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Linking axon transport to regeneration using in vitro laser axotomy

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Neural Regeneration Research 2018年第3期13卷 410-412页

作者： Bart Nieuwenhuis Richard eva John van Geest Centre for Brain Repair Department of Clinical Neurosciences University of Cambridge Cambridge UK Laboratory for Regeneration of Sensorimotor Systems Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences (KNAW) Amsterdam The Netherlands

Spinal cord injury has devastating consequences because adult central nervous system （CNS） neurons do not regenerate their axons after injury. Two key reasons for axon regeneration fail- ure are extrinsic inhibitory factors and a low intrinsic capacity for axon regrowth. Research has therefore focused on overcom- ing extrinsic growth inhibition, and enhancing intrinsic regeneration capacity. Both of these issues will need to be addressed to enable optimal repair of the injured sp＋inal cord.

关键词： CNS ARF Linking axon transport to regeneration using in vitro laser axotomy EFA

Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium

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Science China(Life Sciences) 2022年第3期65卷 500-514页

作者： eva Cai Jingyi Zhang Xuecai Ge Department of Molecular and Cell Biology School of Natural SciencesUniversity of CaliforniaMerced CA 95340USA

The Hedgehog(Hh)signaling is one of the essential signaling pathways during embryogenesis and in *** signal transduction relies on primary cilium,a specialized cell surface organelle viewed as the hub of cell *** kinase A(PKA)has been recognized as a potent negative regulator of the Hh pathway,raising the question of how such a ubiquitous kinase specifically regulates one signaling *** reviewed recent genetic,molecular and biochemical studies that have advanced our mechanistic understanding of PKA’s role in Hh signaling in vertebrates,focusing on the compartmentalized PKA at the centrosome and in the primary *** outlined the recently developed genetic and optical tools that can be harvested to study PKA activities during the course of Hh signal transduction.

关键词： Hedgehog signaling protein kinase A(PKA) primary cilium centrosome compartmentalized cell signaling

Influence of temperature and pressure during thermoforming of softwood pulp

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Journal of Bioresources and Bioproducts 2023年第4期8卷 408-420页

作者： eva Pasquier Robert Skunde Jost Ruwoldt RISE PFI AS Høgskoleringen 6BTrondheim 7491Norway TU-Berlin Institute for Polymer Technology and Polymer PhysicsErnst Reuter Platz 1Berlin 10587Germany

In this study,the influence of thermoforming conditions on the resulting material properties was investigated,which aimed at developing advanced wood-fiber-based materials for the replacement of fossil *** bleached softwood pulps were studied,i.e.,northern bleached softwood Kraft pulp(NBSK)and chemi-thermomechanical softwood pulp(CTMP).The thermoforming conditions were varied between 2–100 MPa and 150–200℃,while pressing sheets of 500 g/m^(2)for 10 min to represent thin-walled packaging more *** our results showed,the temperature had a more pronounced effect on the CTMP substrates than on the Kraft *** was explained by the greater abundance of lignin and hemicelluloses,while fibrillar dimensions and the fines content may play a role in ***,the CTMP exhibited an optimum in terms of tensile strength at intermediate thermoforming *** effect was attributed to two counteracting effects:1)Improved fiber adhesion due to enhanced densification,and 2)embrittlement caused by the loss of *** temperatures likely softened the lignin,enabling fiber collapse and a tighter *** the Kraft substrates,the tensile strength increased linearly with *** pulps showed reduced wetting at elevated thermoforming temperature and pressure,which was attributed to hornification and densification ***,the effect of temperature was again more pronounced for CTMP than for the Kraft *** was concluded that the thermoforming temperature and pressure strongly affected the properties of the final *** chemical composition of the pulps will distinctly affect their response to thermoforming,which could be useful for tailoring cellulose-based replacements for packaging products.

关键词： Thermoforming Molded pulp Fiber-based materials Softwood pulp CTMP NBSK

Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： eva E.Stefanova Angela L.Scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord ***,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of *** this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to *** the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling *** addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous *** our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural *** that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery ***,we compare the secondary processes between key model species and the influence of purinergic signaling in each *** our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

New insights in bilirubin metabolism and their clinical implications

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World Journal of Gastroenterology 2013年第38期19卷 6398-6407页

作者： eva Sticova Milan Jirsa Centre for Experimental Medicine Institute for Clinical and Experimental Medicine14021 Prague 4Czech Republic Third Faculty of Medicine Charles University10000 Prague 10Czech Republic

Bilirubin,a major end product of heme breakdown,is an important constituent of bile,responsible for its characteristic *** recent decades,our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates,mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of *** inherited disorders characterised by impaired bilirubin conjugation(Crigler-Najjar syndrome typeⅠand typeⅡ,Gilbert syndrome)or transport(Dubin-Johnson and Rotor syndrome)result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated ***,disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver *** this review,we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor *** data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood,from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and ***1B proteins are also responsible for liver clearance of bilirubin conjugated in splanchnic organs,such as the intestine and kidney,and for a number of endogenous compounds,xenobiotics and *** of one or both OATP1B proteins thus may have serious impact on toxicity of commonly used drugs cleared by this system such as statins,sartans,methotrexate or *** liverblood cycling of conjugated bilirubin is impaired in cholestatic and parenchymal liver diseases and this impairment most likely contributes to jaundice accompanying these disorders.

关键词： Hyperbilirubinemia Hereditary jaundice UGT1A1 ABCC2 Organic anion transporting polypeptide 1B1 Organic anion transporting polypeptide 1B3

Commentary on: “Scientific evidence is just the starting point:A generalizable process for developing sports injury prevention interventions” by Alex Donaldson et al.

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Journal of Sport and Health Science 2016年第3期5卷 322-323页

作者： eva Ageberg Department of Health Sciences Lund University

In a recent paper,Donaldson et al.~1 argued that lower extremity injuries can be ***-based sports injury preventive exercise programs usually have limited impact on public health because they are not widely adopted or... 详细信息

关键词： sports Commentary on sustained exercise extremity starting injuries prevention preventive programs

Comparison of modelled-and remote sensing-derived daily snow line altitudes at Ulugh Muztagh,northern Tibetan Plateau

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Journal of Mountain Science 2016年第4期13卷 593-613页

作者： Marinka SPIESS eva HUINTJES Christoph SCHNEIDER Department of Geography RWTH Aachen UniversityWiillnerstr.5b52066 AachenGermany Humbold University Berlin Unter den Linden 610099 BerlinGermany

The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth data is available. Using the Moderate-resolution Imaging Spectroradiometer(MODIS) Level 1 radiance Swath Data(MOD02QKM) with a spatial resolution of 250 m, transient snow lines during the months of July to September in 2001 to 2014 are derived. Results are used to calibrate the physical based Coupled Snowpack and Ice surface energy and Mass balance model(COSIMA). The model runs on a representative detail region of Ulugh Muztagh(UM) on a digital elevation model with the same spatial resolution as the MODIS bands. In the absence of field observations, the model is driven solely by dynamically downscaled global analysis data from the High Asia Refined analysis(HAR). We compare remote sensing derived and modelled mean regional transient snow line altitudes in the course of consecutive summer seasons in 2008 to 2010. The resulting snow line altitude(SLA) and annual equilibrium line altitude(ELA) proxy of both methods coincide very well in their interannual variability in accordance with interannual variability of climatic conditions. Since SLAs of both methods do notconsistently agree on a daily basis a usage of remote sensing derived SLAs for model calibration in the absence of field observation data is only limitedly feasible for daily analysis. ELA approximation using the highest SLA at the end of ablation period may not be applied to UM because the negative winter mass balance(MB) is not reflected in the summer SLA. The study reveals moderate negative MB for UM throughout the modelling period. The mean regional MB of UM accounts for-523±410 mm w.e. a-1 in the modelling period. Hence UM seems not to belong to the area of the ‘Karakorum anomaly' comprising a region of positive mass balances in recent years which has its centre presumably in the Western Kunlu

关键词： Ulugh Muztagh Imaging spectroradiometer MODIS COSIMA Energy balance Snow line Tibetan Plateau Kunlun Shan

Secondary protective control for mitigation of protection misoperations in electric power systems

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Journal of Modern Power Systems and Clean Energy 2016年第3期4卷 427-439页

作者： N.eva WU Qiu QIN Department of Electrical and Computer Engineering Binghamton UniversityBinghamtonNY 13902USA

This paper investigates the feasibility of a selective secondary protective control strategy proposed to maximize the likelihood of recovery from misoperations of the existing(primary) protection in a power system. A scalable stochastic discrete-state model is established, taking into consideration of the processes of protection misoperations and their mitigations. Such misoperations have been a main culprit of cascading failures in modern power systems. The likelihood of recovery from protection misoperations is quantified by a set of security indices that formally incorporate the uncertain knowledge of the continuous-state of rotor angles/speed deviations of synchronous generators and that of the discretestate of equipment faults and primary protection misoperations. The proposed secondary protection leverages on the ever more available time-synchronized samples of networked sensors for diagnosis and fault-tolerant control to cost effectively improving power system reliability without altering the existing protection system. The technology readiness for implementing the secondary protective control is examined through a three-area test system.

关键词： Availability and security Fault-tolerance Fault-coverage and fault-diagnosis Hybrid modeling and

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero JoséMarco-Contelles eva Ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling