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A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis

Molecular Plant 2024年第12期17卷 1850-1865页

作者： Michaela Králová Ivona Kubalová Jakub Hajný Karolina Kubiasová Karolína Vagaská zengxiang Ge Michelle Gallei Hana Semerádová Anna Kuchařová Martin Hönig Aline Monzer Martin Kovačik JiříFriml Ondřej Novák eva Benková Yoshihisa Ikeda David zalabák Laboratory of Growth Regulators Faculty of Science of PalackýUniversity and Institute of Experimental Botany AS CRŠlechtitelů2778371 OlomoucCzech Republic Department of Molecular Biology Centre of the Region Hanáfor Biotechnological and Agricultural ResearchFaculty of SciencePalackýUniversityŠlechtitelů2778371 OlomoucCzech Republic Institute of Science and Technology Austria(ISTA) 3400 KlosterneuburgAustria Department of Chemical Biology Faculty of SciencePalackýUniversityŠlechtitelů2778371 OlomoucCzech Republic Institute of Experimental Botany of the Czech Academy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelů3177900 OlomoucCzech Republic These authors contributed equally to this article.

Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of ***,a class of plant hormones,regulate cell division and meristem *** cytokinin signaling pathway is well established in the model plant *** negative feedback mechanisms,tightly controlling cytokinin signaling output,have been described *** this study,we identified a new feedback mechanism executed through alternative splicing of the cytokinin receptor AHK4/CRE1.A novel splicing variant named CRE1int7 results from seventh intron retention,introducing a premature termination codon in the *** showed that CRE1int7 is translated in planta into a truncated receptor lacking the C-terminal receiver domain essential for signal ***1int7 can bind cytokinin but cannot activate the downstream *** present a novel negative feedback mechanism of the cytokinin signaling pathway,facilitated by a decoy receptor that can inactivate canonical cytokinin receptors via dimerization and compete with them for ligand *** proper plant growth and development requires precise control of the cytokinin signaling pathway at several ***1int7 represents a so-far unknown mechanism for fine-tuning the cytokinin signaling pathway in Arabidopsis.

关键词： splicing Arabidopsis decoy

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Celiac disease markers in patients with liver diseases: A single center large scale screening study

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World Journal of Gastroenterology 2012年第43期18卷 6255-6262页

作者： Pavel Drastich eva Honsová Alena Lodererová Marcela Jaresová Aneta Pekáriková Iva Hoffmanová Ludmila Tuková Helena Tlaskalová-Hogenová Julius piák Daniel Sánchez Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Clinical and Transplant Pathology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute of Microbiology Academy of Sciences of the Czech Republic 14220 Prague Czech Republic 2nd Department of Internal Medicine 3rd Faculty of Medicine Charles University 10034 Prague Czech Republic

AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver ***:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.

关键词： Tissue transglutaminase Anti-tissue transglutaminase antibodies Autoimmune liver diseases Wilson's disease Celiac disease Liver transplantation

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Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]

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Photonics Research 2015年第5期3卷 47-59页

作者： Ananth z.Subramanian eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout zeger Hens Gunther Roelkens Roel Baets Photonics Research Group INTEC Department Ghent University-imec Centre for Nano and Biophotonics Ghent University University of California Department of Molecular Biotechnology Ghent University imec Kapeldreef 75 Physics and Chemistry of Nanostructures Ghent University

There is a rapidly growing demand to use silicon and silicon nitride（Si3N4） integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip.

关键词： Invited SOI mode

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Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science Review 2024年第1期11卷 174-184页

作者： Qiaozhi zha Diego Aliaga Radovan Krejci Victoria A.Sinclair Cheng Wu Giancarlo Ciarelli Wiebke Scholz Liine Heikkinen eva Partoll Yvette Gramlich Wei Huang Markus Leiminger Joonas Enroth Otso Per?kyl? Runlong Cai Xuemeng Chen Alkuin Maximilian Koenig Fernando Velarde Isabel Moreno Tuukka Pet?j? Paulo Artaxo Paolo Laj Armin Hansel Samara Carbone Markku Kulmala Marcos Andrade Douglas Worsnop Claudia Mohr Federico Bianchi Institute for Atmospheric and Earth System Research/Physics University of Helsinki Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate Research Stockholm University Department of Chemistry and Molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik GmbH Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental Research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne Research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOMs)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. We performed in situ molecular-level OOMs measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOMs, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOMs are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

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右房复极顺序的研究--应用电解剖标测系统及单相动作电位记录技术

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中国心脏起搏与心电生理杂志 2004年第Z1期18卷 86-87页

作者：李真杨延宗 eva Hertervig Magnus Holm Edgars Grins S Bertil Olsson Shiwen yuan 大连医科大学附属第一医院心脏中心辽宁大连116011 大连医科大学附属第一医院心脏中心辽宁大连116011 瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院

　　目的既往研究表明心房激动以及心房复极的异常在心房颤动的发生和/或维持中起着重要的作用.目前可获得的信息多为心房激动顺序,而对于整体心房复极顺序的研究鲜有报道.本研究应用电解剖标测系统(CARTO)以及单相动作电位记录(MAP)方... 详细信息

　　目的既往研究表明心房激动以及心房复极的异常在心房颤动的发生和/或维持中起着重要的作用.目前可获得的信息多为心房激动顺序,而对于整体心房复极顺序的研究鲜有报道.本研究应用电解剖标测系统(CARTO)以及单相动作电位记录(MAP)方法探求健康猪右房的整体复极活动的规律,以及复极活动与除极活动的关系,以期有助于心房颤动机制的研究.……

关键词：右房复极应用电解剖标测系统单相动作电位心房激动心房颤动活动方法探求信息健康规律

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Prevalence and risk distribution of schistosomiasis among adults in Madagascar:a cross-sectional study

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Infectious Diseases of Poverty 2023年第2期12卷 136-136页

作者： Sarah Katharina Gruninger Tahinamandranto Rasamoelina Rivo Andry Rakotoarivelo Anjarasoa Ravo Razafindrakoto zaraniaina Tahiry Rasolojaona Rodson Morin Rakotozafy Patrick Richard Soloniaina Njary Rakotozandrindrainy Pia Rausche Cheick Oumar Doumbia Anna Jaeger Alexandre zerbo Heidrun von Thien Philipp Klein Govert van Dam Egbert Tannich Norbert Georg Schwarz eva Lorenz Jürgen May Raphael Rakotozandrindrainy Daniela Fusco Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany German Centre for Infection Research (DzIF) Hamburg-Borstel-Lübeck-Riems Germany Centre d’Infectiologie Charles Mérieux (CICM) University of Antananarivo Antananarivo Madagascar Department of Infectious Diseases University of Fianarantsoa Andrainjato Fianarantsoa Madagascar Department of Microbiology and Parasitology University of Antananarivo Antananarivo Madagascar University Clinical Research Centre (UCRC) University of Sciences Technics and Technologies of Bamako (USTTB) Bamako Mali Department of Parasitology Leiden University Medical Centre Leiden The Netherlands National Reference Centre for Tropical Pathogens (NRC) Hamburg Germany Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany Department of Tropical Medicine I University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany

Background The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals,including universal health coverage(UHC).Current control strategies focus on school-aged children,systematically neglecting *** aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of *** In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina,Tsiroanomandidy and Ankazomborona in Madagascar,we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult *** and multivariable logistic regression were performed to evaluate odd *** The highest prevalence of ***,*** and co-infection of both species was 59.5%,61.3%and 3.3%,in Andina and Ankazomborona *** prevalence was observed among males(52.4%)and main contributors to the family income(68.1%).Not working as a farmer and higher age were found to be protective factors for *** Our findings provide evidence that adults are a high-risk group for *** data suggests that,for ensuring basic health as a human right,current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific,holistic and integrated approaches.

关键词： Schistosomiasis Schistosoma haematobium Schistosoma mansoni Universal health coverage Madagascar

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包装材料的生产

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塑料 1991年第6期 52-52页

作者： z

特开平 2-261627本专利介绍通过热封合树脂薄膜层合在一已层合的基材上生产包装材料的方法。此层合片由取向的聚酯树脂薄膜、取向 eva 共聚物树脂薄膜或 PC 组成。此热封合树脂薄膜在低温时比基材有更好的热封合性。通过一个粘合剂涂布... 详细信息

特开平 2-261627本专利介绍通过热封合树脂薄膜层合在一已层合的基材上生产包装材料的方法。此层合片由取向的聚酯树脂薄膜、取向 eva 共聚物树脂薄膜或 PC 组成。此热封合树脂薄膜在低温时比基材有更好的热封合性。通过一个粘合剂涂布于热封合树脂薄膜及层合基材上或其中之一,然后热压两者,粘合剂熔融而层合。此层合片村制成盒状容器可盛装汽油、日本米酒或粉状物。热封合树脂能牢固地附着在基材上,而所用的粘合剂量极少,而且可

关键词：层合热封合基材包装材料树脂

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阵发性心房颤动患者心房不应期的离散度研究

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中国心脏起搏与心电生理杂志 2004年第z1期18卷 93-页

作者：李真杨延宗 eva Hertervig Jonas Carlson Camilla Johansson S Bertil Olsson Shiwen Yuan 大连医科大学附属第一医院心脏中心辽宁大连116011 大连医科大学附属第一医院心脏中心辽宁大连116011 瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院

　　目的研究表明心房颤动(简称房颤)患者心房不应期(AERP)离散度较无房颤患者显著增加,但临床获得多部位心房不应期存在一定难度.单相动作电位记录发现,房颤时心房肌被近乎连续的快速的冲动所激动,基于这一发现,房颤时的颤动间期(AFI)... 详细信息

　　目的研究表明心房颤动(简称房颤)患者心房不应期(AERP)离散度较无房颤患者显著增加,但临床获得多部位心房不应期存在一定难度.单相动作电位记录发现,房颤时心房肌被近乎连续的快速的冲动所激动,基于这一发现,房颤时的颤动间期(AFI)可用来评价AERP.但既往研究中的记录位点的数目、记录长短,所用参数均存在较大差异.本研究采用左、右两房多部位记录,分析多个AFI参数的离散度来评价阵发性房颤患者AERP的离散度.……

关键词：阵发性心房颤动无房颤患者不应期离散度多部位单相动作电位评价近乎连续参数心房肌位点临床

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右房复极离散度的研究--应用电解剖标测系统

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中国心脏起搏与心电生理杂志 2004年第Z1期18卷 86-页

作者：李真杨延宗 eva Hertervig Ole Kongstad Magnus Holm Edgars Grins S Bertil Olsson Shiwen Yuan 大连医科大学附属第一医院心脏中心辽宁大连116011 大连医科大学附属第一医院心脏中心辽宁大连116011 瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院瑞典隆德大学医院

　　目的检测应用电解剖标测系统(CARTO)记录单相动作电位(MAP)以获得全面的右房复极参数的可行性,并进一步探讨复极离散度在阵发性心房颤动(PAF)发生中的作用.……

关键词：右房复极离散度检测应用阵发性心房颤动电解剖标测系统单相动作电位参数

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