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Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第2期11卷 184-193页

作者： Benjamin Singh eva m.Zopf Erin J Howden Gallipoli medical Research Foundation Greenslopes Private HospitalGreenslopesQLD 4120Australia mary macKillop Institute for Health Research Australian Catholic UniversityMelbourneVIC 3000Australia Baker Heart and Diabetes Institute MelbourneVIC 3004Australia

Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer ***:CINAHL,Cochrane,Ebscohost,mEDLINE,Pubmed,ProQuest Health and medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer *** mean differences(SmDs)were calculated to assess effects on physical activity and health-related *** analyses were conducted to assess whether the effects differed by interventions and cancer *** of bias was assessed using the Cochrane risk of bias ***:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 *** trials(n=25,71%)involved pedometer-based physical activity ***(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SmD range 0.54-0.87,pmoderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily *** to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SmD range=0.18-0.66,all pmeters are effective tools that increase physical activity and improve health-related outcomes in individuals with *** how these devices can be implemented for longer-term use with other intervention components remains an area for future research.

关键词： Activity tracker Cancer Exercise Physical activity Wearable

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Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling

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Neural Regeneration Research 2022年第6期17卷 1172-1182页

作者： Bart Nieuwenhuis Richard eva John van Geest Center for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK

much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous *** in the central nervous system fail to regenerate,meaning that injuries or diseases that cause loss of axonal connectivity have life-changing *** 2008,genetic deletion of PTEN was identified as a means of stimulating robust regeneration in the optic *** is a phosphatase that opposes the actions of PI3-kinase,a family of enzymes that function to generate the membrane phospholipid PIP_(3) from PIP_(2)(phosphatidylinositol(3,4,5)-trisphosphate from phosphatidylinositol(4,5)-bisphosphate).Deletion of PTEN therefore allows elevated signaling downstream of PI3-kinase,and was initially demonstrated to promote axon regeneration by signaling through *** recently,additional mechanisms have been identified that contribute to the neuron-intrinsic control of regenerative *** review describes neuronal signaling pathways downstream of PI3-kinase and PIP3,and considers them in relation to both developmental and regenerative axon *** briefly discuss the key neuron-intrinsic mechanisms that govern regenerative ability,and describe how these are affected by signaling through *** highlight the recent finding of a developmental decline in the generation of PIP_(3) as a key reason for regenerative failure,and summarize the studies that target an increase in signaling downstream of PI3-kinase to facilitate regeneration in the adult central nervous ***,we discuss obstacles that remain to be overcome in order to generate a robust strategy for repairing the injured central nervous system through manipulation of PI3-kinase signaling.

关键词： axon cytoskeleton axon regeneration axon transport cell signaling central nervous system growth cone neuroprotection PI3-kinase PI3K PTEN trafficking transcription translation

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The USLE soil erodibility nomograph revisited

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International Soil and Water Conservation Research 2023年第1期11卷 1-13页

作者： eva Corral-Pazos-de-Provens ígor Rapp-Arraras Juan m.Domingo-Santos School of Engineering University of HuelvaE-21007 HuelvaSpain

The nomograph by Wischmeier et al.(1971)for calculating the K-factor in the USLE was extremely useful when there was low access to ***,the generalised calculation of this factor requires the development of analytic *** paper presents a detailed analysis of the nomograph and its underlying equation,which is applicable only when the silt plus very find sand fraction does not exceed 70%.We also examined the quality of fit on the nomograph of the adaptations to the equation that have been proposed,as a means of dealing with those areas where the original equation is not *** models are shown to have areas where the fit is deficient or even ***,the family of curves on the nomograph for the various values taken by the organic matter are not coincident with the mathematical function from which they presumably *** study also identifies those areas of the textural triangle in which the soils originally used in developing the USLE are located,with a view to according a lower predictive value to the contrasting areas in which calculations of the K-factor will necessarily be ***,a new equation for calculating the K-factor is presented,which accurately reproduces the different sections of the nomograph,and allows the poorly functioning graph to be dispensed *** paper ends with a link to a tool in R for simplifying the procedure for calculating the K-factor,taking into account varying situations of data availability.

关键词： K-factor RUSLE Soil texture Organic matter Very find sand Soil loss prediction

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Influence of temperature and pressure during thermoforming of softwood pulp

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Journal of Bioresources and Bioproducts 2023年第4期8卷 408-420页

作者： eva Pasquier Robert Skunde Jost Ruwoldt RISE PFI AS Høgskoleringen 6BTrondheim 7491Norway TU-Berlin Institute for Polymer Technology and Polymer PhysicsErnst Reuter Platz 1Berlin 10587Germany

In this study,the influence of thermoforming conditions on the resulting material properties was investigated,which aimed at developing advanced wood-fiber-based materials for the replacement of fossil *** bleached softwood pulps were studied,i.e.,northern bleached softwood Kraft pulp(NBSK)and chemi-thermomechanical softwood pulp(CTmP).The thermoforming conditions were varied between 2–100 mPa and 150–200℃,while pressing sheets of 500 g/m^(2)for 10 min to represent thin-walled packaging more *** our results showed,the temperature had a more pronounced effect on the CTmP substrates than on the Kraft *** was explained by the greater abundance of lignin and hemicelluloses,while fibrillar dimensions and the fines content may play a role in ***,the CTmP exhibited an optimum in terms of tensile strength at intermediate thermoforming *** effect was attributed to two counteracting effects:1)Improved fiber adhesion due to enhanced densification,and 2)embrittlement caused by the loss of *** temperatures likely softened the lignin,enabling fiber collapse and a tighter *** the Kraft substrates,the tensile strength increased linearly with *** pulps showed reduced wetting at elevated thermoforming temperature and pressure,which was attributed to hornification and densification ***,the effect of temperature was again more pronounced for CTmP than for the Kraft *** was concluded that the thermoforming temperature and pressure strongly affected the properties of the final *** chemical composition of the pulps will distinctly affect their response to thermoforming,which could be useful for tailoring cellulose-based replacements for packaging products.

关键词： Thermoforming molded pulp Fiber-based materials Softwood pulp CTmP NBSK

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SutteARImA:A Novel method for Forecasting the Infant mortality Rate in Indonesia

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Computers, materials & Continua 2022年第3期70卷 6007-6022页

作者： Ansari Saleh Ahmar eva Boj del Val m.A.El Safty Samirah AlZahrani Hamed El-Khawaga Business School Faculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of Statistics Faculty of Mathematics and Natural ScienceUniversitas Negeri MakassarMakassar90224Indonesia Department of Economic Financial and Actuarial MathematicsFaculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of mathematics and Statistics Colleage of SciencesTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Statistics Mathematicsand InsuranceFaculty of CommerceTanta UniversityEgypt Department of Economics and Finance College of Business AdministrationTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

This study focuses on the novel forecasting method(SutteARImA)and its application in predicting Infant mortality Rate data in *** undertakes a comparison of the most popular andwidely used four forecasting methods:ARImA,Neural Networks Time Series(NNAR),Holt-Winters,and *** data used were obtained from the website of the World *** data consisted of the annual infant mortality rate(per 1000 live births)from 1991 to *** determine a suitable and best method for predicting Infantmortality rate,the forecasting results of these four methods were compared based on the mean absolute percentage error(mAPE)and mean squared error(mSE).The results of the study showed that the accuracy level of SutteARImA method(mAPE:0.83%andmSE:0.046)in predicting Infantmortality rate in Indonesia was smaller than the other three forecasting methods,specifically the ARImA(0.2.2)with a mAPE of 1.21%and a mSE of 0.146;the NNAR with a mAPE of 7.95%and a mSE of 3.90;and the Holt-Winters with amAPE of 1.03%and amSE:of 0.083.

关键词： Forecasting infant mortality rate ARImA NNAR holt-winters SutteARImA

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Type 2 diabetes and thyroid cancer:Synergized risk with rising air pollution

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World Journal of Diabetes 2023年第7期14卷 1037-1048页

作者： eva m Kruger Shaimaa A Shehata Eman A Toraih Ahmed A Abdelghany manal S Fawzy School of medicine Tulane UniversityNew OrleansLA 70112United States Department of Forensic medicine and Clinical Toxicology Faculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Division of Endocrine and Oncologic Surgery Department of SurgerySchool of MedicineTulane UniversityNew OrleansLA 70112United States Genetics Unit Department of Histology and Cell BiologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Ophthalmology Faculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of medical Biochemistry and molecular Biology Faculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Biochemistry Faculty of MedicineNorthern Border UniversityArar 1321Saudi Arabia

Diabetes is a complex condition,and the causes are still not fully ***,a growing body of evidence suggests that exposure to air pollution could be linked to an increased risk of ***,exposure to certain pollutants,such as particulate matter and Ozone,has been associated with higher rates of *** the same time,air pollution has also been linked to an increased risk of thyroid *** there is less evidence linking air pollution to thyroid cancer than to diabetes,it is clear that air pollution could have severe implications for thyroid *** pollution could increase the risk of diabetes and thyroid cancer through several *** example,air pollution could increase inflammation in the body,which is linked to an increased risk of diabetes and thyroid *** pollution could also increase oxidative stress,which is linked to an increased risk of diabetes and thyroid ***,air pollution could increase the risk of diabetes and thyroid cancer by affecting the endocrine *** review explores the link between diabetes and air pollution on thyroid *** will discuss the evidence for an association between air pollution exposure and diabetes and thyroid cancer,as well as the potential implications of air pollution for thyroid *** the connections between diabetes,air pollution,and thyroid cancer,it is essential to take preventive measures to reduce the risk of developing the condition.

关键词： Air pollution Diabetes mellitus Health risk Thyroid cancer Thyroid disorders

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Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas m.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez maria Szczepanska Loai A.Eid Hazem S.Awad muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca m.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant m.mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative medicine(ECRRm) Cairo 11511Egypt medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

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A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3221-3224页

作者： Josémanuel García-Heredia marco Pérez eva m.Verdugo-Sivianes maría m.martínez-Ballesteros Sara m.Ortega-Campos Amancio Carnero Instituto de Biomedicina de Sevilla(IBIS)/HUVR/Universidad de Sevilla/CSIC SevillaSpain Departamento de Bioquímica Vegetal y Biología molecular Universidad de SevillaSevillaSpain CIBERONC IS Carlos IIIMadridSpain Departamento de Anatomía Patológica HUVRSevillaSpain Departamento de Lenguajes y Sistemas Informáticos Escuela Superior de Ingeniería InformáticaUniversidad de SevillaSevillaSpain

Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20%of *** treatment for sarcomas is surgical resection,and only some patients are treated with ch... 详细信息

关键词： neoplasms chemotherapy treatment

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Thermoelastic damping in mEmS gyroscopes at high frequencies

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microsystems & Nanoengineering 2023年第1期9卷 137-148页

作者： Daniel Schiwietz eva m.Weig Peter Degenfeld-Schonburg Robert Bosch GmbH Corporate Research71272RenningenGermany Department of Electrical&Computer Engineering Technical University of Munich85748GarchingGermany munich Center for Quantum Science and Technology(mCQST) 80799MunichGermany TUm Center for Quantum Engineering(ZQE) 85748GarchingGermany

microelectromechanical systems(mEmS)gyroscopes are widely used,e.g.,in modern automotive and consumer applications,and require signal stability and accuracy in rather harsh environmental *** many use cases,device reliability must be guaranteed under large external loads at high *** sensitivity of the sensor to such external loads depends strongly on the damping,or rather quality factor,of the high-frequency mechanical modes of the *** this paper,we investigate the influence of thermoelastic damping on several high-frequency modes by comparing finite element simulations with measurements of the quality factor in an application-relevant temperature *** measure the quality factors over different temperatures in vacuum,to extract the relevant thermoelastic material parameters of the polycrystalline mEmS *** simulation results show a good agreement with the measured quantities,therefore proving the applicability of our method for predictive purposes in the mEmS design ***,we are able to uniquely identify the thermoelastic effects and show their significance for the damping of the high-frequency modes of an industrial mEmS *** approach is generic and therefore easily applicable to any mechanical structure with many possible applications in nano-and micromechanical systems.

关键词： uniquely generic quantities

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mINImIZING EXCITATION LIGHT LEAKAGE AND mAXImIZING mEASUREmENT SENSITIVITY FOR mOLECULAR ImAGING WITH NEAR-INFRARED FLUORESCENCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 301-307页

作者： BANGHE ZHU eva m.SEVICK-mURACA Center for molecular Imaging The Brown Foundation Institute of molecular medicine The University of Texas Health Science Center at Houston Houston TX 77030USA

Near-infraredfluorescence(NIRF)imaging involves the separation of weakfluorescence signals from backscattered excitation *** measurement sensitivity of current NIRF imaging systems is limited by the excitation light leakage through *** this contribution,the authors demonstrate that the excitation light leakage can be suppressed upon using appropriatefilter combination and *** excitation light leakage and measurement sensitivity were assessed and compared in this study by computing the transmission ratios of excitation to emission light collected and the signal-to-noise ratios in well-controlled phantom studies with differentfilter combinations and *** appropriatefilter combinations and permutations,we observe as much as two orders of magnitude reduction in the transmission ratio and higher signal-to-noise ratio.

关键词： molecular imaging fluorescence opticalfilter excitation light leakage noise floor

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