy from a well is by applying a model to the geochemical tool’s chemical ***,creating a mineralogical model presents challenges such as the minerals’chemical composition and the decision to include a mineral in the *** traditional application of machine learning can make mineral models less realistic since conventional training is developed based on a set of minerals with different occurrences,lowering some minerals’*** present research proposes the stepped machine learning(SML),a stepped way to use machine learning to create a mineralogical model from chemical and mineralogical data.A database was assembled with the elemental concentration obtained with XRF analyses and the mineral concentrations obtained with XRD *** chemical elements were Al,Ca,Fe,K,Mg,Mn,Na,Si,and *** minerals were calcite,dolomite,quartz,clays,K-feldspar,plagioclase,and *** algorithms were tested:MLP,GAN,Random Forest,and XGBoost,with XGBoost showing the best *** was applied,where a mineral model results are used to train a subsequent *** allowed for a significant improvement in some models,notably to clays with an increase in R 2 from 0.597 to 0.853,quartz an increase from 0.673 to 0.869,and calcite,from 0.758 to 0.862.A decrease in the mean squared error of these minerals’models was also *** model was applied to the geochemical logs from three wells drilled in the Brazilian pre-salt,and the results were compared with XRD *** SML model was able to honor the mineral concentrations for different *** is demonstrated that the integration between machine learning tools and geological knowledge in SML was crucial for creating a representative mineralogical model.

关键词： minerals quartz reservoir

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Measuring the density of the fissula antefenestram and the section of the basal turn of the cochlea:Are they useful in the radiological diagnosis of otosclerosis?

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Journal of Otology 2022年第2期17卷 84-89页

作者： Lucas Resende Lucinda Mangia Gabriel Lucca de oliveira Salvador Bettina Carvalho Rogerio Hamerschmidt Department of Otolaryngology Head and Neck SurgeryHospital de Clínicas da Universidade Federal do ParanaGeneral Carneiro st181CuritibaBrazil Department of Imaging and Radiology Head and Neck SurgeryHospital de Clínicas da Universidade Federal do ParanaGeneral Carneiro st181CuritibaBrazil

Introduction:The role of objective parameters in terms of improvement of the accuracy of highresolution computed tomography(HRCT)of the temporal bone in the diagnosis of otosclerosis remains ***:To investigate the relationship between the density of the fissula antefenestram(FAF)and of the width of the transversal section of the basal turn of the cochlea(BTC),and the diagnosis of ***:This is a retrospective study in which preoperative HRCT data from ears of patients submitted to stapedotomy due to otosclerosis(case group)were *** the control group,normal hearing ears having undergone HRCT for other purposes were *** and control HRCT images were objectively assessed by an experienced blinded *** this evaluation,measurements of the relative radiological density of the FAF and of the transversal section of the BTC were *** results were compared between the ***,a receiver operating characteristic curve was created and the area under the curve(AUC)was calculated for each *** level was set ***:40 ears were included in each *** ears presented reduced values for the relative radiological density on the FAF(p-value<0.0001).Moreover,ears with otosclerosis(p-value:0.022)presented lower transversal section of the *** AUC for these variables reached 0.929 and 0.646,***:Otosclerotic ears present reduced radiological density on the FAF and narrower *** relative density of the FAF also shows a great diagnostic power in the context of this disease.

关键词： Otosclerosis Computed tomography Imaging diagnosis

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