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Genetic characterization of Northeast Asian cattle based on sequence polymorphisms in the complete mitochondrial genome

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Open Journal of Animal Sciences 2012年第4期2卷 217-223页

作者： Jeongsoo Lee Kyung-Tai Lee Sungmin Ahn Seunghwan Lee Dajeong Lim Young-Ju Kim eun-seok cho Kyung-seok Kim Hailu Dadi Tae-Hun Kim Animal Genomics and Bioinformatics Division National Institute of Animal Science Suwon Korea Animal Genomics and Bioinformatics Division National Institute of Animal Science Suwon Korea College of Veterinary Medicine Seoul National University Seoul Korea Department of Animal Science Chungbuk National University Cheongju Korea Lee Gil Ya Cancer and Diabetes Institute Gachon University of Medicine and Science Incheon Korea nimal Genomics and Bioinformatics Division National Institute of Animal Science Suwon Korea

In this study, we analyzed complete mtDNA sequences variation and genetic relationship among taurine, indicine and Bison groups. In total, 107 sequences from different breeds, 45 European (45 Italian), 16 Middle East Asian (seven Iranian and nine Iraqi), 41 Northeast Asian (34 Korean and seven Japanese), two Nellore (Bos indicus) and two American Bison bison (Ame. bison) were obtained from Gen-Bank database. One Korean Hanwoo (Bos taurus) sequence was generated using the SOLiDTM System. In total, 1370 polymorphic sites, representing 8.39% of the complete 107 mtDNA sequences (16,338 bp) were detected and of these, 1186 parsimony informative polymorphic sites were identified. Neighbor-joining tree indicated that Korean, Japanese, Iranian, Iraqi, and Italian cattle were closely related to one another, but are separated from B. Bison. The B. taurus mtDNA polymorphism was greater in the D-loop than in the other regions. The ATP8, ND3, ND5, and ND6 regions were also quite parsimony informative, similar to Cyt b. In addition, this study revealed a distinct genetic difference between Korean cattle and B. indicus.

关键词： Bos taurus Complete Mitochondrial DNA Genome Phylogeny Polymorphism

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Conceptual Design for a Kerosene Fuel-rich Gas-generator of a Turbopump-fed Liquid Rocket Engine

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Journal of Thermal Science 2012年第5期21卷 428-434页

作者： Min Son Jaye Koo Won Kook cho eun seok Lee Graduate Student Korea Aerospace UniversityGoyang Republic of Korea School of Aerospace and Mechanical Engineering Korea Aerospace UniversityGoyang Republic of Korea Korea Aerospace Research Institute Daejeon Republic of Korea

A design method for a kerosene fuel-rich gas-generator of a liquid rocket engine using turbopumps to supply propellant was performed at a conceptual level. The gas-generator creates hot gases, enabling the turbine to operate the turbopumps. A chemical non-equilibrium analysis and a droplet vaporization model were used for the estimation of the burnt gas properties and characteristic chamber length. A premixed counter-flow flame analysis was performed for the prediction of the burnt gas properties, namely the temperature, the specific heat ratio and heat capacity, and the chemical reaction time. To predict the vaporization time, the Spalding model, using a single droplet in convective condition, was used. The minimum residence time in the chamber and the characteristic length were calculated by adding the reaction time and the vaporization time. Using the characteristic length, the design methods for the fuel-rich gas-generator were established. Finally, a parametric study was achieved for the effects of the O/F ratio, mass flow rate, chamber pressure, initial droplet temperature, initial droplet diameter and initial droplet velocity.

关键词： Liquid rocket engine Conceptual design Fuel-rich gas-generator Sensitivity analysis

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SANDWICH-TYPE THEOREMS FOR MEROMORPHIC MULTIVALENT FUNCTIONS ASSOCIATED WITH THE LIU-SRIVASTAVA OPERATOR

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Acta Mathematica Scientia 2012年第3期32卷 929-941页

作者： Nak eun cho Department of Applied Mathematics Pukyong National UniversityBusan 608-737Korea

The purpose of this article is to obtain some subordination and superordi- nation preserving properties of meromorphic multivalent functions in the punctured open unit disk associated with the Liu-Srivastava operator.... 详细信息

关键词： Subordination superordination meromorphic multivalent function Liu- Srivastava operator sandwich-type result

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Subordination and Superordination Properties for a Class of Integral Operators

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Acta Mathematica Sinica,English Series 2010年第3期26卷 515-522页

作者： Nak eun cho Teodor BULBOACA Department of Applied Mathematics Pukyong National University Faculty of Mathematics and Computer Science Babes-Bolyai University

In the present paper, we obtain some subordination- and superordinatiompreserving properties of certain integral operators defined on the space of normalized analytic functions in the open unit disk. The sandwich-type... 详细信息

关键词： differential subordination differential superordination univalent functions convex functions integral operators

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Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung choi eun-Jeong Won Emmanuel Hui Ho-Shik Kim Young-seok cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

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Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2015年第7期21卷 2030-2039页

作者： Young-Sun Nam Nayoun Kim Keon-Il Im Jung-Yeon Lim eun-Sol Lee seok-Goo cho Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematology Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

AIM:To investigate the effects of mesenchymal stem cells(MSCs)on dextran sulfate sodium-induced inflammatory bowel disease(IBD).METHODS:C57BL/6 mice were fed 3.5%(g/L)dextran sulfate *** day seven,the mice received intraperitoneal injections of 1×106 *** survival rate,disease activity index values,and body weight,were monitored *** day ten,colon lengths and histopathologic changes were *** addition,immunoregulatory changes following MSC administration were evaluated by determining the levels of effector T cell responses in the spleen and mesenteric lymph nodes,and the expression levels of inflammatory cytokines in homogenized ***:Intraperitoneal administration of MSCs did not prevent development of colitis and did not reduce the clinicopathologic severity of *** significant difference was evident in either survival rate or disease activity index score between the control and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either colon length or histopathologic ***,the MSC-treated group exhibited elevated levels of interleukin(IL)-6 and transforming growth factor-β,and a reduced level of IL-10,in spleens,mesenteric lymph nodes,and homogenized *** IL-17 level was lower in the mesenteric lymph nodes of the MSC-treated group(P=0.0126).In homogenized colons,the IL-17 and tumor necrosis factor-α(P=0.0092)expression levels were also lower in the treated ***:MSC infusion provided no significanthistopathologic or clinical improvement,thus representing a limited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sulfate sodium Inflammator

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Fekete-Szego problem for close-to-convex functions with respect to a certain convex function dependent on a real parameter

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Frontiers of Mathematics in China 2016年第6期11卷 1471-1500页

作者： Nak eun cho Bogumila KOWALCZYK Adam LECKO Department of Applied Mathematics Pukyong National University Busan 608-737 Korea Department of Complex Analysis University of Warmia and Mazury ul. S}oneczna 54 10-710 Olsztyn Poland

Given α∈[0, 1], let hα（z）：= z/（1 - αz）, z ∈ D ：= {z ∈ C：｜z｜〈 1}. An analytic standardly normalized function f in D is called close-to-convex with respect to hα if there exists δ ∈ （-π/2, π/2） such that Re{e^iδ zf′（z）/hα（z）} 〉 0, z ∈ D. For the class l（hα） of all close-to-convex functions with respect to hα, the Fekete-Szego problem is studied.

关键词： Fekete-Szego problem close-to-convex functions close-to-convex functions with argument δ close-to-convex functions with respect to a convex function functions of bounded turning

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Colonic lipoma covered by hyperplastic epithelium: Case report

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World Journal of Clinical Cases 2013年第3期1卷 124-127页

作者： Ju-Ok Yeom Sun-Young Kim eun-Chul Jang Ji-Youn Yu eun Deok Chang Young-seok cho Division of Gastroenterology Department of Internal MedicineUijeongbu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea Departement of Cilinical Pathology Uijeong-bu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea

Colonic lipomas are submucosal nonepithelial tumors covered by intact or eroded mucosa. In rare cases, alterations in the mucosa covering a lipoma include hyperplasia, adenoma, atrophy, ulceration, and necrosis. Here, we report a case of a colonic lipoma covered by hyperplastic epithelium in a 68-year-old woman. Based on the colonoscopy findings, a snare polypectomy was performed for a presumptive diagnosis of an epithelial lesion; however, the histological examination revealed a colonic submucosal lipoma with overlying hyperplastic epithelium.

关键词： Lipoma Colonic lipomas Hyperplastic Colonoscopy

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Trifluoroethylation of Alkynes： Synthesis of Allylic-CF3 Compounds by Visible-Light Photocatalysis

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Chinese Journal of Chemistry 2016年第5期34卷 459-464页

作者： Geum-bee Roh Naeem Iqbal eun Jin cho Department of Chemistry Chung-Ang University 84 Heukseok-ro Dong/ak-gu Seou106974 Republic of Korea Department of Applied Chemistry Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea

Two types of allylic trifluoromethylated compounds were synthesized by reacting alkynes with CF3CH2I using visible-light photocatalysis. Subtle differences in the catalytic system controlled the selectivity of iodotrifluoroethy- lation and hydrotrifluoroethylation. The iodotrifluoroethylated products were obtained in the presence of [Ru（bpy）3]C12 and TMEDA in CH3CN under visible-light irradiation, whereas hydrotrifluoroethylated products were synthesized usingfac-[Ir（ppy）3] and a mixture of DBU and K2CO3 in DMF. The iodotrifluoroethylation reac- tion worked particularly well, even at gram-scale, and the synthetic utility of iodotrifluoroethylated products was proved by their coupling reactions, providing complex CF3-containing products.

关键词： trifluoroethylation alkyne visible-light photocatalysis

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Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

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Chinese Journal of Natural Medicines 2020年第10期18卷 793-800页

作者： LEE Se-eun OKHLOPKOVA Zhanna LIM Chiyeon cho Suin School of Korean Medicine Pusan National UniversityYangsan-si 50612Republic of Korea Department of Biology North-Eastern Federal UniversityYakutsk 677027Russia College of Medicine Dongguk UniversityGyeonggi-do 10326Republic of Korea

Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia;however,research on this plant is currently ***,although studies have been conducted on the constituents of this plant and their antioxidant effects,data on its various pharmacological activities are still ***,this study examined the anticancer potential of the dried leaves of *** S.(DpL)using human prostate cancer PC-3 *** antioxidant potential of DpL was evaluated by estimating the total flavonoid and total phenolic content(TFC and TPC,respectively).Additionally,we investigated the effects of the DpL ethyl acetate fraction(DpLE)on cell proliferation,intracellular reactive oxygen species(ROS)generation,apoptosis,and cell cycle arrest in this cell *** expression levels of superoxide dismutase(SOD)-1,SOD-2,B-cell lymphoma 2(Bcl-2)and Bcl-2 associated X(Bax)ratio,phospho-protein kinase B(p-AKT),cleaved caspase-8,poly adenosine diphosphate(ADP)ribose polymerase(PARP),and cleaved-PARP were evaluated by western *** results indicated that DpLE causes apoptosis and exerts intracellular ROS-independent anticancer effects on prostate cancer cells,associated with increased SOD-2,cleaved caspase-8,and cleaved-PARP expression and inhibited p-AKT ***,DpLE may be a potential resource for the development of promising chemotherapeutic agents for prostate cancer.

关键词： Dracocephalum palmatum Stephan Prostate cancer Apoptosis Caspase-8

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