Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium

作     者：Eva Cai Jingyi Zhang Xuecai Ge Eva Cai;Jingyi Zhang;Xuecai Ge

作者机构：Department of Molecular and Cell BiologySchool of Natural SciencesUniversity of CaliforniaMerced CA 95340USA 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第3期

页      面：500-514页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：supported by the National Institutes of Health(CA235749) 

主　　题：Hedgehog signaling protein kinase A(PKA) primary cilium centrosome compartmentalized cell signaling 

摘      要：The Hedgehog(Hh)signaling is one of the essential signaling pathways during embryogenesis and in *** signal transduction relies on primary cilium,a specialized cell surface organelle viewed as the hub of cell *** kinase A(PKA)has been recognized as a potent negative regulator of the Hh pathway,raising the question of how such a ubiquitous kinase specifically regulates one signaling *** reviewed recent genetic,molecular and biochemical studies that have advanced our mechanistic understanding of PKA’s role in Hh signaling in vertebrates,focusing on the compartmentalized PKA at the centrosome and in the primary *** outlined the recently developed genetic and optical tools that can be harvested to study PKA activities during the course of Hh signal transduction.