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Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee jeong Hyun Yoon Young-Woong Song Kang Hee cho Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

Trifluoroethylation of Alkynes： Synthesis of Allylic-CF3 Compounds by Visible-Light Photocatalysis

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Chinese Journal of Chemistry 2016年第5期34卷 459-464页

作者： Geum-bee Roh Naeem Iqbal eun Jin cho Department of Chemistry Chung-Ang University 84 Heukseok-ro Dong/ak-gu Seou106974 Republic of Korea Department of Applied Chemistry Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea

Two types of allylic trifluoromethylated compounds were synthesized by reacting alkynes with CF3CH2I using visible-light photocatalysis. Subtle differences in the catalytic system controlled the selectivity of iodotrifluoroethy- lation and hydrotrifluoroethylation. The iodotrifluoroethylated products were obtained in the presence of [Ru（bpy）3]C12 and TMEDA in CH3CN under visible-light irradiation, whereas hydrotrifluoroethylated products were synthesized usingfac-[Ir（ppy）3] and a mixture of DBU and K2CO3 in DMF. The iodotrifluoroethylation reac- tion worked particularly well, even at gram-scale, and the synthetic utility of iodotrifluoroethylated products was proved by their coupling reactions, providing complex CF3-containing products.

关键词： trifluoroethylation alkyne visible-light photocatalysis

Association of chronic viral hepatitis B with insulin resistance

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World Journal of Gastroenterology 2012年第42期18卷 6120-6126页

作者： jeong Gyu Lee Sangyeoup Lee Yun Jin Kim Byung Mann cho Joo Sung Park Hyung Hoi Kim JaeHun Cheong Dong Wook jeong Yu Hyun Lee Young Hye cho Mi Jin Bae eun Jung choi Department of Family Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Medical Education Unit Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Family Medicine Clinic Yangsan Pusan National University HospitalBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Dong-A University Medical CenterBusan 602-715South Korea Department of Laboratory Medicine Biomedical Informatics UnitPusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 602-739South Korea

AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean ***:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this *** diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were ***,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all *** model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin *** participant was categorized into a negative,recovery,or CVHB *** compare variables between groups,a t-test and/or one-way analysis of variance were *** correlation coefficients were computed to present the association between insulin resistance and other *** logistic regression analysis was used to assess the independent association between CVHB and ***:The mean age of men and women were 48.9 and 48.6 years,*** in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P cholesterol(r = 0.134,P < 0.00

关键词：胰岛素抵抗病毒性肝炎慢性 Logistic回归分析协会胰岛素敏感性单向方差分析表面抗原

Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

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Chinese Journal of Natural Medicines 2020年第10期18卷 793-800页

作者： LEE Se-eun OKHLOPKOVA Zhanna LIM Chiyeon cho Suin School of Korean Medicine Pusan National UniversityYangsan-si 50612Republic of Korea Department of Biology North-Eastern Federal UniversityYakutsk 677027Russia College of Medicine Dongguk UniversityGyeonggi-do 10326Republic of Korea

Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia;however,research on this plant is currently ***,although studies have been conducted on the constituents of this plant and their antioxidant effects,data on its various pharmacological activities are still ***,this study examined the anticancer potential of the dried leaves of *** S.(DpL)using human prostate cancer PC-3 *** antioxidant potential of DpL was evaluated by estimating the total flavonoid and total phenolic content(TFC and TPC,respectively).Additionally,we investigated the effects of the DpL ethyl acetate fraction(DpLE)on cell proliferation,intracellular reactive oxygen species(ROS)generation,apoptosis,and cell cycle arrest in this cell *** expression levels of superoxide dismutase(SOD)-1,SOD-2,B-cell lymphoma 2(Bcl-2)and Bcl-2 associated X(Bax)ratio,phospho-protein kinase B(p-AKT),cleaved caspase-8,poly adenosine diphosphate(ADP)ribose polymerase(PARP),and cleaved-PARP were evaluated by western *** results indicated that DpLE causes apoptosis and exerts intracellular ROS-independent anticancer effects on prostate cancer cells,associated with increased SOD-2,cleaved caspase-8,and cleaved-PARP expression and inhibited p-AKT ***,DpLE may be a potential resource for the development of promising chemotherapeutic agents for prostate cancer.

关键词： Dracocephalum palmatum Stephan Prostate cancer Apoptosis Caspase-8

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

All-in-one glycol chitosan nanoparticles for co-delivery of doxorubicin and anti-PD-L1 peptide in cancer immunotherapy

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Bioactive Materials 2023年第10期28卷 358-375页

作者： Sukyung Song Man Kyu Shim Suah Yang Jaewan Lee Wan Su Yun Hanhee cho Yujeong Moon Jin Young Min eun Hee Han Hong Yeol Yoon Kwangmeyung Kim College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul03760Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Bioengineering Korea UniversitySeoul02841Republic of Korea Research Center for Bioconvergence Analysis Korea Basic Science Institute(KBSI)Cheongju28119Republic of Korea Department of Toxicology College of PharmacyChungnam National UniversityDaejeon34134Republic of Korea

Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates and undesirable outcomes to these combination therapies owing to the recycling mechanism of programmed death-ligand 1 (PD-L1) and the systemic toxicity of ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) and doxorubicin (DOX) to targeted tumor tissues for a safe and more effective synergistic immunotherapy. The PP-CNPs, which are prepared by conjugating ᴅ-form PP (NYSKPTDRQYHF) to CNPs, form stable nanoparticles that promote multivalent binding with PD-L1 proteins on the targeted tumor cell surface, resulting in effective lysosomal PD-L1 degradation in contrast with anti-PD-L1 antibody, which induces recycling of endocytosed PD-L1. Consequently, PP-CNPs prevent subcellular PD-L1 recycling and eventually destruct immune escape mechanism in CT26 colon tumor-bearing mice. Moreover, the ICD inducer, DOX is loaded into PP-CNPs (DOX-PP-CNPs) for synergistic ICD and ICB therapy, inducing a large number of damage-associated molecular patterns (DAMPs) in targeted tumor tissues with minimal toxicity in normal tissues. When the DOX-PP-CNPs are intravenously injected into CT26 colon tumor-bearing mice, PP and DOX are efficiently delivered to the tumor tissues via nanoparticle-derived passive and active targeting, which eventually induce both lysosomal PD-L1 degradation and substantial ICD, resulting in a high rate of complete tumor regression (CR: 60%) by a strong antitumor immune response. Collectively, this study demonstrates the superior efficacy of synergistic immunotherapy using all-in-one nanoparticles to deliver PP and DOX to targeted tumor tissues.

关键词： Chitosan nanoparticle Synergistic immunotherapy Immune checkpoint blockade Multivalent binding Immunogenic cell death

Impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第47期29卷 6122-6137页

作者： Ji eun Han Hyo Jung cho Jae Youn Cheong Sun Gyo Lim Min Jae Yang choong-Kyun Noh Gil Ho Lee Soon Sun Kim Department of Gastroenterology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance *** improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical *** hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B *** To assess guideline adherence in South Korean patients with stage B HCC and study its impact on *** A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer *** with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary *** among the groups was compared using the Kaplan-Meier method and the log-rank *** of survival outcomes were identified using multivariable Cox regression *** In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study per

关键词： Hepatocellular carcinoma Barcelona clinic liver cancer stage B Guideline adherence Liver neoplasms Transarterial chemoembolization Liver resection

Characteristics and biological control functions of Bacillus ***8313 as a host-associated probiotic in red sea bream(Pagrus major)aquaculture

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Animal Nutrition 2023年第1期12卷 20-31页

作者： Won Je Jang Kyung-Bon Lee Mi-Hyeon Jeon Su-jeong Lee Sang Woo Hur Seunghan Lee Bong-Joo Lee Jong Min Lee Kang-Woong Kim eun-Woo Lee Department of Biotechnology Pukyong National UniversityBusan48513South Korea Department of Biology Education College of Education Chonnam National UniversityGwangju61186South Korea Biopharmaceutical Engineering Major Division of Applied BioengineeringDong-Eui UniversityBusan47340South Korea Aquafeed Research Center National Institute of Fisheries SciencePohang37517South Korea Department of Smart Fisheries Resources College of Industrial SciencesKongju National UniversityYesan32439South Korea

Host-associated probiotics(HAPs)are bacteria originally isolated from rearing water or the host's gastrointestinal tract in order to enhance the host's growth and *** study investigated the HAP potential of Bacillus ***8313,isolated from wild red sea bream(Pagrus major),through characterization and feeding *** based on in vitro tests showed that PM8313 is safe,confirming its hemolytic,cytotoxic,and antibiotic *** addition,PM8313 showed advantages as a probiotic with high viability in the gastrointestinal model and a high cell adhesion ***-genome sequencing demonstrated that PM8313 has a 4,615,871 bp single circular chromosome and a guaninecytosine content of 45.25%.It also showed the absence of genes encoding virulence factors,such as cytotoxin,enterotoxin,hemolysin,sphingomyelinase,and *** the feeding trial,a supplemental diet of 1×10^(8)CFU/g PM8313 positively altered the weight gain,digestive enzyme activity,and intestinal microbiota composition of red sea *** of nonspecific immune parameters and immune-related gene expression,and a challenge test showed that PM8313 supplementation increases immunity and pathogenic bacteria *** findings suggest that PM8313 should be considered for application as a novel HAP to red sea bream aquaculture.

关键词： Host-associated probiotics Immunity Microbiota Probiotics Red sea bream

Change in subfoveal choroidal thickness after argon laser panretinal photocoagulation

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 505-509页

作者： Ga eun cho Hee Yun cho Yun Taek Kim Department of Ophthalmology Ewha Womans University School of Medicine Department of Ophthalmology Hanyang University School of Medicine

AIMTo evaluate changes in subfoveal choroidal thickness (SFCT) and macular thickness as measured by enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) after argon laser panretinal photocoagu... 详细信息

关键词： choroidal thickness diabetic retinopathy EDI-OCT macular edema panretinal photocoagulation