检索结果-南通市图书馆

Journal of Clinical and Nursing Research 2024年第5期8卷 299-308页

作者： Chunhong Ding evelyn feliciano Graduate School Angeles University FoundationAngeles City 2009Philippines

Objectives:To explore the perception of telenursing among patients with chronic diseases in the selected community hospitals only in Shandong Province,China,and to compare the differences in perception of telenursing among patients with different chronic ***:The purpose sampling method was adopted in this study,and questionnaires were distributed to 324 chronic disease patients in OPD ***:Patients with chronic diseases have higher awareness and acceptance of telenursing,and there are significant differences in their cognition of telenursing ***:The disease characteristics of patients with different chronic diseases and their different needs for telenursing require more considerations in the design and use of telenursing services.

关键词： Chronic disease Telecare Cognition

Bifurcation Analysis Reveals Solution Structures of Phase Field Models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 64-89页

作者： Xinyue evelyn Zhao Long-Qing Chen Wenrui Hao Yanxiang Zhao Department of Mathematics Vanderbilt UniversityNashvilleTN37212USA Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPA16802USA Department of Mathematics Pennsylvania State UniversityUniversity ParkPA16802USA Department of Mathematics The George Washington UniversityWashingtonDC20052US

The phase field method is playing an increasingly important role in understanding and predicting morphological evolution in materials and biological ***,we develop a new analytical approach based on the bifurcation analysis to explore the mathematical solution structure of phase field *** such solution structures not only is of great mathematical interest but also may provide guidance to experimentally or computationally uncover new morphological evolution phenomena in materials undergoing electronic and structural phase *** elucidate the idea,we apply this analytical approach to three representative phase field equations:the Allen-Cahn equation,the Cahn-Hilliard equation,and the Allen-Cahn-Ohta-Kawasaki *** solution structures of these three phase field equations are also verified numerically by the homotopy continuation method.

关键词： Phase field modeling Bifurcations Multiple solutions

Risk factors for long COVID in children and adolescents:a systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： Daniel G.Rayner Elaine Wang Cloris Su Om D.Patel Stephanie Aleluya Alessandra Giglia evelyn Zhu Maha Siddique Department of Health Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRADE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(N=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVID-19,and symptomatic acute COVID-19 are probably associated with an increased risk of long *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of long COVID,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVID in the pediatric *** research is necessary to elucidate the pathophysiology of long COVID.

关键词： COVID-19 Long COVID Post-acute COVID-19 syndrome Pediatrics Risk factors

Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第1期44卷 101-126页

作者： Monika Raab Izabela Kostova Samuel Peña-Llopis Daniela Fietz Monika Kressin Seyed Mohsen Aberoumandi evelyn Ullrich Sven Becker Mourad Sanhaji Klaus Strebhardt Department of Gynecology Medical SchoolGoethe-UniversityFrankfurt am MainGermany Translational Genomics in Solid Tumors West German Cancer CenterUniversity HospitalEssenGermany German Cancer Consortium(DKTK) EssenGermany German Cancer Research Center(DKFZ) HeidelbergGermany Histology and Embryology Institute for Veterinary AnatomyGiessenGermany Franfurt Cancer Institute(FCI) Goethe UniversityFrankfurt am MainGermany German Cancer Consortium(DKTK) Partner site Frankfurt/Mainza partnership between DKFZ and University Hospital FrankfurtFrankfurt am MainGermany Experimental Immunology Department for Children and Adolescents MedicineUniversity Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany

Background:The cellular tumor protein p53(TP53)is a tumor suppressor gene that is frequently mutated in human *** various cancer types,the very aggressive high-grade serous ovarian carcinoma(HGSOC)exhibits the high-est prevalence of TP53 mutations,present in>96%of *** intensive efforts to reactivate p53,no clinical drug has been approved to rescue p53 *** this study,our primary objective was to administer in vitro-transcribed(IVT)wild-type(WT)p53-mRNA to HGSOC cell lines,primary cells,and ortho-topic mouse models,with the aim of exploring its impact on inhibiting tumor growth and dissemination,both in vitro and in ***:To restore the activity of p53,WT p53 was exogenously expressed in HGSOC cell lines using a mammalian vector ***,IVT WT p53 mRNA was delivered into different HGSOC model systems(primary cells and patient-derived organoids)using liposomes and studied for proliferation,cell cycle progression,apoptosis,colony formation,and chromosomal *** alterations induced by p53 mRNA were analyzed using RNA sequencing in OVCAR-8 and primary HGSOC cells,followed by ingenuity path-way *** vivo effects on tumor growth and metastasis were studied using orthotopic xenografts and metastatic intraperitoneal mouse ***:Reactivation of the TP53 tumor suppressor gene was explored in differ-ent HGSOC model systems using newly designed IVT mRNA-based *** introduction of WT p53 mRNA triggered dose-dependent apoptosis,cell cycle arrest,and potent long-lasting inhibition of HGSOC cell *** analysis of OVCAR-8 cells upon mRNA-based p53 reactivation revealed significant alterations in gene expression related to p53 signaling,such as apoptosis,cell cycle regulation,and DNA *** p53 function concurrently reduces chromosomal instability within the HGSOC cells,under-scoring its crucial contribution in safeguarding genomic integrity by moderating the baselin

关键词： apoptosis cell cycle chromosomal instability HGSOC metastatic intraperitoneal mouse model HGSOC orthotopic Xenograft model high-grade serous ovarian cancer in vitro-transcribed p53-mRNA liposomal IVT mRNA delivery system patient-derived organoid patient-derived primary cancer cell

Pharmacokinetics and Bioequivalence Evaluation of Two Rosuvastatin Calcium 20 mg Tablets: A Single Oral Dose, Randomized-Sequence, Open-Label, Two-Period Crossover Study in Healthy Volunteers under Fasting Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2024年第6期12卷 230-243页

作者： evelyn Pena Alfredo Inatti José Gregorio Chacón Department of Clinical Research Industrias Biocontrolled C.A. Caracas Venezuela

Objectives: To compare the rate and extent of absorption of Racor® 20 mg (Rosuvastatin calcium 20 mg) tablet of Laboratorios Leti, S.A.V., with Crestor® 20 mg (Rosuvastatin calcium 20 mg) tablet of AstraZeneca, UK Limited in healthy adult human subjects under fasting conditions. Method: This was an open label, analyst blind, balanced, randomized, two-treatment, two-period, two-sequence, single oral dose, crossover, bioequivalence study in healthy, adult, human subjects under fasting condition. Twenty-four (24) subjects were planned as per the protocol and all subjects completed both periods of the study. The concentrations of Rosuvastatin in plasma were quantitated using a validated LC-MS/MS method of analysis and plasma levels were submitted for statistical analysis. Cmax, AUC0-t, AUC0-∞, Tmax, t1/2, Kel (hrs-1), percent AUC extrapolated [100 * (AUC0-∞ - AUC0-t)/AUC0-∞] (AUC_%Extrapobs) were calculated for rosuvastatin in plasma using SAS® version 9.1.3, SAS Institute. Inc. ***. ANOVA, 90% confidence interval using Schuirmann’s two one-sided test for bioequivalence, power and ratio analysis, for lntransformed pharmacokinetic parameters Cmax, AUC0-t and AUC0-∞ were computed and reported for Rosuvastatin in plasma for BE. Results: Data showed that 90% confidence intervals for the test/reference geometric mean ratios (GMR) of Cmax (95.01 - 112.66), AUC0-t (93.38 - 111.67) and AUC0-∞ (93.65 - 111.29) were within the BE (80% - 125%) acceptance range. Conclusions: Two products formulation, reference (R) Crestor® (rosuvastatin calcium) of AstraZeneca and test (T), Racor® (rosuvastatin calcium) of Laboratorios Leti S.A.V., with a single dose of 20 mg, under fasting conditions were bioequivalent. No severe, serious or unexpected adverse events (AEs) were reported in this study.

关键词： Bioequivalence Rosuvastatin Pharmacokinetics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

护生实施身体评估障碍的整合性综述

International Journal of Nursing Sciences 2021年第1期8卷 120-129,I0008页

作者： Jestoni D.Maniago evelyn E.feliciano Adelina M.Santos Cyrelle L.Agunod Cris S.Adolfo Brian A.Vasquez Abdulrhman Albougami Joseph U.Almazan Department of Nursing College of Applied Medical SciencesMajmaah UniversityAl-Majmaah11952Kingdom of Saudi Arabia Nazarbayev University School of Medicine Nazarbayev UniversityNur-Sultan010000Republic of Kazakhstan

目的通过整合性综述明确护生进行身体评估时遇到的障碍。方法以“barrier(障碍)”“physical assessment(身体评估)”“nursing student(护生)”为检索词在Medline,CINAHL,ScienceDirect,Web of Science,ProQuest及Taylor&Francis Online数据库中进行检索。仅纳入英文文献并经同行评审期刊文章,未设年份限制。结果最终纳入12篇论文,共提取两个方面的内容:障碍因素包括个人困难、护理教学方面的挑战、与临床实践有关的挑战;构建基于能力的教学是减少护生身体评估障碍的方法。学生的能力和经验受到多种因素的影响,这些因素共同阻碍了他们成功进行身体评估。结论研究结果对护生进行身体评估过程中涉及的复杂问题提出了有价值的见解,并为改进实践提供了指导。应共同协作以解决护生在进行常规身体评估时经常面临的问题。此外,应在院校和临床环境中融合运用更具建设性和基于能力培养的教学方法。

关键词：临床工作能力教育,护理身体评估问题解决

Risk Factors for Geo-Helminthiasis in Children Aged 6 - 36 Months in a Rural Health District in Cameroon

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第2期14卷 391-400页

作者： Isabelle Mekone Nkwele Monono Naiza Gervais Talla Kamga Hugues Nana Djeunga Jeannette Epée Ngoue Patricia Epée Eboumbou Suzanne Ngo Um Sap evelyn Mah Mungeh Joseph Kamgno Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Internal Medicine and Paediatrics Faculty of Health Sciences University of Buea Buea Cameroon Centre de Recherche sur les Filarioses et autres Maladies Tropicales (CRFilMT) Yaoundé Cameroon Department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Public Health Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction and Objectives: Soil-Transmitted-Helminthiasis (STH) is a public health problem in Cameroon. The control strategies currently in place, particularly chemoprevention, has shortcomings linked to the target population, which are school-age children. The objective was to determine the prevalence and the risk factors associated with geo-helminthiasis in children aged 0 to 3 years in a rural health district. Method: From December 2020 to May 2021, a descriptive and analytical cross-sectional study of 376 children between 6 and 36 months was carried out in the Akonolinga health district. This was a cluster sampling in 4 health areas. Stool samples were collected and analysed using the mini-FLOTAC method. The results expressed as the number of eggs per gram of stool. A questionnaire on socio-demographic and lifestyle data was administered to the parents. The Chi-squared test was used to measure the association between geo-helminth infection and the data collected. A multivariate analysis using logistic regression was performed (p 0.05). Results: The prevalence of STH was 19.4% (Ascaris lumbricoides: 16% and Trichuris trichiura: 8%). Risk factors were: consumption of contaminated water (AOR = 1.93 [1.03 - 3.6];p = 0.040), early contact of the child with the ground (before age of 4 months) (AOR = 4.9 [2.1 - 11.37];p .001), habit of walking barefoot (AOR = 2.91 [1.1 - 7.97];p = 0.038), and living in a habitat with unpaved ground (AOR = 7.4 [1.55 - 35.7];p = 0.012). Conclusion: The prevalence of STHs in infants was high. Preventive chemotherapy should be extended to this age-group, and other measures intensified.

关键词： Akonolinga Soil-Transmitted-Helminths Children Aged 0 - 3 Years Risk Factors

Anharmonic electron-phonon coupling in ultrasoft and locally disordered perovskites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 744-756页

作者： Marios Zacharias George Volonakis feliciano Giustino Jacky Even Univ Rennes INSA RennesCNRSInstitut FOTON-UMR 6082F-35000 RennesFrance Univ Rennes ENSCRINSA RennesCNRSISCR-UMR 6226F-35000 RennesFrance Oden Institute for Computational Engineering and Sciences The University of Texas at AustinAustinTX 78712USA Department of Physics The University of Texas at AustinAustinTX 78712USA

Anharmonicity and local disorder(polymorphism)are ubiquitous in perovskite physics,inducing various phenomena observed in scattering and spectroscopy *** of these phenomena still lack interpretation from first principles since,hitherto,no approach is available to account for anharmonicity and disorder in electron–phonon ***,relying on the special displacement method,we develop a unified treatment of both and demonstrate that electron–phonon coupling is strongly influenced when we employ polymorphous perovskite *** uncover that polymorphism in halide perovskites leads to vibrational dynamics far from the ideal noninteracting phonon picture and drives the gradual change in their band gap around phase transition *** also clarify that combined band gap corrections arising from disorder,spin-orbit coupling,exchange–correlation functionals of high accuracy,and electron–phonon coupling are all *** findings agree with experiments,suggesting that polymorphism is the key to address pending questions on perovskites’technological applications.

关键词： perovskite phonon harmonic

Effects of Fresh Cupressus sempervirens Leaves Infusion on Growth Performance, Intestinal Microbiota and Haemato-Biochemical Parameters in Broilers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Animal Sciences 2024年第2期14卷 70-87页

作者： Donfack Mikael Noumbissi Marie Noël Bertine Ciemeni Michelle Aimee Tindo Tsamene Romario evelyn Ngwa Bih Djamen Tchantchou Chamberlin Nyembo Kondo Camile Tsafong Jeatsa Franklain Necdem Tsafack Boris Kana Jean Raphaël Animal Nutrition and Production Research Unit Department of Animal Sciences Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Animal Sciences and Plant Technology Faculty of Agronomic Sciences La Sapientia Catholic University of Goma Goma Democratic Republic of Congo

The accumulation of growth-promoting antibiotic residues in animal products and the resistance developed by bacteria in poultry farms has led to a search for natural compounds derived from plants. This study was designed to promote the production performance of broiler chickens using fresh Cupressus sempervirens leaves infusion. Fresh Cupressus sempervirens leaves were harvested, washed, chopped and ground to a paste using a blender and fermented for three days in a closed container at a rate of 500 g/L of water. The solution obtained was filtered and added at the rate of 2, 4, 6, 8 and 10 ml/L of drinking water. The chickens fed on the graded level of the solution were compared to a control ration without an additive and positive control group supplemented with 1 g antibiotic/kg feed. At the finisher phase and throughout the study period, water intake increased significantly (P 0.05) affected by the inclusion of Cupressus sempervirens infusion. Haematological parameters significantly (P < 0.05) increase independently of the rate of incorporation of the infusion into the drinking water, with the exception of RBCs, MCHT and PCT. Serum content in total protein, globulins, LDL cholesterol and triglycerides were significantly (P < 0.05) high with 8 and 10 ml Cupressus sempervirens infusion/litre drinking water as compared to all other treatments. AST, ALT, urea, creatine, albumin, total cholesterol and HDL-cholesterol were not significantly affected. The lactic acid bacteria load increased significantly (P E. coli and salmonella counts decreased significantly (P < 0.05)

关键词： Broilers Cupressus sempervirens Growth Performance Haemato-Biochemical Parameters Intestinal Microbiota

Academic Stress Assessment Using Virtual Reality as an Educational Tool in Spine Surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2024年第2期14卷 114-123页

作者： Diana Chávez Lizárraga Jesús Alberto Pérez Contreras Fernando Alvarado Gómez evelyn Quintero Medina Emmanuel Cantú Chávez Iván Ulises Sámano López Ana Sofía Peña Blesa Department of Neurosurgery ángeles Pedregal Ciudad de México México Department of Traumatology and Orthopedics Hospital Santa Fe Bogotá Colombia

Introduction: The evaluation of academic stress in medical students and residents is a topic of significant interest, given the considerable challenges they face during their learning process with traditional teaching methods. The use of technologies like virtual reality presents an opportunity to enhance their skills through simulations and training. The main objective of this study is to qualitatively assess the stress levels experienced by medical students and residents by integrating virtual reality into their current learning methods, aiming to improve their ability to manage stressors in their practice. Material and Methods: A questionnaire was conducted with 12 medical students and 12 Traumatology and orthopedics residents. The purpose of the questionnaire was to evaluate the levels of academic stress using the SISCO inventory. The stress levels were calculated by transforming average values into percentages, and the following criteria were assigned: 0 to 33% for Mild Stress, 34 to 66% for Moderate Stress, and 67 to 100% for Deep Stress. Then, a virtual reality class focused on spine surgery was provided. Both medical students and residents were trained using the Non Nocere SharpSurgeon software platform and Oculus Quest 2 virtual reality glasses. At the end of the session, a second questionnaire related to the practice with virtual reality was conducted with the same evaluation criteria and a comparative analysis was carried out. Results: 12 undergraduate students from Hospital Angeles Mexico, CDMX and 12 traumatology and orthopedics residents at Hospital Santa Fe, Bogota were evaluated. The students in CDMX reported an average qualitative stress of 28.50% during habitual practices, which decreased to an average of 14.67% after virtual reality practice. Residents in Bogotá experienced an average qualitative stress of 30.50% with their current learning methods but this reduced to an average of 13.92% after using virtual reality. These findings indicate that t

关键词： Virtual Reality Academic Stress Learning Strategies Spine Surgery Training