Trifluoroethylation of Alkynes： Synthesis of Allylic-CF3 Compounds by Visible-Light Photocatalysis
Trifluoroethylation of Alkynes： Synthesis of Allylic-CF3 Compounds by Visible-Light Photocatalysis作者机构：Department of Chemistry Chung-Ang University 84 Heukseok-ro Dong/ak-gu Seou106974 Republic of Korea Department of Applied Chemistry Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2016年第34卷第5期
页 面：459-464页
核心收录：
学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the Chung-Ang University Research Scholarship Grants in 2015 National Research Foundation of Korea
主 题：trifluoroethylation alkyne visible-light photocatalysis
摘 要：Two types of allylic trifluoromethylated compounds were synthesized by reacting alkynes with CF3CH2I using visible-light photocatalysis. Subtle differences in the catalytic system controlled the selectivity of iodotrifluoroethy- lation and hydrotrifluoroethylation. The iodotrifluoroethylated products were obtained in the presence of [Ru（bpy）3]C12 and TMEDA in CH3CN under visible-light irradiation, whereas hydrotrifluoroethylated products were synthesized usingfac-[Ir（ppy）3] and a mixture of DBU and K2CO3 in DMF. The iodotrifluoroethylation reac- tion worked particularly well, even at gram-scale, and the synthetic utility of iodotrifluoroethylated products was proved by their coupling reactions, providing complex CF3-containing products.
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