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Influence of temperature and pressure during thermoforming of softwood pulp

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Journal of Bioresources and Bioproducts 2023年第4期8卷 408-420页

作者： eva Pasquier Robert Skunde Jost Ruwoldt RISE PFI AS Høgskoleringen 6BTrondheim 7491Norway TU-Berlin Institute for Polymer Technology and Polymer PhysicsErnst Reuter Platz 1Berlin 10587Germany

In this study,the influence of thermoforming conditions on the resulting material properties was investigated,which aimed at developing advanced wood-fiber-based materials for the replacement of fossil *** bleached softwood pulps were studied,i.e.,northern bleached softwood Kraft pulp(NBSK)and chemi-thermomechanical softwood pulp(CTMP).The thermoforming conditions were varied between 2–100 MPa and 150–200℃,while pressing sheets of 500 g/m^(2)for 10 min to represent thin-walled packaging more *** our results showed,the temperature had a more pronounced effect on the CTMP substrates than on the Kraft *** was explained by the greater abundance of lignin and hemicelluloses,while fibrillar dimensions and the fines content may play a role in ***,the CTMP exhibited an optimum in terms of tensile strength at intermediate thermoforming *** effect was attributed to two counteracting effects:1)Improved fiber adhesion due to enhanced densification,and 2)embrittlement caused by the loss of *** temperatures likely softened the lignin,enabling fiber collapse and a tighter *** the Kraft substrates,the tensile strength increased linearly with *** pulps showed reduced wetting at elevated thermoforming temperature and pressure,which was attributed to hornification and densification ***,the effect of temperature was again more pronounced for CTMP than for the Kraft *** was concluded that the thermoforming temperature and pressure strongly affected the properties of the final *** chemical composition of the pulps will distinctly affect their response to thermoforming,which could be useful for tailoring cellulose-based replacements for packaging products.

关键词： Thermoforming Molded pulp Fiber-based materials Softwood pulp CTMP NBSK

New insights in bilirubin metabolism and their clinical implications

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World Journal of Gastroenterology 2013年第38期19卷 6398-6407页

作者： eva Sticova Milan Jirsa Centre for Experimental Medicine Institute for Clinical and Experimental Medicine14021 Prague 4Czech Republic Third Faculty of Medicine Charles University10000 Prague 10Czech Republic

Bilirubin,a major end product of heme breakdown,is an important constituent of bile,responsible for its characteristic *** recent decades,our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates,mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of *** inherited disorders characterised by impaired bilirubin conjugation(Crigler-Najjar syndrome typeⅠand typeⅡ,Gilbert syndrome)or transport(Dubin-Johnson and Rotor syndrome)result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated ***,disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver *** this review,we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor *** data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood,from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and ***1B proteins are also responsible for liver clearance of bilirubin conjugated in splanchnic organs,such as the intestine and kidney,and for a number of endogenous compounds,xenobiotics and *** of one or both OATP1B proteins thus may have serious impact on toxicity of commonly used drugs cleared by this system such as statins,sartans,methotrexate or *** liverblood cycling of conjugated bilirubin is impaired in cholestatic and parenchymal liver diseases and this impairment most likely contributes to jaundice accompanying these disorders.

关键词： Hyperbilirubinemia Hereditary jaundice UGT1A1 ABCC2 Organic anion transporting polypeptide 1B1 Organic anion transporting polypeptide 1B3

Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： eva E.Stefanova Angela L.Scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord ***,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of *** this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to *** the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling *** addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous *** our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural *** that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery ***,we compare the secondary processes between key model species and the influence of purinergic signaling in each *** our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2691-2692页

作者： Cristina Municio eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neurobiology of Alzheimer’s disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain

Lactoferrin is an antimicrobial prote in characterized by the exertion of many protective functions,including antibacterial,antifungal,antiviral,and antiparasitic properties,as well as anti-inflammatory and immunomodulatory activities(Kruzel et al.,2017).Lactoferrin is one of the major proteins present in exocrine secretions,including saliva,and is therefore associated with host defense against oral pathogens and control of the oral *** recent years,it has become clear that alterations in the oral microbiome may contribute to opportunistic pathogen infections in the brains of Alzheimer’s disease(AD)patients and thus participate in or contribute to the development of this neurodegenerative disease(Sureda et al.,2020).Pathogenic oral microbes can affect neurological processes by entering brain tissue through various pathways and directly damaging the central nervous *** the central nervous system,oral microbes may trigger an immune response that increases amyloidβ(Aβ)production and may even trigger the Aβcascade to promote the onset of AD,as we discuss in our previous study supporting the“infectious hypothesis”in AD(González-Sánchez et al.,2020).

关键词： Alzheimer infections protective

Commentary on: “Scientific evidence is just the starting point:A generalizable process for developing sports injury prevention interventions” by Alex Donaldson et al.

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Journal of Sport and Health Science 2016年第3期5卷 322-323页

作者： eva Ageberg Department of Health Sciences Lund University

In a recent paper,Donaldson et al.~1 argued that lower extremity injuries can be ***-based sports injury preventive exercise programs usually have limited impact on public health because they are not widely adopted or... 详细信息

关键词： sports Commentary on sustained exercise extremity starting injuries prevention preventive programs

Comparison of modelled-and remote sensing-derived daily snow line altitudes at Ulugh Muztagh,northern Tibetan Plateau

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Journal of Mountain Science 2016年第4期13卷 593-613页

作者： Marinka SPIESS eva HUINTJES Christoph SCHNEIDER Department of Geography RWTH Aachen UniversityWiillnerstr.5b52066 AachenGermany Humbold University Berlin Unter den Linden 610099 BerlinGermany

The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth data is available. Using the Moderate-resolution Imaging Spectroradiometer(MODIS) Level 1 radiance Swath Data(MOD02QKM) with a spatial resolution of 250 m, transient snow lines during the months of July to September in 2001 to 2014 are derived. Results are used to calibrate the physical based Coupled Snowpack and Ice surface energy and Mass balance model(COSIMA). The model runs on a representative detail region of Ulugh Muztagh(UM) on a digital elevation model with the same spatial resolution as the MODIS bands. In the absence of field observations, the model is driven solely by dynamically downscaled global analysis data from the High Asia Refined analysis(HAR). We compare remote sensing derived and modelled mean regional transient snow line altitudes in the course of consecutive summer seasons in 2008 to 2010. The resulting snow line altitude(SLA) and annual equilibrium line altitude(ELA) proxy of both methods coincide very well in their interannual variability in accordance with interannual variability of climatic conditions. Since SLAs of both methods do notconsistently agree on a daily basis a usage of remote sensing derived SLAs for model calibration in the absence of field observation data is only limitedly feasible for daily analysis. ELA approximation using the highest SLA at the end of ablation period may not be applied to UM because the negative winter mass balance(MB) is not reflected in the summer SLA. The study reveals moderate negative MB for UM throughout the modelling period. The mean regional MB of UM accounts for-523±410 mm w.e. a-1 in the modelling period. Hence UM seems not to belong to the area of the ‘Karakorum anomaly' comprising a region of positive mass balances in recent years which has its centre presumably in the Western Kunlu

关键词： Ulugh Muztagh Imaging spectroradiometer MODIS COSIMA Energy balance Snow line Tibetan Plateau Kunlun Shan

Odor cues rather than personality affect tadpole deposition in a neotropical poison frog

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Current Zoology 2024年第3期70卷 332-342页

作者： Melissa Peignier Max Ringler eva Ringler Division of Behavioural Ecology Institute of Ecology and EvolutionUniversity of BernCH-3032 HinterkappelenSwitzerland Messerli Research Institute University of Veterinary Medicine Vienna1210 ViennaAustria Department of Behavioral and Cognitive Biology University of Vienna1030 ViennaAustria Department of Evolutionary Biology University of Vienna1030 ViennaAustria lnstitute of Electronic Music and Acoustics University of Music and Performing Arts Graz8010 GrazAustria

Animals constantly need to evaluate available external and internal information to make appropriate ***,assessing,and acting on relevant cues in contexts such as mate choice,intra-sexual competition,and parental care is particularly important for optimizing individual reproductive *** factors can infuence decision-making,such as external environmental cues and the animal’s own internal state,yet,we have limited knowledge on how animals integrate available ***,we used an entire island population(57 males,53 females,and 1,109 tadpoles)of the neotropical brilliant-thighed poison frog Allobates femoralis to investigate how 2 factors(olfactory cues and personality traits)infuence the ability of males to fnd and use new resources for tadpole *** experimentally manipulated the location of tadpole deposition sites and their associated olfactory cues,and repeatedly measured exploration and boldness in adult *** further reconstructed tadpole deposition choices via inferred parent–offspring relationships of adult frogs and tadpoles deposited in our experimental pools using molecular parentage *** found that the discovery and use of new rearing sites were heavily infuenced by olfactory cues;however,we did not fnd an effect of the measured behavioral traits on resource discovery and *** conclude that in highly dynamic environments such as tropical rainforests,reliable external cues likely take priority over personality traits,helping individuals to discover and make use of reproductive resources.

关键词： animal personality Anura decision-making parental care tadpole transport

Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

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World Journal of Gastroenterology 2009年第31期15卷 3884-3890页

作者： eva Askar Giuliano Ramadori Sabine Mihm Department of Gastroenterology and Endocrinology University Medical CenterGeorg-August-University

AIM:To analyze the correlation between CD14 rs2569190/C-159T single nucleotide polymorphism (SNP) and disease progression in chronic hepatitis ***: Liver biopsy specimens from a total of 137 and 349 patients with chronic hepatitis C were separately evaluated with respect to necroinflammatory activity (grading) and architectural changes (staging). In one group, further histological lesions characteristic for hepatitis C, hepatitis C virus subtypes, and biochemical parameters of liver disease were also investigated. Samples of genomic DNA were genotyped for the respective SNP by 5'-nuclease assays using fluorescent dye-labeled allele-specif ic ***: Genotype distribution did not deviate from the Hardy-Weinberg equilibrium. In the first group, patients homozygous for the variant allele T were found to be younger than C allele carriers (39.6±12.5 vs 45.7±11.5, P=0.008). Among the histological lesions studied, portal lymphoid aggregates were more frequently observed among TT homozygotes than among C carriers (21/37 vs 32/100, P=0.008). The presence of portal lymphoid aggregates was closely correlated with hepatic inflammation (P=0.003) and with bile duct damage (P<0.001). The degree of fibrosis, in contrast, was not found to be related to the CD14 gene C-159T ***: The data suggest a possible relationship between CD14 C-159T polymorphism and the formation of portal lymphoid aggregates, but not liver fibrosis progression in chronic hepatitis C.

关键词： CD14 Endotoxins Hepatitis C virus Inflammation Lipopolysaccharides Liver fibrosis Portal system Single nucleotide polymorphism

Time for a Nuclear Meeting： Protein Trafficking and Chromatin Dynamics Intersect in the Plant Circadian System

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Molecular Plant 2012年第3期5卷 554-565页

作者： eva Herrero Seth J. Davis Max Planck Institute for Plant Breeding Research Carl-von-Linne＇weg 10 50829 Cologne Germany Present address： MRC National Institute for Medical Research The Ridgeway Mill Hill NW7 1AA London UK

Circadian clocks mediate adaptation to the 24-h world. In Arabidopsis, most circadian-clock components act in the nucleus as transcriptional regulators and generate rhythmic oscillations of transcript accumulation. In this review, we focus on post-transcriptional events that modulate the activity of circadian-clock components, such as phosphorylation, ubiquitination and proteasome-mediated degradation, changes in cellular localization, and protein-protein interactions. These processes have been found to be essential for circadian function, not only in plants, but also in other circadian systems. Moreover, light and clock signaling networks are highly interconnected. In the nucleus, light and clock compo- nents work together to generate transcriptional rhythms, leading to a general control of the timing of plant physiological processes.

关键词： circadian light signaling chromatin cellular dynamics ubiquitin/proteasome-mediated proteolysis